JP2016507558A5 - - Google Patents
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- Publication number
- JP2016507558A5 JP2016507558A5 JP2015556998A JP2015556998A JP2016507558A5 JP 2016507558 A5 JP2016507558 A5 JP 2016507558A5 JP 2015556998 A JP2015556998 A JP 2015556998A JP 2015556998 A JP2015556998 A JP 2015556998A JP 2016507558 A5 JP2016507558 A5 JP 2016507558A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- substituted
- coor
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 38
- 125000001072 heteroaryl group Chemical group 0.000 claims 16
- 125000000547 substituted alkyl group Chemical group 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 208000030507 AIDS Diseases 0.000 claims 4
- 230000000840 anti-viral effect Effects 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- 229910052794 bromium Inorganic materials 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 229910052740 iodine Inorganic materials 0.000 claims 3
- 229940126154 HIV entry inhibitor Drugs 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 229960005475 antiinfective agent Drugs 0.000 claims 2
- 239000004599 antimicrobial Substances 0.000 claims 2
- 239000003443 antiviral agent Substances 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000002835 hiv fusion inhibitor Substances 0.000 claims 2
- 230000002519 immonomodulatory effect Effects 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- 125000006564 (C4-C8) cycloalkyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 150000003536 tetrazoles Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361761403P | 2013-02-06 | 2013-02-06 | |
| US61/761,403 | 2013-02-06 | ||
| PCT/US2014/014647 WO2014123889A1 (en) | 2013-02-06 | 2014-02-04 | C-19 modified triterpenoids with hiv maturation inhibitory activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016507558A JP2016507558A (ja) | 2016-03-10 |
| JP2016507558A5 true JP2016507558A5 (https=) | 2016-12-15 |
| JP6186010B2 JP6186010B2 (ja) | 2017-08-23 |
Family
ID=50150818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015556998A Expired - Fee Related JP6186010B2 (ja) | 2013-02-06 | 2014-02-04 | Ｈｉｖ成熟阻害活性を有するｃ−１９修飾トリテルペノイド類 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20140221361A1 (https=) |
| EP (1) | EP2953960A1 (https=) |
| JP (1) | JP6186010B2 (https=) |
| KR (1) | KR20150115881A (https=) |
| CN (1) | CN105121454A (https=) |
| AR (1) | AR094684A1 (https=) |
| AU (1) | AU2014215468B2 (https=) |
| BR (1) | BR112015018491A2 (https=) |
| CA (1) | CA2900124A1 (https=) |
| EA (1) | EA027371B1 (https=) |
| IL (1) | IL240289A0 (https=) |
| MX (1) | MX2015010003A (https=) |
| SG (1) | SG11201505639SA (https=) |
| TW (1) | TW201443073A (https=) |
| WO (1) | WO2014123889A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8906889B2 (en) * | 2012-02-15 | 2014-12-09 | Bristol-Myers Squibb Company | C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity |
| RU2018105352A (ru) | 2015-07-28 | 2019-08-29 | ГлаксоСмитКлайн Интеллекчуал Проперти (N2) Лимитед | Производные бетулина для предупреждения или лечения ВИЧ-инфекций |
| WO2017017609A1 (en) | 2015-07-28 | 2017-02-02 | Glaxosmithkline Intellectual Property (No.2) Limited | Betuin derivatives for preventing or treating hiv infections |
| WO2017025901A1 (en) * | 2015-08-11 | 2017-02-16 | Hetero Research Foundation | Novel c28-analogues with c3-modifications of triterpene derivatives as hiv inhibitors |
| RU2018112958A (ru) | 2015-09-24 | 2019-10-28 | ГлаксоСмитКлайн Интеллекчуал Проперти (N2) Лимитед | Соединения с ингибирующей созревание ВИЧ активностью |
| WO2017125870A1 (en) | 2016-01-20 | 2017-07-27 | Glaxosmithkline Intellectual Property (No.2) Limited | Amine derivatives of lupanes with hiv maturation inhibitory activity |
| AR107512A1 (es) * | 2016-02-04 | 2018-05-09 | VIIV HEALTHCARE UK Nº 5 LTD | Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1 |
| WO2017149518A1 (en) * | 2016-03-04 | 2017-09-08 | Hetero Labs Limited | C-3 novel triterpene with c-17 amine derivatives as hiv inhibitors |
| WO2018002848A1 (en) * | 2016-06-30 | 2018-01-04 | VIIV Healthcare UK (No.5) Limited | Azadecalin derivatives as inhibitors of human immunodeficiency virus replication |
| EP3506902A4 (en) * | 2016-08-31 | 2020-04-22 | VIIV Healthcare Company | COMBINATIONS AND USES AND TREATMENTS THEREOF |
| WO2018044853A1 (en) * | 2016-08-31 | 2018-03-08 | Viiv Healthcare Conpany | Combinations and uses and treatments thereof |
| ES2970042T3 (es) | 2018-04-24 | 2024-05-24 | Viiv Healthcare Uk No 5 Ltd | Compuestos con actividad inhibidora de la maduración del VIH |
| CA3101643C (en) | 2018-06-29 | 2023-02-21 | Dfh Therapeutics | Triterpene amine derivatives |
| SI3924361T1 (sl) | 2019-02-11 | 2024-02-29 | Hetero Labs Limited | Novi derivati triterpena kot zaviralci virusa hiv |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2694048B2 (ja) * | 1991-05-09 | 1997-12-24 | 日立建機株式会社 | 建設機械の油圧駆動装置 |
| US5413999A (en) | 1991-11-08 | 1995-05-09 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
| FR2683531B1 (fr) * | 1991-11-13 | 1993-12-31 | Rhone Poulenc Rorer Sa | Nouveaux derives du lupane, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| US5679828A (en) | 1995-06-05 | 1997-10-21 | Biotech Research Labs, Inc. | Betulinic acid and dihydrobetulinic acid derivatives and uses therefor |
| US20020137755A1 (en) | 2000-12-04 | 2002-09-26 | Bilodeau Mark T. | Tyrosine kinase inhibitors |
| US20040110785A1 (en) | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US7365221B2 (en) | 2002-09-26 | 2008-04-29 | Panacos Pharmaceuticals, Inc. | Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof |
| US7745625B2 (en) | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
| EP1730163A4 (en) | 2004-03-17 | 2009-12-30 | Panacos Pharmaceuticals Inc | Pharmaceutical salts of 3-O- (3,3-dimethylsuccinyl) betulinic acid |
| TW200628161A (en) | 2004-11-12 | 2006-08-16 | Panacos Pharmaceuticals Inc | Novel betulin derivatives, preparation thereof and use thereof |
| WO2008115281A2 (en) | 2006-10-16 | 2008-09-25 | Myriad Genetics, Inc. | Compounds for treating viral infections |
| CA2714049A1 (en) | 2008-02-14 | 2009-08-20 | Virochem Pharma Inc. | Novel 17.beta. lupane derivatives |
| US9067966B2 (en) | 2009-07-14 | 2015-06-30 | Hetero Research Foundation, Hetero Drugs Ltd. | Lupeol-type triterpene derivatives as antivirals |
| CN103038245B (zh) | 2010-06-04 | 2015-03-25 | 百时美施贵宝公司 | 作为hiv成熟抑制剂的c-3经修饰的桦木酸衍生物 |
| US8802661B2 (en) | 2010-06-04 | 2014-08-12 | Bristol-Myers Squibb Company | C-28 amides of modified C-3 betulinic acid derivatives as HIV maturation inhibitors |
| CN103270736B (zh) | 2010-06-29 | 2016-08-10 | 华为技术有限公司 | 一种网络设备 |
| KR101886467B1 (ko) * | 2011-01-31 | 2018-08-07 | 비브 헬스케어 유케이 (넘버4) 리미티드 | Hiv 성숙 억제 활성을 갖는 c-17 및 c-3 변형 트리테르페노이드 |
| PL2670764T3 (pl) * | 2011-01-31 | 2016-02-29 | Bristol Myers Squibb Co | C-28 aminy zmodyfikowanych C-3 pochodnych kwasu betulinowego jako inhibitory dojrzewania HIV |
| US8906889B2 (en) | 2012-02-15 | 2014-12-09 | Bristol-Myers Squibb Company | C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity |
| WO2013160810A2 (en) * | 2012-04-24 | 2013-10-31 | Hetero Research Foundation | Novel betulinic acid derivatives as hiv inhibitors |
| US8889854B2 (en) | 2012-05-07 | 2014-11-18 | Bristol-Myers Squibb Company | C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity |
-
2014
- 2014-02-04 SG SG11201505639SA patent/SG11201505639SA/en unknown
- 2014-02-04 US US14/172,389 patent/US20140221361A1/en not_active Abandoned
- 2014-02-04 WO PCT/US2014/014647 patent/WO2014123889A1/en not_active Ceased
- 2014-02-04 JP JP2015556998A patent/JP6186010B2/ja not_active Expired - Fee Related
- 2014-02-04 CA CA2900124A patent/CA2900124A1/en not_active Abandoned
- 2014-02-04 KR KR1020157023907A patent/KR20150115881A/ko not_active Withdrawn
- 2014-02-04 MX MX2015010003A patent/MX2015010003A/es unknown
- 2014-02-04 EP EP14705662.6A patent/EP2953960A1/en not_active Withdrawn
- 2014-02-04 EA EA201591406A patent/EA027371B1/ru not_active IP Right Cessation
- 2014-02-04 BR BR112015018491A patent/BR112015018491A2/pt not_active Application Discontinuation
- 2014-02-04 CN CN201480019576.0A patent/CN105121454A/zh active Pending
- 2014-02-04 AU AU2014215468A patent/AU2014215468B2/en not_active Ceased
- 2014-02-05 TW TW103103839A patent/TW201443073A/zh unknown
- 2014-02-06 AR ARP140100400A patent/AR094684A1/es unknown
-
2015
- 2015-08-02 IL IL240289A patent/IL240289A0/en unknown
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