UA102115C2 - Дизамещенные фталазиновые антагонисты сигнального пути hedgehog - Google Patents

Дизамещенные фталазиновые антагонисты сигнального пути hedgehog

Info

Publication number
UA102115C2
UA102115C2 UAA201105364A UAA201105364A UA102115C2 UA 102115 C2 UA102115 C2 UA 102115C2 UA A201105364 A UAA201105364 A UA A201105364A UA A201105364 A UAA201105364 A UA A201105364A UA 102115 C2 UA102115 C2 UA 102115C2
Authority
UA
Ukraine
Prior art keywords
hedgehog pathway
pathway antagonists
disubstituted phthalazine
phthalazine hedgehog
disubstituted
Prior art date
Application number
UAA201105364A
Other languages
English (en)
Ukrainian (uk)
Inventor
Джоли Эн Бастиан
Филип Артур Хипскинд
Даниэль Джон Селл
Такако Уилсон
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41566219&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA102115(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of UA102115C2 publication Critical patent/UA102115C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Это изобретение предлагает новые 1,4-дизамещенные фталазиновые антагонисты сигнального пути hedgehog, полезные при лечении рака.
UAA201105364A 2008-11-03 2009-10-22 Дизамещенные фталазиновые антагонисты сигнального пути hedgehog UA102115C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11070308P 2008-11-03 2008-11-03
PCT/US2009/061573 WO2010062507A1 (en) 2008-11-03 2009-10-22 Disubstituted phthalazine hedgehog pathway antagonists

Publications (1)

Publication Number Publication Date
UA102115C2 true UA102115C2 (ru) 2013-06-10

Family

ID=41566219

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201105364A UA102115C2 (ru) 2008-11-03 2009-10-22 Дизамещенные фталазиновые антагонисты сигнального пути hedgehog

Country Status (30)

Country Link
US (1) US8404687B2 (ru)
EP (1) EP2364185B1 (ru)
JP (1) JP2012507535A (ru)
KR (1) KR101335746B1 (ru)
CN (1) CN102202737B (ru)
AU (1) AU2009320251C1 (ru)
BR (1) BRPI0921437A2 (ru)
CA (1) CA2742539C (ru)
CL (1) CL2011000979A1 (ru)
CO (1) CO6382123A2 (ru)
CR (1) CR20110202A (ru)
CY (1) CY1114023T1 (ru)
DK (1) DK2364185T3 (ru)
EA (1) EA018931B1 (ru)
EC (1) ECSP11011021A (ru)
ES (1) ES2418479T3 (ru)
HK (1) HK1159010A1 (ru)
HR (1) HRP20130527T1 (ru)
IL (1) IL211841A0 (ru)
MA (1) MA32726B1 (ru)
MX (1) MX2011004683A (ru)
NZ (1) NZ591945A (ru)
PE (1) PE20110433A1 (ru)
PL (1) PL2364185T3 (ru)
PT (1) PT2364185E (ru)
SI (1) SI2364185T1 (ru)
TN (1) TN2011000166A1 (ru)
UA (1) UA102115C2 (ru)
WO (1) WO2010062507A1 (ru)
ZA (1) ZA201102448B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA100684C2 (ru) * 2007-03-15 2013-01-25 Новартіс Аг Производные бензила и пиридинила как модуляторы сигнального пути hedgehog
NZ588001A (en) 2008-04-29 2012-06-29 Lilly Co Eli Disubstituted phthalazine hedgehog pathway antagonists
US20100041663A1 (en) * 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
CN102216292B (zh) 2008-11-17 2014-08-13 伊莱利利公司 四取代的哒嗪hedgehog途径拮抗剂
PL2358698T3 (pl) 2008-11-17 2013-01-31 Lilly Co Eli Czteropodstawione pirydazyny jako antagoniści szlaku HEDGEHOG
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
WO2015073691A1 (en) 2013-11-14 2015-05-21 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of bmp signaling
CN105985319B (zh) * 2015-02-11 2019-02-26 复旦大学 芳基酞嗪化合物及其制备方法和用途
CN105985321B (zh) * 2015-02-11 2018-10-26 复旦大学 吡唑酞嗪化合物及其制备方法和用途
CN105985320B (zh) * 2015-02-11 2018-10-26 复旦大学 苄基酞嗪化合物及其制备方法和用途
WO2024064245A1 (en) * 2022-09-23 2024-03-28 Merck Sharp & Dohme Llc Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
EP0876366B1 (en) 1996-01-15 2001-07-25 Janssen Pharmaceutica N.V. Angiogenesis inhibiting pyridazinamines
EP0882717B1 (en) * 1996-10-01 2010-09-08 Kyowa Hakko Kirin Co., Ltd. Nitrogenous heterocyclic compounds
EP1067939B1 (en) 1998-04-09 2015-09-16 The Johns Hopkins University Use of steroidal alkaloid derivatives as inhibitors of hedgehog protein signaling pathways
US6432970B2 (en) * 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
DE60016402T2 (de) 1999-06-08 2005-10-27 Lorantis Ltd. Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges
CA2483311A1 (en) 2002-04-22 2003-10-30 Philip A. Beachy Modulators of hedgehog signaling pathways, compositions and uses related thereto
AU2003265853A1 (en) 2002-08-29 2004-03-19 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
WO2005033288A2 (en) * 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
WO2005080378A1 (ja) 2004-02-24 2005-09-01 Mitsubishi Pharma Corporation 縮合ピリダジン誘導体
AU2005260102A1 (en) 2004-05-08 2006-01-12 Novartis International Pharmaceutical Ltd. 3-aryl-5,6-disubstituted pyridazines
PL1789390T3 (pl) * 2004-09-02 2012-04-30 Genentech Inc Pirydylowe inhibitory szlaku sygnałowego hedgehog
EP1900731A1 (de) 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
UA100684C2 (ru) 2007-03-15 2013-01-25 Новартіс Аг Производные бензила и пиридинила как модуляторы сигнального пути hedgehog
US8153633B2 (en) * 2007-06-25 2012-04-10 Amgen Inc. Phthalazine compounds, compositions and methods of use
WO2009035568A1 (en) 2007-09-07 2009-03-19 Amgen Inc. Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling
NZ588001A (en) * 2008-04-29 2012-06-29 Lilly Co Eli Disubstituted phthalazine hedgehog pathway antagonists
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
CN102216292B (zh) 2008-11-17 2014-08-13 伊莱利利公司 四取代的哒嗪hedgehog途径拮抗剂
PL2358698T3 (pl) 2008-11-17 2013-01-31 Lilly Co Eli Czteropodstawione pirydazyny jako antagoniści szlaku HEDGEHOG
AR077014A1 (es) * 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Also Published As

Publication number Publication date
CN102202737B (zh) 2014-03-26
TN2011000166A1 (en) 2012-12-17
NZ591945A (en) 2012-10-26
KR101335746B1 (ko) 2013-12-12
ECSP11011021A (es) 2011-06-30
JP2012507535A (ja) 2012-03-29
PT2364185E (pt) 2013-07-24
AU2009320251A1 (en) 2010-06-03
MA32726B1 (fr) 2011-10-02
PE20110433A1 (es) 2011-07-09
CY1114023T1 (el) 2016-07-27
CA2742539A1 (en) 2010-06-03
ES2418479T3 (es) 2013-08-14
EP2364185B1 (en) 2013-05-22
BRPI0921437A2 (pt) 2018-10-30
HRP20130527T1 (en) 2013-07-31
US20110190304A1 (en) 2011-08-04
HK1159010A1 (en) 2012-07-27
MX2011004683A (es) 2011-06-20
US8404687B2 (en) 2013-03-26
ZA201102448B (en) 2012-09-26
EP2364185A1 (en) 2011-09-14
EA201170640A1 (ru) 2011-12-30
CR20110202A (es) 2011-06-09
KR20110066212A (ko) 2011-06-16
AU2009320251C1 (en) 2013-08-15
WO2010062507A1 (en) 2010-06-03
IL211841A0 (en) 2011-06-30
AU2009320251B2 (en) 2013-01-24
CA2742539C (en) 2014-05-06
DK2364185T3 (da) 2013-06-03
CO6382123A2 (es) 2012-02-15
PL2364185T3 (pl) 2013-10-31
SI2364185T1 (sl) 2013-07-31
CL2011000979A1 (es) 2011-10-07
EA018931B1 (ru) 2013-11-29
CN102202737A (zh) 2011-09-28

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