JP2016505044A5 - - Google Patents
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- Publication number
- JP2016505044A5 JP2016505044A5 JP2015553858A JP2015553858A JP2016505044A5 JP 2016505044 A5 JP2016505044 A5 JP 2016505044A5 JP 2015553858 A JP2015553858 A JP 2015553858A JP 2015553858 A JP2015553858 A JP 2015553858A JP 2016505044 A5 JP2016505044 A5 JP 2016505044A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- cyclodextrin
- compound
- nitroxyl donor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 229920000858 Cyclodextrin Polymers 0.000 claims 16
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical group O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 14
- ZZRODMXZJNLQGD-UHFFFAOYSA-N ONS(=O)=O Chemical compound ONS(=O)=O ZZRODMXZJNLQGD-UHFFFAOYSA-N 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- ODUCDPQEXGNKDN-UHFFFAOYSA-N nitroxyl Chemical compound O=N ODUCDPQEXGNKDN-UHFFFAOYSA-N 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 7
- NZAQRZWBQUIBSF-UHFFFAOYSA-N 4-(4-sulfobutoxy)butane-1-sulfonic acid Chemical class OS(=O)(=O)CCCCOCCCCS(O)(=O)=O NZAQRZWBQUIBSF-UHFFFAOYSA-N 0.000 claims 4
- 229960004853 betadex Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical group [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 claims 4
- 239000000872 buffer Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 206010007556 Cardiac failure acute Diseases 0.000 claims 2
- 239000001116 FEMA 4028 Substances 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 2
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims 2
- 239000006172 buffering agent Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 235000011056 potassium acetate Nutrition 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 239000012062 aqueous buffer Substances 0.000 claims 1
- 239000008057 potassium phosphate buffer Substances 0.000 claims 1
- 0 Cc1ccc(*)[o]1 Chemical compound Cc1ccc(*)[o]1 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361754237P | 2013-01-18 | 2013-01-18 | |
| US61/754,237 | 2013-01-18 | ||
| US201361782781P | 2013-03-14 | 2013-03-14 | |
| US61/782,781 | 2013-03-14 | ||
| PCT/US2014/012089 WO2014113700A1 (en) | 2013-01-18 | 2014-01-17 | Pharmaceutical compositions comprising nitroxyl donors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019096869A Division JP6801045B2 (ja) | 2013-01-18 | 2019-05-23 | ニトロキシル供与体を含む医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505044A JP2016505044A (ja) | 2016-02-18 |
| JP2016505044A5 true JP2016505044A5 (cg-RX-API-DMAC7.html) | 2017-02-23 |
| JP6533159B2 JP6533159B2 (ja) | 2019-06-19 |
Family
ID=50064795
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015553856A Expired - Fee Related JP6449171B2 (ja) | 2013-01-18 | 2014-01-17 | 治療指数の改善されたニトロキシル供与体 |
| JP2015553858A Expired - Fee Related JP6533159B2 (ja) | 2013-01-18 | 2014-01-17 | ニトロキシル供与体を含む医薬組成物 |
| JP2017005276A Expired - Fee Related JP6311038B2 (ja) | 2013-01-18 | 2017-01-16 | 治療指数の改善されたニトロキシル供与体 |
| JP2018228317A Active JP6656345B2 (ja) | 2013-01-18 | 2018-12-05 | 治療指数の改善されたニトロキシル供与体 |
| JP2019096869A Expired - Fee Related JP6801045B2 (ja) | 2013-01-18 | 2019-05-23 | ニトロキシル供与体を含む医薬組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015553856A Expired - Fee Related JP6449171B2 (ja) | 2013-01-18 | 2014-01-17 | 治療指数の改善されたニトロキシル供与体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017005276A Expired - Fee Related JP6311038B2 (ja) | 2013-01-18 | 2017-01-16 | 治療指数の改善されたニトロキシル供与体 |
| JP2018228317A Active JP6656345B2 (ja) | 2013-01-18 | 2018-12-05 | 治療指数の改善されたニトロキシル供与体 |
| JP2019096869A Expired - Fee Related JP6801045B2 (ja) | 2013-01-18 | 2019-05-23 | ニトロキシル供与体を含む医薬組成物 |
Country Status (29)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ595770A (en) | 2006-03-17 | 2013-04-26 | Univ Johns Hopkins | N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors |
| CN108409662B (zh) | 2011-10-17 | 2021-10-26 | 约翰斯霍普金斯大学 | 作为hno供体的经羟胺取代的米氏酸、巴比妥酸和吡唑啉酮衍生物 |
| LT3284463T (lt) | 2013-01-18 | 2019-11-11 | Cardioxyl Pharmaceuticals Inc | Nitroksilo donorai, pasižymintys geresniais terapiniais rodikliais |
| ES2734060T3 (es) | 2014-01-17 | 2019-12-04 | Cardioxyl Pharmaceuticals Inc | Donadores de nitroxilo de N-hidroximetanosulfonamida |
| US9682938B2 (en) | 2014-05-27 | 2017-06-20 | Cardioxyl Pharmaceuticals, Inc. | Pyrazolone derivatives as nitroxyl donors |
| US9464061B2 (en) | 2014-05-27 | 2016-10-11 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives |
| EP3348548A4 (en) | 2015-09-07 | 2019-04-03 | Zhejiang Huahai Pharmaceutical Co., Ltd | STAIN OXIDE-RELIEFING PRODRUG MOLECULE |
| EP3365325A1 (en) | 2015-10-19 | 2018-08-29 | Cardioxyl Pharmaceuticals Inc. | N-hydroxylsulfonamide derivatives as nitroxyl donors |
| WO2017070081A1 (en) | 2015-10-19 | 2017-04-27 | Cardioxyl Pharmaceuticals, Inc. | Pyrazolone derivatives as nitroxyl donors |
| EP3490975B1 (en) | 2016-07-28 | 2021-05-05 | The Johns Hopkins University | O-substituted hydroxamic acids |
| US11083704B2 (en) * | 2017-01-03 | 2021-08-10 | Bristol-Myers Squibb Company | Method of administering nitroxyl donating compounds |
| EP3612175B1 (en) * | 2017-04-18 | 2025-09-10 | Genfit | Combination of elafibranor with an anti-nash, anti-fibrotic or anti-cholestatic agent |
| CN116283762B (zh) * | 2023-03-28 | 2025-08-12 | 昆山市第一人民医院 | 一种用于制备白鲜碱的中间体化合物及其制备方法、白鲜碱的制备方法 |
| WO2025043108A1 (en) | 2023-08-23 | 2025-02-27 | Bristol -Myers S Quibb Company | Co-crystals of nitroxyl donating compounds |
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| US4798824A (en) | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| JPH01221371A (ja) | 1988-02-29 | 1989-09-04 | Hokko Chem Ind Co Ltd | 環状オキシアミン誘導体の製造方法 |
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| CN108409662B (zh) | 2011-10-17 | 2021-10-26 | 约翰斯霍普金斯大学 | 作为hno供体的经羟胺取代的米氏酸、巴比妥酸和吡唑啉酮衍生物 |
| EP2914579A1 (en) | 2012-11-01 | 2015-09-09 | The Johns Hopkins University | Controlled hno release through intramolecular cyclization-elimination |
| LT3284463T (lt) | 2013-01-18 | 2019-11-11 | Cardioxyl Pharmaceuticals Inc | Nitroksilo donorai, pasižymintys geresniais terapiniais rodikliais |
| ES2734060T3 (es) | 2014-01-17 | 2019-12-04 | Cardioxyl Pharmaceuticals Inc | Donadores de nitroxilo de N-hidroximetanosulfonamida |
| US9464061B2 (en) | 2014-05-27 | 2016-10-11 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives |
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2014
- 2014-01-17 LT LT17195759T patent/LT3284463T/lt unknown
- 2014-01-17 HU HUE17195759A patent/HUE046722T2/hu unknown
- 2014-01-17 RU RU2015134581A patent/RU2676277C2/ru active
- 2014-01-17 SG SG10201913286PA patent/SG10201913286PA/en unknown
- 2014-01-17 MX MX2015009269A patent/MX363843B/es active IP Right Grant
- 2014-01-17 HR HRP20182144TT patent/HRP20182144T1/hr unknown
- 2014-01-17 BR BR112015017251-2A patent/BR112015017251B1/pt active IP Right Grant
- 2014-01-17 KR KR1020157022192A patent/KR102277165B1/ko active Active
- 2014-01-17 ES ES14703010T patent/ES2705240T3/es active Active
- 2014-01-17 BR BR112015017241-5A patent/BR112015017241B1/pt active IP Right Grant
- 2014-01-17 SG SG10201913441RA patent/SG10201913441RA/en unknown
- 2014-01-17 EP EP17195759.0A patent/EP3284463B1/en active Active
- 2014-01-17 TW TW103101913A patent/TWI686193B/zh active
- 2014-01-17 HU HUE14703009A patent/HUE036589T2/hu unknown
- 2014-01-17 LT LTEP14703009.2T patent/LT2945620T/lt unknown
- 2014-01-17 CN CN201910446030.8A patent/CN110179777B/zh active Active
- 2014-01-17 ES ES17195759T patent/ES2751922T3/es active Active
- 2014-01-17 EP EP19181338.5A patent/EP3567031A1/en not_active Withdrawn
- 2014-01-17 SI SI201431361T patent/SI3284463T1/sl unknown
- 2014-01-17 TW TW107143952A patent/TWI712409B/zh not_active IP Right Cessation
- 2014-01-17 WO PCT/US2014/012085 patent/WO2014113696A1/en not_active Ceased
- 2014-01-17 EP EP18190818.7A patent/EP3427728B1/en active Active
- 2014-01-17 ES ES18190818T patent/ES2882279T3/es active Active
- 2014-01-17 SM SM20190027T patent/SMT201900027T1/it unknown
- 2014-01-17 TR TR2018/02211T patent/TR201802211T4/tr unknown
- 2014-01-17 HU HUE14703010A patent/HUE041861T2/hu unknown
- 2014-01-17 US US14/158,456 patent/US8987326B2/en active Active
- 2014-01-17 JP JP2015553856A patent/JP6449171B2/ja not_active Expired - Fee Related
- 2014-01-17 KR KR1020157022200A patent/KR102177899B1/ko not_active Expired - Fee Related
- 2014-01-17 US US14/761,934 patent/US10245249B2/en active Active
- 2014-01-17 RS RSP20191352 patent/RS59434B1/sr unknown
- 2014-01-17 CN CN201810074807.8A patent/CN108610312A/zh active Pending
- 2014-01-17 PL PL17195759T patent/PL3284463T3/pl unknown
- 2014-01-17 TW TW103101912A patent/TWI619491B/zh not_active IP Right Cessation
- 2014-01-17 PT PT14703010T patent/PT2945621T/pt unknown
- 2014-01-17 CA CA2898443A patent/CA2898443C/en active Active
- 2014-01-17 EP EP14703009.2A patent/EP2945620B1/en active Active
- 2014-01-17 NZ NZ709985A patent/NZ709985A/en unknown
- 2014-01-17 NZ NZ748769A patent/NZ748769A/en unknown
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- 2014-01-17 NZ NZ748771A patent/NZ748771A/en unknown
- 2014-01-17 AU AU2014207408A patent/AU2014207408C1/en active Active
- 2014-01-17 NZ NZ709986A patent/NZ709986A/en unknown
- 2014-01-17 SI SI201430983T patent/SI2945621T1/sl unknown
- 2014-01-17 SI SI201430507T patent/SI2945620T1/en unknown
- 2014-01-17 SG SG11201505568PA patent/SG11201505568PA/en unknown
- 2014-01-17 RS RS20180099A patent/RS56968B1/sr unknown
- 2014-01-17 PL PL14703010T patent/PL2945621T3/pl unknown
- 2014-01-17 MX MX2015009276A patent/MX373176B/es active IP Right Grant
- 2014-01-17 SG SG10201802855TA patent/SG10201802855TA/en unknown
- 2014-01-17 LT LTEP14703010.0T patent/LT2945621T/lt unknown
- 2014-01-17 SG SG11201505567RA patent/SG11201505567RA/en unknown
- 2014-01-17 RS RS20181599A patent/RS58174B1/sr unknown
- 2014-01-17 CA CA2898445A patent/CA2898445C/en active Active
- 2014-01-17 SM SM20190575T patent/SMT201900575T1/it unknown
- 2014-01-17 PT PT171957590T patent/PT3284463T/pt unknown
- 2014-01-17 ES ES14703009.2T patent/ES2659969T3/es active Active
- 2014-01-17 HR HRP20180121TT patent/HRP20180121T1/hr unknown
- 2014-01-17 AU AU2014207404A patent/AU2014207404B2/en active Active
- 2014-01-17 CN CN201480013223.XA patent/CN105142627B/zh active Active
- 2014-01-17 DK DK17195759T patent/DK3284463T3/da active
- 2014-01-17 RU RU2015134583A patent/RU2684916C2/ru active
- 2014-01-17 SM SM20180088T patent/SMT201800088T1/it unknown
- 2014-01-17 EP EP14703010.0A patent/EP2945621B1/en active Active
- 2014-01-17 CN CN201480013565.1A patent/CN105073105B/zh active Active
- 2014-01-17 SG SG10201802862WA patent/SG10201802862WA/en unknown
- 2014-01-17 PT PT147030092T patent/PT2945620T/pt unknown
- 2014-01-17 JP JP2015553858A patent/JP6533159B2/ja not_active Expired - Fee Related
- 2014-01-17 RU RU2018143994A patent/RU2018143994A/ru unknown
- 2014-01-17 WO PCT/US2014/012089 patent/WO2014113700A1/en not_active Ceased
- 2014-01-17 DK DK14703010.0T patent/DK2945621T3/en active
- 2014-01-17 DK DK14703009.2T patent/DK2945620T3/en active
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2015
- 2015-03-07 US US14/641,377 patent/US9156804B2/en active Active
- 2015-07-13 IL IL239906A patent/IL239906B/en active IP Right Grant
- 2015-07-15 IL IL239952A patent/IL239952B/en active IP Right Grant
- 2015-07-15 ZA ZA2015/05090A patent/ZA201505090B/en unknown
- 2015-10-09 US US14/880,173 patent/US9586896B2/en active Active
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2016
- 2016-07-07 ZA ZA2016/04798A patent/ZA201604798B/en unknown
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2017
- 2017-01-10 AU AU2017200147A patent/AU2017200147B2/en active Active
- 2017-01-16 JP JP2017005276A patent/JP6311038B2/ja not_active Expired - Fee Related
- 2017-02-13 US US15/430,946 patent/US9968584B2/en active Active
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2018
- 2018-01-12 CY CY20181100038T patent/CY1120535T1/el unknown
- 2018-04-23 IL IL258882A patent/IL258882A/en active IP Right Grant
- 2018-04-24 US US15/960,993 patent/US10213408B2/en active Active
- 2018-05-09 AU AU2018203240A patent/AU2018203240B2/en active Active
- 2018-05-09 IL IL25923318A patent/IL259233B/en active IP Right Grant
- 2018-08-20 HK HK18110676.0A patent/HK1251170B/en unknown
- 2018-10-05 AU AU2018241168A patent/AU2018241168B2/en active Active
- 2018-12-05 JP JP2018228317A patent/JP6656345B2/ja active Active
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2019
- 2019-01-08 US US16/242,139 patent/US10517847B2/en active Active
- 2019-01-15 CY CY20191100046T patent/CY1121480T1/el unknown
- 2019-03-29 US US16/370,443 patent/US10548872B2/en active Active
- 2019-05-23 JP JP2019096869A patent/JP6801045B2/ja not_active Expired - Fee Related
- 2019-10-16 CY CY20191101084T patent/CY1122177T1/el unknown
- 2019-10-23 HR HRP20191919TT patent/HRP20191919T8/hr unknown
- 2019-12-23 US US16/724,657 patent/US10792273B2/en active Active
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2020
- 2020-01-31 US US16/779,015 patent/US11304924B2/en active Active
- 2020-10-05 US US17/063,372 patent/US11273143B2/en active Active
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2022
- 2022-03-14 US US17/694,500 patent/US11786501B2/en active Active
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2023
- 2023-09-22 US US18/371,722 patent/US12186301B2/en active Active
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