DE69118690D1 - Eine permanente menschliche hepatogene zellinie und seine verwendung in der unterstützung der leberfunktion - Google Patents

Eine permanente menschliche hepatogene zellinie und seine verwendung in der unterstützung der leberfunktion

Info

Publication number
DE69118690D1
DE69118690D1 DE69118690T DE69118690T DE69118690D1 DE 69118690 D1 DE69118690 D1 DE 69118690D1 DE 69118690 T DE69118690 T DE 69118690T DE 69118690 T DE69118690 T DE 69118690T DE 69118690 D1 DE69118690 D1 DE 69118690D1
Authority
DE
Germany
Prior art keywords
hepatogenic
cell line
liver function
liver
permanent human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69118690T
Other languages
English (en)
Other versions
DE69118690T2 (de
Inventor
James Kelly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Original Assignee
Baylor College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College of Medicine filed Critical Baylor College of Medicine
Application granted granted Critical
Publication of DE69118690D1 publication Critical patent/DE69118690D1/de
Publication of DE69118690T2 publication Critical patent/DE69118690T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69118690T 1990-05-16 1991-05-07 Eine permanente menschliche hepatogene zellinie und seine verwendung in der unterstützung der leberfunktion Expired - Lifetime DE69118690T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52407590A 1990-05-16 1990-05-16
PCT/US1991/002939 WO1991018087A1 (en) 1990-05-16 1991-05-07 A permanent human hepatocyte cell line and its use in a liver assist device (lad)

Publications (2)

Publication Number Publication Date
DE69118690D1 true DE69118690D1 (de) 1996-05-15
DE69118690T2 DE69118690T2 (de) 1997-01-09

Family

ID=24087663

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69118690T Expired - Lifetime DE69118690T2 (de) 1990-05-16 1991-05-07 Eine permanente menschliche hepatogene zellinie und seine verwendung in der unterstützung der leberfunktion

Country Status (9)

Country Link
US (1) US5290684A (de)
EP (1) EP0532522B1 (de)
JP (1) JP3117994B2 (de)
AT (1) ATE136582T1 (de)
AU (1) AU646045B2 (de)
CA (1) CA2081782C (de)
DE (1) DE69118690T2 (de)
ES (1) ES2089213T3 (de)
WO (1) WO1991018087A1 (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866420A (en) * 1993-10-08 1999-02-02 The United States Of America As Represented By The Secretary Of Agriculture Artificial liver device
CA2146735C (en) * 1994-04-11 2007-02-20 Chise Tateno Liver parenchymal cells having clonal growth ability, method for obtaining same, method for subculturing same, and subculturing system of primary hepatocytes
US5876956A (en) * 1995-05-15 1999-03-02 Johns Hopkins University School Of Medicine Methods for identification or purification of cells containing an enzymatic intracellular marker
ATE297702T1 (de) * 1995-10-26 2005-07-15 Paul P Latta Induktion von immunologischer toleranz
US5869243A (en) * 1996-03-05 1999-02-09 Rhode Island Hospital Immortalized hepatocytes
US5827729A (en) * 1996-04-23 1998-10-27 Advanced Tissue Sciences Diffusion gradient bioreactor and extracorporeal liver device using a three-dimensional liver tissue
US5837733A (en) * 1997-02-26 1998-11-17 Wisconsin Alumni Research Foundation Method for reducing secetion of apolipoprotein B in animals by administering conjugated linoleic acid
US5955353A (en) * 1997-05-22 1999-09-21 Excorp Medical, Inc. Hollow fiber bioreactor with an extrafilament flow plug
US6653105B2 (en) 1998-02-11 2003-11-25 Vitagen, Inc. Clonal cells and cell lines derived from C3A cells and methods of making and using them
EP1063289A1 (de) * 1998-03-03 2000-12-27 JMS Co., Ltd. Leberzellklonen für künstliche Leber und extrakorporale Leberunterstützungsvorrichtung
ATE373079T1 (de) 1999-06-21 2007-09-15 Gen Hospital Corp Zellkultursysteme und verfahren für einrichtungen zur organunterstützung
AU2001242738A1 (en) * 2000-03-22 2001-10-03 Katsutoshi Naruse Novel artificial organ system
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
AU2001293074A1 (en) * 2000-09-25 2002-04-08 Walter Reed Army Institute Of Research Human liver cell line
US7781186B2 (en) * 2000-09-25 2010-08-24 The United States Of America As Represented By The Secretary Of The Army Screening methods using normal human liver cell line
EP1392814B1 (de) * 2001-04-25 2007-06-13 Cornell Research Foundation, Inc. Anlagen und verfahren für zellkulturen auf pharmacokinetischer basis
US20070037277A1 (en) * 2001-04-25 2007-02-15 Michael Shuler Pharmacokinetic-based culture system with biological barriers
US20070048727A1 (en) * 2001-04-25 2007-03-01 Michael Shuler Biliary barrier
WO2003060061A1 (en) * 2001-12-21 2003-07-24 Organogenesis Inc. Chamber with adjustable volume for cell culture and organ assist
WO2003080649A2 (en) * 2002-03-20 2003-10-02 Regents Of The University Of Minnesota Induction of hepatocyte proliferation in vitro by inhibition of cell cycle inhibitors
ATE513838T1 (de) 2002-09-20 2011-07-15 Promega Corp Auf lumineszenz basierende verfahren und sonden zur messung der cytochrom-p450-aktivität
WO2005074657A2 (en) * 2004-02-02 2005-08-18 The General Hospital Corporation Modified organ support devices
CN101005871A (zh) 2004-04-27 2007-07-25 生命治疗有限公司 代谢性解毒系统和方法
US7674456B2 (en) * 2004-06-14 2010-03-09 Charles Wiseman Breast cancer cell lines and uses thereof
EP1781776A2 (de) * 2004-07-29 2007-05-09 Stem Cell Innovations, Inc. Differenzierung von stammzellen
US8435787B2 (en) * 2005-05-10 2013-05-07 Rutgers, The State University Of New Jersey Alginate polyelectrolyte encapsulation of embryonic stem cells
EP2778234B1 (de) * 2005-05-31 2017-09-27 Promega Corporation Luminogene und fluorogene verbindungen und verfahren für den nachweis von molekülen oder leiden
DE102006005526B4 (de) 2006-02-07 2007-10-25 Universität Rostock Verwendung von humanen Hepatozyten zur Ermittlung der Leberfunktion und Leberregeneration
US20080064088A1 (en) * 2006-09-08 2008-03-13 Michael Shuler Devices and methods for pharmacokinetic-based cell culture system
PL2578081T3 (pl) * 2006-10-11 2016-09-30 Kompozycje, sposoby i urządzenia do leczenia chorób wątroby
ITTO20060937A1 (it) * 2006-12-29 2008-06-30 Medestea Biotech S R L Linee cellulari immortali differenziate atte a produrre albumina e fattori di crescita, procedimenti per la loro preparazione da una linea cellulare leucemica e loro usi.
US20120177610A1 (en) 2007-09-19 2012-07-12 Kieu Hoang Manufacturing and Purification Processes of Complex Protein found in Fraction IV to make a separated Apo, Transferrin , and Alpha 1 Anti strepsin (A1AT) or A combined Transferrin / Apo/Human Albumin/A1AT and all new found proteins
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
CN102124096B (zh) 2008-07-16 2014-10-22 儿童医疗中心有限公司 具有微通道的器官模仿装置及其使用和制造方法
US8288559B2 (en) * 2008-08-18 2012-10-16 Promega Corporation Luminogenic compounds and methods to detect cytochrome P450 3A enzymes
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
EP2334234A4 (de) 2008-09-19 2013-03-20 Tandem Diabetes Care Inc Vorrichtung zur messung der konzentration eines gelösten stoffs und entsprechende verfahren
EP2932994B1 (de) 2009-07-30 2017-11-08 Tandem Diabetes Care, Inc. Neue o-ringdichtung und ausgabevorrichtung sowie tragbare infusionspumpe dazu
JP6122388B2 (ja) 2011-02-28 2017-04-26 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 細胞培養システム
US9599604B2 (en) * 2011-12-09 2017-03-21 University Of Florida Research Foundation, Incorporated Flow chambers, methods of using the flow chamber, and methods of making the flow chamber
US9725687B2 (en) 2011-12-09 2017-08-08 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
TW201335181A (zh) * 2012-01-31 2013-09-01 Kieu Hoang ５５種新發現的蛋白質之序列及其應用
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
CN103087989A (zh) 2013-02-01 2013-05-08 湖南省肿瘤医院 一种人肝癌细胞系hlcz01及其应用
EP2958992A1 (de) 2013-02-22 2015-12-30 Cellular Dynamics International, Inc. Hepatozytenproduktion über vorwärtsprogrammierung durch kombination aus gentechnik und chemotechnik
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US10081609B2 (en) 2013-03-15 2018-09-25 The Broad Institute, Inc. Compounds for inducing proliferation and differentiation of cells, and methods of use thereof
US9603995B2 (en) 2013-03-15 2017-03-28 Tandem Diabetes Care. Inc. Device and method for setting therapeutic parameters for an infusion device
WO2015013332A1 (en) 2013-07-22 2015-01-29 President And Fellows Of Harvard College Microfluidic cartridge assembly
CA2934662C (en) 2013-12-20 2024-02-20 President And Fellows Of Harvard College Low shear microfluidic devices and methods of use and manufacturing thereof
US9790537B2 (en) 2014-01-29 2017-10-17 Promega Corporation Quinone-masked probes as labeling reagents for cell uptake measurements
WO2015164228A1 (en) 2014-04-21 2015-10-29 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
GB2546424A (en) 2014-07-14 2017-07-19 Harvard College Systems and methods for improved performance of fluidic and microfluidic systems
US10202569B2 (en) 2015-07-24 2019-02-12 President And Fellows Of Harvard College Radial microfluidic devices and methods of use
JP6800987B2 (ja) 2015-10-19 2020-12-16 フジフィルム セルラー ダイナミクス，インコーポレイテッド ウイルス受容性多能性幹細胞（ｐｓｃ）由来肝細胞の生産
EP3397753B1 (de) 2015-12-30 2021-10-27 FUJIFILM Cellular Dynamics, Inc. Bildung von mikrogewebe mit stammzellen aus menschlichen hepatozyten
US12104174B2 (en) 2016-09-13 2024-10-01 President And Fellows Of Harvard College Methods relating to intestinal organ-on-a-chip
WO2018053143A1 (en) * 2016-09-14 2018-03-22 Vital Therapies, Inc. Composition and method for inducing anti-apoptosis, survival, or proliferation of a cell
US20190350192A1 (en) * 2016-10-28 2019-11-21 Vital Therapies, Inc. Use of conditioned media from extracorporeal blood detoxifying system to supplement organ perfusion solutions
US20210162125A1 (en) * 2018-02-28 2021-06-03 Pop Test Oncology Llc Medical Devices and Uses Thereof
JP7556502B2 (ja) 2019-05-09 2024-09-26 フジフィルム セルラー ダイナミクス，インコーポレイテッド ヘパトサイトの作製方法
US20230383261A1 (en) 2020-10-14 2023-11-30 Sana Biotechnology, Inc. Hepatocyte-like cells
MX2023013186A (es) 2021-05-07 2023-12-06 Astellas Inst For Regenerative Medicine Metodos de generacion de hepatocitos maduros.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3935066A (en) * 1969-07-03 1976-01-27 Burroughs Wellcome Co. Cell lines
US4393133A (en) * 1980-06-12 1983-07-12 The Wistar Institute Of Anatomy And Biology Human hepatoma derived cell line, process for preparation thereof, and uses therefor
US4416986A (en) * 1981-01-16 1983-11-22 Merck & Co., Inc. Methods of producing HBsAg
US4853324A (en) * 1985-12-02 1989-08-01 Viles Joseph M Liver assist device employing transformed cell lines
WO1991015573A1 (en) * 1990-04-03 1991-10-17 Southwest Foundation For Biomedical Research An immortalized primate hepatocyte cell line

Also Published As

Publication number Publication date
AU7791891A (en) 1991-12-10
EP0532522B1 (de) 1996-04-10
ATE136582T1 (de) 1996-04-15
CA2081782C (en) 2004-08-24
EP0532522A4 (en) 1993-06-30
AU646045B2 (en) 1994-02-03
EP0532522A1 (de) 1993-03-24
WO1991018087A1 (en) 1991-11-28
CA2081782A1 (en) 1991-11-17
DE69118690T2 (de) 1997-01-09
JP3117994B2 (ja) 2000-12-18
ES2089213T3 (es) 1996-10-01
US5290684A (en) 1994-03-01
JPH05508312A (ja) 1993-11-25

Similar Documents

Publication Publication Date Title
ATE136582T1 (de) Eine permanente menschliche hepatogene zellinie und seine verwendung in der unterstützung der leberfunktion
NO872786D0 (no) Fremgangsmaate for rengjoering av roersystem i badeanlegg og anordning for gjennomfoering av fremgangsmaaten.
NO177862C (no) Flytende sammensetning innbefattende vann, overflateaktivt middel og opplöst overflateaktivt middel-desolubiliserende elektrolytt
DK0457950T3 (da) Anvendelse af stearidonsyre til behandling af inflammatorisk betingede sygdomme
FI873714A0 (fi) Byggnadspanel med skiktkonstruktion och foerfarande foer dess framstaellning.
DE69123178D1 (de) Verwendung von Uridin zur pharmakologischen Behandlung der peripheren Komplikationen bei Diabetes
IT7868418A0 (it) Sopporto per deodoranti da applicare ai vasi di gabinetti e simili
DK728688A (da) Middel til nedsaettelse af blodcholesterolniveauet
IT7823069A0 (it) Procedimento e dispositivo per la filtrazione discontinua di sospensioni.
NO882596L (no) Fremgangsmaate og anordning for vippet innretting av flytende krystaller med forbedret fotostabilitet.
NO783269L (no) Apparat for frembringelse av akustiske signaler i vann
BE863125A (fr) Elements pour supporter et renforcer des ensembles vitres etanches
IT7925034A0 (it) Bagno di elettroplaccatura erelativo procedimento di elettroplaccatura.
DK55990D0 (da) Faste baerematerialer til anvendelse i biosystemer
DK631989D0 (da) Anti-plakmiddel og/eller middel til behandling af lidelser i mundhulen
FI873231A (fi) Anordning foer bearbetning av aendor i roerformiga delar.
IT8248546A0 (it) Bagno e procedimento per la elettro deposizione di rutenio
RO75679A (ro) Procedeu si instalatie pentru tratarea materialelor in vrac
KR840007379U (ko) 변기 및 세면유니트의 횡방향분기관 지지장치
NO924720D0 (no) Fremgangsmaate for fremstilling av flytende krystall-celler
NO924808L (no) Fremgangsmaate for fremstilling av flytende krystallceller
FI822761A0 (fi) Foerfarande och anordning foer justering av karmar i ljusoeppningar
IT9000507U1 (it) Elemento scatolare portante da utilizzare per il supporto di lavabi e di altri accessori di arredamento per bagno.
Keefe Flood Frequency Analysis Concerns in the Atlantic Region
DK663787A (da) Fremgangsmaade til tilbageholdelse og bevarelse af aktiviteten af mikroorganismer

Legal Events

Date Code Title Description
8364 No opposition during term of opposition