JP2016508713A5 - - Google Patents
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- Publication number
- JP2016508713A5 JP2016508713A5 JP2015548545A JP2015548545A JP2016508713A5 JP 2016508713 A5 JP2016508713 A5 JP 2016508713A5 JP 2015548545 A JP2015548545 A JP 2015548545A JP 2015548545 A JP2015548545 A JP 2015548545A JP 2016508713 A5 JP2016508713 A5 JP 2016508713A5
- Authority
- JP
- Japan
- Prior art keywords
- allele
- mismatch
- nucleic acid
- mutant
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108700028369 Alleles Proteins 0.000 claims 45
- 150000007523 nucleic acids Chemical group 0.000 claims 27
- 108020004707 nucleic acids Proteins 0.000 claims 18
- 102000039446 nucleic acids Human genes 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 17
- 108091034117 Oligonucleotide Proteins 0.000 claims 16
- 238000009830 intercalation Methods 0.000 claims 16
- 230000002687 intercalation Effects 0.000 claims 16
- 239000011159 matrix material Substances 0.000 claims 16
- 238000000034 method Methods 0.000 claims 16
- 239000007801 affinity label Substances 0.000 claims 12
- 239000011541 reaction mixture Substances 0.000 claims 12
- 239000002773 nucleotide Substances 0.000 claims 10
- 125000003729 nucleotide group Chemical group 0.000 claims 10
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 8
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 8
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 8
- 108091033319 polynucleotide Proteins 0.000 claims 8
- 102000040430 polynucleotide Human genes 0.000 claims 8
- 239000002157 polynucleotide Substances 0.000 claims 8
- 229960002685 biotin Drugs 0.000 claims 5
- 239000011616 biotin Substances 0.000 claims 5
- 238000010438 heat treatment Methods 0.000 claims 4
- 239000000463 material Substances 0.000 claims 4
- 238000005406 washing Methods 0.000 claims 4
- 230000003321 amplification Effects 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 238000009396 hybridization Methods 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 238000000137 annealing Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261740895P | 2012-12-21 | 2012-12-21 | |
| US61/740,895 | 2012-12-21 | ||
| PCT/EP2013/077282 WO2014096126A1 (en) | 2012-12-21 | 2013-12-19 | Compounds and methods for the enrichment of mutated nucleic acid from a mixture |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016508713A JP2016508713A (ja) | 2016-03-24 |
| JP2016508713A5 true JP2016508713A5 (enExample) | 2017-01-12 |
Family
ID=49886901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015548545A Pending JP2016508713A (ja) | 2012-12-21 | 2013-12-19 | 混合物からの変異核酸の富化のための化合物及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9279146B2 (enExample) |
| EP (1) | EP2935619B1 (enExample) |
| JP (1) | JP2016508713A (enExample) |
| CN (1) | CN104903464B (enExample) |
| CA (1) | CA2894212C (enExample) |
| WO (1) | WO2014096126A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3246416T3 (pl) | 2011-04-15 | 2024-09-30 | The Johns Hopkins University | Bezpieczny system sekwencjonowania |
| CN109457030B (zh) | 2012-10-29 | 2022-02-18 | 约翰·霍普金斯大学 | 卵巢和子宫内膜癌的帕帕尼科拉乌测试 |
| US11286531B2 (en) | 2015-08-11 | 2022-03-29 | The Johns Hopkins University | Assaying ovarian cyst fluid |
| EP3665308A1 (en) | 2017-08-07 | 2020-06-17 | The Johns Hopkins University | Methods and materials for assessing and treating cancer |
| EP3505643A1 (en) | 2017-12-28 | 2019-07-03 | Vito NV | Methods for detecting nucleotide variants |
| CN108998504A (zh) * | 2018-08-08 | 2018-12-14 | 鲍伟胜 | 一种提高基因突变检测灵敏度的方法 |
| BR112022015909A2 (pt) | 2020-02-14 | 2022-10-04 | Univ Johns Hopkins | Métodos e materiais para avaliação de ácidos nucleicos |
| GB2603203A (en) * | 2021-02-02 | 2022-08-03 | Univ Heriot Watt | Method for enriching nucelic acids |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6120992A (en) | 1993-11-04 | 2000-09-19 | Valigene Corporation | Use of immobilized mismatch binding protein for detection of mutations and polymorphisms, and allele identification in a diseased human |
| US6027877A (en) * | 1993-11-04 | 2000-02-22 | Gene Check, Inc. | Use of immobilized mismatch binding protein for detection of mutations and polymorphisms, purification of amplified DNA samples and allele identification |
| US6630301B1 (en) | 1997-03-14 | 2003-10-07 | The Penn State Research Foundation | Detection of extracellular tumor-associated nucleic acid in blood plasma or serum |
| EP0929694A4 (en) | 1996-03-15 | 2002-05-02 | Penn State Res Found | DETECTION OF TUMOR-RELATED EXTRACELLULAR NUCLEIC ACID USING PLASMA OR BLOOD SERUM USING NUCLEIC ACID AMPLIFICATION TESTS |
| US6031098A (en) | 1997-08-11 | 2000-02-29 | California Institute Of Technology | Detection and treatment of duplex polynucleotide damage |
| SE9902741D0 (sv) | 1999-07-19 | 1999-07-19 | Boerries Kemper | Method for the enrichment of heteroduplexes and its use in mutation detection |
| US20020132244A1 (en) | 2000-09-27 | 2002-09-19 | Xiao-Cheng Li-Sucholeiki | Methods for detecting rare polymorphic variants in genomic DNA sequences |
| WO2002057492A1 (en) | 2000-12-08 | 2002-07-25 | California Institute Of Technology | Methods and compositions for detecting polynucleotide duplex damage |
| GB2382137A (en) | 2001-11-20 | 2003-05-21 | Mats Gullberg | Nucleic acid enrichment |
| CN101370945B (zh) | 2005-10-14 | 2011-12-28 | 克利夫兰州立大学 | 用于鉴别大量野生型dna背景中多个dna突变标记的方法 |
| US20070154892A1 (en) | 2005-12-30 | 2007-07-05 | Simon Wain-Hobson | Differential amplification of mutant nucleic acids by PCR in a mixure of nucleic acids |
| WO2007084380A2 (en) | 2006-01-13 | 2007-07-26 | California Institute Of Technology | Compounds and methods for nucleic acid mismatch detection |
| ES2665500T3 (es) | 2010-03-08 | 2018-04-26 | Dana-Farber Cancer Institute, Inc. | Enriquecimiento de una PCR por COLD completa con secuencia de bloqueo de referencia |
| US20120164641A1 (en) | 2010-12-22 | 2012-06-28 | Roche Molecular Systems, Inc. | Methods and Compositions for Detecting Mutation in the Human Epidermal Growth Factor Receptor Gene |
| WO2013077282A1 (ja) | 2011-11-25 | 2013-05-30 | シャープ株式会社 | 液晶表示パネルの検査方法 |
-
2013
- 2013-12-06 US US14/098,789 patent/US9279146B2/en active Active
- 2013-12-19 EP EP13814889.5A patent/EP2935619B1/en active Active
- 2013-12-19 CN CN201380066924.5A patent/CN104903464B/zh active Active
- 2013-12-19 CA CA2894212A patent/CA2894212C/en active Active
- 2013-12-19 WO PCT/EP2013/077282 patent/WO2014096126A1/en not_active Ceased
- 2013-12-19 JP JP2015548545A patent/JP2016508713A/ja active Pending
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