JP2016216487A5 - - Google Patents
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- Publication number
- JP2016216487A5 JP2016216487A5 JP2016137461A JP2016137461A JP2016216487A5 JP 2016216487 A5 JP2016216487 A5 JP 2016216487A5 JP 2016137461 A JP2016137461 A JP 2016137461A JP 2016137461 A JP2016137461 A JP 2016137461A JP 2016216487 A5 JP2016216487 A5 JP 2016216487A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- joint
- stem cells
- mesenchymal stem
- allogeneic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 36
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 27
- 210000001519 tissue Anatomy 0.000 claims 21
- 230000000735 allogeneic effect Effects 0.000 claims 19
- 241001465754 Metazoa Species 0.000 claims 14
- 230000006378 damage Effects 0.000 claims 13
- 208000027418 Wounds and injury Diseases 0.000 claims 9
- 208000014674 injury Diseases 0.000 claims 9
- 238000004519 manufacturing process Methods 0.000 claims 9
- 239000007924 injection Substances 0.000 claims 6
- 238000002347 injection Methods 0.000 claims 6
- 210000001503 joint Anatomy 0.000 claims 6
- 208000006820 Arthralgia Diseases 0.000 claims 4
- 210000000845 cartilage Anatomy 0.000 claims 4
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims 4
- 229940099552 hyaluronan Drugs 0.000 claims 4
- 229920002674 hyaluronan Polymers 0.000 claims 4
- 210000000629 knee joint Anatomy 0.000 claims 4
- 201000008482 osteoarthritis Diseases 0.000 claims 4
- 210000000323 shoulder joint Anatomy 0.000 claims 4
- 230000002123 temporal effect Effects 0.000 claims 4
- 210000001738 temporomandibular joint Anatomy 0.000 claims 4
- 241001272720 Medialuna californiensis Species 0.000 claims 3
- 239000002504 physiological saline solution Substances 0.000 claims 2
- 238000005728 strengthening Methods 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 208000018937 joint inflammation Diseases 0.000 claims 1
- 230000005499 meniscus Effects 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19954900P | 2000-04-25 | 2000-04-25 | |
| US60/199,549 | 2000-04-25 | ||
| US23610600P | 2000-09-28 | 2000-09-28 | |
| US60/236,106 | 2000-09-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015035361A Division JP2015128633A (ja) | 2000-04-25 | 2015-02-25 | 動物の関節修復のための医薬組成物調製への間葉幹細胞の使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016216487A JP2016216487A (ja) | 2016-12-22 |
| JP2016216487A5 true JP2016216487A5 (enExample) | 2017-04-27 |
| JP6382262B2 JP6382262B2 (ja) | 2018-08-29 |
Family
ID=26894885
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001577964A Expired - Lifetime JP5090604B2 (ja) | 2000-04-25 | 2001-04-24 | 動物の関節修復のための医薬組成物調製への間葉幹細胞の使用法 |
| JP2012141003A Expired - Lifetime JP5792686B2 (ja) | 2000-04-25 | 2012-06-22 | 動物の関節修復のための医薬組成物調製への間葉幹細胞の使用法 |
| JP2015035361A Pending JP2015128633A (ja) | 2000-04-25 | 2015-02-25 | 動物の関節修復のための医薬組成物調製への間葉幹細胞の使用法 |
| JP2016137461A Expired - Lifetime JP6382262B2 (ja) | 2000-04-25 | 2016-07-12 | 動物の関節修復のための医薬組成物調製への間葉幹細胞の使用法 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001577964A Expired - Lifetime JP5090604B2 (ja) | 2000-04-25 | 2001-04-24 | 動物の関節修復のための医薬組成物調製への間葉幹細胞の使用法 |
| JP2012141003A Expired - Lifetime JP5792686B2 (ja) | 2000-04-25 | 2012-06-22 | 動物の関節修復のための医薬組成物調製への間葉幹細胞の使用法 |
| JP2015035361A Pending JP2015128633A (ja) | 2000-04-25 | 2015-02-25 | 動物の関節修復のための医薬組成物調製への間葉幹細胞の使用法 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US20020005205A1 (enExample) |
| EP (1) | EP1276486B2 (enExample) |
| JP (4) | JP5090604B2 (enExample) |
| AT (1) | ATE489101T1 (enExample) |
| AU (2) | AU2001257236B2 (enExample) |
| CA (1) | CA2405345C (enExample) |
| DE (1) | DE60143517D1 (enExample) |
| ES (1) | ES2353061T5 (enExample) |
| PT (1) | PT1276486E (enExample) |
| WO (1) | WO2001080865A2 (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60143517D1 (de) * | 2000-04-25 | 2011-01-05 | Osiris Therapeutics Inc | Wiederherstellung der gelenken mit mesenchymalen stammzellen |
| DE10139783C1 (de) * | 2001-08-14 | 2003-04-17 | Transtissue Technologies Gmbh | Zellzusammensetzungen zur Behandlung von Osteoarthrose, sowie Verfahren zu deren Herstellung |
| US20030109038A1 (en) | 2001-12-07 | 2003-06-12 | Thies R. Scott | Chondrocyte precursors derived from human embryonic stem cells |
| AR047712A1 (es) | 2002-09-07 | 2006-02-15 | Royal Veterinary College | Metodo de tratamiento de una lesion de tejido esqueletico blando natural administrando una composicion de celulas madre mesenquimatosas |
| EP2450433A3 (en) | 2003-10-08 | 2012-08-08 | Vet-Stem Inc | Methods of preparing and using stem cell compositions and kits comprising the same |
| US8012693B2 (en) | 2003-12-16 | 2011-09-06 | 3M Innovative Properties Company | Analysis of chemically crosslinked cellular samples |
| ES2544689T3 (es) * | 2004-03-22 | 2015-09-02 | Mesoblast International Sàrl | Células madre mesenquimales y usos de las mismas |
| AU2015252160A1 (en) * | 2004-03-22 | 2015-11-26 | Mesoblast International Sarl | Mesenchymal stem cells and uses therefor |
| WO2005093044A1 (en) * | 2004-03-22 | 2005-10-06 | Osiris Therapeutics, Inc. | Mesenchymal stem cells and uses therefor |
| AU2012205269B2 (en) * | 2004-03-22 | 2015-08-27 | Mesoblast International Sarl | Mesenchymal stem cells and uses therefor |
| US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
| US20110177492A1 (en) * | 2005-06-16 | 2011-07-21 | 3M Innovative Properties Company | Method of classifying chemically crosslinked cellular samples using mass spectra |
| EP1924606A4 (en) | 2005-08-25 | 2010-01-13 | Repair Technologies Inc | DEVICES, COMPOSITIONS AND METHODS FOR PROTECTING AND REPAIRING CELLS AND TISSUE |
| GB0600972D0 (en) * | 2006-01-18 | 2006-03-01 | Univ Leeds | Enrichment of cells |
| NZ594639A (en) | 2006-03-07 | 2013-04-26 | Geeta Shroff | Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation |
| US20080260703A1 (en) * | 2007-04-23 | 2008-10-23 | Medistem Labortories | Treatment of Insulin Resistance and Diabetes |
| US9095562B2 (en) * | 2007-07-05 | 2015-08-04 | Regenerative Sciences, Inc. | Methods and compositions for optimized expansion and implantation of mesenchymal stem cells |
| TWI603736B (zh) * | 2007-08-06 | 2017-11-01 | 安吉歐公司 | 活體內產生、修補及／或維持結締組織的方法 |
| ES2704153T3 (es) * | 2007-08-06 | 2019-03-14 | Mesoblast Inc | Células STRO-1brillantes para su uso en el tratamiento de enfermedades de tejidos conectivos |
| AU2013203054B2 (en) * | 2007-08-06 | 2017-05-18 | Mesoblast, Inc. | Methods of generating, repairing and/or maintaining connective tissue in vivo |
| US20110200642A1 (en) | 2007-12-19 | 2011-08-18 | Regenerative Sciences, Llc | Compositions and Methods to Promote Implantation and Engrafment of Stem Cells |
| DK2252290T3 (en) | 2008-02-15 | 2018-03-05 | Bone Therapeutics Sa | PHARMACEUTICAL COMPOSITION FOR USE FOR TREATMENT AND / OR PREVENTION OF OSTEOARTICULAR DISEASES |
| EP2090308A1 (en) * | 2008-02-15 | 2009-08-19 | Bone Therapeutics | Pharmaceutical composition for the treatment or prevention of osteoarticular diseases |
| AU2009214044B2 (en) * | 2008-02-15 | 2014-08-14 | Bone Therapeutics | Pharmaceutical composition for use in the treatment or prevention of osteoarticular diseases |
| US20110052533A1 (en) | 2008-03-14 | 2011-03-03 | Regenerative Sciences, Llc | Compositions and Methods for Cartilage Repair |
| KR101776959B1 (ko) | 2008-06-25 | 2017-09-08 | 메소블라스트, 아이엔씨. | 추간판의 치료 및/또는 재구성 |
| US8343480B2 (en) * | 2008-11-14 | 2013-01-01 | Howmedica Osteonics Corp. | Administration of stem or progenitor cells to a joint to enhance recovery from joint surgery |
| US9192695B2 (en) | 2008-11-20 | 2015-11-24 | Allosource | Allografts combined with tissue derived stem cells for bone healing |
| JP2012510874A (ja) | 2008-12-05 | 2012-05-17 | リジェネレイティブ サイエンシーズ， エルエルシー | 無血管組織の修復を促進するための方法及び組成物 |
| WO2010099463A2 (en) | 2009-02-27 | 2010-09-02 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Joint bioscaffolds |
| IT1394570B1 (it) * | 2009-07-02 | 2012-07-05 | Fidia Farmaceutici | Materiale biologico adatto per la terapia dell osteoartrosi del danno dei legamenti e per il trattamento delle patologie delle articolazioni. |
| WO2011047058A2 (en) * | 2009-10-13 | 2011-04-21 | Allocure Inc. | Assay for the prediction of therapeutic effectiveness of mesenchymal stromal cells, and methods of using same |
| US9113950B2 (en) | 2009-11-04 | 2015-08-25 | Regenerative Sciences, Llc | Therapeutic delivery device |
| CN103180435A (zh) * | 2010-08-31 | 2013-06-26 | 库克通用生物技术有限责任公司 | 用于治疗动物疾病的全身的同种异体干细胞疗法 |
| US20120087933A1 (en) | 2010-10-08 | 2012-04-12 | Samson Tom | Enhanced msc preparations |
| US8709401B2 (en) | 2011-02-25 | 2014-04-29 | Howmedica Osteonics Corp. | Primed stem cells and uses thereof to treat inflammatory conditions in joints |
| US9133438B2 (en) | 2011-06-29 | 2015-09-15 | Biorestorative Therapies, Inc. | Brown fat cell compositions and methods |
| GB201202319D0 (en) | 2012-02-10 | 2012-03-28 | Orbsen Therapeutics Ltd | Stromal stem cells |
| US9457051B2 (en) * | 2013-01-22 | 2016-10-04 | Animal Cell Therapies, Inc. | Use of stem cells or progenitor cells to treat, delay, prevent, or repair tearing of cruciate ligaments |
| US10272118B2 (en) | 2013-02-12 | 2019-04-30 | Replicel Life Sciences Inc. | Compositions and methods for treating and repairing tendons |
| CA2894750C (en) | 2013-02-22 | 2021-12-14 | Allosource | Cartilage mosaic compositions and methods |
| CA2895140C (en) | 2013-03-15 | 2021-07-13 | Allosource | Perforated osteochondral allograft compositions |
| WO2014150784A1 (en) | 2013-03-15 | 2014-09-25 | Allosource | Cell repopulated collagen matrix for soft tissue repair and regeneration |
| US20150010606A1 (en) * | 2013-07-08 | 2015-01-08 | Arthrex, Inc. | Intra-articular injection and implant attachment of molecule consisting of lubricin and extracellular superoxide dismutase or hyaluronic acid and extracellular superoxide dismutase |
| US9597099B2 (en) * | 2013-07-29 | 2017-03-21 | Covidien Lp | Energy-based treatment methods for refractory gout |
| EP3028722B1 (en) | 2013-08-01 | 2018-11-28 | TWO CELLS Co., Ltd. | Cartilage-damage treatment agent and method for producing same |
| MX2016009867A (es) | 2014-01-28 | 2017-01-11 | Medivation Technologies Inc | Terapias dirigidas. |
| EP3074506A1 (en) | 2014-02-12 | 2016-10-05 | National University of Ireland, Galway | Selection and use of stem cells |
| US10500233B2 (en) * | 2014-02-12 | 2019-12-10 | Replicel Life Sciences Inc. | Compositions and methods for treating bone, joints and cartilage |
| RU2559089C1 (ru) * | 2014-04-22 | 2015-08-10 | Государственное автономное учреждение здравоохранения "Республиканская клиническая больница Министерства здравоохранения Республики Татарстан" | Способ восстановления дефектов гиалинового хряща суставных поверхностей суставов конечностей |
| EP3209768A1 (en) | 2014-07-25 | 2017-08-30 | Recellerate Inc. | Methods of treating exercise-induced pulmonary hemorrhage |
| TWI566774B (zh) | 2014-10-06 | 2017-01-21 | 佛教慈濟醫療財團法人花蓮慈濟醫院 | 治療關節疾病的組成物及其方法 |
| RU2644650C2 (ru) | 2014-12-01 | 2018-02-13 | Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" | Материал стволовых клеток и способ его получения |
| WO2017019832A1 (en) | 2015-07-29 | 2017-02-02 | Medivation Technologies, Inc. | Methods and compositions using repair cells and cationic dyes |
| KR101720329B1 (ko) | 2015-12-11 | 2017-03-28 | 주식회사 에이티앤씨 | 무선통신 단말기용 nfc 및 mst 공용 안테나 장치 |
| RU2708329C2 (ru) | 2016-05-31 | 2019-12-05 | Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" | Материал стволовых клеток, композиции и способы применения |
| CN106075585B (zh) * | 2016-07-08 | 2019-06-21 | 福建师范大学 | 一种基于人工肌腱支架材料的组织工程化人工肌腱移植物的制备方法 |
| US20190247439A1 (en) * | 2016-10-07 | 2019-08-15 | Cytori Therapetics, Inc. | Regenerative cell therapy for musculoskeletal disorders |
| US9980984B2 (en) | 2016-10-13 | 2018-05-29 | Kenneth Allen Pettine | Treatment of inflammation of osteoarthritic knees with mesenchymal stem cells |
| WO2018092769A1 (ja) | 2016-11-15 | 2018-05-24 | 株式会社カネカ | 胎児付属物に由来する間葉系幹細胞を含む細胞集団とその製造方法、及び医薬組成物 |
| CN110234329A (zh) * | 2017-01-27 | 2019-09-13 | 辛特拉股份公司 | 骨骼和软骨损害或疾病的预防和治疗 |
| AU2018372631B2 (en) | 2017-11-22 | 2025-06-05 | Mesoblast International Sarl | Cellular compositions and methods of treatment I |
| JP7454379B2 (ja) | 2017-12-28 | 2024-03-22 | 株式会社カネカ | 接着性幹細胞を含む細胞集団とその製造方法、及び医薬組成物 |
| US20210047621A1 (en) | 2018-03-12 | 2021-02-18 | Universidade Do Porto | Compositions for use in the treatment of musculoskeletal conditions and methods for producing the same leveraging the synergistic activity of two different types of mesenchymal stromal/stem cells |
| JP7530893B2 (ja) | 2019-06-14 | 2024-08-08 | 株式会社カネカ | 間葉系細胞を含む細胞集団、それを含む医薬組成物、及び、その製造方法 |
| US11583402B2 (en) | 2019-07-16 | 2023-02-21 | William Baumgartl | Method for treating joint pain |
| CA3149572A1 (en) * | 2019-08-30 | 2021-03-04 | Ashlee WATTS | Xenogen-free mesenchymal stem cell compositions and methods of use |
| US20220290105A1 (en) * | 2019-11-26 | 2022-09-15 | Cells For Cells S.A. | Mesenchymal stem cells with enhanced therapeutic properties |
| WO2021226373A2 (en) | 2020-05-08 | 2021-11-11 | Gallant Pet, Inc. | Uterine-derived regenerative cell compositions and uses thereof |
| US12278085B2 (en) | 2022-04-06 | 2025-04-15 | Applied Materials Israel Ltd. | Hybrid scanning electron microscopy and acousto-optic based metrology |
| WO2025076042A1 (en) * | 2023-10-02 | 2025-04-10 | MAM Holdings of West Florida, L.L.C. | Mesenchymal stem cell-mediated treatments for the prevention and targeted treatment of injured tissues and promotion of tissue repair, healing, and regeneration |
| CN120866212B (zh) * | 2025-09-28 | 2026-02-24 | 山东省泉溪生物技术有限公司 | 一种用于膝关节炎治疗的羊膜间充质干细胞及其制备方法与应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL68218A (en) * | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
| US5053050A (en) * | 1988-04-29 | 1991-10-01 | Samuel Itay | Compositions for repair of cartilage and bone |
| US5399493A (en) * | 1989-06-15 | 1995-03-21 | The Regents Of The University Of Michigan | Methods and compositions for the optimization of human hematopoietic progenitor cell cultures |
| FR2667788B1 (fr) * | 1990-10-12 | 1994-12-02 | Oreal | Utilisation d'hydroxyalkylamino-9,10-anthraquinones pour la teinture de fibres keratiniques humaines, composition cosmetique les contenant en association avec des colorants azouiques et nitres. |
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5206023A (en) * | 1991-01-31 | 1993-04-27 | Robert F. Shaw | Method and compositions for the treatment and repair of defects or lesions in cartilage |
| US5326357A (en) * | 1992-03-18 | 1994-07-05 | Mount Sinai Hospital Corporation | Reconstituted cartridge tissue |
| US5736396A (en) * | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| US5906934A (en) * | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
| US5716616A (en) * | 1995-03-28 | 1998-02-10 | Thomas Jefferson University | Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects |
| ATE288480T1 (de) * | 1995-11-16 | 2005-02-15 | Univ Case Western Reserve | Chondrogene in vitro induktion von menschlichen mensenchymalen stammzellen |
| US6482231B1 (en) * | 1995-11-20 | 2002-11-19 | Giovanni Abatangelo | Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative |
| DK2111876T3 (da) * | 1995-12-18 | 2011-12-12 | Angiodevice Internat Gmbh | Tværbundne polymerpræparater og fremgangsmåder til anvendelse deraf |
| US6200606B1 (en) * | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
| US5842477A (en) * | 1996-02-21 | 1998-12-01 | Advanced Tissue Sciences, Inc. | Method for repairing cartilage |
| WO1998051317A1 (en) * | 1997-05-13 | 1998-11-19 | Osiris Therapeutics, Inc. | Osteoarthritis cartilage regeneration using human mesenchymal stem cells |
| CA2212300A1 (en) * | 1997-08-04 | 1999-02-04 | Abdellatif Chenite | In vitro or in vivo gelfying chitosan and therapeutic uses thereof |
| US6082364A (en) * | 1997-12-15 | 2000-07-04 | Musculoskeletal Development Enterprises, Llc | Pluripotential bone marrow cell line and methods of using the same |
| PT1062321E (pt) * | 1998-03-13 | 2005-05-31 | Osiris Therapeutics Inc | Utilizacoes para celulas estaminais mesenquimais humanas nao autologas |
| IT1299488B1 (it) * | 1998-06-01 | 2000-03-16 | Afatec S R L | Tubo corrugato bimetallico e procedimento per la sua realizzazione |
| EP1154734B1 (en) * | 1999-02-12 | 2014-10-01 | ProChon Biotech Ltd. | Injectable collagen-based system for delivery of cells |
| US6716616B1 (en) * | 1999-09-28 | 2004-04-06 | Lexicon Genetics Incorporated | Human kinase proteins and polynucleotides encoding the same |
| DE60143517D1 (de) * | 2000-04-25 | 2011-01-05 | Osiris Therapeutics Inc | Wiederherstellung der gelenken mit mesenchymalen stammzellen |
-
2001
- 2001-04-24 DE DE60143517T patent/DE60143517D1/de not_active Expired - Lifetime
- 2001-04-24 JP JP2001577964A patent/JP5090604B2/ja not_active Expired - Lifetime
- 2001-04-24 US US09/841,413 patent/US20020005205A1/en not_active Abandoned
- 2001-04-24 CA CA2405345A patent/CA2405345C/en not_active Expired - Lifetime
- 2001-04-24 AU AU2001257236A patent/AU2001257236B2/en not_active Expired
- 2001-04-24 WO PCT/US2001/013267 patent/WO2001080865A2/en not_active Ceased
- 2001-04-24 AT AT01930730T patent/ATE489101T1/de not_active IP Right Cessation
- 2001-04-24 EP EP01930730.5A patent/EP1276486B2/en not_active Expired - Lifetime
- 2001-04-24 PT PT01930730T patent/PT1276486E/pt unknown
- 2001-04-24 ES ES01930730.5T patent/ES2353061T5/es not_active Expired - Lifetime
- 2001-04-24 AU AU5723601A patent/AU5723601A/xx active Pending
-
2008
- 2008-06-03 US US12/132,290 patent/US20090041730A1/en not_active Abandoned
-
2012
- 2012-02-22 US US13/402,444 patent/US20120148548A1/en not_active Abandoned
- 2012-06-22 JP JP2012141003A patent/JP5792686B2/ja not_active Expired - Lifetime
-
2013
- 2013-01-16 US US13/743,004 patent/US9050178B2/en not_active Expired - Fee Related
-
2015
- 2015-02-25 JP JP2015035361A patent/JP2015128633A/ja active Pending
- 2015-04-16 US US14/687,963 patent/US9814580B2/en not_active Expired - Fee Related
-
2016
- 2016-07-12 JP JP2016137461A patent/JP6382262B2/ja not_active Expired - Lifetime
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