JP2019507774A5 - - Google Patents
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- JP2019507774A5 JP2019507774A5 JP2018546884A JP2018546884A JP2019507774A5 JP 2019507774 A5 JP2019507774 A5 JP 2019507774A5 JP 2018546884 A JP2018546884 A JP 2018546884A JP 2018546884 A JP2018546884 A JP 2018546884A JP 2019507774 A5 JP2019507774 A5 JP 2019507774A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- membered
- heteroatoms
- alkyl
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000001072 heteroaryl group Chemical group 0.000 claims 57
- 125000005842 heteroatom Chemical group 0.000 claims 53
- 229910052760 oxygen Inorganic materials 0.000 claims 53
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 38
- 125000000217 alkyl group Chemical group 0.000 claims 35
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 31
- 150000001875 compounds Chemical class 0.000 claims 28
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 27
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 26
- 125000003545 alkoxy group Chemical group 0.000 claims 25
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 25
- 229910052736 halogen Inorganic materials 0.000 claims 24
- 150000002367 halogens Chemical class 0.000 claims 24
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 23
- 125000001424 substituent group Chemical group 0.000 claims 23
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 22
- 125000002619 bicyclic group Chemical group 0.000 claims 22
- 229910052717 sulfur Inorganic materials 0.000 claims 21
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 20
- 125000003118 aryl group Chemical group 0.000 claims 19
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 19
- 125000002877 alkyl aryl group Chemical group 0.000 claims 18
- KWEDUNSJJZVRKR-UHFFFAOYSA-N carbononitridic azide Chemical compound [N-]=[N+]=NC#N KWEDUNSJJZVRKR-UHFFFAOYSA-N 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 17
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 239000000651 prodrug Substances 0.000 claims 16
- 229940002612 prodrug Drugs 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 16
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
- 125000003107 substituted aryl group Chemical group 0.000 claims 14
- 229910052757 nitrogen Inorganic materials 0.000 claims 13
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 12
- 125000003003 spiro group Chemical group 0.000 claims 11
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 10
- 229910052799 carbon Inorganic materials 0.000 claims 10
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 9
- -1 C3-6Alkoxyalkyl Chemical group 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 9
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 9
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 8
- 208000015181 infectious disease Diseases 0.000 claims 8
- 229920006395 saturated elastomer Polymers 0.000 claims 8
- 241000700605 Viruses Species 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- PIGFYZPCRLYGLF-UHFFFAOYSA-N Aluminum nitride Chemical compound [Al]#N PIGFYZPCRLYGLF-UHFFFAOYSA-N 0.000 claims 4
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims 4
- 229910052711 selenium Inorganic materials 0.000 claims 4
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 241000711549 Hepacivirus C Species 0.000 claims 3
- 230000004071 biological effect Effects 0.000 claims 3
- 125000005243 carbonyl alkyl group Chemical group 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 3
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 2
- 241000710781 Flaviviridae Species 0.000 claims 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 2
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 2
- 206010057293 West Nile viral infection Diseases 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 150000008064 anhydrides Chemical class 0.000 claims 2
- 239000003443 antiviral agent Substances 0.000 claims 2
- 125000001769 aryl amino group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 150000004820 halides Chemical class 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 150000002466 imines Chemical class 0.000 claims 2
- LBQAJLBSGOBDQF-UHFFFAOYSA-N nitro azanylidynemethanesulfonate Chemical compound [O-][N+](=O)OS(=O)(=O)C#N LBQAJLBSGOBDQF-UHFFFAOYSA-N 0.000 claims 2
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 2
- 150000002923 oximes Chemical class 0.000 claims 2
- 125000005328 phosphinyl group Chemical group [PH2](=O)* 0.000 claims 2
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 2
- 125000005499 phosphonyl group Chemical group 0.000 claims 2
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims 2
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims 2
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 150000007970 thio esters Chemical class 0.000 claims 2
- 150000003568 thioethers Chemical class 0.000 claims 2
- HCMJWOGOISXSDL-UHFFFAOYSA-N (2-isothiocyanato-1-phenylethyl)benzene Chemical compound C=1C=CC=CC=1C(CN=C=S)C1=CC=CC=C1 HCMJWOGOISXSDL-UHFFFAOYSA-N 0.000 claims 1
- 108091033409 CRISPR Proteins 0.000 claims 1
- 208000001490 Dengue Diseases 0.000 claims 1
- 206010012310 Dengue fever Diseases 0.000 claims 1
- 208000037262 Hepatitis delta Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 101710200424 Inosine-5'-monophosphate dehydrogenase Proteins 0.000 claims 1
- 108700011259 MicroRNAs Proteins 0.000 claims 1
- 229940123066 Polymerase inhibitor Drugs 0.000 claims 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 1
- 229910018482 SF5 Inorganic materials 0.000 claims 1
- 108091027967 Small hairpin RNA Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 241000710886 West Nile virus Species 0.000 claims 1
- 208000003152 Yellow Fever Diseases 0.000 claims 1
- 241000907316 Zika virus Species 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 210000000234 capsid Anatomy 0.000 claims 1
- 208000025729 dengue disease Diseases 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 208000029570 hepatitis D virus infection Diseases 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 claims 1
- 239000002924 silencing RNA Substances 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 230000029302 virus maturation Effects 0.000 claims 1
- 0 CC*N(C)C(C)* Chemical compound CC*N(C)C(C)* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662305865P | 2016-03-09 | 2016-03-09 | |
| US62/305,865 | 2016-03-09 | ||
| PCT/US2017/021551 WO2017156255A1 (en) | 2016-03-09 | 2017-03-09 | Elimination of hepatitis b virus with antiviral agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019507774A JP2019507774A (ja) | 2019-03-22 |
| JP2019507774A5 true JP2019507774A5 (https=) | 2020-04-23 |
| JP7126947B2 JP7126947B2 (ja) | 2022-08-29 |
Family
ID=59789853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018546884A Active JP7126947B2 (ja) | 2016-03-09 | 2017-03-09 | 抗ウイルス剤によるｂ型肝炎ウイルスの排除 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10752584B2 (https=) |
| EP (1) | EP3426633A4 (https=) |
| JP (1) | JP7126947B2 (https=) |
| KR (1) | KR102390675B1 (https=) |
| CN (1) | CN109153640B (https=) |
| AU (1) | AU2017231817B2 (https=) |
| BR (1) | BR112018068177B1 (https=) |
| CA (1) | CA3016879A1 (https=) |
| CL (1) | CL2018002549A1 (https=) |
| CO (1) | CO2018009382A2 (https=) |
| EA (1) | EA201892034A1 (https=) |
| IL (1) | IL261650B2 (https=) |
| MX (1) | MX2018010775A (https=) |
| PE (1) | PE20190118A1 (https=) |
| PH (1) | PH12018550150B1 (https=) |
| SG (1) | SG11201807569WA (https=) |
| WO (1) | WO2017156255A1 (https=) |
| ZA (1) | ZA201806651B (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015191907A1 (en) | 2014-06-11 | 2015-12-17 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| EP3954369B1 (en) | 2015-07-24 | 2025-08-20 | Lumos Pharma, Inc. | Salts and prodrugs of 1-methyl-d-tryptophan |
| US11963972B2 (en) | 2016-03-23 | 2024-04-23 | Emory University | Antiviral agents and nucleoside analogs for treatment of Zika virus |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| CN108250121A (zh) * | 2016-12-28 | 2018-07-06 | 上海长森药业有限公司 | 磺酰胺-芳基酰胺类化合物及其治疗乙型肝炎的药物用途 |
| WO2019118358A1 (en) | 2017-12-11 | 2019-06-20 | VenatoRx Pharmaceuticals, Inc. | Hepatitis b capsid assembly modulators |
| WO2019154343A1 (zh) * | 2018-02-09 | 2019-08-15 | 正大天晴药业集团股份有限公司 | 衣壳蛋白装配抑制剂、其药物组合物和用途 |
| PL3759109T3 (pl) * | 2018-02-26 | 2024-03-04 | Gilead Sciences, Inc. | Podstawione związki pirolizyny jako inhibitory replikacji hbv |
| CN115974753A (zh) * | 2018-03-30 | 2023-04-18 | 正大天晴药业集团股份有限公司 | 含有n杂五元环化合物和用途 |
| KR102752886B1 (ko) * | 2018-05-25 | 2025-01-09 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | 2,3-디히드로-1h-피롤리진-7-포름아미드 유도체 및 그 사용 |
| DE202019005471U1 (de) | 2018-06-11 | 2020-09-17 | VenatoRx Pharmaceuticals, Inc. | Hepatitis B Kapsid-Assemblierungsmodulatoren |
| BR112021006403A2 (pt) * | 2018-10-05 | 2021-07-06 | Univ Emory | agentes monômeros e multiméricos anti-hbv |
| EA202092159A1 (ru) * | 2019-01-25 | 2020-12-15 | Чиа Тай Тянцин Фармасьютикал Груп Ко., Лтд. | Содержащий n-гетероциклическое пятичленное кольцо ингибитор сборки капсидного белка, его фармацевтическая композиция и их применение |
| WO2020156494A1 (zh) * | 2019-01-31 | 2020-08-06 | 正大天晴药业集团股份有限公司 | 含有吡咯并杂环的衣壳蛋白装配抑制剂 |
| MX2021010145A (es) * | 2019-02-22 | 2021-09-14 | Janssen Sciences Ireland Unlimited Co | Derivados de amida utiles en el tratamiento de una infeccion por vhb o de enfermedades inducidas por vhb. |
| CN121108187A (zh) | 2019-04-03 | 2025-12-12 | 阿里戈斯治疗公司 | 吡咯化合物 |
| PH12021552953A1 (en) | 2019-05-30 | 2022-07-25 | Aligos Therapeutics Inc | Tricyclic compounds |
| EP3980406A4 (en) * | 2019-06-06 | 2023-06-28 | Aligos Therapeutics, Inc. | Heterocyclic compounds |
| WO2020255013A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and capsid assembly modulators being amide derivatives |
| WO2021058001A1 (zh) * | 2019-09-29 | 2021-04-01 | 正大天晴药业集团股份有限公司 | N杂五元环化合物的晶型及其应用 |
| ES3064043T3 (en) | 2019-09-29 | 2026-04-22 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Crystalline forms of a capsid protein assembly inhibitor containing a pyrrole ring, and application thereof |
| AU2020385034B2 (en) * | 2019-11-13 | 2024-11-14 | Xi'an Xintong Pharmaceutical Research Co., Ltd. | HBV inhibitor and use thereof |
| WO2021119081A1 (en) * | 2019-12-10 | 2021-06-17 | VenatoRx Pharmaceuticals, Inc. | Hepatitis b capsid assembly modulators |
| WO2021197486A1 (zh) * | 2020-04-03 | 2021-10-07 | 东莞市东阳光新药研发有限公司 | 新型螺环类化合物及其在药物中的应用 |
| CN114075206B (zh) * | 2020-08-17 | 2025-03-14 | 广东东阳光药业股份有限公司 | 新型稠环类化合物及其在药物中的应用 |
| AU2021387908A1 (en) | 2020-11-24 | 2023-06-22 | Aligos Therapeutics, Inc. | Tricyclic compounds |
| CN114685514A (zh) * | 2020-12-29 | 2022-07-01 | 广东东阳光药业有限公司 | 新型酰胺吡咯类化合物及其在药物中的应用 |
| WO2022156758A1 (zh) * | 2021-01-22 | 2022-07-28 | 广东东阳光药业有限公司 | 新型酰胺吡咯类化合物及其在药物中的用途 |
| CN118974014B (zh) * | 2022-03-17 | 2026-01-27 | 成都微芯药业有限公司 | 吡咯酰胺类化合物及其制备方法和用途 |
| CN116120219A (zh) * | 2022-12-27 | 2023-05-16 | 吉斯凯(苏州)制药有限公司 | 一种多取代吡咯类化合物及其制备方法和在制备hbv衣壳蛋白抑制剂中的应用 |
| WO2024149314A1 (zh) * | 2023-01-12 | 2024-07-18 | 成都微芯药业有限公司 | 氨基噻吩类化合物、其制备方法及用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3085368A1 (en) * | 2011-07-01 | 2016-10-26 | Baruch S. Blumberg Institute | Sulfamoylbenzamide derivatives as antiviral agents against hbv infection |
| WO2013096744A1 (en) * | 2011-12-21 | 2013-06-27 | Novira Therapeutics, Inc. | Hepatitis b antiviral agents |
| TWI651300B (zh) * | 2013-05-17 | 2019-02-21 | 健生科學愛爾蘭無限公司 | 胺磺醯基吡咯醯胺衍生物及其作為用於治療ｂ型肝炎藥物的用途 |
| DK3024819T3 (en) * | 2013-07-25 | 2018-06-06 | Janssen Sciences Ireland Uc | GLYOXAMIDE-SUBSTITUTED PYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICINES FOR TREATING HEPATITIS B |
| KR102290189B1 (ko) * | 2013-10-23 | 2021-08-17 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 카르복스아미드 유도체 및 ｂ형 간염 치료용 의약으로서의 이의 용도 |
| WO2015118057A1 (en) * | 2014-02-06 | 2015-08-13 | Janssen Sciences Ireland Uc | Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
-
2017
- 2017-03-09 US US16/082,747 patent/US10752584B2/en active Active
- 2017-03-09 JP JP2018546884A patent/JP7126947B2/ja active Active
- 2017-03-09 WO PCT/US2017/021551 patent/WO2017156255A1/en not_active Ceased
- 2017-03-09 PE PE2018001794A patent/PE20190118A1/es unknown
- 2017-03-09 MX MX2018010775A patent/MX2018010775A/es unknown
- 2017-03-09 SG SG11201807569WA patent/SG11201807569WA/en unknown
- 2017-03-09 AU AU2017231817A patent/AU2017231817B2/en active Active
- 2017-03-09 EP EP17764083.6A patent/EP3426633A4/en active Pending
- 2017-03-09 CA CA3016879A patent/CA3016879A1/en active Pending
- 2017-03-09 IL IL261650A patent/IL261650B2/en unknown
- 2017-03-09 KR KR1020187029087A patent/KR102390675B1/ko active Active
- 2017-03-09 EA EA201892034A patent/EA201892034A1/ru unknown
- 2017-03-09 CO CONC2018/0009382A patent/CO2018009382A2/es unknown
- 2017-03-09 PH PH1/2018/550150A patent/PH12018550150B1/en unknown
- 2017-03-09 BR BR112018068177-6A patent/BR112018068177B1/pt active IP Right Grant
- 2017-03-09 CN CN201780026961.1A patent/CN109153640B/zh active Active
-
2018
- 2018-09-06 CL CL2018002549A patent/CL2018002549A1/es unknown
- 2018-10-05 ZA ZA2018/06651A patent/ZA201806651B/en unknown
-
2020
- 2020-08-20 US US16/998,944 patent/US11629125B2/en active Active
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