MX2016005764A - Formulacion en suspension acuosa que comprende nanoparticulas de antibioticos macrolidos. - Google Patents
Formulacion en suspension acuosa que comprende nanoparticulas de antibioticos macrolidos.Info
- Publication number
- MX2016005764A MX2016005764A MX2016005764A MX2016005764A MX2016005764A MX 2016005764 A MX2016005764 A MX 2016005764A MX 2016005764 A MX2016005764 A MX 2016005764A MX 2016005764 A MX2016005764 A MX 2016005764A MX 2016005764 A MX2016005764 A MX 2016005764A
- Authority
- MX
- Mexico
- Prior art keywords
- aqueous suspension
- antibacterial agent
- nanoparticles
- suspension preparation
- macrolide antibacterial
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Biochemistry (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
[Problema] El propósito de la presente invención es proporcionar una preparación en suspensión acuosa que comprende un antibacteriano macrólido como componente activo. Específicamente, el propósito de la presente invención es proporcionar una composición farmacéutica que comprende un antibacteriano macrólido como componente activo y que puede tener uso práctico. [Solución] La presente invención proporciona: una preparación en suspensión acuosa caracterizada porque comprende nanopartículas de un antibacteriano macrólido y un estabilizante de dispersión; una suspensión acuosa en la que tamaño de partícula promedio de las nanopartículas es de 500 nm o menos y el tamaño de partícula D90 es 1500 nm o menos; una composición farmacéutica administrada por vía parenteral que comprende esta preparación en suspensión acuosa; una preparación inyectable; y colirio o gotas óticas, en términos más específicos, colirio para el tratamiento o prevención de enfermedades inflamatorias del ojo o gotas óticas para el tratamiento o prevención de enfermedades inflamatorias del oído.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013231796 | 2013-11-08 | ||
PCT/JP2014/005603 WO2015068397A1 (ja) | 2013-11-08 | 2014-11-07 | マクロライド系抗菌剤のナノ微粒子を含有する水性懸濁液剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016005764A true MX2016005764A (es) | 2017-01-05 |
Family
ID=53041191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016005764A MX2016005764A (es) | 2013-11-08 | 2014-11-07 | Formulacion en suspension acuosa que comprende nanoparticulas de antibioticos macrolidos. |
Country Status (13)
Country | Link |
---|---|
US (1) | US10792248B2 (es) |
EP (1) | EP3067045A4 (es) |
JP (1) | JP6407882B2 (es) |
KR (2) | KR20160079781A (es) |
CN (1) | CN105658203B (es) |
AU (1) | AU2014345193C1 (es) |
BR (1) | BR112016010358B1 (es) |
CA (1) | CA2929361C (es) |
IL (1) | IL245406B (es) |
MX (1) | MX2016005764A (es) |
RU (1) | RU2707748C2 (es) |
TW (3) | TWI747209B (es) |
WO (1) | WO2015068397A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20160079781A (ko) * | 2013-11-08 | 2016-07-06 | 액티버스 파마 컴퍼니 리미티드 | 매크롤라이드계 항균제의 나노미립자를 함유하는 수성 현탁액제 |
WO2020223158A1 (en) * | 2019-04-30 | 2020-11-05 | The Medical College Of Wisconsin, Inc. | Trans-tympanic membrane delivery platform and uses thereof |
CN113484436B (zh) * | 2021-07-06 | 2022-07-12 | 云南中烟工业有限责任公司 | 同时测定抑菌纸张中五种禁限用物质含量的方法及其用途 |
US20230226541A1 (en) * | 2022-01-18 | 2023-07-20 | Hollister Incorporated | Fluid absorption test tube |
WO2023229667A1 (en) * | 2022-05-24 | 2023-11-30 | The Cleveland Clinic Foundation | Topical angiotensin ii receptor blockers (arbs) for treating eye conditions |
CN116686841B (zh) * | 2023-06-07 | 2024-07-19 | 丽珠集团新北江制药股份有限公司 | 一种含有多烯烃大环内酯类物质的液态组合物的制备方法 |
WO2024121651A1 (en) * | 2023-11-10 | 2024-06-13 | Amiri ِAmir Ali | A liquid herbal antibiotic and a powder herbal antibiotic containing a herbal antibacterial formulation |
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JP2577742B2 (ja) * | 1986-07-18 | 1997-02-05 | 中外製薬株式会社 | 安定な顆粒球コロニ−刺激因子含有製剤 |
NZ233827A (en) | 1989-05-26 | 1991-06-25 | Abbott Lab | Pharmaceutical composition comprising clarithromycin, triglyceride oil and stabilising agent |
AU6461090A (en) | 1989-10-30 | 1991-05-02 | Abbott Laboratories | Injectable formulation for lipophilic drugs |
US5085864A (en) | 1989-10-30 | 1992-02-04 | Abbott Laboratories | Injectable formulation for lipophilic drugs |
JP2785981B2 (ja) * | 1989-11-20 | 1998-08-13 | 株式会社資生堂 | 乳化組成物 |
US7205279B2 (en) * | 1995-10-25 | 2007-04-17 | Novartis Ag | Pharmaceutical compositions |
DE4440337A1 (de) | 1994-11-11 | 1996-05-15 | Dds Drug Delivery Services Ges | Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit |
JP2001511780A (ja) * | 1997-02-04 | 2001-08-14 | アボツト・ラボラトリーズ | 鎮痛性非経口リポソーム配合物 |
US7056893B2 (en) * | 1999-03-31 | 2006-06-06 | Insite Vision, Inc. | Topical treatment for prevention of ocular infections |
US7732404B2 (en) * | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
US20030195179A1 (en) | 2000-08-25 | 2003-10-16 | Shirou Sawa | Aqueous suspension preparations |
CA2492488A1 (en) | 2002-07-16 | 2004-01-22 | Elan Pharma International, Ltd. | Liquid dosage compositions of stable nanoparticulate active agents |
US7220431B2 (en) | 2002-11-27 | 2007-05-22 | Regents Of The University Of Minnesota | Methods and compositions for applying pharmacologic agents to the ear |
CA2591744A1 (en) * | 2004-12-21 | 2006-06-29 | Pfizer Products Inc. | Stable non-dihydrate azithromycin oral suspensions |
US20070015719A1 (en) * | 2005-07-07 | 2007-01-18 | Elan Pharma International Limited | Nanoparticulate clarithromycin formulations |
JP5112669B2 (ja) * | 2005-09-30 | 2013-01-09 | 富山化学工業株式会社 | 難溶性薬物のナノ微粒子を含有する水性懸濁液剤 |
WO2007056205A2 (en) * | 2005-11-04 | 2007-05-18 | Eastman Chemical Company | Carboxyalkylcellulose esters for administration of poorly soluble pharmaceutically active agents |
PL2076244T3 (pl) * | 2006-10-10 | 2017-05-31 | Jina Pharmaceuticals Inc. | Układy wodne do wytwarzania związków farmaceutycznych na bazie lipidów; kompozycje, sposoby, oraz ich zastosowanie |
US20100068251A1 (en) * | 2006-10-10 | 2010-03-18 | Jina Pharmaceuticals, Inc. | Aqueous Systems For The Preparation Of Lipid Based Pharmaceutical Compounds; Compositions, Methods, And Uses Thereof |
TWI405590B (zh) | 2007-04-06 | 2013-08-21 | Activus Pharma Co Ltd | 微粉碎化有機化合物粒子之製法 |
US20080160043A1 (en) * | 2007-07-16 | 2008-07-03 | Kim Moo-Sung | Preparation method of beta-glucan from schizophyllum commune and composition for external application comprising the same |
WO2009029046A1 (en) * | 2007-08-29 | 2009-03-05 | Agency For Science, Technology And Research | Sugar-based surfactant microemulsions containing essential oils for cosmetic and pharmaceutical use |
CN102099013A (zh) | 2008-07-14 | 2011-06-15 | 奥德纳米有限公司 | 用于治疗耳部病症的控制释放凋亡调节组合物和方法 |
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EP2335686A1 (en) * | 2009-12-21 | 2011-06-22 | LEK Pharmaceuticals d.d. | An aqueous intravenous nanosuspension with reduced adverse effects |
MX341663B (es) | 2012-05-11 | 2016-08-30 | Activus Pharma Co Ltd | Nanopolvo de compuesto organico, metodo para producirlo y su suspension. |
KR20160079781A (ko) * | 2013-11-08 | 2016-07-06 | 액티버스 파마 컴퍼니 리미티드 | 매크롤라이드계 항균제의 나노미립자를 함유하는 수성 현탁액제 |
-
2014
- 2014-11-07 KR KR1020167010042A patent/KR20160079781A/ko active Application Filing
- 2014-11-07 TW TW109109685A patent/TWI747209B/zh active
- 2014-11-07 JP JP2015546301A patent/JP6407882B2/ja active Active
- 2014-11-07 TW TW103138831A patent/TW201521785A/zh unknown
- 2014-11-07 KR KR1020217013681A patent/KR102345084B1/ko active IP Right Grant
- 2014-11-07 TW TW107116897A patent/TWI691341B/zh active
- 2014-11-07 AU AU2014345193A patent/AU2014345193C1/en active Active
- 2014-11-07 WO PCT/JP2014/005603 patent/WO2015068397A1/ja active Application Filing
- 2014-11-07 US US15/034,437 patent/US10792248B2/en active Active
- 2014-11-07 CA CA2929361A patent/CA2929361C/en active Active
- 2014-11-07 MX MX2016005764A patent/MX2016005764A/es unknown
- 2014-11-07 CN CN201480058606.9A patent/CN105658203B/zh active Active
- 2014-11-07 EP EP14860926.6A patent/EP3067045A4/en active Pending
- 2014-11-07 BR BR112016010358-0A patent/BR112016010358B1/pt active IP Right Grant
- 2014-11-07 RU RU2016122544A patent/RU2707748C2/ru active
-
2016
- 2016-05-01 IL IL245406A patent/IL245406B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
TW201828923A (zh) | 2018-08-16 |
KR20160079781A (ko) | 2016-07-06 |
TWI747209B (zh) | 2021-11-21 |
JPWO2015068397A1 (ja) | 2017-03-09 |
RU2707748C2 (ru) | 2019-11-29 |
CN105658203B (zh) | 2021-03-16 |
BR112016010358A2 (es) | 2017-08-08 |
AU2014345193A1 (en) | 2016-06-02 |
KR20210054068A (ko) | 2021-05-12 |
US20160271057A1 (en) | 2016-09-22 |
EP3067045A1 (en) | 2016-09-14 |
CN105658203A (zh) | 2016-06-08 |
US10792248B2 (en) | 2020-10-06 |
BR112016010358B1 (pt) | 2022-07-26 |
EP3067045A4 (en) | 2016-11-16 |
TW201521785A (zh) | 2015-06-16 |
AU2014345193C1 (en) | 2020-09-10 |
CA2929361C (en) | 2022-05-31 |
CA2929361A1 (en) | 2015-05-14 |
WO2015068397A1 (ja) | 2015-05-14 |
RU2016122544A (ru) | 2017-12-13 |
IL245406A0 (en) | 2016-06-30 |
IL245406B (en) | 2021-03-25 |
RU2016122544A3 (es) | 2018-05-29 |
KR102345084B1 (ko) | 2021-12-29 |
TW202027726A (zh) | 2020-08-01 |
TWI691341B (zh) | 2020-04-21 |
AU2014345193B2 (en) | 2020-03-05 |
JP6407882B2 (ja) | 2018-10-17 |
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