JP2016501515A - 血小板標的化治療 - Google Patents

血小板標的化治療 Download PDF

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Publication number
JP2016501515A
JP2016501515A JP2015539804A JP2015539804A JP2016501515A JP 2016501515 A JP2016501515 A JP 2016501515A JP 2015539804 A JP2015539804 A JP 2015539804A JP 2015539804 A JP2015539804 A JP 2015539804A JP 2016501515 A JP2016501515 A JP 2016501515A
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gene
nucleotides
vector
platelets
expression
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JP2015539804A
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English (en)
Japanese (ja)
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JP2016501515A5 (OSRAM
Inventor
ウィルコックス，デイヴィッド，エー．
ヘーバーリクター，サンドラ，エル．
Original Assignee
プレートレット ターゲテッド セラピューティクス，エルエルシー
プレートレット ターゲテッド セラピューティクス，エルエルシー
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Application filed by プレートレット ターゲテッド セラピューティクス，エルエルシー, プレートレット ターゲテッド セラピューティクス，エルエルシー filed Critical プレートレット ターゲテッド セラピューティクス，エルエルシー
Publication of JP2016501515A publication Critical patent/JP2016501515A/ja
Publication of JP2016501515A5 publication Critical patent/JP2016501515A5/ja
Priority to JP2018135886A priority Critical patent/JP6975105B2/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/7055—Integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2015539804A 2012-10-24 2013-10-24 血小板標的化治療 Pending JP2016501515A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2018135886A JP6975105B2 (ja) 2012-10-24 2018-07-19 血小板標的化治療

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261717951P 2012-10-24 2012-10-24
US61/717,951 2012-10-24
PCT/US2013/066651 WO2014066663A1 (en) 2012-10-24 2013-10-24 Platelet targeted treatment

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018135886A Division JP6975105B2 (ja) 2012-10-24 2018-07-19 血小板標的化治療

Publications (2)

Publication Number Publication Date
JP2016501515A true JP2016501515A (ja) 2016-01-21
JP2016501515A5 JP2016501515A5 (OSRAM) 2016-11-10

Family

ID=50545271

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015539804A Pending JP2016501515A (ja) 2012-10-24 2013-10-24 血小板標的化治療
JP2018135886A Active JP6975105B2 (ja) 2012-10-24 2018-07-19 血小板標的化治療

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018135886A Active JP6975105B2 (ja) 2012-10-24 2018-07-19 血小板標的化治療

Country Status (12)

Country Link
US (4) US9982034B2 (OSRAM)
EP (2) EP3859004A1 (OSRAM)
JP (2) JP2016501515A (OSRAM)
KR (1) KR101819803B1 (OSRAM)
BR (1) BR112015009229B1 (OSRAM)
CA (1) CA2888982C (OSRAM)
DK (1) DK2912186T3 (OSRAM)
ES (1) ES2854754T3 (OSRAM)
IL (1) IL238417B (OSRAM)
PL (1) PL2912186T3 (OSRAM)
WO (1) WO2014066663A1 (OSRAM)
ZA (1) ZA201502945B (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017011550A1 (en) 2015-07-13 2017-01-19 University Of Utah Research Foundation Methods of making red blood cells and platelets in vitro and uses thereof
KR102592176B1 (ko) 2018-01-05 2023-10-20 플레이틀렛 바이오제네시스, 인크. 거핵구 생성을 위한 조성물 및 방법
WO2020006539A1 (en) 2018-06-29 2020-01-02 Platelet Biogenesis, Inc. Compositions for drug delivery and methods of use thereof
KR20210072034A (ko) * 2018-10-05 2021-06-16 유타대학연구재단 변형된 수용체를 포함하는 혈소판을 제조하는 방법 및 이의 용도
EP3887402A4 (en) 2018-11-30 2022-10-26 Cellphire, Inc. PLATELETS AS RELEASING AGENT
US11767511B2 (en) 2018-11-30 2023-09-26 Cellphire, Inc. Platelets as delivery agents
EP3937631A4 (en) * 2019-03-13 2023-01-04 Cellphire Inc. DOG PLALETLET PREPARATIONS
US11529587B2 (en) 2019-05-03 2022-12-20 Cellphire, Inc. Materials and methods for producing blood products
CA3150936A1 (en) 2019-08-16 2021-02-25 Cellphire, Inc. Thrombosomes as an antiplatelet agent reversal agent
US20210308066A1 (en) 2020-02-04 2021-10-07 Cellphire, Inc. Anti-fibrinolytic loaded platelets
DE102020111571A1 (de) 2020-03-11 2021-09-16 Immatics US, Inc. Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren
US20220273724A1 (en) 2021-02-17 2022-09-01 Cellphire Inc. Freeze-dried platelet derivative compositions for treating antiplatelet induced coagulopathy

Citations (3)

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JP2000333687A (ja) * 1999-04-27 2000-12-05 Aventis Behring Gmbh 血液凝固因子の組織特異的発現のためのｄｎａ構築体
US20040192599A1 (en) * 2001-06-15 2004-09-30 Schuh Andre C Gene therapy for hemophilia a
US20120225028A1 (en) * 2011-03-02 2012-09-06 Moshe Cohen Compositions and methods for mobilization of stem cells

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IL101715A (en) 1991-05-02 2005-06-19 Amgen Inc Recombinant dna-derived cholera toxin subunit analogs
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US20040192599A1 (en) * 2001-06-15 2004-09-30 Schuh Andre C Gene therapy for hemophilia a
US20120225028A1 (en) * 2011-03-02 2012-09-06 Moshe Cohen Compositions and methods for mobilization of stem cells

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Also Published As

Publication number Publication date
PL2912186T3 (pl) 2021-06-14
ES2854754T3 (es) 2021-09-22
CA2888982C (en) 2020-07-21
JP2018161152A (ja) 2018-10-18
CA2888982A1 (en) 2014-05-01
BR112015009229A2 (pt) 2017-11-14
WO2014066663A1 (en) 2014-05-01
US10294291B2 (en) 2019-05-21
BR112015009229B1 (pt) 2021-07-20
EP3859004A1 (en) 2021-08-04
JP6975105B2 (ja) 2021-12-01
IL238417A0 (en) 2015-06-30
US20190270791A1 (en) 2019-09-05
EP2912186A4 (en) 2016-06-08
US20180009874A1 (en) 2018-01-11
IL238417B (en) 2019-07-31
US20240270822A1 (en) 2024-08-15
KR101819803B1 (ko) 2018-01-17
US20150344541A1 (en) 2015-12-03
EP2912186A1 (en) 2015-09-02
US9982034B2 (en) 2018-05-29
DK2912186T3 (da) 2021-02-22
ZA201502945B (en) 2016-11-30
KR20150069017A (ko) 2015-06-22
EP2912186B1 (en) 2021-01-06
HK1211986A1 (en) 2016-06-03

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