GB202112937D0 - Production of hepatocytes - Google Patents

Production of hepatocytes

Info

Publication number
GB202112937D0
GB202112937D0 GBGB2112937.4A GB202112937A GB202112937D0 GB 202112937 D0 GB202112937 D0 GB 202112937D0 GB 202112937 A GB202112937 A GB 202112937A GB 202112937 D0 GB202112937 D0 GB 202112937D0
Authority
GB
United Kingdom
Prior art keywords
hepatocytes
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB2112937.4A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cambridge Enterprise Ltd
Original Assignee
Cambridge Enterprise Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Enterprise Ltd filed Critical Cambridge Enterprise Ltd
Priority to GBGB2112937.4A priority Critical patent/GB202112937D0/en
Publication of GB202112937D0 publication Critical patent/GB202112937D0/en
Priority to PCT/EP2022/075292 priority patent/WO2023036983A1/en
Priority to CA3230650A priority patent/CA3230650A1/en
Priority to IL311233A priority patent/IL311233A/en
Priority to CN202280061355.4A priority patent/CN117999342A/en
Priority to AU2022342368A priority patent/AU2022342368A1/en
Priority to KR1020247009489A priority patent/KR20240056530A/en
Priority to EP22786310.7A priority patent/EP4399277A1/en
Priority to JP2024514685A priority patent/JP2024531593A/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5067—Liver cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Physiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
GBGB2112937.4A 2021-09-10 2021-09-10 Production of hepatocytes Ceased GB202112937D0 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
GBGB2112937.4A GB202112937D0 (en) 2021-09-10 2021-09-10 Production of hepatocytes
PCT/EP2022/075292 WO2023036983A1 (en) 2021-09-10 2022-09-12 Production of hepatocytes
CA3230650A CA3230650A1 (en) 2021-09-10 2022-09-12 Production of hepatocytes
IL311233A IL311233A (en) 2021-09-10 2022-09-12 Production of hepatocytes
CN202280061355.4A CN117999342A (en) 2021-09-10 2022-09-12 Production of hepatocytes
AU2022342368A AU2022342368A1 (en) 2021-09-10 2022-09-12 Production of hepatocytes
KR1020247009489A KR20240056530A (en) 2021-09-10 2022-09-12 production of liver cells
EP22786310.7A EP4399277A1 (en) 2021-09-10 2022-09-12 Production of hepatocytes
JP2024514685A JP2024531593A (en) 2021-09-10 2022-09-12 Preparation of hepatocytes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB2112937.4A GB202112937D0 (en) 2021-09-10 2021-09-10 Production of hepatocytes

Publications (1)

Publication Number Publication Date
GB202112937D0 true GB202112937D0 (en) 2021-10-27

Family

ID=78149432

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB2112937.4A Ceased GB202112937D0 (en) 2021-09-10 2021-09-10 Production of hepatocytes

Country Status (9)

Country Link
EP (1) EP4399277A1 (en)
JP (1) JP2024531593A (en)
KR (1) KR20240056530A (en)
CN (1) CN117999342A (en)
AU (1) AU2022342368A1 (en)
CA (1) CA3230650A1 (en)
GB (1) GB202112937D0 (en)
IL (1) IL311233A (en)
WO (1) WO2023036983A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8481317B2 (en) * 2010-04-13 2013-07-09 Cellular Dynamics International, Inc. Hepatocyte production by forward programming
WO2015164228A1 (en) * 2014-04-21 2015-10-29 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
GB201619876D0 (en) 2016-11-24 2017-01-11 Cambridge Entpr Ltd Controllable transcription
US20220127580A1 (en) * 2019-02-26 2022-04-28 Peking University Compositions and methods for reprograming non-hepatocyte cells into hepatocyte cells

Also Published As

Publication number Publication date
WO2023036983A1 (en) 2023-03-16
CN117999342A (en) 2024-05-07
IL311233A (en) 2024-05-01
EP4399277A1 (en) 2024-07-17
JP2024531593A (en) 2024-08-29
CA3230650A1 (en) 2023-03-16
AU2022342368A1 (en) 2024-03-28
KR20240056530A (en) 2024-04-30

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)