JP2016216487A5 - - Google Patents
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- Publication number
- JP2016216487A5 JP2016216487A5 JP2016137461A JP2016137461A JP2016216487A5 JP 2016216487 A5 JP2016216487 A5 JP 2016216487A5 JP 2016137461 A JP2016137461 A JP 2016137461A JP 2016137461 A JP2016137461 A JP 2016137461A JP 2016216487 A5 JP2016216487 A5 JP 2016216487A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- joint
- stem cells
- mesenchymal stem
- allogeneic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 36
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 27
- 210000001519 tissue Anatomy 0.000 claims 21
- 230000000735 allogeneic effect Effects 0.000 claims 19
- 241001465754 Metazoa Species 0.000 claims 14
- 230000006378 damage Effects 0.000 claims 13
- 208000027418 Wounds and injury Diseases 0.000 claims 9
- 208000014674 injury Diseases 0.000 claims 9
- 238000004519 manufacturing process Methods 0.000 claims 9
- 239000007924 injection Substances 0.000 claims 6
- 238000002347 injection Methods 0.000 claims 6
- 210000001503 joint Anatomy 0.000 claims 6
- 208000006820 Arthralgia Diseases 0.000 claims 4
- 210000000845 cartilage Anatomy 0.000 claims 4
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims 4
- 229940099552 hyaluronan Drugs 0.000 claims 4
- 229920002674 hyaluronan Polymers 0.000 claims 4
- 210000000629 knee joint Anatomy 0.000 claims 4
- 201000008482 osteoarthritis Diseases 0.000 claims 4
- 210000000323 shoulder joint Anatomy 0.000 claims 4
- 230000002123 temporal effect Effects 0.000 claims 4
- 210000001738 temporomandibular joint Anatomy 0.000 claims 4
- 241001272720 Medialuna californiensis Species 0.000 claims 3
- 239000002504 physiological saline solution Substances 0.000 claims 2
- 238000005728 strengthening Methods 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 208000018937 joint inflammation Diseases 0.000 claims 1
- 230000005499 meniscus Effects 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19954900P | 2000-04-25 | 2000-04-25 | |
| US60/199,549 | 2000-04-25 | ||
| US23610600P | 2000-09-28 | 2000-09-28 | |
| US60/236,106 | 2000-09-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015035361A Division JP2015128633A (ja) | 2000-04-25 | 2015-02-25 | 動物の関節修復のための医薬組成物調製への間葉幹細胞の使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016216487A JP2016216487A (ja) | 2016-12-22 |
| JP2016216487A5 true JP2016216487A5 (enExample) | 2017-04-27 |
| JP6382262B2 JP6382262B2 (ja) | 2018-08-29 |
Family
ID=26894885
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001577964A Expired - Lifetime JP5090604B2 (ja) | 2000-04-25 | 2001-04-24 | 動物の関節修復のための医薬組成物調製への間葉幹細胞の使用法 |
| JP2012141003A Expired - Lifetime JP5792686B2 (ja) | 2000-04-25 | 2012-06-22 | 動物の関節修復のための医薬組成物調製への間葉幹細胞の使用法 |
| JP2015035361A Pending JP2015128633A (ja) | 2000-04-25 | 2015-02-25 | 動物の関節修復のための医薬組成物調製への間葉幹細胞の使用法 |
| JP2016137461A Expired - Lifetime JP6382262B2 (ja) | 2000-04-25 | 2016-07-12 | 動物の関節修復のための医薬組成物調製への間葉幹細胞の使用法 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001577964A Expired - Lifetime JP5090604B2 (ja) | 2000-04-25 | 2001-04-24 | 動物の関節修復のための医薬組成物調製への間葉幹細胞の使用法 |
| JP2012141003A Expired - Lifetime JP5792686B2 (ja) | 2000-04-25 | 2012-06-22 | 動物の関節修復のための医薬組成物調製への間葉幹細胞の使用法 |
| JP2015035361A Pending JP2015128633A (ja) | 2000-04-25 | 2015-02-25 | 動物の関節修復のための医薬組成物調製への間葉幹細胞の使用法 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US20020005205A1 (enExample) |
| EP (1) | EP1276486B2 (enExample) |
| JP (4) | JP5090604B2 (enExample) |
| AT (1) | ATE489101T1 (enExample) |
| AU (2) | AU5723601A (enExample) |
| CA (1) | CA2405345C (enExample) |
| DE (1) | DE60143517D1 (enExample) |
| ES (1) | ES2353061T5 (enExample) |
| PT (1) | PT1276486E (enExample) |
| WO (1) | WO2001080865A2 (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2353061T5 (es) * | 2000-04-25 | 2014-04-07 | Osiris Therapeutics, Inc. | Reparación de articulaciones utilizando células madre mesenquimatosas |
| DE10139783C1 (de) * | 2001-08-14 | 2003-04-17 | Transtissue Technologies Gmbh | Zellzusammensetzungen zur Behandlung von Osteoarthrose, sowie Verfahren zu deren Herstellung |
| US20030109038A1 (en) * | 2001-12-07 | 2003-06-12 | Thies R. Scott | Chondrocyte precursors derived from human embryonic stem cells |
| AR047712A1 (es) * | 2002-09-07 | 2006-02-15 | Royal Veterinary College | Metodo de tratamiento de una lesion de tejido esqueletico blando natural administrando una composicion de celulas madre mesenquimatosas |
| SG146691A1 (en) | 2003-10-08 | 2008-10-30 | Vet Stem Inc | Methods of preparing and using stem cell compositions and kits comprising the same |
| US8012693B2 (en) * | 2003-12-16 | 2011-09-06 | 3M Innovative Properties Company | Analysis of chemically crosslinked cellular samples |
| EP2298863B1 (en) | 2004-03-22 | 2015-07-22 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
| AU2012205269B2 (en) * | 2004-03-22 | 2015-08-27 | Mesoblast International Sarl | Mesenchymal stem cells and uses therefor |
| AU2015252160A1 (en) * | 2004-03-22 | 2015-11-26 | Mesoblast International Sarl | Mesenchymal stem cells and uses therefor |
| ES2708627T3 (es) * | 2004-03-22 | 2019-04-10 | Mesoblast Int Sarl | Células madre mesenquimales y sus usos |
| US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
| ATE548651T1 (de) * | 2005-06-16 | 2012-03-15 | 3M Innovative Properties Co | Verfahren zur klassifizierung chemisch quervernetzter zellulärer proben unter verwendung von massenspektren |
| WO2007025166A2 (en) | 2005-08-25 | 2007-03-01 | Repair Technologies, Inc. | Devices, compositions and methods for the protection and repair of cells and tissues |
| GB0600972D0 (en) * | 2006-01-18 | 2006-03-01 | Univ Leeds | Enrichment of cells |
| CN103893211A (zh) * | 2006-03-07 | 2014-07-02 | 吉塔·什罗夫 | 包含人胚胎干细胞和其衍生物的组合物、其使用方法和制备方法 |
| US20080260703A1 (en) * | 2007-04-23 | 2008-10-23 | Medistem Labortories | Treatment of Insulin Resistance and Diabetes |
| US9095562B2 (en) * | 2007-07-05 | 2015-08-04 | Regenerative Sciences, Inc. | Methods and compositions for optimized expansion and implantation of mesenchymal stem cells |
| KR102167440B1 (ko) * | 2007-08-06 | 2020-10-20 | 메소블라스트, 아이엔씨. | 생체 내에서 결합 조직을 생성, 복구 및/또는 유지하는 방법 |
| CN101827603B (zh) | 2007-08-06 | 2013-03-06 | 成血管细胞系统公司 | 用于体内生成、修复和/或维护结缔组织的方法 |
| AU2013203054B2 (en) * | 2007-08-06 | 2017-05-18 | Mesoblast, Inc. | Methods of generating, repairing and/or maintaining connective tissue in vivo |
| WO2009085969A2 (en) | 2007-12-19 | 2009-07-09 | Regenerative Sciences, Llc | Compositions and methods to promote implantation and engrafment of stem cells |
| BRPI0905369C8 (pt) | 2008-02-15 | 2021-05-25 | Bone Therapeutics | composição farmacêutica, uso da composição farmacêutica e kit compartimentado |
| EP2090308A1 (en) * | 2008-02-15 | 2009-08-19 | Bone Therapeutics | Pharmaceutical composition for the treatment or prevention of osteoarticular diseases |
| JP5728234B2 (ja) * | 2008-02-15 | 2015-06-03 | ボーン・セラピューティクス | 骨関節疾患の治療又は予防において使用するための医薬組成物 |
| WO2009114785A2 (en) | 2008-03-14 | 2009-09-17 | Regenerative Sciences, Inc. | Compositions and methods for cartilage repair |
| US8858932B2 (en) | 2008-06-25 | 2014-10-14 | Mesoblast, Inc. | Repair and/or reconstitution of invertebral discs |
| WO2010056336A1 (en) * | 2008-11-14 | 2010-05-20 | Howmedica Osteonics Corp. | Cells for joint fluid |
| US9192695B2 (en) | 2008-11-20 | 2015-11-24 | Allosource | Allografts combined with tissue derived stem cells for bone healing |
| KR20120006481A (ko) | 2008-12-05 | 2012-01-18 | 리제너러티브 사이언시즈, 엘엘씨 | 무혈관 조직의 복구를 촉진하기 위한 방법 및 조성물 |
| WO2010099463A2 (en) | 2009-02-27 | 2010-09-02 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Joint bioscaffolds |
| IT1394570B1 (it) * | 2009-07-02 | 2012-07-05 | Fidia Farmaceutici | Materiale biologico adatto per la terapia dell osteoartrosi del danno dei legamenti e per il trattamento delle patologie delle articolazioni. |
| CA2777783A1 (en) * | 2009-10-13 | 2011-04-21 | Allocure Inc. | Assay for the prediction of therapeutic effectiveness of mesenchymal stromal cells, and methods of using same |
| US9113950B2 (en) | 2009-11-04 | 2015-08-25 | Regenerative Sciences, Llc | Therapeutic delivery device |
| PT2611906T (pt) * | 2010-08-31 | 2024-04-16 | Gallant Pet Inc | Terapias sistémicas com células estaminais alogénicas para tratamento de doenças em gatos e cães |
| EP4663241A3 (en) | 2010-10-08 | 2026-03-25 | Mesoblast International Sàrl | Enhanced msc preparations |
| US8709401B2 (en) | 2011-02-25 | 2014-04-29 | Howmedica Osteonics Corp. | Primed stem cells and uses thereof to treat inflammatory conditions in joints |
| WO2013003595A1 (en) | 2011-06-29 | 2013-01-03 | Biorestorative Therapies, Inc. | Brown fat cell compositions and methods |
| GB201202319D0 (en) | 2012-02-10 | 2012-03-28 | Orbsen Therapeutics Ltd | Stromal stem cells |
| US9457051B2 (en) * | 2013-01-22 | 2016-10-04 | Animal Cell Therapies, Inc. | Use of stem cells or progenitor cells to treat, delay, prevent, or repair tearing of cruciate ligaments |
| KR102252223B1 (ko) | 2013-02-12 | 2021-05-14 | 리플리셀 라이프 사이언시스 인크. | 힘줄 치료 및 회복을 위한 조성물 및 방법 |
| WO2014130883A2 (en) | 2013-02-22 | 2014-08-28 | Allosource | Cartilage mosaic compositions and methods |
| KR102312720B1 (ko) | 2013-03-15 | 2021-10-13 | 알로소스 | 연조직 회복 및 재생을 위한 세포 재배치된 콜라겐 매트릭스 |
| EP2967874B1 (en) | 2013-03-15 | 2019-11-20 | AlloSource | Perforated osteochondral allograft compositions |
| US20150010606A1 (en) * | 2013-07-08 | 2015-01-08 | Arthrex, Inc. | Intra-articular injection and implant attachment of molecule consisting of lubricin and extracellular superoxide dismutase or hyaluronic acid and extracellular superoxide dismutase |
| US9597099B2 (en) * | 2013-07-29 | 2017-03-21 | Covidien Lp | Energy-based treatment methods for refractory gout |
| AU2014297188B2 (en) * | 2013-08-01 | 2017-05-11 | Two Cells Co., Ltd. | Cartilage-damage treatment agent and method for producing same |
| US20170119907A1 (en) | 2014-01-28 | 2017-05-04 | Medivation Technologies, Inc. | Targeted Therapeutics |
| WO2015123477A1 (en) * | 2014-02-12 | 2015-08-20 | Replicel Life Sciences Inc. | Compositions and methods for treating bone, joints and cartilage |
| US20170044497A1 (en) | 2014-02-12 | 2017-02-16 | National University Of Ireland, Galway | Selection and use of stem cells |
| RU2559089C1 (ru) * | 2014-04-22 | 2015-08-10 | Государственное автономное учреждение здравоохранения "Республиканская клиническая больница Министерства здравоохранения Республики Татарстан" | Способ восстановления дефектов гиалинового хряща суставных поверхностей суставов конечностей |
| WO2016015007A1 (en) | 2014-07-25 | 2016-01-28 | Recellerate, Inc. | Methods of treating exercise-induced pulmonary hemorrhage |
| TWI566774B (zh) * | 2014-10-06 | 2017-01-21 | 佛教慈濟醫療財團法人花蓮慈濟醫院 | 治療關節疾病的組成物及其方法 |
| RU2644650C2 (ru) | 2014-12-01 | 2018-02-13 | Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" | Материал стволовых клеток и способ его получения |
| WO2017019832A1 (en) | 2015-07-29 | 2017-02-02 | Medivation Technologies, Inc. | Methods and compositions using repair cells and cationic dyes |
| KR101720329B1 (ko) | 2015-12-11 | 2017-03-28 | 주식회사 에이티앤씨 | 무선통신 단말기용 nfc 및 mst 공용 안테나 장치 |
| RU2708329C2 (ru) | 2016-05-31 | 2019-12-05 | Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" | Материал стволовых клеток, композиции и способы применения |
| CN106075585B (zh) * | 2016-07-08 | 2019-06-21 | 福建师范大学 | 一种基于人工肌腱支架材料的组织工程化人工肌腱移植物的制备方法 |
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| US9980984B2 (en) | 2016-10-13 | 2018-05-29 | Kenneth Allen Pettine | Treatment of inflammation of osteoarthritic knees with mesenchymal stem cells |
| CN109952371A (zh) | 2016-11-15 | 2019-06-28 | 株式会社钟化 | 包含来自胎儿附属物的间充质系干细胞的细胞群、其制备方法、以及医药组合物 |
| DK3573630T3 (da) * | 2017-01-27 | 2021-06-07 | Xintela Ab | Forebyggelse og behandling af skader eller sygdom i knogler og brusk |
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| WO2019132026A1 (ja) | 2017-12-28 | 2019-07-04 | 株式会社カネカ | 接着性幹細胞を含む細胞集団とその製造方法、及び医薬組成物 |
| WO2019175773A1 (en) | 2018-03-12 | 2019-09-19 | Universidade Do Porto | Compositions for use in the treatment of musculoskeletal conditions and methods for producing the same leveraging the synergistic activity of two different types of mesenchymal stromal/stem cells |
| WO2020251020A1 (ja) | 2019-06-14 | 2020-12-17 | 株式会社カネカ | 間葉系細胞を含む細胞集団、それを含む医薬組成物、及び、その製造方法 |
| US11583402B2 (en) | 2019-07-16 | 2023-02-21 | William Baumgartl | Method for treating joint pain |
| US20220348880A1 (en) * | 2019-08-30 | 2022-11-03 | The Texas A&M University System | Xenogen-Free Mesenchymal Stem Cell Compositions and Methods of Use |
| WO2021105926A2 (en) * | 2019-11-26 | 2021-06-03 | Cells For Cells S.A. | Mesenchymal stem cells with enhanced therapeutic properties |
| WO2021226373A2 (en) | 2020-05-08 | 2021-11-11 | Gallant Pet, Inc. | Uterine-derived regenerative cell compositions and uses thereof |
| US12278085B2 (en) | 2022-04-06 | 2025-04-15 | Applied Materials Israel Ltd. | Hybrid scanning electron microscopy and acousto-optic based metrology |
| WO2025076042A1 (en) * | 2023-10-02 | 2025-04-10 | MAM Holdings of West Florida, L.L.C. | Mesenchymal stem cell-mediated treatments for the prevention and targeted treatment of injured tissues and promotion of tissue repair, healing, and regeneration |
| CN120866212B (zh) * | 2025-09-28 | 2026-02-24 | 山东省泉溪生物技术有限公司 | 一种用于膝关节炎治疗的羊膜间充质干细胞及其制备方法与应用 |
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| US5053050A (en) * | 1988-04-29 | 1991-10-01 | Samuel Itay | Compositions for repair of cartilage and bone |
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| FR2667788B1 (fr) * | 1990-10-12 | 1994-12-02 | Oreal | Utilisation d'hydroxyalkylamino-9,10-anthraquinones pour la teinture de fibres keratiniques humaines, composition cosmetique les contenant en association avec des colorants azouiques et nitres. |
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-
2001
- 2001-04-24 ES ES01930730.5T patent/ES2353061T5/es not_active Expired - Lifetime
- 2001-04-24 AU AU5723601A patent/AU5723601A/xx active Pending
- 2001-04-24 EP EP01930730.5A patent/EP1276486B2/en not_active Expired - Lifetime
- 2001-04-24 JP JP2001577964A patent/JP5090604B2/ja not_active Expired - Lifetime
- 2001-04-24 CA CA2405345A patent/CA2405345C/en not_active Expired - Lifetime
- 2001-04-24 WO PCT/US2001/013267 patent/WO2001080865A2/en not_active Ceased
- 2001-04-24 DE DE60143517T patent/DE60143517D1/de not_active Expired - Lifetime
- 2001-04-24 AT AT01930730T patent/ATE489101T1/de not_active IP Right Cessation
- 2001-04-24 AU AU2001257236A patent/AU2001257236B2/en not_active Expired
- 2001-04-24 PT PT01930730T patent/PT1276486E/pt unknown
- 2001-04-24 US US09/841,413 patent/US20020005205A1/en not_active Abandoned
-
2008
- 2008-06-03 US US12/132,290 patent/US20090041730A1/en not_active Abandoned
-
2012
- 2012-02-22 US US13/402,444 patent/US20120148548A1/en not_active Abandoned
- 2012-06-22 JP JP2012141003A patent/JP5792686B2/ja not_active Expired - Lifetime
-
2013
- 2013-01-16 US US13/743,004 patent/US9050178B2/en not_active Expired - Fee Related
-
2015
- 2015-02-25 JP JP2015035361A patent/JP2015128633A/ja active Pending
- 2015-04-16 US US14/687,963 patent/US9814580B2/en not_active Expired - Fee Related
-
2016
- 2016-07-12 JP JP2016137461A patent/JP6382262B2/ja not_active Expired - Lifetime
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