JP2016507526A5 - - Google Patents
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- Publication number
- JP2016507526A5 JP2016507526A5 JP2015556185A JP2015556185A JP2016507526A5 JP 2016507526 A5 JP2016507526 A5 JP 2016507526A5 JP 2015556185 A JP2015556185 A JP 2015556185A JP 2015556185 A JP2015556185 A JP 2015556185A JP 2016507526 A5 JP2016507526 A5 JP 2016507526A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- sulfasalazine
- composition according
- polymer
- pvp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 claims 11
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 claims 11
- 229960001940 sulfasalazine Drugs 0.000 claims 11
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 claims 11
- 208000015122 neurodegenerative disease Diseases 0.000 claims 8
- 229920000642 polymer Polymers 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 229920003083 Kollidon® VA64 Polymers 0.000 claims 4
- 206010053395 Progressive multiple sclerosis Diseases 0.000 claims 4
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 4
- 238000000338 in vitro Methods 0.000 claims 4
- 230000004770 neurodegeneration Effects 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000010922 spray-dried dispersion Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361759933P | 2013-02-01 | 2013-02-01 | |
| US61/759,933 | 2013-02-01 | ||
| US201361780340P | 2013-03-13 | 2013-03-13 | |
| US61/780,340 | 2013-03-13 | ||
| PCT/US2014/014290 WO2014121137A2 (en) | 2013-02-01 | 2014-01-31 | Compositions and methods for the treatment of neurodegenerative and other diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018079284A Division JP2018123159A (ja) | 2013-02-01 | 2018-04-17 | 神経変性およびその他の疾患の治療用組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016507526A JP2016507526A (ja) | 2016-03-10 |
| JP2016507526A5 true JP2016507526A5 (enExample) | 2017-02-23 |
| JP6328146B2 JP6328146B2 (ja) | 2018-05-23 |
Family
ID=50382538
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015556185A Expired - Fee Related JP6328146B2 (ja) | 2013-02-01 | 2014-01-31 | 神経変性およびその他の疾患の治療用組成物および方法 |
| JP2018079284A Pending JP2018123159A (ja) | 2013-02-01 | 2018-04-17 | 神経変性およびその他の疾患の治療用組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018079284A Pending JP2018123159A (ja) | 2013-02-01 | 2018-04-17 | 神経変性およびその他の疾患の治療用組成物および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US9597339B2 (enExample) |
| EP (1) | EP2950797B1 (enExample) |
| JP (2) | JP6328146B2 (enExample) |
| KR (1) | KR20150139830A (enExample) |
| CN (1) | CN105163735B (enExample) |
| AU (2) | AU2014212109B2 (enExample) |
| CA (1) | CA2899032A1 (enExample) |
| ES (1) | ES2752021T3 (enExample) |
| IL (1) | IL240206A0 (enExample) |
| WO (1) | WO2014121137A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014212109B2 (en) * | 2013-02-01 | 2018-05-31 | Glialogix, Inc. | Compositions and methods for the treatment of neurodegenerative and other diseases |
| KR102364840B1 (ko) * | 2014-11-05 | 2022-02-18 | 삼성전자주식회사 | 신경세포의 탈수초화와 연관된 질환을 치료하기 위한 약학적 조성물 및 그를 이용하는 방법 |
| US20160199393A1 (en) * | 2015-01-08 | 2016-07-14 | China Medical University | Methods of treating brain ischemia or hypoxia |
| ES2650175B1 (es) * | 2016-04-15 | 2019-02-04 | Servicio Andaluz De Salud | Tratamiento de enfermedades neurodegenerativas |
| CN109414507A (zh) * | 2016-04-26 | 2019-03-01 | 美国圣路易斯大学 | 用于预防和治疗神经退行性疾病的高度选择性腺苷a3受体亚型激动剂 |
| US20180110760A1 (en) | 2016-10-21 | 2018-04-26 | Glialogix, Inc. | Compositions and methods for the treatmentof neurodegenerative and other diseases |
| US10473672B2 (en) * | 2017-02-09 | 2019-11-12 | Kaohsiung Chang Gung Memorial Hospital | Methods for diagnosing and treating Alzheimers disease using G72 protein and SLC7A11 mRNA as biomarkers |
| US20230210871A1 (en) * | 2017-10-12 | 2023-07-06 | The Limited Company Research And Development Company "Medbiopharm" | Use of sulfasalazine as an inhibitor of the formation of advanced glycation end products |
| JP6603815B2 (ja) * | 2017-11-21 | 2019-11-06 | 積水化学工業株式会社 | 皮膚外用剤 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2396145A (en) | 1940-12-14 | 1946-03-05 | Pharmscia Ab | Heterocyclic sulphonamido azo compounds |
| FR2608988B1 (fr) | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules |
| NZ292980A (en) | 1994-09-29 | 1999-02-25 | Andaris Ltd | Smooth, spherical water-soluble microparticles as therapeutic or diagnostic vehicles |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| ITMI962356A1 (it) | 1996-11-13 | 1998-05-13 | Uni Degli Studi Di Brescia D I | Uso di composti derivati da molecole ad attivita' antinfiammatoria di tipo non steroideo per la prevenzione e il trattamento di |
| DE69732306T2 (de) | 1997-01-16 | 2006-01-12 | Massachusetts Institute Of Technology, Cambridge | Zubereitung von partikelhaltigen arzneimitteln zur inhalation |
| ES2198922T3 (es) | 1998-06-24 | 2004-02-01 | Advanced Inhalation Research, Inc. | Particulas porosas grandes emitadas por un inhalador. |
| AU758351B2 (en) | 1998-08-25 | 2003-03-20 | Alkermes, Inc. | Stable spray-dried protein formulations |
| US6586008B1 (en) | 1999-08-25 | 2003-07-01 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles during spray drying |
| KR100417623B1 (ko) | 2000-03-28 | 2004-02-05 | 주식회사 뉴로테크 | 뇌질환 예방 및 치료용 조성물 |
| CA2307278A1 (en) | 2000-04-28 | 2001-10-28 | University Of British Columbia | Use of n-heterocyclic substituted salicylic acids for inhibition of cellular uptake of cystine |
| JP2005523260A (ja) | 2002-02-01 | 2005-08-04 | ファイザー・プロダクツ・インク | 圧力ノズルを用いた均質噴霧乾燥固体非晶質薬剤分散体の製造方法 |
| PT1469833T (pt) | 2002-02-01 | 2021-07-13 | Bend Res Inc | Método para produzir dispersões de fármaco amorfo sólido seco por pulverização homogéneas utilizando aparelho de secagem por pulverização modificado |
| CL2004001884A1 (es) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
| US20060045865A1 (en) | 2004-08-27 | 2006-03-02 | Spherics, Inc. | Controlled regional oral delivery |
| US8748445B2 (en) | 2004-10-27 | 2014-06-10 | The Uab Research Foundation | Methods for treating glioma |
| JP5368093B2 (ja) | 2005-08-31 | 2013-12-18 | アブラクシス バイオサイエンス， エルエルシー | 増大した安定性を有する難水溶性薬剤の組成物および調製の方法 |
| US20070053869A1 (en) | 2005-09-02 | 2007-03-08 | Yuichi Sugiyama | Formulation and method for enhancement of gastrointestinal absorption of pharmaceutical agents |
| GB0602123D0 (en) * | 2006-02-02 | 2006-03-15 | Novartis Ag | Organic compounds |
| KR20080090493A (ko) | 2006-02-02 | 2008-10-08 | 노파르티스 아게 | 결절성 경화증의 치료 |
| US7964585B2 (en) | 2006-03-14 | 2011-06-21 | Case Western Reserve University | Composition and method of treating peripheral neuropathy |
| KR101468053B1 (ko) | 2006-08-31 | 2014-12-02 | 앱탈리스 파마테크, 인코포레이티드 | 약 염기성 약물의 고용체를 포함하는 약물 전달 시스템 |
| US8309129B2 (en) | 2007-05-03 | 2012-11-13 | Bend Research, Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
| US9724362B2 (en) | 2007-12-06 | 2017-08-08 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
| KR20100126452A (ko) * | 2008-02-28 | 2010-12-01 | 바이알 - 포르텔라 앤드 씨에이 에스에이 | 난용성 약물용 약학적 조성물 |
| DK2113254T3 (da) * | 2008-04-28 | 2012-12-03 | Txcell | Sammensætninger til behandling af en inflammatorisk autoimmun sygdom |
| TW201438738A (zh) | 2008-09-16 | 2014-10-16 | 建南德克公司 | 治療進展型多發性硬化症之方法 |
| WO2010111132A2 (en) | 2009-03-27 | 2010-09-30 | Bend Research, Inc. | Spray-drying process |
| US9084976B2 (en) | 2010-09-03 | 2015-07-21 | Bend Research, Inc. | Spray-drying apparatus and methods of using the same |
| PT2611530T (pt) | 2010-09-03 | 2019-05-09 | Bend Res Inc | Aparelho de secagem por pulverização e métodos de utilização do mesmo |
| WO2013115965A1 (en) | 2012-01-31 | 2013-08-08 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
| AU2014212109B2 (en) * | 2013-02-01 | 2018-05-31 | Glialogix, Inc. | Compositions and methods for the treatment of neurodegenerative and other diseases |
| EP3089736B1 (en) | 2013-12-31 | 2025-07-23 | Ascendia Pharmaceuticals, LLC | Pharmaceutical compositions for poorly water-soluble compounds |
-
2014
- 2014-01-31 AU AU2014212109A patent/AU2014212109B2/en not_active Ceased
- 2014-01-31 US US14/170,405 patent/US9597339B2/en not_active Expired - Fee Related
- 2014-01-31 CA CA2899032A patent/CA2899032A1/en not_active Abandoned
- 2014-01-31 WO PCT/US2014/014290 patent/WO2014121137A2/en not_active Ceased
- 2014-01-31 KR KR1020157023718A patent/KR20150139830A/ko not_active Withdrawn
- 2014-01-31 CN CN201480019892.8A patent/CN105163735B/zh not_active Expired - Fee Related
- 2014-01-31 ES ES14712798T patent/ES2752021T3/es active Active
- 2014-01-31 JP JP2015556185A patent/JP6328146B2/ja not_active Expired - Fee Related
- 2014-01-31 EP EP14712798.9A patent/EP2950797B1/en active Active
-
2015
- 2015-07-29 IL IL240206A patent/IL240206A0/en unknown
-
2016
- 2016-11-30 US US15/365,843 patent/US9980978B2/en not_active Expired - Fee Related
- 2016-11-30 US US15/365,835 patent/US9974798B2/en not_active Expired - Fee Related
-
2017
- 2017-02-10 US US15/430,294 patent/US9918997B2/en not_active Expired - Fee Related
-
2018
- 2018-04-17 JP JP2018079284A patent/JP2018123159A/ja active Pending
- 2018-04-17 US US15/955,020 patent/US10398713B2/en not_active Expired - Fee Related
- 2018-08-28 AU AU2018222921A patent/AU2018222921A1/en not_active Abandoned
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