JP2016204373A5 - - Google Patents
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- Publication number
- JP2016204373A5 JP2016204373A5 JP2016084307A JP2016084307A JP2016204373A5 JP 2016204373 A5 JP2016204373 A5 JP 2016204373A5 JP 2016084307 A JP2016084307 A JP 2016084307A JP 2016084307 A JP2016084307 A JP 2016084307A JP 2016204373 A5 JP2016204373 A5 JP 2016204373A5
- Authority
- JP
- Japan
- Prior art keywords
- ppm
- crystalline form
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- values
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000001237 Raman spectrum Methods 0.000 claims 9
- 238000004922 13C solid-state nuclear magnetic resonance spectroscopy Methods 0.000 claims 7
- 238000001228 spectrum Methods 0.000 claims 7
- 238000000634 powder X-ray diffraction Methods 0.000 claims 6
- VJCVKWFBWAVYOC-UIXXXISESA-N 1-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-3-(4-cyanophenyl)urea (Z)-but-2-enedioic acid Chemical compound OC(=O)\C=C/C(O)=O.CN1CC[C@H](C[C@@H]1c1nc2ccccc2[nH]1)NC(=O)Nc1ccc(cc1)C#N VJCVKWFBWAVYOC-UIXXXISESA-N 0.000 claims 2
- 238000010276 construction Methods 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562152108P | 2015-04-24 | 2015-04-24 | |
| US62/152108 | 2015-04-24 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016204373A JP2016204373A (ja) | 2016-12-08 |
| JP2016204373A5 true JP2016204373A5 (enExample) | 2017-11-09 |
| JP6345728B2 JP6345728B2 (ja) | 2018-06-20 |
Family
ID=55806563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016084307A Active JP6345728B2 (ja) | 2015-04-24 | 2016-04-20 | １−（（２ｒ，４ｒ）−２−（１ｈ−ベンゾ［ｄ］イミダゾール−２−イル）−１−メチルピペリジン−４−イル）−３−（４−シアノフェニル）尿素マレイン酸塩の結晶性形態 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US10414748B2 (enExample) |
| EP (2) | EP3666768B1 (enExample) |
| JP (1) | JP6345728B2 (enExample) |
| KR (2) | KR102078444B1 (enExample) |
| CN (1) | CN107531667A (enExample) |
| AR (1) | AR104391A1 (enExample) |
| AU (1) | AU2016251940C1 (enExample) |
| BR (1) | BR112017021075B1 (enExample) |
| CA (2) | CA2983387C (enExample) |
| CY (2) | CY1124056T1 (enExample) |
| DK (2) | DK3286176T3 (enExample) |
| ES (2) | ES2923593T3 (enExample) |
| HK (1) | HK1243416A1 (enExample) |
| HU (2) | HUE059506T2 (enExample) |
| IL (1) | IL255224B (enExample) |
| MX (1) | MX375384B (enExample) |
| PL (2) | PL3666768T3 (enExample) |
| PT (2) | PT3666768T (enExample) |
| RU (1) | RU2717564C2 (enExample) |
| SG (1) | SG11201707863QA (enExample) |
| SI (2) | SI3666768T1 (enExample) |
| TW (1) | TWI646093B (enExample) |
| WO (1) | WO2016170451A1 (enExample) |
| ZA (1) | ZA201706391B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112017021075B1 (pt) | 2015-04-24 | 2021-08-03 | Pfizer Inc. | Forma cristalina de maleato de 1-((2r,4r)-2-(1h- benzo[d]imidazol-2-il)-1-metilpiperidin-4-il)-3-(4- cianofenil)ureia e composição farmacêutica |
| US20230107634A1 (en) * | 2020-01-28 | 2023-04-06 | Teva Pharmaceuticals International Gmbh | Processes for the preparation of glasdegib and salt thereof and solid state forms of glasdegib maleate and process for preparation thereof |
| EP4126237B1 (en) | 2020-03-26 | 2024-04-10 | LEK Pharmaceuticals d.d. | Dimaleate form of 1-((2r,4r)-2-(1h-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea |
| WO2023002362A1 (en) | 2021-07-22 | 2023-01-26 | Pfizer Inc. | Treatment of hematological malignancy |
| WO2023017541A1 (en) * | 2021-08-12 | 2023-02-16 | Msn Laboratories Private Limited, R&D Center | Improved process for the preparation of 1-((2r,4r)-2-(1h-benzo[d]imidazol-2-yl)-1-methyl piperidin-4-yl)-3-(4-cyanophenyl)urea maleate |
| CN114668849B (zh) * | 2021-12-31 | 2024-01-23 | 中国人民解放军军事科学院军事医学研究院 | Shh通路调控生物节律及其相关应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0325956D0 (en) * | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| US8253800B2 (en) | 2006-06-28 | 2012-08-28 | Nikon Corporation | Tracking device, automatic focusing device, and camera |
| ME00962B (me) * | 2007-06-29 | 2012-06-20 | Pfizer | Benzimidazolski derivati |
| BR112017021075B1 (pt) * | 2015-04-24 | 2021-08-03 | Pfizer Inc. | Forma cristalina de maleato de 1-((2r,4r)-2-(1h- benzo[d]imidazol-2-il)-1-metilpiperidin-4-il)-3-(4- cianofenil)ureia e composição farmacêutica |
-
2016
- 2016-04-13 BR BR112017021075-4A patent/BR112017021075B1/pt active IP Right Grant
- 2016-04-13 DK DK16718016.5T patent/DK3286176T3/da active
- 2016-04-13 EP EP20151107.8A patent/EP3666768B1/en active Active
- 2016-04-13 ES ES20151107T patent/ES2923593T3/es active Active
- 2016-04-13 SI SI201631561T patent/SI3666768T1/sl unknown
- 2016-04-13 DK DK20151107.8T patent/DK3666768T3/da active
- 2016-04-13 SI SI201630639T patent/SI3286176T1/sl unknown
- 2016-04-13 HU HUE20151107A patent/HUE059506T2/hu unknown
- 2016-04-13 PT PT201511078T patent/PT3666768T/pt unknown
- 2016-04-13 RU RU2017137269A patent/RU2717564C2/ru active
- 2016-04-13 KR KR1020177030098A patent/KR102078444B1/ko active Active
- 2016-04-13 PL PL20151107.8T patent/PL3666768T3/pl unknown
- 2016-04-13 AU AU2016251940A patent/AU2016251940C1/en active Active
- 2016-04-13 PL PL16718016T patent/PL3286176T3/pl unknown
- 2016-04-13 KR KR1020197009092A patent/KR20190038677A/ko not_active Withdrawn
- 2016-04-13 WO PCT/IB2016/052107 patent/WO2016170451A1/en not_active Ceased
- 2016-04-13 SG SG11201707863QA patent/SG11201707863QA/en unknown
- 2016-04-13 MX MX2017013645A patent/MX375384B/es active IP Right Grant
- 2016-04-13 HU HUE16718016A patent/HUE048664T2/hu unknown
- 2016-04-13 CN CN201680023699.0A patent/CN107531667A/zh active Pending
- 2016-04-13 PT PT167180165T patent/PT3286176T/pt unknown
- 2016-04-13 EP EP16718016.5A patent/EP3286176B1/en active Active
- 2016-04-13 HK HK18103046.8A patent/HK1243416A1/zh unknown
- 2016-04-13 US US15/567,433 patent/US10414748B2/en active Active
- 2016-04-13 CA CA2983387A patent/CA2983387C/en active Active
- 2016-04-13 ES ES16718016T patent/ES2774053T3/es active Active
- 2016-04-20 CA CA2927736A patent/CA2927736A1/en not_active Abandoned
- 2016-04-20 JP JP2016084307A patent/JP6345728B2/ja active Active
- 2016-04-22 TW TW105112723A patent/TWI646093B/zh active
- 2016-04-22 AR ARP160101150A patent/AR104391A1/es unknown
-
2017
- 2017-09-21 ZA ZA2017/06391A patent/ZA201706391B/en unknown
- 2017-10-24 IL IL255224A patent/IL255224B/en active IP Right Grant
-
2019
- 2019-07-25 US US16/521,742 patent/US11168066B2/en active Active
-
2020
- 2020-02-19 CY CY20201100155T patent/CY1124056T1/el unknown
-
2021
- 2021-10-06 US US17/494,938 patent/US11891373B2/en active Active
- 2021-10-06 US US17/494,923 patent/US11891372B2/en active Active
-
2022
- 2022-07-06 CY CY20221100461T patent/CY1125333T1/el unknown
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