JP6328146B2 - 神経変性およびその他の疾患の治療用組成物および方法 - Google Patents

神経変性およびその他の疾患の治療用組成物および方法 Download PDF

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Publication number
JP6328146B2
JP6328146B2 JP2015556185A JP2015556185A JP6328146B2 JP 6328146 B2 JP6328146 B2 JP 6328146B2 JP 2015556185 A JP2015556185 A JP 2015556185A JP 2015556185 A JP2015556185 A JP 2015556185A JP 6328146 B2 JP6328146 B2 JP 6328146B2
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sulfasalazine
pharmaceutical composition
certain embodiments
patient
formulated
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Japanese (ja)
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JP2016507526A5 (enExample
JP2016507526A (ja
Inventor
サディアス・クロムウェル・リーダー
マーク・ウェイド・ムーア
ダグラス・アラン・ロレンツ
デイビッド・キース・ライオン
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Glialogix Inc
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Glialogix Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2015556185A 2013-02-01 2014-01-31 神経変性およびその他の疾患の治療用組成物および方法 Expired - Fee Related JP6328146B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361759933P 2013-02-01 2013-02-01
US61/759,933 2013-02-01
US201361780340P 2013-03-13 2013-03-13
US61/780,340 2013-03-13
PCT/US2014/014290 WO2014121137A2 (en) 2013-02-01 2014-01-31 Compositions and methods for the treatment of neurodegenerative and other diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018079284A Division JP2018123159A (ja) 2013-02-01 2018-04-17 神経変性およびその他の疾患の治療用組成物および方法

Publications (3)

Publication Number Publication Date
JP2016507526A JP2016507526A (ja) 2016-03-10
JP2016507526A5 JP2016507526A5 (enExample) 2017-02-23
JP6328146B2 true JP6328146B2 (ja) 2018-05-23

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JP2015556185A Expired - Fee Related JP6328146B2 (ja) 2013-02-01 2014-01-31 神経変性およびその他の疾患の治療用組成物および方法
JP2018079284A Pending JP2018123159A (ja) 2013-02-01 2018-04-17 神経変性およびその他の疾患の治療用組成物および方法

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JP2018079284A Pending JP2018123159A (ja) 2013-02-01 2018-04-17 神経変性およびその他の疾患の治療用組成物および方法

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Country Link
US (5) US9597339B2 (enExample)
EP (1) EP2950797B1 (enExample)
JP (2) JP6328146B2 (enExample)
KR (1) KR20150139830A (enExample)
CN (1) CN105163735B (enExample)
AU (2) AU2014212109B2 (enExample)
CA (1) CA2899032A1 (enExample)
ES (1) ES2752021T3 (enExample)
IL (1) IL240206A0 (enExample)
WO (1) WO2014121137A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018123159A (ja) * 2013-02-01 2018-08-09 グリアロジクス・インコーポレイテッドＧｌｉａｌｏｇｉｘ， Ｉｎｃ． 神経変性およびその他の疾患の治療用組成物および方法

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US20160199393A1 (en) * 2015-01-08 2016-07-14 China Medical University Methods of treating brain ischemia or hypoxia
ES2650175B1 (es) * 2016-04-15 2019-02-04 Servicio Andaluz De Salud Tratamiento de enfermedades neurodegenerativas
US20190343860A1 (en) * 2016-04-26 2019-11-14 Saint Louis University Highly selective adenosine a3 receptor subtype agonists for the prevention and treatment of neurodegenerative disorders
WO2018075865A1 (en) * 2016-10-21 2018-04-26 Glialogix, Inc. Compositions for the treatment of neurodegenerative diseases
US10473672B2 (en) * 2017-02-09 2019-11-12 Kaohsiung Chang Gung Memorial Hospital Methods for diagnosing and treating Alzheimers disease using G72 protein and SLC7A11 mRNA as biomarkers
RU2680844C1 (ru) * 2017-10-12 2019-02-28 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Применение сульфасалазина в качестве ингибитора образования конечных продуктов гликирования
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018123159A (ja) * 2013-02-01 2018-08-09 グリアロジクス・インコーポレイテッドＧｌｉａｌｏｇｉｘ， Ｉｎｃ． 神経変性およびその他の疾患の治療用組成物および方法

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Publication number Publication date
JP2016507526A (ja) 2016-03-10
WO2014121137A3 (en) 2014-11-27
US9597339B2 (en) 2017-03-21
US9974798B2 (en) 2018-05-22
US20170079991A1 (en) 2017-03-23
JP2018123159A (ja) 2018-08-09
US20140221321A1 (en) 2014-08-07
CN105163735B (zh) 2018-12-11
ES2752021T3 (es) 2020-04-02
WO2014121137A2 (en) 2014-08-07
US10398713B2 (en) 2019-09-03
EP2950797A2 (en) 2015-12-09
US20170165279A1 (en) 2017-06-15
US9980978B2 (en) 2018-05-29
US9918997B2 (en) 2018-03-20
CN105163735A (zh) 2015-12-16
KR20150139830A (ko) 2015-12-14
CA2899032A1 (en) 2014-08-07
IL240206A0 (en) 2015-09-24
AU2018222921A1 (en) 2018-09-20
US20190015431A1 (en) 2019-01-17
EP2950797B1 (en) 2019-09-11
AU2014212109A1 (en) 2015-08-06
US20170079990A1 (en) 2017-03-23
AU2014212109B2 (en) 2018-05-31

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