JP2019507774A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019507774A5 JP2019507774A5 JP2018546884A JP2018546884A JP2019507774A5 JP 2019507774 A5 JP2019507774 A5 JP 2019507774A5 JP 2018546884 A JP2018546884 A JP 2018546884A JP 2018546884 A JP2018546884 A JP 2018546884A JP 2019507774 A5 JP2019507774 A5 JP 2019507774A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- membered
- heteroatoms
- alkyl
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001072 heteroaryl group Chemical group 0.000 claims 57
- 125000005842 heteroatom Chemical group 0.000 claims 53
- 229910052760 oxygen Inorganic materials 0.000 claims 53
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 38
- 125000000217 alkyl group Chemical group 0.000 claims 35
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 31
- 150000001875 compounds Chemical class 0.000 claims 28
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 27
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 26
- 125000003545 alkoxy group Chemical group 0.000 claims 25
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 25
- 229910052736 halogen Inorganic materials 0.000 claims 24
- 150000002367 halogens Chemical class 0.000 claims 24
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 23
- 125000001424 substituent group Chemical group 0.000 claims 23
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 22
- 125000002619 bicyclic group Chemical group 0.000 claims 22
- 229910052717 sulfur Inorganic materials 0.000 claims 21
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 20
- 125000003118 aryl group Chemical group 0.000 claims 19
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 19
- 125000002877 alkyl aryl group Chemical group 0.000 claims 18
- KWEDUNSJJZVRKR-UHFFFAOYSA-N carbononitridic azide Chemical compound [N-]=[N+]=NC#N KWEDUNSJJZVRKR-UHFFFAOYSA-N 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 17
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 239000000651 prodrug Substances 0.000 claims 16
- 229940002612 prodrug Drugs 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 16
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
- 125000003107 substituted aryl group Chemical group 0.000 claims 14
- 229910052757 nitrogen Inorganic materials 0.000 claims 13
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 12
- 125000003003 spiro group Chemical group 0.000 claims 11
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 10
- 229910052799 carbon Inorganic materials 0.000 claims 10
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 9
- -1 C3-6Alkoxyalkyl Chemical group 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 9
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 9
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 8
- 208000015181 infectious disease Diseases 0.000 claims 8
- 229920006395 saturated elastomer Polymers 0.000 claims 8
- 241000700605 Viruses Species 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- PIGFYZPCRLYGLF-UHFFFAOYSA-N Aluminum nitride Chemical compound [Al]#N PIGFYZPCRLYGLF-UHFFFAOYSA-N 0.000 claims 4
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims 4
- 229910052711 selenium Inorganic materials 0.000 claims 4
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 241000711549 Hepacivirus C Species 0.000 claims 3
- 230000004071 biological effect Effects 0.000 claims 3
- 125000005243 carbonyl alkyl group Chemical group 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 3
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 2
- 241000710781 Flaviviridae Species 0.000 claims 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 2
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 2
- 206010057293 West Nile viral infection Diseases 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 150000008064 anhydrides Chemical class 0.000 claims 2
- 239000003443 antiviral agent Substances 0.000 claims 2
- 125000001769 aryl amino group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 150000004820 halides Chemical class 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 150000002466 imines Chemical class 0.000 claims 2
- LBQAJLBSGOBDQF-UHFFFAOYSA-N nitro azanylidynemethanesulfonate Chemical compound [O-][N+](=O)OS(=O)(=O)C#N LBQAJLBSGOBDQF-UHFFFAOYSA-N 0.000 claims 2
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 2
- 150000002923 oximes Chemical class 0.000 claims 2
- 125000005328 phosphinyl group Chemical group [PH2](=O)* 0.000 claims 2
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 2
- 125000005499 phosphonyl group Chemical group 0.000 claims 2
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims 2
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims 2
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 150000007970 thio esters Chemical class 0.000 claims 2
- 150000003568 thioethers Chemical class 0.000 claims 2
- HCMJWOGOISXSDL-UHFFFAOYSA-N (2-isothiocyanato-1-phenylethyl)benzene Chemical compound C=1C=CC=CC=1C(CN=C=S)C1=CC=CC=C1 HCMJWOGOISXSDL-UHFFFAOYSA-N 0.000 claims 1
- 108091033409 CRISPR Proteins 0.000 claims 1
- 208000001490 Dengue Diseases 0.000 claims 1
- 206010012310 Dengue fever Diseases 0.000 claims 1
- 208000037262 Hepatitis delta Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 101710200424 Inosine-5'-monophosphate dehydrogenase Proteins 0.000 claims 1
- 108700011259 MicroRNAs Proteins 0.000 claims 1
- 229940123066 Polymerase inhibitor Drugs 0.000 claims 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 1
- 229910018482 SF5 Inorganic materials 0.000 claims 1
- 108091027967 Small hairpin RNA Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 241000710886 West Nile virus Species 0.000 claims 1
- 208000003152 Yellow Fever Diseases 0.000 claims 1
- 241000907316 Zika virus Species 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 210000000234 capsid Anatomy 0.000 claims 1
- 208000025729 dengue disease Diseases 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 208000029570 hepatitis D virus infection Diseases 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 claims 1
- 239000002924 silencing RNA Substances 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 230000029302 virus maturation Effects 0.000 claims 1
- 0 CC*N(C)C(C)* Chemical compound CC*N(C)C(C)* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662305865P | 2016-03-09 | 2016-03-09 | |
| US62/305,865 | 2016-03-09 | ||
| PCT/US2017/021551 WO2017156255A1 (en) | 2016-03-09 | 2017-03-09 | Elimination of hepatitis b virus with antiviral agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019507774A JP2019507774A (ja) | 2019-03-22 |
| JP2019507774A5 true JP2019507774A5 (https=) | 2020-04-23 |
| JP7126947B2 JP7126947B2 (ja) | 2022-08-29 |
Family
ID=59789853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018546884A Active JP7126947B2 (ja) | 2016-03-09 | 2017-03-09 | 抗ウイルス剤によるｂ型肝炎ウイルスの排除 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10752584B2 (https=) |
| EP (1) | EP3426633A4 (https=) |
| JP (1) | JP7126947B2 (https=) |
| KR (1) | KR102390675B1 (https=) |
| CN (1) | CN109153640B (https=) |
| AU (1) | AU2017231817B2 (https=) |
| BR (1) | BR112018068177B1 (https=) |
| CA (1) | CA3016879A1 (https=) |
| CL (1) | CL2018002549A1 (https=) |
| CO (1) | CO2018009382A2 (https=) |
| EA (1) | EA201892034A1 (https=) |
| IL (1) | IL261650B2 (https=) |
| MX (1) | MX2018010775A (https=) |
| PE (1) | PE20190118A1 (https=) |
| PH (1) | PH12018550150B1 (https=) |
| SG (1) | SG11201807569WA (https=) |
| WO (1) | WO2017156255A1 (https=) |
| ZA (1) | ZA201806651B (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3154989T (pt) | 2014-06-11 | 2021-05-18 | Venatorx Pharmaceuticals Inc | Inibidores de beta-lactamase |
| EP4659747A2 (en) | 2015-07-24 | 2025-12-10 | Lumos Pharma, Inc. | Salts and prodrugs of 1-methyl-d-tryptophan |
| WO2017165489A1 (en) | 2016-03-23 | 2017-09-28 | Emory University | Antiviral agents for treating zika and dengue virus infections |
| JOP20190024A1 (ar) * | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| CN108250121A (zh) * | 2016-12-28 | 2018-07-06 | 上海长森药业有限公司 | 磺酰胺-芳基酰胺类化合物及其治疗乙型肝炎的药物用途 |
| WO2019118358A1 (en) | 2017-12-11 | 2019-06-20 | VenatoRx Pharmaceuticals, Inc. | Hepatitis b capsid assembly modulators |
| WO2019154343A1 (zh) * | 2018-02-09 | 2019-08-15 | 正大天晴药业集团股份有限公司 | 衣壳蛋白装配抑制剂、其药物组合物和用途 |
| JP7050165B2 (ja) | 2018-02-26 | 2022-04-07 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｂｖ複製阻害剤としての置換ピロリジン化合物 |
| WO2019185016A1 (zh) | 2018-03-30 | 2019-10-03 | 正大天晴药业集团股份有限公司 | 含有n杂五元环的衣壳蛋白装配抑制剂、其药物组合物和用途 |
| CN113549079A (zh) | 2018-05-25 | 2021-10-26 | 正大天晴药业集团股份有限公司 | 2,3-二氢-1h-吡咯嗪-7-甲酰胺类衍生物及其应用 |
| JP2021527638A (ja) * | 2018-06-11 | 2021-10-14 | ベナトルクス ファーマシューティカルズ，インク． | Ｂ型肝炎カプシドアセンブリモジュレーター |
| US20230056135A1 (en) * | 2018-10-05 | 2023-02-23 | Emory University | Monomer and multimeric anti-hbv agents |
| EA202092159A1 (ru) * | 2019-01-25 | 2020-12-15 | Чиа Тай Тянцин Фармасьютикал Груп Ко., Лтд. | Содержащий n-гетероциклическое пятичленное кольцо ингибитор сборки капсидного белка, его фармацевтическая композиция и их применение |
| CN113365999B (zh) * | 2019-01-31 | 2023-04-14 | 正大天晴药业集团股份有限公司 | 含有吡咯并杂环的衣壳蛋白装配抑制剂 |
| WO2020169784A1 (en) | 2019-02-22 | 2020-08-27 | Janssen Sciences Ireland Unlimited Company | Amide derivatives useful in the treatment of hbv infection or hbv-induced diseases |
| MX2021012105A (es) * | 2019-04-03 | 2021-11-03 | Aligos Therapeutics Inc | Compuestos de pirrol. |
| CN113906029A (zh) | 2019-05-30 | 2022-01-07 | 阿里戈斯治疗公司 | 三环化合物 |
| AU2020289537A1 (en) * | 2019-06-06 | 2021-11-25 | Aligos Therapeutics, Inc. | Heterocyclic compounds |
| WO2020255013A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and capsid assembly modulators being amide derivatives |
| AU2020355384B2 (en) | 2019-09-29 | 2025-12-18 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Crystalline form of capsid protein assembly inhibitor containing N hetero five-membered ring, and application thereof |
| US12384745B2 (en) | 2019-09-29 | 2025-08-12 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Crystal form of five-membered n heterocyclic compound, and application thereof |
| EP4245372A3 (en) | 2019-11-13 | 2023-11-22 | Xi'An Xintong Pharmaceutical Research Co., Ltd. | Hbv inhibitor and use thereof |
| US20230107941A1 (en) * | 2019-12-10 | 2023-04-06 | VenatoRx Pharmaceuticals, Inc. | Hepatitis b capsid assembly modulators |
| CN113493441B (zh) * | 2020-04-03 | 2024-07-09 | 广东东阳光药业股份有限公司 | 新型螺环类化合物及其在药物中的应用 |
| CN114075206B (zh) * | 2020-08-17 | 2025-03-14 | 广东东阳光药业股份有限公司 | 新型稠环类化合物及其在药物中的应用 |
| EP4251625A4 (en) | 2020-11-24 | 2024-10-09 | Aligos Therapeutics, Inc. | Tricyclic compounds |
| CN114685514A (zh) * | 2020-12-29 | 2022-07-01 | 广东东阳光药业有限公司 | 新型酰胺吡咯类化合物及其在药物中的应用 |
| WO2022156758A1 (zh) * | 2021-01-22 | 2022-07-28 | 广东东阳光药业有限公司 | 新型酰胺吡咯类化合物及其在药物中的用途 |
| CN118974014B (zh) * | 2022-03-17 | 2026-01-27 | 成都微芯药业有限公司 | 吡咯酰胺类化合物及其制备方法和用途 |
| CN116120219A (zh) * | 2022-12-27 | 2023-05-16 | 吉斯凯(苏州)制药有限公司 | 一种多取代吡咯类化合物及其制备方法和在制备hbv衣壳蛋白抑制剂中的应用 |
| CN119173508B (zh) * | 2023-01-12 | 2025-11-04 | 成都微芯药业有限公司 | 氨基噻吩类化合物、其制备方法及用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5977347B2 (ja) * | 2011-07-01 | 2016-08-24 | バルーク エス．ブルームバーグ インスティテュート | Ｈｂｖ感染に対する抗ウイルス剤としてのスルファモイルベンズアミド誘導体 |
| BR112014015197A8 (pt) * | 2011-12-21 | 2017-06-13 | Novira Therapeutics Inc | agentes antivirais de hepatite b |
| TWI733288B (zh) | 2013-05-17 | 2021-07-11 | 愛爾蘭商健生科學愛爾蘭無限公司 | 胺磺醯基吡咯醯胺衍生物及其作為用於治療ｂ型肝炎藥物的用途 |
| HRP20180791T1 (hr) | 2013-07-25 | 2018-09-07 | Janssen Sciences Ireland Uc | Glioksamid supstituirani derivati pirolamida i njihova uporaba kao lijekova za liječenje hepatitisa b |
| CA2923712C (en) | 2013-10-23 | 2021-11-02 | Janssen Sciences Ireland Uc | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| TW201620893A (zh) * | 2014-02-06 | 2016-06-16 | 健生科學愛爾蘭無限公司 | 磺醯胺基吡咯醯胺衍生物及其用作治療ｂ型肝炎之醫藥品的用途 |
-
2017
- 2017-03-09 CO CONC2018/0009382A patent/CO2018009382A2/es unknown
- 2017-03-09 PE PE2018001794A patent/PE20190118A1/es unknown
- 2017-03-09 EA EA201892034A patent/EA201892034A1/ru unknown
- 2017-03-09 US US16/082,747 patent/US10752584B2/en active Active
- 2017-03-09 SG SG11201807569WA patent/SG11201807569WA/en unknown
- 2017-03-09 IL IL261650A patent/IL261650B2/en unknown
- 2017-03-09 CA CA3016879A patent/CA3016879A1/en active Pending
- 2017-03-09 WO PCT/US2017/021551 patent/WO2017156255A1/en not_active Ceased
- 2017-03-09 KR KR1020187029087A patent/KR102390675B1/ko active Active
- 2017-03-09 EP EP17764083.6A patent/EP3426633A4/en active Pending
- 2017-03-09 JP JP2018546884A patent/JP7126947B2/ja active Active
- 2017-03-09 PH PH1/2018/550150A patent/PH12018550150B1/en unknown
- 2017-03-09 BR BR112018068177-6A patent/BR112018068177B1/pt active IP Right Grant
- 2017-03-09 MX MX2018010775A patent/MX2018010775A/es unknown
- 2017-03-09 CN CN201780026961.1A patent/CN109153640B/zh active Active
- 2017-03-09 AU AU2017231817A patent/AU2017231817B2/en active Active
-
2018
- 2018-09-06 CL CL2018002549A patent/CL2018002549A1/es unknown
- 2018-10-05 ZA ZA2018/06651A patent/ZA201806651B/en unknown
-
2020
- 2020-08-20 US US16/998,944 patent/US11629125B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019507774A5 (https=) | ||
| RU2405774C2 (ru) | Гетероциклические ингибиторы аспартилпротеазы | |
| RU2428428C2 (ru) | Серусодержащие соединения, действующие как ингибиторы сериновой протеазы ns3 вируса гепатита с | |
| CL2022000587A1 (es) | Profármacos antivirales y formulaciones de los mismos | |
| RU2018127728A (ru) | Слитые трициклические гетероциклические соединения в качестве ингибиторов интегразы вич | |
| RU2014113539A (ru) | Тетрациклические гетероциклические соединения и способы их применения для лечения вирусных заболеваний | |
| JP2019500387A5 (https=) | ||
| JP2020521741A5 (https=) | ||
| WO2019143902A3 (en) | Substituted heterocycles as antiviral agents | |
| AR057716A1 (es) | Inhibidores de las serina proteasas y composiciones farmaceuticas | |
| EA201992082A1 (ru) | Ингибитор поверхностного антигена вируса гепатита b | |
| JP2005519916A5 (https=) | ||
| JP2016522172A5 (https=) | ||
| CA2573346A1 (en) | Hepatitis c inhibitor peptide analogs | |
| JP2011523651A5 (https=) | ||
| JP2012504126A5 (https=) | ||
| EA200800932A1 (ru) | Модифицированные 4`-нуклеозиды в качестве противовирусных агентов | |
| EA202090514A1 (ru) | Противовирусное средство против гепатита в | |
| JP2015525220A5 (https=) | ||
| CY1113809T1 (el) | Μακροκυκλικα καρβοξυλικα οξεα και ακυλοσουλφοναμιδικες ενωσεις ως αναστολεις της αντιγραφης του hcv | |
| RU2016122908A (ru) | Соединения дигидропиримидина и их применение в фармацевтических препаратах | |
| EA200700338A1 (ru) | Ингибиторы рнк-зависимой рнк-полимеразы вируса гепатита с и композиции и способы лечения с их использованием | |
| CA2490200A1 (en) | 2' and 3'-nucleoside prodrugs for treating flaviviridae infections | |
| MY154683A (en) | Pharmaceutical composition for a hepatitis c viral protease inhibitor | |
| AR058025A1 (es) | Procesos de obtencion de pirroles y productos intermedios para la preparacion de inhibidores de proteasa |