JP2016508726A - 組み合わせた遺伝的および化学的操作によるフォワードプログラミングを介した肝細胞の産生 - Google Patents
組み合わせた遺伝的および化学的操作によるフォワードプログラミングを介した肝細胞の産生 Download PDFInfo
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- JP2016508726A JP2016508726A JP2015558982A JP2015558982A JP2016508726A JP 2016508726 A JP2016508726 A JP 2016508726A JP 2015558982 A JP2015558982 A JP 2015558982A JP 2015558982 A JP2015558982 A JP 2015558982A JP 2016508726 A JP2016508726 A JP 2016508726A
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5067—Liver cells
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/33—Insulin
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
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- C12N2501/999—Small molecules not provided for elsewhere
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C12N2510/00—Genetically modified cells
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- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361768301P | 2013-02-22 | 2013-02-22 | |
| US61/768,301 | 2013-02-22 | ||
| PCT/US2014/017588 WO2014130770A1 (en) | 2013-02-22 | 2014-02-21 | Hepatocyte production via forward programming by combined genetic and chemical engineering |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016508726A true JP2016508726A (ja) | 2016-03-24 |
| JP2016508726A5 JP2016508726A5 (enExample) | 2016-12-01 |
Family
ID=50336502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015558982A Pending JP2016508726A (ja) | 2013-02-22 | 2014-02-21 | 組み合わせた遺伝的および化学的操作によるフォワードプログラミングを介した肝細胞の産生 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20140242595A1 (enExample) |
| EP (1) | EP2958992A1 (enExample) |
| JP (1) | JP2016508726A (enExample) |
| CN (1) | CN105229144A (enExample) |
| AU (1) | AU2014218807A1 (enExample) |
| CA (1) | CA2901747A1 (enExample) |
| IL (1) | IL240747A0 (enExample) |
| WO (1) | WO2014130770A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018518941A (ja) * | 2016-04-15 | 2018-07-19 | サクラ ファインテック ユー.エス.エー., インコーポレイテッド | 高温時の蒸発を低減する方法 |
| JP2019535272A (ja) * | 2016-11-16 | 2019-12-12 | アリール バイオテクノロジー アンド ファーマシューティカルズ, インコーポレイテッド | Rnaでの幹細胞分化による肝細胞の誘導 |
| JP2024012479A (ja) * | 2018-02-05 | 2024-01-30 | オーデンツ セラピューティクス,インコーポレーテッド | 転写調節要素及びその使用 |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8497124B2 (en) | 2011-12-05 | 2013-07-30 | Factor Bioscience Inc. | Methods and products for reprogramming cells to a less differentiated state |
| CN104830906B (zh) * | 2014-02-12 | 2018-09-04 | 北京维通达生物技术有限公司 | 一种重编程获得功能性人肝脏实质细胞的方法 |
| SG11201704291QA (en) | 2014-11-26 | 2017-06-29 | Accelerated Biosciences Corp | Induced hepatocytes and uses thereof |
| EP3543339A1 (en) | 2015-02-13 | 2019-09-25 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| US10006084B2 (en) | 2015-04-30 | 2018-06-26 | Sakura Finetek U.S.A., Inc. | Methods to reduce evaporation during elevated temperature |
| JP6937513B2 (ja) * | 2015-09-11 | 2021-09-22 | 国立研究開発法人理化学研究所 | 転写因子結合部位特異的なdna脱メチル化方法 |
| US10093903B2 (en) | 2015-10-19 | 2018-10-09 | FUJIFILM Cellular Dynamics, Inc. | Production of virus-receptive pluripotent stem cell (PSC)-derived hepatocytes |
| WO2017117333A1 (en) | 2015-12-30 | 2017-07-06 | Cellular Dynamics International, Inc. | Microtissue formation using stem cell-derived human hepatocytes |
| CN109803977B (zh) | 2016-08-17 | 2023-03-17 | 菲克特生物科学股份有限公司 | 核酸产品及其施用方法 |
| CN108060120B (zh) * | 2016-11-07 | 2022-11-04 | 云南济慈再生医学研究院有限公司 | 用于分化的细胞重编程的小分子化合物组合、试剂盒及应用 |
| WO2019070888A1 (en) * | 2017-10-03 | 2019-04-11 | Children's Hospital And Clinics Of Minnesota | VECTORS AND METHODS OF USE |
| CN110055217B (zh) * | 2019-01-29 | 2021-03-30 | 中国人民解放军军事科学院军事医学研究院 | 获得巨核细胞及血小板的方法 |
| WO2021003462A1 (en) | 2019-07-03 | 2021-01-07 | Factor Bioscience Inc. | Cationic lipids and uses thereof |
| US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| CN111004770B (zh) * | 2019-09-25 | 2022-08-23 | 中国人民解放军军事科学院军事医学研究院 | 功能性肝细胞诱导方法及其专用三维诱导培养基和应用 |
| EP4061400A4 (en) * | 2019-11-20 | 2024-01-10 | Cornell University | Generation of kidney glomerular specific endothelial cells and methods of use |
| CN114480253B (zh) * | 2022-01-30 | 2023-02-28 | 深圳市三启生物技术有限公司 | 多能干细胞定向诱导分化为肝细胞的培养基及培养方法和用途 |
| CN114480495A (zh) * | 2022-02-14 | 2022-05-13 | 深圳市三启生物技术有限公司 | 一种alb融合蛋白的表达方法及其应用 |
| WO2025096798A2 (en) * | 2023-10-31 | 2025-05-08 | The Children's Medical Center Corporation | Endothelial cell factors and methods thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009542215A (ja) * | 2006-06-28 | 2009-12-03 | ザ ユニバーシティー オブ カンザス | 臍帯マトリックスに由来する幹細胞を肝細胞系細胞へ分化させる方法 |
| US20100062527A1 (en) * | 2008-09-09 | 2010-03-11 | University Of Southern California | Induction, propagation and isolation of liver progenitor cells |
| WO2011130402A2 (en) * | 2010-04-13 | 2011-10-20 | Cellular Dynamics International, Inc. | Hepatocyte production by forward programming |
| JP2012509085A (ja) * | 2008-11-20 | 2012-04-19 | ヤンセン バイオテツク,インコーポレーテツド | マイクロキャリア上での多能性幹細胞の培養 |
| WO2013018851A1 (ja) * | 2011-08-02 | 2013-02-07 | 独立行政法人国立がん研究センター | 誘導肝幹細胞から肝分化誘導する方法及び誘導肝前駆細胞 |
Family Cites Families (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5510254A (en) | 1986-04-18 | 1996-04-23 | Advanced Tissue Sciences, Inc. | Three dimensional cell and tissue culture system |
| GB2197915B (en) | 1986-11-19 | 1990-11-14 | Rolls Royce Plc | Improvements in or relating to fluid bearings |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5302523A (en) | 1989-06-21 | 1994-04-12 | Zeneca Limited | Transformation of plant cells |
| DK0412700T3 (da) | 1989-08-03 | 1998-04-06 | Univ California | Fremgangsmåde til isolering af føtale cytrophoblastceller |
| US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US5550318A (en) | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US5322783A (en) | 1989-10-17 | 1994-06-21 | Pioneer Hi-Bred International, Inc. | Soybean transformation by microparticle bombardment |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5635387A (en) | 1990-04-23 | 1997-06-03 | Cellpro, Inc. | Methods and device for culturing human hematopoietic cells and their precursors |
| WO1991018087A1 (en) | 1990-05-16 | 1991-11-28 | Baylor College Of Medicine | A permanent human hepatocyte cell line and its use in a liver assist device (lad) |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5811094A (en) | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
| US5837539A (en) | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
| US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| US5610042A (en) | 1991-10-07 | 1997-03-11 | Ciba-Geigy Corporation | Methods for stable transformation of wheat |
| US5460964A (en) | 1992-04-03 | 1995-10-24 | Regents Of The University Of Minnesota | Method for culturing hematopoietic cells |
| AU4543193A (en) | 1992-06-22 | 1994-01-24 | Henry E. Young | Scar inhibitory factor and use thereof |
| DE69334225D1 (de) | 1992-07-07 | 2008-07-31 | Japan Tobacco Inc | Verfahren zur transformation einer monokotyledon pflanze |
| US5702932A (en) | 1992-07-20 | 1997-12-30 | University Of Florida | Microinjection methods to transform arthropods with exogenous DNA |
| EP0652965A1 (en) | 1992-07-27 | 1995-05-17 | Pioneer Hi-Bred International, Inc. | An improved method of agrobacterium-mediated transformation of cultured soybean cells |
| DE4228457A1 (de) | 1992-08-27 | 1994-04-28 | Beiersdorf Ag | Herstellung von heterodimerem PDGF-AB mit Hilfe eines bicistronischen Vektorsystems in Säugerzellen |
| GB9222888D0 (en) | 1992-10-30 | 1992-12-16 | British Tech Group | Tomography |
| GB9223084D0 (en) | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
| US5409813A (en) | 1993-09-30 | 1995-04-25 | Systemix, Inc. | Method for mammalian cell separation from a mixture of cell populations |
| US6268212B1 (en) | 1993-10-18 | 2001-07-31 | Amgen Inc. | Tissue specific transgene expression |
| US5656610A (en) | 1994-06-21 | 1997-08-12 | University Of Southern California | Producing a protein in a mammal by injection of a DNA-sequence into the tongue |
| FR2722208B1 (fr) | 1994-07-05 | 1996-10-04 | Inst Nat Sante Rech Med | Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique |
| US5776747A (en) | 1994-07-20 | 1998-07-07 | Cytotherapeutics, Inc. | Method for controlling the distribution of cells within a bioartificial organ using polycthylene oxide-poly (dimethylsiloxane) copolymer |
| US5935849A (en) | 1994-07-20 | 1999-08-10 | Cytotherapeutics, Inc. | Methods and compositions of growth control for cells encapsulated within bioartificial organs |
| US5677136A (en) | 1994-11-14 | 1997-10-14 | Systemix, Inc. | Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5525625A (en) | 1995-01-24 | 1996-06-11 | Warner-Lambert Company | 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders |
| US5736396A (en) | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| US7410773B2 (en) | 1995-02-02 | 2008-08-12 | Ghazi Jaswinder Dhoot | Method of preparing an undifferentiated cell |
| US5837670A (en) | 1995-04-18 | 1998-11-17 | Hartshorn; Richard Timothy | Detergent compositions having suds suppressing properties |
| US5908782A (en) | 1995-06-05 | 1999-06-01 | Osiris Therapeutics, Inc. | Chemically defined medium for human mesenchymal stem cells |
| US5837234A (en) | 1995-06-07 | 1998-11-17 | Cytotherapeutics, Inc. | Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| US5780448A (en) | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
| US5928906A (en) | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
| US5827740A (en) | 1996-07-30 | 1998-10-27 | Osiris Therapeutics, Inc. | Adipogenic differentiation of human mesenchymal stem cells |
| US5945100A (en) | 1996-07-31 | 1999-08-31 | Fbp Corporation | Tumor delivery vehicles |
| US5981274A (en) | 1996-09-18 | 1999-11-09 | Tyrrell; D. Lorne J. | Recombinant hepatitis virus vectors |
| US20030040038A1 (en) | 1997-08-22 | 2003-02-27 | Steven F. Dowdy | Inducible regulatory system and use thereof |
| US5994624A (en) | 1997-10-20 | 1999-11-30 | Cotton Incorporated | In planta method for the production of transgenic plants |
| EP1025204A4 (en) | 1997-10-23 | 2001-02-28 | Geron Corp | Methods and materials for the growth of primate-derived primordial stem cells |
| US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
| US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
| ES2317707T3 (es) | 1998-12-07 | 2009-04-16 | Duke University | Metodo de aislamiento de celulas troncales. |
| DE60001229T2 (de) | 1999-04-09 | 2003-10-30 | Smithkline Beecham Corp., Philadelphia | Triarylimidazole |
| AUPQ147799A0 (en) | 1999-07-07 | 1999-07-29 | Medvet Science Pty. Ltd. | Mesenchymal precursor cell |
| US7015037B1 (en) | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| AR029803A1 (es) | 2000-02-21 | 2003-07-16 | Smithkline Beecham Plc | Imidazoles sustituidos con piridilo y composiciones farmaceuticas que las comprenden |
| GB0007405D0 (en) | 2000-03-27 | 2000-05-17 | Smithkline Beecham Corp | Compounds |
| US6458589B1 (en) | 2000-04-27 | 2002-10-01 | Geron Corporation | Hepatocyte lineage cells derived from pluripotent stem cells |
| AU2001263199B2 (en) | 2000-05-17 | 2004-09-16 | Asterias Biotherapeutics, Inc. | Neural progenitor cell populations |
| US7351813B2 (en) | 2000-06-20 | 2008-04-01 | The Board Of Trustees Of The Leland Stanford Junior University | Liver-specific gene expression cassettes, and methods of use |
| JP2004501664A (ja) | 2000-06-30 | 2004-01-22 | ボード・オブ・リージェンツ,ザ・ユニヴァーシティ・オヴ・テキサス・システム | 標的化薬剤送達のための腫瘍組織を浸潤する細胞特異的な内部移行ペプチドの単離 |
| US20030082561A1 (en) | 2000-07-21 | 2003-05-01 | Takashi Sera | Zinc finger domain recognition code and uses thereof |
| WO2002040468A1 (en) | 2000-11-16 | 2002-05-23 | Smithkline Beecham Corporation | Compounds |
| GB0102668D0 (en) | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
| US20030211603A1 (en) | 2001-08-14 | 2003-11-13 | Earp David J. | Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells |
| ATE438708T1 (de) | 2001-11-15 | 2009-08-15 | Childrens Medical Center | Verfahren zur isolierung, expansion und differenzierung fötaler stammzellen aus chorionzotte, fruchtwasser und plazenta und therapeutische verwendungen davon |
| CA2478374C (en) | 2002-03-13 | 2009-01-06 | Eli M. Wallace | N3 alkylated benzimidazole derivatives as mek inhibitors |
| DE10224242A1 (de) | 2002-05-29 | 2003-12-11 | Max Delbrueck Centrum | Frog Prince, ein Transposonvektor für den Gentransfer bei Wirbeltieren |
| US7422736B2 (en) | 2002-07-26 | 2008-09-09 | Food Industry Research And Development Institute | Somatic pluripotent cells |
| US7407776B2 (en) | 2003-09-19 | 2008-08-05 | Sangamo Biosciences, Inc. | Engineered zinc finger proteins for regulation of gene expression |
| EP1783205B1 (en) | 2004-06-18 | 2024-02-21 | Riken | Method of inducing the differentiation of embryonic stem cells into nerve by serum-free suspension culture |
| US7442548B2 (en) | 2004-09-08 | 2008-10-28 | Wisconsin Alumni Research Foundation | Culturing human embryonic stem cells in medium containing pipecholic acid and gamma amino butyric acid |
| US20070116680A1 (en) | 2005-11-18 | 2007-05-24 | Rensselaer Polytechnic Institute | Stem cells within gel microenvironments |
| JP5797551B2 (ja) | 2008-04-22 | 2015-10-21 | フエー・イー・ベー・フエー・ゼツト・ウエー | 肝特異的核酸調節要素ならびにその方法および用途 |
| EP2206723A1 (en) | 2009-01-12 | 2010-07-14 | Bonas, Ulla | Modular DNA-binding domains |
| AU2010363437B2 (en) * | 2010-11-01 | 2015-11-19 | Kabushiki Kaisha Maghouse | Soil improvement device |
-
2014
- 2014-02-21 CN CN201480022500.3A patent/CN105229144A/zh active Pending
- 2014-02-21 CA CA2901747A patent/CA2901747A1/en not_active Abandoned
- 2014-02-21 US US14/186,620 patent/US20140242595A1/en not_active Abandoned
- 2014-02-21 WO PCT/US2014/017588 patent/WO2014130770A1/en not_active Ceased
- 2014-02-21 JP JP2015558982A patent/JP2016508726A/ja active Pending
- 2014-02-21 EP EP14711342.7A patent/EP2958992A1/en not_active Withdrawn
- 2014-02-21 AU AU2014218807A patent/AU2014218807A1/en not_active Abandoned
-
2015
- 2015-08-20 IL IL240747A patent/IL240747A0/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009542215A (ja) * | 2006-06-28 | 2009-12-03 | ザ ユニバーシティー オブ カンザス | 臍帯マトリックスに由来する幹細胞を肝細胞系細胞へ分化させる方法 |
| US20100062527A1 (en) * | 2008-09-09 | 2010-03-11 | University Of Southern California | Induction, propagation and isolation of liver progenitor cells |
| JP2012509085A (ja) * | 2008-11-20 | 2012-04-19 | ヤンセン バイオテツク,インコーポレーテツド | マイクロキャリア上での多能性幹細胞の培養 |
| WO2011130402A2 (en) * | 2010-04-13 | 2011-10-20 | Cellular Dynamics International, Inc. | Hepatocyte production by forward programming |
| WO2013018851A1 (ja) * | 2011-08-02 | 2013-02-07 | 独立行政法人国立がん研究センター | 誘導肝幹細胞から肝分化誘導する方法及び誘導肝前駆細胞 |
Non-Patent Citations (2)
| Title |
|---|
| ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (1988) VOL.263, NO.2, PP.378-386, JPN6017032491, ISSN: 0003629139 * |
| JOURNAL OF CELL SCIENCE (2012) VOL.125, PP.5609-5620, JPN6017032489, ISSN: 0003629138 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018518941A (ja) * | 2016-04-15 | 2018-07-19 | サクラ ファインテック ユー.エス.エー., インコーポレイテッド | 高温時の蒸発を低減する方法 |
| JP2019535272A (ja) * | 2016-11-16 | 2019-12-12 | アリール バイオテクノロジー アンド ファーマシューティカルズ, インコーポレイテッド | Rnaでの幹細胞分化による肝細胞の誘導 |
| JP2024012479A (ja) * | 2018-02-05 | 2024-01-30 | オーデンツ セラピューティクス,インコーポレーテッド | 転写調節要素及びその使用 |
| JP7776477B2 (ja) | 2018-02-05 | 2025-11-26 | オーデンツ セラピューティクス,インコーポレーテッド | 転写調節要素及びその使用 |
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| AU2014218807A1 (en) | 2015-09-03 |
| CA2901747A1 (en) | 2014-08-28 |
| CN105229144A (zh) | 2016-01-06 |
| IL240747A0 (en) | 2015-10-29 |
| EP2958992A1 (en) | 2015-12-30 |
| US20140242595A1 (en) | 2014-08-28 |
| WO2014130770A1 (en) | 2014-08-28 |
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