ES2089213T3 - Una linea celular permanente de hepatocitos humanos y su uso en un dispositivo de asistencia hepatica. - Google Patents

Una linea celular permanente de hepatocitos humanos y su uso en un dispositivo de asistencia hepatica.

Info

Publication number
ES2089213T3
ES2089213T3 ES91909110T ES91909110T ES2089213T3 ES 2089213 T3 ES2089213 T3 ES 2089213T3 ES 91909110 T ES91909110 T ES 91909110T ES 91909110 T ES91909110 T ES 91909110T ES 2089213 T3 ES2089213 T3 ES 2089213T3
Authority
ES
Spain
Prior art keywords
hepatic
hepatocitos
human
cell line
assistance device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91909110T
Other languages
English (en)
Inventor
James H Kelly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Original Assignee
Baylor College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College of Medicine filed Critical Baylor College of Medicine
Application granted granted Critical
Publication of ES2089213T3 publication Critical patent/ES2089213T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Transplantation (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

SE DISPONEN LINEAS DE CELULA PERMANENTES QUE MUESTRAN ACTIVIDAD BIOLOGICA ESPECIFICA DE HIGADO A UN NIVEL EFICAZ PARA AYUDAR A UN SUJETO QUE SUFRE DE FALLO O INSUFICIENCIA HEPATICA. LAS CELULAS SON UTILES EN EL TRATAMIENTO DE VARIOS TRASTORNOS HEPATICOS. ASIMISMO SE MUESTRAN METODOS PARA EL USO DE LA CELULAS EN DISPOSITIVOS DE ASISTENCIA A HEPATICA Y METODOS PARA PRODUCIR DISPOSITIVOS DE ASISTENCIA HEPATICA.
ES91909110T 1990-05-16 1991-05-07 Una linea celular permanente de hepatocitos humanos y su uso en un dispositivo de asistencia hepatica. Expired - Lifetime ES2089213T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52407590A 1990-05-16 1990-05-16

Publications (1)

Publication Number Publication Date
ES2089213T3 true ES2089213T3 (es) 1996-10-01

Family

ID=24087663

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91909110T Expired - Lifetime ES2089213T3 (es) 1990-05-16 1991-05-07 Una linea celular permanente de hepatocitos humanos y su uso en un dispositivo de asistencia hepatica.

Country Status (9)

Country Link
US (1) US5290684A (es)
EP (1) EP0532522B1 (es)
JP (1) JP3117994B2 (es)
AT (1) ATE136582T1 (es)
AU (1) AU646045B2 (es)
CA (1) CA2081782C (es)
DE (1) DE69118690T2 (es)
ES (1) ES2089213T3 (es)
WO (1) WO1991018087A1 (es)

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US5876956A (en) * 1995-05-15 1999-03-02 Johns Hopkins University School Of Medicine Methods for identification or purification of cells containing an enzymatic intracellular marker
ATE297702T1 (de) * 1995-10-26 2005-07-15 Paul P Latta Induktion von immunologischer toleranz
US5869243A (en) * 1996-03-05 1999-02-09 Rhode Island Hospital Immortalized hepatocytes
US5827729A (en) * 1996-04-23 1998-10-27 Advanced Tissue Sciences Diffusion gradient bioreactor and extracorporeal liver device using a three-dimensional liver tissue
US5837733A (en) * 1997-02-26 1998-11-17 Wisconsin Alumni Research Foundation Method for reducing secetion of apolipoprotein B in animals by administering conjugated linoleic acid
US5955353A (en) * 1997-05-22 1999-09-21 Excorp Medical, Inc. Hollow fiber bioreactor with an extrafilament flow plug
US6653105B2 (en) * 1998-02-11 2003-11-25 Vitagen, Inc. Clonal cells and cell lines derived from C3A cells and methods of making and using them
EP1063289A1 (en) * 1998-03-03 2000-12-27 JMS Co., Ltd. Liver cell clones for artifical liver and extracorporeal liver assist device
ATE373079T1 (de) 1999-06-21 2007-09-15 Gen Hospital Corp Zellkultursysteme und verfahren für einrichtungen zur organunterstützung
AU2001242738A1 (en) * 2000-03-22 2001-10-03 Katsutoshi Naruse Novel artificial organ system
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AU2001293074A1 (en) * 2000-09-25 2002-04-08 Walter Reed Army Institute Of Research Human liver cell line
US7781186B2 (en) * 2000-09-25 2010-08-24 The United States Of America As Represented By The Secretary Of The Army Screening methods using normal human liver cell line
US20070037277A1 (en) * 2001-04-25 2007-02-15 Michael Shuler Pharmacokinetic-based culture system with biological barriers
JP4260627B2 (ja) * 2001-04-25 2009-04-30 コーネル リサーチ ファンデイション インコーポレイテッド 薬物動態学に基づく細胞培養システムのためのデバイスおよび方法
US20070048727A1 (en) * 2001-04-25 2007-03-01 Michael Shuler Biliary barrier
WO2003060061A1 (en) * 2001-12-21 2003-07-24 Organogenesis Inc. Chamber with adjustable volume for cell culture and organ assist
WO2003080649A2 (en) * 2002-03-20 2003-10-02 Regents Of The University Of Minnesota Induction of hepatocyte proliferation in vitro by inhibition of cell cycle inhibitors
WO2004027378A2 (en) * 2002-09-20 2004-04-01 Promega Corporation Luminescence-based methods and probes for measuring cytochrome p450 activity
WO2005074657A2 (en) * 2004-02-02 2005-08-18 The General Hospital Corporation Modified organ support devices
AU2005240515B2 (en) * 2004-04-27 2010-09-23 Vital Therapies, Inc. Metabolic detoxification system and method
US7674456B2 (en) * 2004-06-14 2010-03-09 Charles Wiseman Breast cancer cell lines and uses thereof
EP1781776A2 (en) * 2004-07-29 2007-05-09 Stem Cell Innovations, Inc. Differentiation of stem cells
WO2006122147A2 (en) * 2005-05-10 2006-11-16 Rutgers, The State University Of New Jersey Alginate poly-l-lysine encapsulation as a technology for controlled differentiation of embryonic stem cells
EP2272972A1 (en) 2005-05-31 2011-01-12 Promega Corporation Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
DE102006005526B4 (de) 2006-02-07 2007-10-25 Universität Rostock Verwendung von humanen Hepatozyten zur Ermittlung der Leberfunktion und Leberregeneration
US20080064088A1 (en) * 2006-09-08 2008-03-13 Michael Shuler Devices and methods for pharmacokinetic-based cell culture system
PT2578081E (pt) 2006-10-11 2016-06-17 Massachusetts Inst Technology Composições, métodos e dispositivos para o tratamento de doenças hepáticas
ITTO20060937A1 (it) * 2006-12-29 2008-06-30 Medestea Biotech S R L Linee cellulari immortali differenziate atte a produrre albumina e fattori di crescita, procedimenti per la loro preparazione da una linea cellulare leucemica e loro usi.
US20120177610A1 (en) 2007-09-19 2012-07-12 Kieu Hoang Manufacturing and Purification Processes of Complex Protein found in Fraction IV to make a separated Apo, Transferrin , and Alpha 1 Anti strepsin (A1AT) or A combined Transferrin / Apo/Human Albumin/A1AT and all new found proteins
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
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US9725687B2 (en) 2011-12-09 2017-08-08 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
US9599604B2 (en) * 2011-12-09 2017-03-21 University Of Florida Research Foundation, Incorporated Flow chambers, methods of using the flow chamber, and methods of making the flow chamber
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US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
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Also Published As

Publication number Publication date
AU7791891A (en) 1991-12-10
CA2081782C (en) 2004-08-24
AU646045B2 (en) 1994-02-03
EP0532522B1 (en) 1996-04-10
EP0532522A4 (en) 1993-06-30
JPH05508312A (ja) 1993-11-25
EP0532522A1 (en) 1993-03-24
US5290684A (en) 1994-03-01
WO1991018087A1 (en) 1991-11-28
DE69118690T2 (de) 1997-01-09
JP3117994B2 (ja) 2000-12-18
DE69118690D1 (de) 1996-05-15
ATE136582T1 (de) 1996-04-15
CA2081782A1 (en) 1991-11-17

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