JP2016503786A5 - - Google Patents
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- Publication number
- JP2016503786A5 JP2016503786A5 JP2015548838A JP2015548838A JP2016503786A5 JP 2016503786 A5 JP2016503786 A5 JP 2016503786A5 JP 2015548838 A JP2015548838 A JP 2015548838A JP 2015548838 A JP2015548838 A JP 2015548838A JP 2016503786 A5 JP2016503786 A5 JP 2016503786A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- triazol
- piperidine
- carboxylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 9
- 206010016654 Fibrosis Diseases 0.000 claims 6
- -1 3,5-dichlorobenzyl Chemical group 0.000 claims 5
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 3
- 208000003251 Pruritus Diseases 0.000 claims 3
- 208000006673 asthma Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 230000007882 cirrhosis Effects 0.000 claims 3
- 208000019425 cirrhosis of liver Diseases 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000004761 fibrosis Effects 0.000 claims 3
- 208000017169 kidney disease Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- SKMSWZDQKZXGPM-UHFFFAOYSA-N (3,5-dichlorophenyl)methyl 4-[2-oxo-2-[2-(2h-triazol-4-yl)ethylamino]ethyl]piperidine-1-carboxylate Chemical compound ClC1=CC(Cl)=CC(COC(=O)N2CCC(CC(=O)NCCC=3N=NNC=3)CC2)=C1 SKMSWZDQKZXGPM-UHFFFAOYSA-N 0.000 claims 1
- GAMSNABJTRSYDT-UHFFFAOYSA-N (3,5-dichlorophenyl)methyl 4-[4-(2h-triazol-4-yl)butanoylamino]piperidine-1-carboxylate Chemical compound ClC1=CC(Cl)=CC(COC(=O)N2CCC(CC2)NC(=O)CCCC=2N=NNC=2)=C1 GAMSNABJTRSYDT-UHFFFAOYSA-N 0.000 claims 1
- BGTUNXZYEFXERH-UHFFFAOYSA-N (3,5-dichlorophenyl)methyl 4-[[3-(2h-triazol-4-yl)propanoylamino]methyl]piperidine-1-carboxylate Chemical compound ClC1=CC(Cl)=CC(COC(=O)N2CCC(CNC(=O)CCC=3NN=NC=3)CC2)=C1 BGTUNXZYEFXERH-UHFFFAOYSA-N 0.000 claims 1
- XZOSUJGCZYHQHE-UHFFFAOYSA-N (3,5-dichlorophenyl)methyl 4-[[4-(2h-triazol-4-yl)butanoylamino]methyl]piperidine-1-carboxylate Chemical compound ClC1=CC(Cl)=CC(COC(=O)N2CCC(CNC(=O)CCCC=3NN=NC=3)CC2)=C1 XZOSUJGCZYHQHE-UHFFFAOYSA-N 0.000 claims 1
- MTZCQEFEIXRSMB-UHFFFAOYSA-N [3-cyano-5-(trifluoromethoxy)phenyl]methyl 4-[4-(2h-triazol-4-yl)butanoylamino]piperidine-1-carboxylate Chemical compound N#CC1=CC(OC(F)(F)F)=CC(COC(=O)N2CCC(CC2)NC(=O)CCCC=2N=NNC=2)=C1 MTZCQEFEIXRSMB-UHFFFAOYSA-N 0.000 claims 1
- OTQCFKGHQGIJNY-UHFFFAOYSA-N [3-cyano-5-(trifluoromethyl)phenyl]methyl 4-[4-(2h-triazol-4-yl)butanoylamino]piperidine-1-carboxylate Chemical compound N#CC1=CC(C(F)(F)F)=CC(COC(=O)N2CCC(CC2)NC(=O)CCCC=2N=NNC=2)=C1 OTQCFKGHQGIJNY-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261739214P | 2012-12-19 | 2012-12-19 | |
| US61/739,214 | 2012-12-19 | ||
| US201361787796P | 2013-03-15 | 2013-03-15 | |
| US61/787,796 | 2013-03-15 | ||
| US201361903928P | 2013-11-13 | 2013-11-13 | |
| US61/903,928 | 2013-11-13 | ||
| PCT/IB2013/061047 WO2014097151A2 (en) | 2012-12-19 | 2013-12-17 | Autotaxin inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016503786A JP2016503786A (ja) | 2016-02-08 |
| JP2016503786A5 true JP2016503786A5 (show.php) | 2017-02-09 |
| JP6363616B2 JP6363616B2 (ja) | 2018-07-25 |
Family
ID=50070613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015548838A Expired - Fee Related JP6363616B2 (ja) | 2012-12-19 | 2013-12-17 | オートタキシン阻害剤 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9630945B2 (show.php) |
| EP (1) | EP2935249B1 (show.php) |
| JP (1) | JP6363616B2 (show.php) |
| KR (1) | KR20150095888A (show.php) |
| CN (1) | CN104968656B (show.php) |
| AU (1) | AU2013365742B2 (show.php) |
| BR (1) | BR112015014372A8 (show.php) |
| CA (1) | CA2895448A1 (show.php) |
| CL (1) | CL2015001731A1 (show.php) |
| CR (1) | CR20150326A (show.php) |
| EA (1) | EA028509B1 (show.php) |
| ES (1) | ES2715682T3 (show.php) |
| HK (1) | HK1212348A1 (show.php) |
| IL (1) | IL239435A0 (show.php) |
| MX (1) | MX2015007936A (show.php) |
| PE (1) | PE20151067A1 (show.php) |
| PH (1) | PH12015501385A1 (show.php) |
| SG (1) | SG11201504633PA (show.php) |
| TN (1) | TN2015000278A1 (show.php) |
| TW (1) | TW201427946A (show.php) |
| UY (1) | UY35210A (show.php) |
| WO (1) | WO2014097151A2 (show.php) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3632919T3 (da) | 2012-04-26 | 2022-11-14 | Bristol Myers Squibb Co | Farmaceutiske sammensætninger omfattende imidazothiadiazol- og imidazopyrazinderivater som proteaseaktiverede receptor 4-(par4)- hæmmere til behandling af blodpladeaggregering |
| TWI568722B (zh) | 2012-06-15 | 2017-02-01 | 葛蘭馬克製藥公司 | 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物 |
| ES2649156T3 (es) | 2013-01-14 | 2018-01-10 | Incyte Holdings Corporation | Compuestos bicíclicos de carboxamida aromática útiles como inhibidores de quinasas Pim |
| ES2941292T3 (es) | 2013-01-15 | 2023-05-19 | Incyte Holdings Corp | Tiazolecarboxamidas y compuestos de piridinecarboxamida útiles como inhibidores de PIM quinasa |
| KR20160034920A (ko) * | 2013-07-30 | 2016-03-30 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 과도한 발한의 치료를 위한 국소 조성물 및 그의 사용 방법 |
| AR097431A1 (es) | 2013-08-23 | 2016-03-16 | Incyte Corp | Compuestos de carboxamida de furo y tienopiridina útiles como inhibidores de quinasas pim |
| EP3046909A4 (en) | 2013-09-17 | 2017-03-29 | Pharmakea, Inc. | Heterocyclic vinyl autotaxin inhibitor compounds |
| WO2015042053A1 (en) | 2013-09-17 | 2015-03-26 | Pharmakea, Inc. | Vinyl autotaxin inhibitor compounds |
| US9850203B2 (en) | 2013-09-26 | 2017-12-26 | Pharmakea, Inc. | Autotaxin inhibitor compounds |
| CR20160290A (es) | 2013-11-22 | 2016-09-28 | Pharmakea Inc | Inhibidores tetracíclicos de autotaxina |
| ES2875899T3 (es) | 2013-11-22 | 2021-11-11 | Sabre Therapeutics Llc | Compuestos inhibidores de autotaxina |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9051320B1 (en) | 2014-08-18 | 2015-06-09 | Pharmakea, Inc. | Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor |
| MY188447A (en) * | 2014-08-19 | 2021-12-09 | Shanghai Haihe Pharmaceutical Co Ltd | Indazole compounds as fger kinase inhibitor, preparation and use thereof |
| BR112017015455A2 (pt) * | 2015-01-20 | 2018-01-23 | Novartis Ag | agentes de imagiologia pet |
| GB201501870D0 (en) * | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| JP6873919B2 (ja) * | 2015-05-27 | 2021-05-19 | セイバー セラピューティクス エルエルシー | オートタキシン阻害剤とその使用 |
| WO2016196244A1 (en) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
| US10118904B2 (en) | 2015-06-05 | 2018-11-06 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of Demyelinating Diseases |
| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| US9920032B2 (en) | 2015-10-02 | 2018-03-20 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| CA3037369A1 (en) | 2016-09-18 | 2018-03-22 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Yap1 inhibitors that target the interaction of yap1 with oct4 |
| WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
| WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
| WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
| WO2019113487A1 (en) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
| PE20211450A1 (es) | 2018-03-14 | 2021-08-05 | H Lee Moffitt Cancer Ct & Res | Inhibidores de yap1 que dirigen la interaccion de yap1 con oct4 |
| KR102755257B1 (ko) | 2018-09-21 | 2025-01-14 | 화이자 인코포레이티드 | Ccr6 억제제로서 유용한 n-치환된-디옥소시클로부테닐아미노-3-히드록시-피콜린아미드 |
| HUE066940T2 (hu) | 2019-07-22 | 2024-09-28 | Boehringer Ingelheim Int | N-metil, N-(6-(metoxi)piridazin-3-il)amin-származékok, mint autotaxin (ATX) modulátorok gyulladásos légúti vagy fibrotikus betegségek kezelésére |
| US12383547B2 (en) | 2020-07-01 | 2025-08-12 | Vanderbilt University | Methods of treatment for a kidney disease |
| WO2022053651A2 (en) | 2020-09-10 | 2022-03-17 | Precirix N.V. | Antibody fragment against fap |
| KR102502940B1 (ko) * | 2021-11-30 | 2023-02-24 | 주식회사 넥스트젠바이오사이언스 | 오토탁신 저해제로서의 신규 화합물 및 이의 용도 |
| WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
| IL318992A (en) | 2022-05-02 | 2025-04-01 | Precirix N V | Cancer treatment through advance directives |
| KR102587919B1 (ko) * | 2022-07-22 | 2023-10-11 | 주식회사 넥스트젠바이오사이언스 | 신규한 헤테로사이클릭 화합물 및 이를 포함하는 오토탁신 저해용 약학 조성물 |
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-
2013
- 2013-12-17 US US14/653,649 patent/US9630945B2/en not_active Expired - Fee Related
- 2013-12-17 HK HK16100333.8A patent/HK1212348A1/xx unknown
- 2013-12-17 EP EP13828825.3A patent/EP2935249B1/en active Active
- 2013-12-17 CN CN201380071957.9A patent/CN104968656B/zh not_active Expired - Fee Related
- 2013-12-17 BR BR112015014372A patent/BR112015014372A8/pt not_active Application Discontinuation
- 2013-12-17 KR KR1020157019063A patent/KR20150095888A/ko not_active Withdrawn
- 2013-12-17 WO PCT/IB2013/061047 patent/WO2014097151A2/en not_active Ceased
- 2013-12-17 ES ES13828825T patent/ES2715682T3/es active Active
- 2013-12-17 SG SG11201504633PA patent/SG11201504633PA/en unknown
- 2013-12-17 EA EA201591166A patent/EA028509B1/ru not_active IP Right Cessation
- 2013-12-17 AU AU2013365742A patent/AU2013365742B2/en not_active Ceased
- 2013-12-17 PE PE2015001055A patent/PE20151067A1/es not_active Application Discontinuation
- 2013-12-17 MX MX2015007936A patent/MX2015007936A/es unknown
- 2013-12-17 CA CA2895448A patent/CA2895448A1/en not_active Abandoned
- 2013-12-17 US US14/109,935 patent/US20140171404A1/en not_active Abandoned
- 2013-12-17 JP JP2015548838A patent/JP6363616B2/ja not_active Expired - Fee Related
- 2013-12-18 TW TW102147021A patent/TW201427946A/zh unknown
- 2013-12-19 UY UY0001035210A patent/UY35210A/es not_active Application Discontinuation
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2015
- 2015-06-15 IL IL239435A patent/IL239435A0/en unknown
- 2015-06-16 TN TNP2015000278A patent/TN2015000278A1/fr unknown
- 2015-06-17 PH PH12015501385A patent/PH12015501385A1/en unknown
- 2015-06-18 CL CL2015001731A patent/CL2015001731A1/es unknown
- 2015-06-19 CR CR20150326A patent/CR20150326A/es unknown