SI2364185T1 - Disubstituirani ftalazini kot antagonisti signalne poti hedgehog - Google Patents

Disubstituirani ftalazini kot antagonisti signalne poti hedgehog

Info

Publication number
SI2364185T1
SI2364185T1 SI200930625T SI200930625T SI2364185T1 SI 2364185 T1 SI2364185 T1 SI 2364185T1 SI 200930625 T SI200930625 T SI 200930625T SI 200930625 T SI200930625 T SI 200930625T SI 2364185 T1 SI2364185 T1 SI 2364185T1
Authority
SI
Slovenia
Prior art keywords
hedgehog pathway
pathway antagonists
disubstituted phthalazine
phthalazine hedgehog
disubstituted
Prior art date
Application number
SI200930625T
Other languages
English (en)
Slovenian (sl)
Inventor
Jolie Anne Bastian
Philip Arthur Hipskind
Daniel Jon Sall
Takako Wilson
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41566219&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2364185(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of SI2364185T1 publication Critical patent/SI2364185T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI200930625T 2008-11-03 2009-10-22 Disubstituirani ftalazini kot antagonisti signalne poti hedgehog SI2364185T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11070308P 2008-11-03 2008-11-03
PCT/US2009/061573 WO2010062507A1 (en) 2008-11-03 2009-10-22 Disubstituted phthalazine hedgehog pathway antagonists
EP09740613.6A EP2364185B1 (en) 2008-11-03 2009-10-22 Disubstituted phthalazine hedgehog pathway antagonists

Publications (1)

Publication Number Publication Date
SI2364185T1 true SI2364185T1 (sl) 2013-07-31

Family

ID=41566219

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200930625T SI2364185T1 (sl) 2008-11-03 2009-10-22 Disubstituirani ftalazini kot antagonisti signalne poti hedgehog

Country Status (29)

Country Link
US (1) US8404687B2 (show.php)
EP (1) EP2364185B1 (show.php)
JP (1) JP2012507535A (show.php)
KR (1) KR101335746B1 (show.php)
CN (1) CN102202737B (show.php)
AU (1) AU2009320251C1 (show.php)
BR (1) BRPI0921437A2 (show.php)
CA (1) CA2742539C (show.php)
CL (1) CL2011000979A1 (show.php)
CO (1) CO6382123A2 (show.php)
CR (1) CR20110202A (show.php)
CY (1) CY1114023T1 (show.php)
DK (1) DK2364185T3 (show.php)
EA (1) EA018931B1 (show.php)
EC (1) ECSP11011021A (show.php)
ES (1) ES2418479T3 (show.php)
HR (1) HRP20130527T1 (show.php)
IL (1) IL211841A0 (show.php)
MA (1) MA32726B1 (show.php)
MX (1) MX2011004683A (show.php)
NZ (1) NZ591945A (show.php)
PE (1) PE20110433A1 (show.php)
PL (1) PL2364185T3 (show.php)
PT (1) PT2364185E (show.php)
SI (1) SI2364185T1 (show.php)
TN (1) TN2011000166A1 (show.php)
UA (1) UA102115C2 (show.php)
WO (1) WO2010062507A1 (show.php)
ZA (1) ZA201102448B (show.php)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0809193A2 (pt) * 2007-03-15 2014-09-23 Novartis Ag Compostos orgânicos e seus usos
UA102250C2 (ru) 2008-04-29 2013-06-25 Эли Лилли Энд Компани Двухзамещенные фталазины - антагонисты проводящего пути hedgehog
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
US8445493B2 (en) 2008-11-17 2013-05-21 Eli Lilly And Company Tetrasubstituted pyridazines hedgehog pathway antagonists
PT2358698E (pt) 2008-11-17 2012-10-24 Lilly Co Eli Antagonistas da via hedgehog de piridazina tetrasubstituída
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
WO2015073691A1 (en) 2013-11-14 2015-05-21 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of bmp signaling
CN105985319B (zh) * 2015-02-11 2019-02-26 复旦大学 芳基酞嗪化合物及其制备方法和用途
CN105985320B (zh) * 2015-02-11 2018-10-26 复旦大学 苄基酞嗪化合物及其制备方法和用途
CN105985321B (zh) * 2015-02-11 2018-10-26 复旦大学 吡唑酞嗪化合物及其制备方法和用途
AU2021360767A1 (en) 2020-10-13 2023-04-27 Endeavor Biomedicines, Inc. Methods of treating fibrosis
EP4590672A1 (en) * 2022-09-23 2025-07-30 Merck Sharp & Dohme LLC Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3
WO2025188802A1 (en) 2024-03-05 2025-09-12 Endeavor Biomedicines, Inc. Methods of improving lung function

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
EP0876366B1 (en) 1996-01-15 2001-07-25 Janssen Pharmaceutica N.V. Angiogenesis inhibiting pyridazinamines
KR100622323B1 (ko) * 1996-10-01 2006-11-30 교와 핫꼬 고교 가부시끼가이샤 질소-함유헤테로고리화합물
US6432970B2 (en) 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
JP5067986B2 (ja) 1998-04-09 2012-11-07 ジョンズ ホプキンズ ユニヴァーシティー スクール オブ メディシン ヘッジホッグシグナリング経路の阻害剤としてのステロイドアルカロイド誘導体の使用
GB0013674D0 (en) 1999-06-08 2000-07-26 Lorantis Ltd Therapeutic use
DE60322869D1 (de) 2002-04-22 2008-09-25 Univ Johns Hopkins Modulatoren von hedgehog signalpfaden, zusammensetzungen und verwandte verwendungen
WO2004020599A2 (en) 2002-08-29 2004-03-11 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
WO2005033288A2 (en) * 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
TW200533356A (en) 2004-02-24 2005-10-16 Mitsubishi Pharma Corp Fused pyridazine derivatives
WO2006004589A2 (en) 2004-05-08 2006-01-12 Neurogen Corporation 3-aryl-5,6-disubstituted pyridazines
US7888364B2 (en) * 2004-09-02 2011-02-15 Curis, Inc. Pyridyl inhibitors of hedgehog signalling
EP1900731A1 (de) 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
BRPI0809193A2 (pt) 2007-03-15 2014-09-23 Novartis Ag Compostos orgânicos e seus usos
EP2170866B1 (en) * 2007-06-25 2014-08-13 Amgen Inc. Phthalazine compounds, compositions and methods of use
CA2697682A1 (en) 2007-09-07 2009-03-19 Amgen Inc. Annelated pyridazines for the treatment of tumors driven by inapropriate hedgehog signalling
UA102250C2 (ru) 2008-04-29 2013-06-25 Эли Лилли Энд Компани Двухзамещенные фталазины - антагонисты проводящего пути hedgehog
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
PT2358698E (pt) 2008-11-17 2012-10-24 Lilly Co Eli Antagonistas da via hedgehog de piridazina tetrasubstituída
US8445493B2 (en) 2008-11-17 2013-05-21 Eli Lilly And Company Tetrasubstituted pyridazines hedgehog pathway antagonists
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Also Published As

Publication number Publication date
TN2011000166A1 (en) 2012-12-17
MA32726B1 (fr) 2011-10-02
CY1114023T1 (el) 2016-07-27
EA201170640A1 (ru) 2011-12-30
ZA201102448B (en) 2012-09-26
KR20110066212A (ko) 2011-06-16
US20110190304A1 (en) 2011-08-04
CN102202737A (zh) 2011-09-28
CA2742539A1 (en) 2010-06-03
CL2011000979A1 (es) 2011-10-07
EP2364185A1 (en) 2011-09-14
NZ591945A (en) 2012-10-26
CA2742539C (en) 2014-05-06
AU2009320251A1 (en) 2010-06-03
UA102115C2 (ru) 2013-06-10
PT2364185E (pt) 2013-07-24
MX2011004683A (es) 2011-06-20
EA018931B1 (ru) 2013-11-29
JP2012507535A (ja) 2012-03-29
DK2364185T3 (da) 2013-06-03
CN102202737B (zh) 2014-03-26
CO6382123A2 (es) 2012-02-15
EP2364185B1 (en) 2013-05-22
IL211841A0 (en) 2011-06-30
AU2009320251C1 (en) 2013-08-15
PE20110433A1 (es) 2011-07-09
US8404687B2 (en) 2013-03-26
HRP20130527T1 (en) 2013-07-31
HK1159010A1 (en) 2012-07-27
PL2364185T3 (pl) 2013-10-31
CR20110202A (es) 2011-06-09
BRPI0921437A2 (pt) 2018-10-30
ES2418479T3 (es) 2013-08-14
AU2009320251B2 (en) 2013-01-24
KR101335746B1 (ko) 2013-12-12
WO2010062507A1 (en) 2010-06-03
ECSP11011021A (es) 2011-06-30

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