SI3666768T1 - Postopek priprave kristalne oblike 1-((2R, 4R)-2-(1H-benzo(D)imidazol -2-il)-1-metilpiperidil-4-il)-3-(4-cianofenil)urea maleata; kristalne oblike 1-((2R, 4R)-2-(1H-benzo(d)imidazol-2-il)-1-metilpiperidin-4-il -3-(4-cianofenil)urea imidazol kompleksa (1:1) - Google Patents

Postopek priprave kristalne oblike 1-((2R, 4R)-2-(1H-benzo(D)imidazol -2-il)-1-metilpiperidil-4-il)-3-(4-cianofenil)urea maleata; kristalne oblike 1-((2R, 4R)-2-(1H-benzo(d)imidazol-2-il)-1-metilpiperidin-4-il -3-(4-cianofenil)urea imidazol kompleksa (1:1)

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Publication number
SI3666768T1
SI3666768T1 SI201631561T SI201631561T SI3666768T1 SI 3666768 T1 SI3666768 T1 SI 3666768T1 SI 201631561 T SI201631561 T SI 201631561T SI 201631561 T SI201631561 T SI 201631561T SI 3666768 T1 SI3666768 T1 SI 3666768T1
Authority
SI
Slovenia
Prior art keywords
methylpiperidin
cyanophenyl
imidazol
benzo
crystalline form
Prior art date
Application number
SI201631561T
Other languages
English (en)
Inventor
Eric Christian Hansen
Christopher Scott Seadeek
Anil Mahadeo Rane
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55806563&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI3666768(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of SI3666768T1 publication Critical patent/SI3666768T1/sl

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI201631561T 2015-04-24 2016-04-13 Postopek priprave kristalne oblike 1-((2R, 4R)-2-(1H-benzo(D)imidazol -2-il)-1-metilpiperidil-4-il)-3-(4-cianofenil)urea maleata; kristalne oblike 1-((2R, 4R)-2-(1H-benzo(d)imidazol-2-il)-1-metilpiperidin-4-il -3-(4-cianofenil)urea imidazol kompleksa (1:1) SI3666768T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562152108P 2015-04-24 2015-04-24
EP20151107.8A EP3666768B1 (en) 2015-04-24 2016-04-13 Preparation process of a crystalline form of 1-((2r,4r)-2-(1h-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate; a crystalline form of 1-((2r,4r)-2-(1h-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea imidazole complex (1:1)

Publications (1)

Publication Number Publication Date
SI3666768T1 true SI3666768T1 (sl) 2022-09-30

Family

ID=55806563

Family Applications (2)

Application Number Title Priority Date Filing Date
SI201631561T SI3666768T1 (sl) 2015-04-24 2016-04-13 Postopek priprave kristalne oblike 1-((2R, 4R)-2-(1H-benzo(D)imidazol -2-il)-1-metilpiperidil-4-il)-3-(4-cianofenil)urea maleata; kristalne oblike 1-((2R, 4R)-2-(1H-benzo(d)imidazol-2-il)-1-metilpiperidin-4-il -3-(4-cianofenil)urea imidazol kompleksa (1:1)
SI201630639T SI3286176T1 (sl) 2015-04-24 2016-04-13 Kristalne oblike 1-((2R,4R)-2-(1H-benzo(D)imidazol-2-IL)-1-metilpiperidin-4-IL)-3-(4- cianofenil)urea maleata

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI201630639T SI3286176T1 (sl) 2015-04-24 2016-04-13 Kristalne oblike 1-((2R,4R)-2-(1H-benzo(D)imidazol-2-IL)-1-metilpiperidin-4-IL)-3-(4- cianofenil)urea maleata

Country Status (24)

Country Link
US (4) US10414748B2 (sl)
EP (2) EP3666768B1 (sl)
JP (1) JP6345728B2 (sl)
KR (2) KR20190038677A (sl)
CN (1) CN107531667A (sl)
AR (1) AR104391A1 (sl)
AU (1) AU2016251940C1 (sl)
BR (1) BR112017021075B1 (sl)
CA (2) CA2983387C (sl)
CY (1) CY1124056T1 (sl)
DK (2) DK3286176T3 (sl)
ES (2) ES2923593T3 (sl)
HK (1) HK1243416A1 (sl)
HU (2) HUE048664T2 (sl)
IL (1) IL255224B (sl)
MX (1) MX2017013645A (sl)
PL (2) PL3286176T3 (sl)
PT (2) PT3666768T (sl)
RU (1) RU2717564C2 (sl)
SG (1) SG11201707863QA (sl)
SI (2) SI3666768T1 (sl)
TW (1) TWI646093B (sl)
WO (1) WO2016170451A1 (sl)
ZA (1) ZA201706391B (sl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE048664T2 (hu) 2015-04-24 2020-07-28 Pfizer 1-((2R,4R)-2-(1H-benzo[D]imidazol-2-il)-l-metilpiperidin-4-il)-3-(4-cianofenil)-karbamid-maleát kristályformái
US20230107634A1 (en) 2020-01-28 2023-04-06 Teva Pharmaceuticals International Gmbh Processes for the preparation of glasdegib and salt thereof and solid state forms of glasdegib maleate and process for preparation thereof
WO2021191278A1 (en) 2020-03-26 2021-09-30 Lek Pharmaceuticals D.D. Dimaleate form of 1-((2r,4r)-2-(1h-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea
WO2023002362A1 (en) 2021-07-22 2023-01-26 Pfizer Inc. Treatment of hematological malignancy
WO2023017541A1 (en) * 2021-08-12 2023-02-16 Msn Laboratories Private Limited, R&D Center Improved process for the preparation of 1-((2r,4r)-2-(1h-benzo[d]imidazol-2-yl)-1-methyl piperidin-4-yl)-3-(4-cyanophenyl)urea maleate
CN114668849B (zh) * 2021-12-31 2024-01-23 中国人民解放军军事科学院军事医学研究院 Shh通路调控生物节律及其相关应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0325956D0 (en) * 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
US8253800B2 (en) 2006-06-28 2012-08-28 Nikon Corporation Tracking device, automatic focusing device, and camera
NZ581889A (en) * 2007-06-29 2011-05-27 Pfizer Benzimidazole derivatives
HUE048664T2 (hu) 2015-04-24 2020-07-28 Pfizer 1-((2R,4R)-2-(1H-benzo[D]imidazol-2-il)-l-metilpiperidin-4-il)-3-(4-cianofenil)-karbamid-maleát kristályformái

Also Published As

Publication number Publication date
WO2016170451A1 (en) 2016-10-27
PL3666768T3 (pl) 2022-09-19
SI3286176T1 (sl) 2020-04-30
US11891372B2 (en) 2024-02-06
RU2717564C2 (ru) 2020-03-24
AU2016251940C1 (en) 2019-04-11
CY1124056T1 (el) 2022-03-24
EP3286176B1 (en) 2020-01-15
EP3286176A1 (en) 2018-02-28
US20180086731A1 (en) 2018-03-29
AR104391A1 (es) 2017-07-19
JP6345728B2 (ja) 2018-06-20
US20220024894A1 (en) 2022-01-27
PT3666768T (pt) 2022-07-22
HUE048664T2 (hu) 2020-07-28
CA2983387C (en) 2022-08-16
TW201702238A (zh) 2017-01-16
ES2774053T3 (es) 2020-07-16
KR102078444B1 (ko) 2020-02-17
JP2016204373A (ja) 2016-12-08
US20190382368A1 (en) 2019-12-19
BR112017021075A2 (pt) 2018-07-03
SG11201707863QA (en) 2017-11-29
PT3286176T (pt) 2020-02-24
MX2017013645A (es) 2018-03-08
IL255224B (en) 2021-01-31
KR20170129245A (ko) 2017-11-24
US10414748B2 (en) 2019-09-17
IL255224A0 (en) 2017-12-31
DK3286176T3 (da) 2020-03-02
CA2927736A1 (en) 2016-10-24
PL3286176T3 (pl) 2020-11-30
HK1243416A1 (zh) 2018-07-13
TWI646093B (zh) 2019-01-01
EP3666768A1 (en) 2020-06-17
RU2017137269A3 (sl) 2019-09-13
HUE059506T2 (hu) 2022-11-28
CA2983387A1 (en) 2016-10-27
KR20190038677A (ko) 2019-04-08
US11891373B2 (en) 2024-02-06
RU2017137269A (ru) 2019-05-24
DK3666768T3 (da) 2022-06-27
ZA201706391B (en) 2020-12-23
US11168066B2 (en) 2021-11-09
BR112017021075B1 (pt) 2021-08-03
NZ735719A (en) 2020-11-27
AU2016251940B2 (en) 2018-08-30
US20220024893A1 (en) 2022-01-27
CN107531667A (zh) 2018-01-02
ES2923593T3 (es) 2022-09-28
EP3666768B1 (en) 2022-06-15
AU2016251940A1 (en) 2017-10-12

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