JP2012507535A5 - - Google Patents
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- Publication number
- JP2012507535A5 JP2012507535A5 JP2011534624A JP2011534624A JP2012507535A5 JP 2012507535 A5 JP2012507535 A5 JP 2012507535A5 JP 2011534624 A JP2011534624 A JP 2011534624A JP 2011534624 A JP2011534624 A JP 2011534624A JP 2012507535 A5 JP2012507535 A5 JP 2012507535A5
- Authority
- JP
- Japan
- Prior art keywords
- acceptable salt
- pharmaceutically acceptable
- hydrogen
- fluoro
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11070308P | 2008-11-03 | 2008-11-03 | |
| US61/110,703 | 2008-11-03 | ||
| PCT/US2009/061573 WO2010062507A1 (en) | 2008-11-03 | 2009-10-22 | Disubstituted phthalazine hedgehog pathway antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012507535A JP2012507535A (ja) | 2012-03-29 |
| JP2012507535A5 true JP2012507535A5 (show.php) | 2012-12-13 |
Family
ID=41566219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011534624A Pending JP2012507535A (ja) | 2008-11-03 | 2009-10-22 | 二置換フタラジンヘッジホッグ経路アンタゴニスト |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8404687B2 (show.php) |
| EP (1) | EP2364185B1 (show.php) |
| JP (1) | JP2012507535A (show.php) |
| KR (1) | KR101335746B1 (show.php) |
| CN (1) | CN102202737B (show.php) |
| AU (1) | AU2009320251C1 (show.php) |
| BR (1) | BRPI0921437A2 (show.php) |
| CA (1) | CA2742539C (show.php) |
| CL (1) | CL2011000979A1 (show.php) |
| CO (1) | CO6382123A2 (show.php) |
| CR (1) | CR20110202A (show.php) |
| CY (1) | CY1114023T1 (show.php) |
| DK (1) | DK2364185T3 (show.php) |
| EA (1) | EA018931B1 (show.php) |
| EC (1) | ECSP11011021A (show.php) |
| ES (1) | ES2418479T3 (show.php) |
| HR (1) | HRP20130527T1 (show.php) |
| IL (1) | IL211841A0 (show.php) |
| MA (1) | MA32726B1 (show.php) |
| MX (1) | MX2011004683A (show.php) |
| NZ (1) | NZ591945A (show.php) |
| PE (1) | PE20110433A1 (show.php) |
| PL (1) | PL2364185T3 (show.php) |
| PT (1) | PT2364185E (show.php) |
| SI (1) | SI2364185T1 (show.php) |
| TN (1) | TN2011000166A1 (show.php) |
| UA (1) | UA102115C2 (show.php) |
| WO (1) | WO2010062507A1 (show.php) |
| ZA (1) | ZA201102448B (show.php) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0809193A2 (pt) * | 2007-03-15 | 2014-09-23 | Novartis Ag | Compostos orgânicos e seus usos |
| UA102250C2 (ru) | 2008-04-29 | 2013-06-25 | Эли Лилли Энд Компани | Двухзамещенные фталазины - антагонисты проводящего пути hedgehog |
| US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| US8445493B2 (en) | 2008-11-17 | 2013-05-21 | Eli Lilly And Company | Tetrasubstituted pyridazines hedgehog pathway antagonists |
| PT2358698E (pt) | 2008-11-17 | 2012-10-24 | Lilly Co Eli | Antagonistas da via hedgehog de piridazina tetrasubstituída |
| AR077014A1 (es) | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
| WO2015073691A1 (en) | 2013-11-14 | 2015-05-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating cancer by activation of bmp signaling |
| CN105985319B (zh) * | 2015-02-11 | 2019-02-26 | 复旦大学 | 芳基酞嗪化合物及其制备方法和用途 |
| CN105985320B (zh) * | 2015-02-11 | 2018-10-26 | 复旦大学 | 苄基酞嗪化合物及其制备方法和用途 |
| CN105985321B (zh) * | 2015-02-11 | 2018-10-26 | 复旦大学 | 吡唑酞嗪化合物及其制备方法和用途 |
| AU2021360767A1 (en) | 2020-10-13 | 2023-04-27 | Endeavor Biomedicines, Inc. | Methods of treating fibrosis |
| EP4590672A1 (en) * | 2022-09-23 | 2025-07-30 | Merck Sharp & Dohme LLC | Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3 |
| WO2025188802A1 (en) | 2024-03-05 | 2025-09-12 | Endeavor Biomedicines, Inc. | Methods of improving lung function |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1293565A (en) | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
| EP0876366B1 (en) | 1996-01-15 | 2001-07-25 | Janssen Pharmaceutica N.V. | Angiogenesis inhibiting pyridazinamines |
| KR100622323B1 (ko) * | 1996-10-01 | 2006-11-30 | 교와 핫꼬 고교 가부시끼가이샤 | 질소-함유헤테로고리화합물 |
| US6432970B2 (en) | 1998-04-09 | 2002-08-13 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| JP5067986B2 (ja) | 1998-04-09 | 2012-11-07 | ジョンズ ホプキンズ ユニヴァーシティー スクール オブ メディシン | ヘッジホッグシグナリング経路の阻害剤としてのステロイドアルカロイド誘導体の使用 |
| GB0013674D0 (en) | 1999-06-08 | 2000-07-26 | Lorantis Ltd | Therapeutic use |
| DE60322869D1 (de) | 2002-04-22 | 2008-09-25 | Univ Johns Hopkins | Modulatoren von hedgehog signalpfaden, zusammensetzungen und verwandte verwendungen |
| WO2004020599A2 (en) | 2002-08-29 | 2004-03-11 | Curis, Inc. | Hedgehog antagonists, methods and uses related thereto |
| WO2005033288A2 (en) * | 2003-09-29 | 2005-04-14 | The Johns Hopkins University | Hedgehog pathway antagonists |
| TW200533356A (en) | 2004-02-24 | 2005-10-16 | Mitsubishi Pharma Corp | Fused pyridazine derivatives |
| WO2006004589A2 (en) | 2004-05-08 | 2006-01-12 | Neurogen Corporation | 3-aryl-5,6-disubstituted pyridazines |
| US7888364B2 (en) * | 2004-09-02 | 2011-02-15 | Curis, Inc. | Pyridyl inhibitors of hedgehog signalling |
| EP1900731A1 (de) | 2006-09-07 | 2008-03-19 | Bayer Schering Pharma Aktiengesellschaft | N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren |
| BRPI0809193A2 (pt) | 2007-03-15 | 2014-09-23 | Novartis Ag | Compostos orgânicos e seus usos |
| EP2170866B1 (en) * | 2007-06-25 | 2014-08-13 | Amgen Inc. | Phthalazine compounds, compositions and methods of use |
| CA2697682A1 (en) | 2007-09-07 | 2009-03-19 | Amgen Inc. | Annelated pyridazines for the treatment of tumors driven by inapropriate hedgehog signalling |
| UA102250C2 (ru) | 2008-04-29 | 2013-06-25 | Эли Лилли Энд Компани | Двухзамещенные фталазины - антагонисты проводящего пути hedgehog |
| US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| PT2358698E (pt) | 2008-11-17 | 2012-10-24 | Lilly Co Eli | Antagonistas da via hedgehog de piridazina tetrasubstituída |
| US8445493B2 (en) | 2008-11-17 | 2013-05-21 | Eli Lilly And Company | Tetrasubstituted pyridazines hedgehog pathway antagonists |
| AR077014A1 (es) | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
-
2009
- 2009-10-22 PL PL09740613T patent/PL2364185T3/pl unknown
- 2009-10-22 US US13/122,212 patent/US8404687B2/en not_active Expired - Fee Related
- 2009-10-22 WO PCT/US2009/061573 patent/WO2010062507A1/en not_active Ceased
- 2009-10-22 MX MX2011004683A patent/MX2011004683A/es active IP Right Grant
- 2009-10-22 JP JP2011534624A patent/JP2012507535A/ja active Pending
- 2009-10-22 NZ NZ591945A patent/NZ591945A/xx not_active IP Right Cessation
- 2009-10-22 KR KR1020117010063A patent/KR101335746B1/ko not_active Expired - Fee Related
- 2009-10-22 AU AU2009320251A patent/AU2009320251C1/en not_active Ceased
- 2009-10-22 UA UAA201105364A patent/UA102115C2/ru unknown
- 2009-10-22 EA EA201170640A patent/EA018931B1/ru not_active IP Right Cessation
- 2009-10-22 BR BRPI0921437A patent/BRPI0921437A2/pt not_active IP Right Cessation
- 2009-10-22 PT PT97406136T patent/PT2364185E/pt unknown
- 2009-10-22 SI SI200930625T patent/SI2364185T1/sl unknown
- 2009-10-22 HR HRP20130527AT patent/HRP20130527T1/hr unknown
- 2009-10-22 CA CA2742539A patent/CA2742539C/en not_active Expired - Fee Related
- 2009-10-22 PE PE2011000937A patent/PE20110433A1/es not_active Application Discontinuation
- 2009-10-22 ES ES09740613T patent/ES2418479T3/es active Active
- 2009-10-22 EP EP09740613.6A patent/EP2364185B1/en active Active
- 2009-10-22 DK DK09740613.6T patent/DK2364185T3/da active
- 2009-10-22 CN CN200980143394.3A patent/CN102202737B/zh not_active Expired - Fee Related
-
2011
- 2011-03-21 IL IL211841A patent/IL211841A0/en unknown
- 2011-04-01 ZA ZA2011/02448A patent/ZA201102448B/en unknown
- 2011-04-07 TN TN2011000166A patent/TN2011000166A1/fr unknown
- 2011-04-15 CR CR20110202A patent/CR20110202A/es not_active Application Discontinuation
- 2011-04-22 MA MA33790A patent/MA32726B1/fr unknown
- 2011-05-02 CL CL2011000979A patent/CL2011000979A1/es unknown
- 2011-05-02 EC EC2011011021A patent/ECSP11011021A/es unknown
- 2011-05-11 CO CO11058054A patent/CO6382123A2/es active IP Right Grant
-
2013
- 2013-06-05 CY CY20131100447T patent/CY1114023T1/el unknown