JP2016508713A - 混合物からの変異核酸の富化のための化合物及び方法 - Google Patents

混合物からの変異核酸の富化のための化合物及び方法 Download PDF

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Publication number
JP2016508713A
JP2016508713A JP2015548545A JP2015548545A JP2016508713A JP 2016508713 A JP2016508713 A JP 2016508713A JP 2015548545 A JP2015548545 A JP 2015548545A JP 2015548545 A JP2015548545 A JP 2015548545A JP 2016508713 A JP2016508713 A JP 2016508713A
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Prior art keywords
allele
mismatch
nucleic acid
mutant
double
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JP2015548545A
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Japanese (ja)
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JP2016508713A5 (enExample
Inventor
グプタ アマー
グプタ アマー
シェーンブルナー ナンシー
シェーンブルナー ナンシー
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0073—Rhodium compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
JP2015548545A 2012-12-21 2013-12-19 混合物からの変異核酸の富化のための化合物及び方法 Pending JP2016508713A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261740895P 2012-12-21 2012-12-21
US61/740,895 2012-12-21
PCT/EP2013/077282 WO2014096126A1 (en) 2012-12-21 2013-12-19 Compounds and methods for the enrichment of mutated nucleic acid from a mixture

Publications (2)

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JP2016508713A true JP2016508713A (ja) 2016-03-24
JP2016508713A5 JP2016508713A5 (enExample) 2017-01-12

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JP2015548545A Pending JP2016508713A (ja) 2012-12-21 2013-12-19 混合物からの変異核酸の富化のための化合物及び方法

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Country Link
US (1) US9279146B2 (enExample)
EP (1) EP2935619B1 (enExample)
JP (1) JP2016508713A (enExample)
CN (1) CN104903464B (enExample)
CA (1) CA2894212C (enExample)
WO (1) WO2014096126A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3246416T3 (da) 2011-04-15 2024-09-02 Univ Johns Hopkins Sikkert sekventeringssystem
ES2886507T5 (es) 2012-10-29 2024-11-15 Univ Johns Hopkins Prueba de Papanicolaou para cánceres de ovario y de endometrio
WO2017027653A1 (en) 2015-08-11 2017-02-16 The Johns Hopkins University Assaying ovarian cyst fluid
CN111868260B (zh) 2017-08-07 2025-02-21 约翰斯霍普金斯大学 用于评估和治疗癌症的方法和材料
EP3505643A1 (en) 2017-12-28 2019-07-03 Vito NV Methods for detecting nucleotide variants
CN108998504A (zh) * 2018-08-08 2018-12-14 鲍伟胜 一种提高基因突变检测灵敏度的方法
CN115516108A (zh) 2020-02-14 2022-12-23 约翰斯霍普金斯大学 评估核酸的方法和材料
GB2603203A (en) * 2021-02-02 2022-08-03 Univ Heriot Watt Method for enriching nucelic acids

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09504699A (ja) * 1993-11-04 1997-05-13 ジーン チェック、インク． 変異及び多型性の検出、増幅されたｄｎａサンプルの精製、及び対立遺伝子の同定のための、固定化ミスマッチ結合蛋白質の使用
US6031098A (en) * 1997-08-11 2000-02-29 California Institute Of Technology Detection and treatment of duplex polynucleotide damage
WO2001005800A2 (en) * 1999-07-18 2001-01-25 Borries Kemper A method for the enrichment of heteroduplexes and its use in mutation detection
WO2007084380A2 (en) * 2006-01-13 2007-07-26 California Institute Of Technology Compounds and methods for nucleic acid mismatch detection

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US6120992A (en) 1993-11-04 2000-09-19 Valigene Corporation Use of immobilized mismatch binding protein for detection of mutations and polymorphisms, and allele identification in a diseased human
US6156504A (en) 1996-03-15 2000-12-05 The Penn State Research Foundation Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays
US6630301B1 (en) 1997-03-14 2003-10-07 The Penn State Research Foundation Detection of extracellular tumor-associated nucleic acid in blood plasma or serum
US20020132244A1 (en) 2000-09-27 2002-09-19 Xiao-Cheng Li-Sucholeiki Methods for detecting rare polymorphic variants in genomic DNA sequences
US6808884B2 (en) 2000-12-08 2004-10-26 California Institute Of Technology Methods and compositions for detecting polynucleotide duplex damage and errors
GB2382137A (en) 2001-11-20 2003-05-21 Mats Gullberg Nucleic acid enrichment
WO2007047572A2 (en) 2005-10-14 2007-04-26 Cleveland State University Methods for identifying multiple dna alteration markers in a large background of wild-type dna
US20070154892A1 (en) 2005-12-30 2007-07-05 Simon Wain-Hobson Differential amplification of mutant nucleic acids by PCR in a mixure of nucleic acids
JP5795341B2 (ja) 2010-03-08 2015-10-14 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 参照ブロック配列によるｆｕｌｌＣＯＬＤ−ＰＣＲ濃縮
US20120164641A1 (en) 2010-12-22 2012-06-28 Roche Molecular Systems, Inc. Methods and Compositions for Detecting Mutation in the Human Epidermal Growth Factor Receptor Gene
WO2013077282A1 (ja) 2011-11-25 2013-05-30 シャープ株式会社 液晶表示パネルの検査方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09504699A (ja) * 1993-11-04 1997-05-13 ジーン チェック、インク． 変異及び多型性の検出、増幅されたｄｎａサンプルの精製、及び対立遺伝子の同定のための、固定化ミスマッチ結合蛋白質の使用
US6031098A (en) * 1997-08-11 2000-02-29 California Institute Of Technology Detection and treatment of duplex polynucleotide damage
WO2001005800A2 (en) * 1999-07-18 2001-01-25 Borries Kemper A method for the enrichment of heteroduplexes and its use in mutation detection
WO2007084380A2 (en) * 2006-01-13 2007-07-26 California Institute Of Technology Compounds and methods for nucleic acid mismatch detection

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PNAS, 2006, VOL. 103, NO. 42, PP. 15359-15363, JPN6017033395, ISSN: 0003637292 *
PNAS, 2007, VOL. 104, NO. 2, PP. 429-434, JPN6017033396, ISSN: 0003637293 *

Also Published As

Publication number Publication date
CA2894212C (en) 2018-09-04
EP2935619B1 (en) 2017-09-06
CN104903464B (zh) 2018-04-24
CA2894212A1 (en) 2014-06-26
US9279146B2 (en) 2016-03-08
US20140308664A1 (en) 2014-10-16
EP2935619A1 (en) 2015-10-28
CN104903464A (zh) 2015-09-09
WO2014096126A1 (en) 2014-06-26

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