DE69118690T2 - Eine permanente menschliche hepatogene zellinie und seine verwendung in der unterstützung der leberfunktion - Google Patents

Eine permanente menschliche hepatogene zellinie und seine verwendung in der unterstützung der leberfunktion

Info

Publication number
DE69118690T2
DE69118690T2 DE69118690T DE69118690T DE69118690T2 DE 69118690 T2 DE69118690 T2 DE 69118690T2 DE 69118690 T DE69118690 T DE 69118690T DE 69118690 T DE69118690 T DE 69118690T DE 69118690 T2 DE69118690 T2 DE 69118690T2
Authority
DE
Germany
Prior art keywords
hepatogenic
cell line
liver function
liver
permanent human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69118690T
Other languages
English (en)
Other versions
DE69118690D1 (de
Inventor
James Kelly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Original Assignee
Baylor College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College of Medicine filed Critical Baylor College of Medicine
Application granted granted Critical
Publication of DE69118690D1 publication Critical patent/DE69118690D1/de
Publication of DE69118690T2 publication Critical patent/DE69118690T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
DE69118690T 1990-05-16 1991-05-07 Eine permanente menschliche hepatogene zellinie und seine verwendung in der unterstützung der leberfunktion Expired - Lifetime DE69118690T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52407590A 1990-05-16 1990-05-16
PCT/US1991/002939 WO1991018087A1 (en) 1990-05-16 1991-05-07 A permanent human hepatocyte cell line and its use in a liver assist device (lad)

Publications (2)

Publication Number Publication Date
DE69118690D1 DE69118690D1 (de) 1996-05-15
DE69118690T2 true DE69118690T2 (de) 1997-01-09

Family

ID=24087663

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69118690T Expired - Lifetime DE69118690T2 (de) 1990-05-16 1991-05-07 Eine permanente menschliche hepatogene zellinie und seine verwendung in der unterstützung der leberfunktion

Country Status (9)

Country Link
US (1) US5290684A (de)
EP (1) EP0532522B1 (de)
JP (1) JP3117994B2 (de)
AT (1) ATE136582T1 (de)
AU (1) AU646045B2 (de)
CA (1) CA2081782C (de)
DE (1) DE69118690T2 (de)
ES (1) ES2089213T3 (de)
WO (1) WO1991018087A1 (de)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866420A (en) * 1993-10-08 1999-02-02 The United States Of America As Represented By The Secretary Of Agriculture Artificial liver device
CA2146735C (en) * 1994-04-11 2007-02-20 Chise Tateno Liver parenchymal cells having clonal growth ability, method for obtaining same, method for subculturing same, and subculturing system of primary hepatocytes
US5876956A (en) * 1995-05-15 1999-03-02 Johns Hopkins University School Of Medicine Methods for identification or purification of cells containing an enzymatic intracellular marker
ATE297702T1 (de) * 1995-10-26 2005-07-15 Paul P Latta Induktion von immunologischer toleranz
US5869243A (en) * 1996-03-05 1999-02-09 Rhode Island Hospital Immortalized hepatocytes
US5827729A (en) * 1996-04-23 1998-10-27 Advanced Tissue Sciences Diffusion gradient bioreactor and extracorporeal liver device using a three-dimensional liver tissue
US5837733A (en) * 1997-02-26 1998-11-17 Wisconsin Alumni Research Foundation Method for reducing secetion of apolipoprotein B in animals by administering conjugated linoleic acid
US5955353A (en) * 1997-05-22 1999-09-21 Excorp Medical, Inc. Hollow fiber bioreactor with an extrafilament flow plug
US6653105B2 (en) 1998-02-11 2003-11-25 Vitagen, Inc. Clonal cells and cell lines derived from C3A cells and methods of making and using them
EP1063289A1 (de) * 1998-03-03 2000-12-27 JMS Co., Ltd. Leberzellklonen für künstliche Leber und extrakorporale Leberunterstützungsvorrichtung
WO2000078932A1 (en) 1999-06-21 2000-12-28 The General Hospital Corporation Cell culture systems and methods for organ assist devices
WO2001070302A1 (fr) * 2000-03-22 2001-09-27 Katsutoshi Naruse Nouveau systeme d'organe artificiel
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
WO2002026942A2 (en) * 2000-09-25 2002-04-04 Walter Reed Army Institute Of Research Human liver cell line
US7781186B2 (en) * 2000-09-25 2010-08-24 The United States Of America As Represented By The Secretary Of The Army Screening methods using normal human liver cell line
AU2002359234B2 (en) * 2001-04-25 2007-11-15 Cornell Research Foundation, Inc. Devices and methods for pharmacokinetic-based cell culture system
US20070048727A1 (en) * 2001-04-25 2007-03-01 Michael Shuler Biliary barrier
US20070037277A1 (en) * 2001-04-25 2007-02-15 Michael Shuler Pharmacokinetic-based culture system with biological barriers
JP4355212B2 (ja) * 2001-12-21 2009-10-28 オーガノジェネシス インコーポレーテッド 細胞培養及び臓器補助用の可変容量チャンバ
WO2003080649A2 (en) * 2002-03-20 2003-10-02 Regents Of The University Of Minnesota Induction of hepatocyte proliferation in vitro by inhibition of cell cycle inhibitors
WO2004027378A2 (en) * 2002-09-20 2004-04-01 Promega Corporation Luminescence-based methods and probes for measuring cytochrome p450 activity
WO2005074657A2 (en) * 2004-02-02 2005-08-18 The General Hospital Corporation Modified organ support devices
CA2564859C (en) * 2004-04-27 2013-04-09 Vital Therapies, Inc. Metabolic detoxification system and method
US7674456B2 (en) * 2004-06-14 2010-03-09 Charles Wiseman Breast cancer cell lines and uses thereof
WO2006015209A2 (en) * 2004-07-29 2006-02-09 Stem Cell Innovations, Inc. Differentiation of stem cells
US8435787B2 (en) * 2005-05-10 2013-05-07 Rutgers, The State University Of New Jersey Alginate polyelectrolyte encapsulation of embryonic stem cells
EP2778234B1 (de) * 2005-05-31 2017-09-27 Promega Corporation Luminogene und fluorogene verbindungen und verfahren für den nachweis von molekülen oder leiden
DE102006005526B4 (de) 2006-02-07 2007-10-25 Universität Rostock Verwendung von humanen Hepatozyten zur Ermittlung der Leberfunktion und Leberregeneration
US20080064088A1 (en) * 2006-09-08 2008-03-13 Michael Shuler Devices and methods for pharmacokinetic-based cell culture system
DK2578081T3 (en) 2006-10-11 2016-06-27 Massachusetts Gen Hospital Compositions, methods and devices for the treatment of liver disease
ITTO20060937A1 (it) * 2006-12-29 2008-06-30 Medestea Biotech S R L Linee cellulari immortali differenziate atte a produrre albumina e fattori di crescita, procedimenti per la loro preparazione da una linea cellulare leucemica e loro usi.
US20120177610A1 (en) 2007-09-19 2012-07-12 Kieu Hoang Manufacturing and Purification Processes of Complex Protein found in Fraction IV to make a separated Apo, Transferrin , and Alpha 1 Anti strepsin (A1AT) or A combined Transferrin / Apo/Human Albumin/A1AT and all new found proteins
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
ES2672201T3 (es) 2008-07-16 2018-06-13 Children's Medical Center Corporation Dispositivo de imitación de órganos con microcanales y métodos de uso
WO2010021686A1 (en) * 2008-08-18 2010-02-25 Promega Corporation Luminogenic compounds and methods to detect cytochrome p450 3a enzymes
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
CA2737461A1 (en) 2008-09-19 2010-03-25 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
EP2459251B1 (de) 2009-07-30 2014-03-12 Tandem Diabetes Care, Inc. Infusionspumpensystem mit einwegkartusche mit druckentlüftung und druckfeedback
KR101957923B1 (ko) 2011-02-28 2019-03-14 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 세포 배양 시스템
WO2013086284A1 (en) * 2011-12-09 2013-06-13 University Of Florida Research Foundation, Inc. Flow chambers, methods of using the flow chamber, and methods of making the flow chamber
US9725687B2 (en) 2011-12-09 2017-08-08 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
TW201335181A (zh) * 2012-01-31 2013-09-01 Kieu Hoang ５５種新發現的蛋白質之序列及其應用
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
CN103087989A (zh) 2013-02-01 2013-05-08 湖南省肿瘤医院 一种人肝癌细胞系hlcz01及其应用
US20140242595A1 (en) 2013-02-22 2014-08-28 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US10081609B2 (en) 2013-03-15 2018-09-25 The Broad Institute, Inc. Compounds for inducing proliferation and differentiation of cells, and methods of use thereof
US9603995B2 (en) 2013-03-15 2017-03-28 Tandem Diabetes Care. Inc. Device and method for setting therapeutic parameters for an infusion device
WO2015013332A1 (en) 2013-07-22 2015-01-29 President And Fellows Of Harvard College Microfluidic cartridge assembly
US11119093B2 (en) 2013-12-20 2021-09-14 President And Fellows Of Harvard College Low shear microfluidic devices and methods of use and manufacturing thereof
WO2015116867A1 (en) 2014-01-29 2015-08-06 Promega Corporation Quinone-masked probes as labeling reagents for cell uptake measurements
WO2015164228A1 (en) 2014-04-21 2015-10-29 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
GB2546424A (en) 2014-07-14 2017-07-19 Harvard College Systems and methods for improved performance of fluidic and microfluidic systems
WO2017019542A1 (en) 2015-07-24 2017-02-02 President And Fellows Of Harvard College Radial microfluidic devices and methods of use
WO2017070145A1 (en) 2015-10-19 2017-04-27 Cellular Dynamics International, Inc. Production of virus-receptive pluripotent stem cell (psc)-derived hepatocytes
EP3397753B1 (de) 2015-12-30 2021-10-27 FUJIFILM Cellular Dynamics, Inc. Bildung von mikrogewebe mit stammzellen aus menschlichen hepatozyten
AU2017326179B2 (en) 2016-09-13 2022-12-08 President And Fellows Of Harvard College Methods relating to intestinal organ-on-a-chip
WO2018053143A1 (en) * 2016-09-14 2018-03-22 Vital Therapies, Inc. Composition and method for inducing anti-apoptosis, survival, or proliferation of a cell
US20190350192A1 (en) * 2016-10-28 2019-11-21 Vital Therapies, Inc. Use of conditioned media from extracorporeal blood detoxifying system to supplement organ perfusion solutions
CA3138348A1 (en) 2019-05-09 2020-11-12 FUJIFILM Cellular Dynamics, Inc. Methods for the production of hepatocytes
WO2022081760A1 (en) 2020-10-14 2022-04-21 Sana Biotechnology, Inc. Hepatocyte-like cells
KR20240005887A (ko) 2021-05-07 2024-01-12 아스텔라스 인스티튜트 포 리제너러티브 메디슨 성숙한 간세포를 발생시키는 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3935066A (en) * 1969-07-03 1976-01-27 Burroughs Wellcome Co. Cell lines
US4393133A (en) * 1980-06-12 1983-07-12 The Wistar Institute Of Anatomy And Biology Human hepatoma derived cell line, process for preparation thereof, and uses therefor
US4416986A (en) * 1981-01-16 1983-11-22 Merck & Co., Inc. Methods of producing HBsAg
US4853324A (en) * 1985-12-02 1989-08-01 Viles Joseph M Liver assist device employing transformed cell lines
WO1991015573A1 (en) * 1990-04-03 1991-10-17 Southwest Foundation For Biomedical Research An immortalized primate hepatocyte cell line

Also Published As

Publication number Publication date
EP0532522B1 (de) 1996-04-10
ES2089213T3 (es) 1996-10-01
JP3117994B2 (ja) 2000-12-18
CA2081782C (en) 2004-08-24
WO1991018087A1 (en) 1991-11-28
AU646045B2 (en) 1994-02-03
ATE136582T1 (de) 1996-04-15
JPH05508312A (ja) 1993-11-25
DE69118690D1 (de) 1996-05-15
CA2081782A1 (en) 1991-11-17
AU7791891A (en) 1991-12-10
EP0532522A4 (en) 1993-06-30
EP0532522A1 (de) 1993-03-24
US5290684A (en) 1994-03-01

Similar Documents

Publication Publication Date Title
ATE136582T1 (de) Eine permanente menschliche hepatogene zellinie und seine verwendung in der unterstützung der leberfunktion
NO177862C (no) Flytende sammensetning innbefattende vann, overflateaktivt middel og opplöst overflateaktivt middel-desolubiliserende elektrolytt
DK0457950T3 (da) Anvendelse af stearidonsyre til behandling af inflammatorisk betingede sygdomme
DE69125063T2 (de) Platin-Elektroformung und Platin-Elektroplattierung
DE69123178D1 (de) Verwendung von Uridin zur pharmakologischen Behandlung der peripheren Komplikationen bei Diabetes
IT7868418A0 (it) Sopporto per deodoranti da applicare ai vasi di gabinetti e simili
DE69534632T2 (de) Clotrimazol-Metaboliten bei der Behandlung von Sichelzellenkrankheit
NO882596L (no) Fremgangsmaate og anordning for vippet innretting av flytende krystaller med forbedret fotostabilitet.
NO783269L (no) Apparat for frembringelse av akustiske signaler i vann
LU78908A1 (fr) Elements pour supporter et renforcer des ensembles vitres etanches
DK4591A (da) Fremgangsmaade med frembringelse af stimuleringssignaler til maksimering af det dynamiske omraade ved beregning af frekvenssvarfunktioner
IT8050005A0 (it) Bagno e procedimento di strappamento elettrolitico
DK631989D0 (da) Anti-plakmiddel og/eller middel til behandling af lidelser i mundhulen
FI873231A (fi) Anordning foer bearbetning av aendor i roerformiga delar.
IT8247833A0 (it) Derivato di colesterolo idrosolubile dotato di attivita' farmacologica e procedimento di preparazione
DE69305081D1 (de) Verbesserte scharniervorrichtung zum befestigen von brille und deckel am wc
BE867898A (nl) Werkwijze en inrichting voor het biologisch zuiveren van afvalwater
IT1094302B (it) Struttura di mobile e suoni elementi per il rilassamento dell'organismo
NO924720D0 (no) Fremgangsmaate for fremstilling av flytende krystall-celler
NO924808D0 (no) Fremgangsmaate for fremstilling av flytende krystallceller
FI822761A0 (fi) Foerfarande och anordning foer justering av karmar i ljusoeppningar
NL7804308A (nl) Dragerplaat en werkwijze voor de vervaardiging daarvan.
BE862888A (fr) Cartouche et procede pour la fixation rapide de tiges d'ancrage dans les trous de forage
IT224945Z2 (it) Elemento scatolare portante da utilizzare per il supporto di lavabi e di altri accessori di arredamento per bagno.
Keefe Flood Frequency Analysis Concerns in the Atlantic Region

Legal Events

Date Code Title Description
8364 No opposition during term of opposition