PE20211450A1 - Inhibidores de yap1 que dirigen la interaccion de yap1 con oct4 - Google Patents
Inhibidores de yap1 que dirigen la interaccion de yap1 con oct4Info
- Publication number
- PE20211450A1 PE20211450A1 PE2020001409A PE2020001409A PE20211450A1 PE 20211450 A1 PE20211450 A1 PE 20211450A1 PE 2020001409 A PE2020001409 A PE 2020001409A PE 2020001409 A PE2020001409 A PE 2020001409A PE 20211450 A1 PE20211450 A1 PE 20211450A1
- Authority
- PE
- Peru
- Prior art keywords
- yap1
- oct4
- interaction
- inhibitors
- directing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Referido a un compuesto de la formula I, en la que, la linea recortada representa un enlace que se encuentra presente o ausente; n es 0, 1 o 2; Ar es fenilo, piridinilo, pirimidinilo o pirazinilo; R1 es alquilo C1-C8, cicloalquilo C3-C6 o arilo C6, los cuales se encuentran opcionalmente sustituidos con uno o mas grupos seleccionados; R2 es halo, OH, alcoxilo C1-C8, entre otros; R3 es CH2OH, CO2H, CO2-C1-alquilo C6, entre otros; o una sal farmaceuticamente aceptable de estos. Estos compuestos son inhibidores de YAP1 que dirigen la interaccion de YAP1 con OCT4, evitando la autorrenovacion de celulas tipo madre de una poblacion lateral de lineas celulares tales como cancer de pulmon y mimetismo vascular. Tambien se refiere a metodos para producir dichos compuestos y su uso en el tratamiento del cancer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862643032P | 2018-03-14 | 2018-03-14 | |
PCT/US2019/022337 WO2019178401A1 (en) | 2018-03-14 | 2019-03-14 | Yap1 inhibitors that target the interaction of yap1 with oct4 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20211450A1 true PE20211450A1 (es) | 2021-08-05 |
Family
ID=67908080
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2020001409A PE20211450A1 (es) | 2018-03-14 | 2019-03-14 | Inhibidores de yap1 que dirigen la interaccion de yap1 con oct4 |
Country Status (16)
Country | Link |
---|---|
US (1) | US11685725B2 (es) |
EP (1) | EP3765015A4 (es) |
JP (1) | JP2021515785A (es) |
KR (1) | KR20210006334A (es) |
CN (1) | CN111989100A (es) |
AU (1) | AU2019236196A1 (es) |
BR (1) | BR112020018642A2 (es) |
CA (1) | CA3093913A1 (es) |
CL (1) | CL2020002364A1 (es) |
EA (1) | EA202092174A1 (es) |
IL (1) | IL277314A (es) |
MX (1) | MX2020009519A (es) |
PE (1) | PE20211450A1 (es) |
SG (1) | SG11202008854TA (es) |
WO (1) | WO2019178401A1 (es) |
ZA (1) | ZA202005702B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111073858A (zh) * | 2020-01-05 | 2020-04-28 | 浙江大学 | 一种yap1基因修饰的间充质干细胞及其制备方法 |
JPWO2023042901A1 (es) * | 2021-09-16 | 2023-03-23 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5998444A (en) | 1995-10-24 | 1999-12-07 | Zeneca Ltd. | Piperidinyl compounds as NK1 or NK2 antagonists |
CA2359114A1 (en) | 1999-01-25 | 2000-07-27 | Elan Pharmaceuticals, Inc. | Compounds which inhibit leukocyte adhesion mediated by vla-4 |
US6977264B2 (en) | 2001-07-25 | 2005-12-20 | Amgen Inc. | Substituted piperidines and methods of use |
DK1539739T3 (da) | 2002-08-16 | 2011-03-07 | Janssen Pharmaceutica Nv | Piperidinylforbindelser, der selektivt binder integriner |
AR047537A1 (es) | 2004-02-10 | 2006-01-25 | Janssen Pharmaceutica Nv | Piridazinonaureas como antagonistas de integrinas |
WO2005121090A1 (en) * | 2004-06-02 | 2005-12-22 | Abbott Laboratories | Substituted piperidines that have antiangiogenic activity |
WO2009044918A1 (ja) | 2007-10-05 | 2009-04-09 | Takeda Pharmaceutical Company Limited | ニューロメジンu誘導体 |
AR071377A1 (es) | 2008-04-18 | 2010-06-16 | Arete Therapeutics Inc | Inhibidores de epoxido hidrolasa soluble |
GB0807828D0 (en) | 2008-04-29 | 2008-06-04 | Vantia Ltd | Aminopyridine derivatives |
FR2952934B1 (fr) | 2009-11-23 | 2012-06-22 | Sanofi Aventis | Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique |
WO2011094890A1 (en) | 2010-02-02 | 2011-08-11 | Argusina Inc. | Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators |
CN102946882B (zh) | 2010-02-02 | 2016-05-18 | 格斯有限公司 | 苯基丙氨酸衍生物及其作为非肽glp-1受体调节剂的用途 |
WO2013188138A1 (en) | 2012-06-11 | 2013-12-19 | The Regents Of The University Of California | Inhibitors of hippo-yap signaling pathway |
SG11201504633PA (en) | 2012-12-19 | 2015-07-30 | Novartis Ag | Autotaxin inhibitors |
AR097279A1 (es) | 2013-08-09 | 2016-03-02 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx |
EP3208280A4 (en) | 2014-10-17 | 2018-10-10 | Bao Kang Biomedical Healthcare Inc | High activity tumour inhibitor and preparation method and use thereof |
WO2018053446A1 (en) * | 2016-09-18 | 2018-03-22 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Yap1 inhibitors that target the interaction of yap1 with oct4 |
UY37956A (es) | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
UY37957A (es) | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
MX2020009438A (es) | 2018-03-14 | 2022-05-11 | Kandy Therapeutics Ltd | Formulacion farmaceutica novedosa que comprende antagonistas del receptor dual nk-1/nk-3. |
-
2019
- 2019-03-14 KR KR1020207029090A patent/KR20210006334A/ko unknown
- 2019-03-14 CN CN201980026471.0A patent/CN111989100A/zh active Pending
- 2019-03-14 CA CA3093913A patent/CA3093913A1/en not_active Abandoned
- 2019-03-14 PE PE2020001409A patent/PE20211450A1/es unknown
- 2019-03-14 WO PCT/US2019/022337 patent/WO2019178401A1/en unknown
- 2019-03-14 US US16/980,538 patent/US11685725B2/en active Active
- 2019-03-14 MX MX2020009519A patent/MX2020009519A/es unknown
- 2019-03-14 AU AU2019236196A patent/AU2019236196A1/en not_active Abandoned
- 2019-03-14 EA EA202092174A patent/EA202092174A1/ru unknown
- 2019-03-14 BR BR112020018642-2A patent/BR112020018642A2/pt not_active Application Discontinuation
- 2019-03-14 JP JP2020548656A patent/JP2021515785A/ja active Pending
- 2019-03-14 EP EP19766810.6A patent/EP3765015A4/en not_active Withdrawn
- 2019-03-14 SG SG11202008854TA patent/SG11202008854TA/en unknown
-
2020
- 2020-09-11 CL CL2020002364A patent/CL2020002364A1/es unknown
- 2020-09-13 IL IL277314A patent/IL277314A/en unknown
- 2020-09-14 ZA ZA2020/05702A patent/ZA202005702B/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL277314A (en) | 2020-10-29 |
MX2020009519A (es) | 2020-10-22 |
KR20210006334A (ko) | 2021-01-18 |
US20210363128A1 (en) | 2021-11-25 |
SG11202008854TA (en) | 2020-10-29 |
CA3093913A1 (en) | 2019-09-19 |
US11685725B2 (en) | 2023-06-27 |
ZA202005702B (en) | 2022-04-28 |
CL2020002364A1 (es) | 2021-01-29 |
WO2019178401A1 (en) | 2019-09-19 |
BR112020018642A2 (pt) | 2020-12-29 |
CN111989100A (zh) | 2020-11-24 |
AU2019236196A1 (en) | 2020-10-08 |
JP2021515785A (ja) | 2021-06-24 |
EP3765015A1 (en) | 2021-01-20 |
EP3765015A4 (en) | 2021-12-15 |
EA202092174A1 (ru) | 2021-01-15 |
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