JP2016047845A5 - - Google Patents
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- JP2016047845A5 JP2016047845A5 JP2015247222A JP2015247222A JP2016047845A5 JP 2016047845 A5 JP2016047845 A5 JP 2016047845A5 JP 2015247222 A JP2015247222 A JP 2015247222A JP 2015247222 A JP2015247222 A JP 2015247222A JP 2016047845 A5 JP2016047845 A5 JP 2016047845A5
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- 150000007523 nucleic acids Chemical group 0.000 claims description 43
- 102100038449 Claudin-6 Human genes 0.000 claims description 41
- 101000882898 Homo sapiens Claudin-6 Proteins 0.000 claims description 41
- 238000000034 method Methods 0.000 claims description 18
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims description 17
- 108020004707 nucleic acids Proteins 0.000 claims description 17
- 102000039446 nucleic acids Human genes 0.000 claims description 17
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 12
- 239000000427 antigen Substances 0.000 claims description 8
- 102000036639 antigens Human genes 0.000 claims description 8
- 108091007433 antigens Proteins 0.000 claims description 8
- 239000012634 fragment Substances 0.000 claims description 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 25
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 16
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 16
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 16
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 16
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 16
- 239000013604 expression vector Substances 0.000 claims 4
- 210000003527 eukaryotic cell Anatomy 0.000 claims 3
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- 238000012258 culturing Methods 0.000 claims 1
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- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
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- 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 2
- 208000036832 Adenocarcinoma of ovary Diseases 0.000 description 2
- 206010004146 Basal cell carcinoma Diseases 0.000 description 2
- 206010004593 Bile duct cancer Diseases 0.000 description 2
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- 102100038423 Claudin-3 Human genes 0.000 description 2
- 102100038447 Claudin-4 Human genes 0.000 description 2
- 208000019487 Clear cell papillary renal cell carcinoma Diseases 0.000 description 2
- 206010009944 Colon cancer Diseases 0.000 description 2
- 208000032320 Germ cell tumor of testis Diseases 0.000 description 2
- 101000882908 Homo sapiens Claudin-3 Proteins 0.000 description 2
- 101000882890 Homo sapiens Claudin-4 Proteins 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 2
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 description 2
- 206010033128 Ovarian cancer Diseases 0.000 description 2
- 206010061328 Ovarian epithelial cancer Diseases 0.000 description 2
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- 206010061902 Pancreatic neoplasm Diseases 0.000 description 2
- 206010039491 Sarcoma Diseases 0.000 description 2
- 208000000453 Skin Neoplasms Diseases 0.000 description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 description 2
- 208000024313 Testicular Neoplasms Diseases 0.000 description 2
- 208000033133 Testicular seminomatous germ cell tumor Diseases 0.000 description 2
- 206010057644 Testis cancer Diseases 0.000 description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 2
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- 206010017758 gastric cancer Diseases 0.000 description 2
- 201000010536 head and neck cancer Diseases 0.000 description 2
- 208000014829 head and neck neoplasm Diseases 0.000 description 2
- 210000004408 hybridoma Anatomy 0.000 description 2
- 201000002312 ileal neoplasm Diseases 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
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- 201000007270 liver cancer Diseases 0.000 description 2
- 208000014018 liver neoplasm Diseases 0.000 description 2
- 201000005249 lung adenocarcinoma Diseases 0.000 description 2
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- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- 230000009401 metastasis Effects 0.000 description 2
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- 206010061289 metastatic neoplasm Diseases 0.000 description 2
- 230000002611 ovarian Effects 0.000 description 2
- 208000013371 ovarian adenocarcinoma Diseases 0.000 description 2
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- 201000002528 pancreatic cancer Diseases 0.000 description 2
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- 201000011549 stomach cancer Diseases 0.000 description 2
- 206010042863 synovial sarcoma Diseases 0.000 description 2
- 208000001608 teratocarcinoma Diseases 0.000 description 2
- 201000003120 testicular cancer Diseases 0.000 description 2
- 208000002918 testicular germ cell tumor Diseases 0.000 description 2
- 208000024662 testicular seminoma Diseases 0.000 description 2
- 208000004238 testicular teratoma Diseases 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 206010044412 transitional cell carcinoma Diseases 0.000 description 2
- 201000005112 urinary bladder cancer Diseases 0.000 description 2
- 206010046766 uterine cancer Diseases 0.000 description 2
- 208000006332 Choriocarcinoma Diseases 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- 208000006265 Renal cell carcinoma Diseases 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 210000004252 chorionic villi Anatomy 0.000 description 1
- 230000005757 colony formation Effects 0.000 description 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000006882 induction of apoptosis Effects 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 210000002445 nipple Anatomy 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000005740 tumor formation Effects 0.000 description 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26020209P | 2009-11-11 | 2009-11-11 | |
| US61/260,202 | 2009-11-11 | ||
| EP09014136A EP2322555A1 (en) | 2009-11-11 | 2009-11-11 | Antibodies specific for claudin 6 (CLDN6) |
| EP09014136.7 | 2009-11-11 | ||
| US36161810P | 2010-07-06 | 2010-07-06 | |
| EP10006956 | 2010-07-06 | ||
| US61/361,618 | 2010-07-06 | ||
| EP10006956.6 | 2010-07-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012538239A Division JP5889196B2 (ja) | 2009-11-11 | 2010-11-11 | クローディン６（ｃｌｄｎ６）に特異的な抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017075017A Division JP6502992B2 (ja) | 2009-11-11 | 2017-04-05 | クローディン６（ｃｌｄｎ６）に特異的な抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016047845A JP2016047845A (ja) | 2016-04-07 |
| JP2016047845A5 true JP2016047845A5 (OSRAM) | 2016-06-23 |
| JP6125604B2 JP6125604B2 (ja) | 2017-05-10 |
Family
ID=43480734
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012538239A Active JP5889196B2 (ja) | 2009-11-11 | 2010-11-11 | クローディン６（ｃｌｄｎ６）に特異的な抗体 |
| JP2015247222A Active JP6125604B2 (ja) | 2009-11-11 | 2015-12-18 | クローディン６（ｃｌｄｎ６）に特異的な抗体 |
| JP2017075017A Active JP6502992B2 (ja) | 2009-11-11 | 2017-04-05 | クローディン６（ｃｌｄｎ６）に特異的な抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012538239A Active JP5889196B2 (ja) | 2009-11-11 | 2010-11-11 | クローディン６（ｃｌｄｎ６）に特異的な抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017075017A Active JP6502992B2 (ja) | 2009-11-11 | 2017-04-05 | クローディン６（ｃｌｄｎ６）に特異的な抗体 |
Country Status (29)
| Country | Link |
|---|---|
| US (5) | US9487584B2 (OSRAM) |
| EP (4) | EP2499161B8 (OSRAM) |
| JP (3) | JP5889196B2 (OSRAM) |
| KR (4) | KR102317098B1 (OSRAM) |
| CN (4) | CN102741289B (OSRAM) |
| AU (3) | AU2010318316B2 (OSRAM) |
| BR (1) | BR112012011143B1 (OSRAM) |
| CA (2) | CA2775373C (OSRAM) |
| CY (2) | CY1120300T1 (OSRAM) |
| DK (2) | DK3305813T3 (OSRAM) |
| ES (3) | ES2784483T3 (OSRAM) |
| HR (2) | HRP20171749T1 (OSRAM) |
| HU (2) | HUE049404T2 (OSRAM) |
| IL (2) | IL218628B (OSRAM) |
| LT (2) | LT2499161T (OSRAM) |
| ME (1) | ME02943B (OSRAM) |
| MX (3) | MX385874B (OSRAM) |
| NO (1) | NO2499161T3 (OSRAM) |
| NZ (2) | NZ734307A (OSRAM) |
| PL (3) | PL3305813T3 (OSRAM) |
| PT (2) | PT3305813T (OSRAM) |
| RS (2) | RS60168B1 (OSRAM) |
| RU (1) | RU2675997C2 (OSRAM) |
| SG (2) | SG10201500975YA (OSRAM) |
| SI (2) | SI3305813T1 (OSRAM) |
| SM (1) | SMT201700566T1 (OSRAM) |
| UA (2) | UA128302C2 (OSRAM) |
| WO (1) | WO2011057788A1 (OSRAM) |
| ZA (1) | ZA201202418B (OSRAM) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6358588A (ja) * | 1986-08-29 | 1988-03-14 | Toshiba Corp | バ−コ−ド読取装置 |
| DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| US12492253B1 (en) * | 2008-02-25 | 2025-12-09 | Xencor, Inc. | Anti-human C5 antibodies |
| NZ594480A (en) | 2009-02-20 | 2013-11-29 | Ganymed Pharmaceuticals Ag | Methods and compositions for diagnosis and treatment of cancer |
| HRP20171749T1 (hr) | 2009-11-11 | 2018-01-26 | Ganymed Pharmaceuticals Gmbh | Protutijela specifična za claudin 6 (cldn6) |
| EP2404936A1 (en) | 2010-07-06 | 2012-01-11 | Ganymed Pharmaceuticals AG | Cancer therapy using CLDN6 target-directed antibodies in vivo |
| TWI807362B (zh) | 2010-11-30 | 2023-07-01 | 日商中外製藥股份有限公司 | 細胞傷害誘導治療劑 |
| AU2012258087B2 (en) * | 2011-05-13 | 2017-07-20 | Astellas Pharma Inc. | Antibodies for treatment of cancer expressing claudin 6 |
| PT3026064T (pt) * | 2011-05-13 | 2018-12-17 | Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh | Anticorpos para tratamento de cancro que expressa claudina 6 |
| CN103320381B (zh) * | 2012-03-23 | 2015-04-15 | 上海市儿童医院 | 一种多能干细胞表面标志物及其用途 |
| ES2702315T3 (es) | 2012-08-24 | 2019-02-28 | Univ California | Anticuerpos y vacunas para su uso en tratar cánceres ROR1 e inhibir metástasis |
| US10093736B2 (en) * | 2012-11-13 | 2018-10-09 | Biontech Ag | Agents for treatment of claudin expressing cancer diseases |
| EP3766903A3 (en) * | 2012-11-13 | 2021-02-17 | BioNTech SE | Bispecific anti claudin xcd3 antibodies for treatment of claudin expressing cancer diseases |
| EP3747465A1 (en) * | 2013-07-31 | 2020-12-09 | BioNTech AG | Diagnosis and therapy of cancer involving cancer stem cells |
| WO2015014376A1 (en) * | 2013-07-31 | 2015-02-05 | Biontech Ag | Diagnosis and therapy of cancer involving cancer stem cells |
| RU2016122041A (ru) * | 2013-11-06 | 2017-12-11 | ЭББВИ СТЕМСЕНТРКС ЭлЭлСи | Новые анти-клаудин антитела и способы их применения |
| JPWO2015068847A1 (ja) | 2013-11-11 | 2017-03-09 | 中外製薬株式会社 | 改変された抗体可変領域を含む抗原結合分子 |
| DK3708579T3 (da) * | 2014-04-01 | 2024-07-22 | Biontech Cell & Gene Therapies Gmbh | Claudin-6-specifikke immunreceptorer og t-celleepitoper |
| MA40921A (fr) * | 2014-11-05 | 2017-09-12 | Abbvie Stemcentrx Llc | Récepteurs antigéniques chimériques anti-cldn et procédés d'utilisation |
| EP4632120A2 (en) | 2014-11-11 | 2025-10-15 | Chugai Seiyaku Kabushiki Kaisha | Library of antigen-binding molecules including modified antibody variable region |
| MX2018016330A (es) | 2016-06-27 | 2020-02-17 | Univ California | Combinaciones para tratamiento del cáncer. |
| EP3556771B1 (en) | 2016-12-07 | 2024-10-02 | Osaka University | Anti-claudin 5 antibody, and medicine containing said antibody |
| WO2018207638A1 (ja) * | 2017-05-08 | 2018-11-15 | 国立大学法人大阪大学 | 抗ｃｌｄｎ－５抗体、及びその抗体を含有する医薬 |
| WO2019048040A1 (en) | 2017-09-06 | 2019-03-14 | Ganymed Pharmaceuticals Gmbh | ANTIBODIES USEFUL IN THE DIAGNOSIS OF CANCER |
| AU2018342527B2 (en) | 2017-09-29 | 2024-06-27 | Daiichi Sankyo Company, Limited | Antibody-pyrrolobenzodiazepine derivative conjugate |
| EP3720963A4 (en) | 2017-12-05 | 2021-12-08 | Chugai Seiyaku Kabushiki Kaisha | ANTIGEN BINDING MOLECULE INCLUDING A VARIABLE REGION OF MODIFIED ANTIBODIES BINDING TO CD3 AND CD137 |
| US20210054076A1 (en) * | 2018-01-05 | 2021-02-25 | Chugai Seiyaku Kabushiki Kaisha | Cytotoxicity-inducing therapeutic agent |
| JP7374499B2 (ja) * | 2018-10-09 | 2023-11-07 | 公立大学法人福島県立医科大学 | 子宮体癌患者の予後予測バイオマーカー |
| CA3129834A1 (en) | 2019-02-15 | 2020-08-20 | Integral Molecular, Inc. | Claudin 6 antibodies and uses thereof |
| BR112021018608A2 (pt) | 2019-03-20 | 2021-11-23 | Univ California | Anticorpos para claudina-6 e conjugados de fármaco |
| CN113631229B (zh) | 2019-03-25 | 2025-09-23 | 第一三共株式会社 | 抗体－吡咯并苯并二氮杂卓衍生物偶联物 |
| JP7359864B2 (ja) * | 2019-07-10 | 2023-10-11 | 中外製薬株式会社 | クローディン６結合分子およびその使用 |
| CN111087465B (zh) * | 2019-12-24 | 2020-12-08 | 广州医科大学 | 一种针对密蛋白6的抗体偶联药物及应用 |
| MX2022012092A (es) | 2020-03-31 | 2022-10-13 | Chugai Pharmaceutical Co Ltd | Moleculas de union al antigeno multiespecificas dirigidas a claudina-6 y sus usos. |
| CA3212530A1 (en) * | 2021-03-05 | 2022-09-09 | Shanghai GenBase Biotechnology Co., Ltd. | Anti-cldn6 antibody and use thereof |
| CN117157319A (zh) | 2021-03-09 | 2023-12-01 | Xencor股份有限公司 | 结合cd3和cldn6的异二聚抗体 |
| WO2023053282A1 (ja) | 2021-09-29 | 2023-04-06 | 中外製薬株式会社 | がんの治療に用いるための細胞傷害誘導治療剤 |
| KR20250046264A (ko) * | 2022-07-29 | 2025-04-02 | 레전드 바이오테크 아일랜드 리미티드 | 클라우딘6 겹합 모이어티 및 이의 용도 |
| CN119947760A (zh) | 2022-10-31 | 2025-05-06 | 安斯泰来制药株式会社 | 包含Toll样受体7/8双激动剂化合物的抗体药物复合体 |
| EP4626933A1 (en) | 2022-11-30 | 2025-10-08 | Integral Molecular, Inc. | Antibodies directed to claudin 6, including bispecific formats thereof |
| CN116064622B (zh) * | 2023-02-13 | 2023-10-13 | 优睿赛思(武汉)生物科技有限公司 | Claudin6-mCherry报告基因CHO-K1稳转细胞株制备及应用 |
| WO2024235175A1 (zh) | 2023-05-12 | 2024-11-21 | 智泽童康(广州)生物科技有限公司 | 抗cldn6抗体及其用途 |
| WO2024243561A1 (en) | 2023-05-25 | 2024-11-28 | The Regents Of The University Of California | Methods of treating cancer |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| CN119371534B (zh) * | 2024-08-21 | 2025-05-27 | 百吉生物医药(广州)股份有限公司 | 一种紧密连接蛋白抗体e02及其应用 |
| CN119320451B (zh) * | 2024-08-21 | 2025-05-16 | 百吉生物医药(广州)股份有限公司 | 一种紧密连接蛋白抗体d03及其应用 |
| CN118754987B (zh) * | 2024-08-21 | 2025-02-11 | 广州百吉生物制药有限公司 | 一种紧密连接蛋白抗体h04及其应用 |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| GB8809129D0 (en) | 1988-04-18 | 1988-05-18 | Celltech Ltd | Recombinant dna methods vectors and host cells |
| US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
| GB9019812D0 (en) | 1990-09-11 | 1990-10-24 | Scotgen Ltd | Novel antibodies for treatment and prevention of infection in animals and man |
| US5830755A (en) | 1995-03-27 | 1998-11-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | T-cell receptors and their use in therapeutic and diagnostic methods |
| US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5677139A (en) | 1995-04-21 | 1997-10-14 | President And Fellows Of Harvard College | In vitro differentiation of CD34+ progenitor cells into T lymphocytes |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| WO2000078961A1 (en) | 1999-06-23 | 2000-12-28 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US5928631A (en) | 1997-06-09 | 1999-07-27 | The Procter & Gamble Company | Methods for controlling environmental odors on the body using compositions comprising uncomplexed cyclodextrins |
| US20020127584A1 (en) | 1997-09-18 | 2002-09-12 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US5932445A (en) | 1997-11-07 | 1999-08-03 | Incyte Pharmaceuticals, Inc. | Signal peptide-containing proteins |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| CA2339043A1 (en) | 1998-09-01 | 2000-03-09 | Genentech, Inc. | Further pro polypeptides and sequences thereof |
| JP2003524384A (ja) * | 1998-11-03 | 2003-08-19 | アドヘレックス テクノロジーズ インコーポレイテッド | クラウディン媒介機能を調節するための化合物および方法 |
| CA2362423A1 (en) | 1998-12-17 | 2000-06-22 | Human Genome Sciences, Inc. | 47 human secreted proteins |
| CA2361743A1 (en) | 1999-02-22 | 2000-08-31 | Michael G. Walker | Genes associated with diseases of the colon |
| ES2287020T3 (es) | 1999-06-02 | 2007-12-16 | Genentech, Inc. | Procedimiento y composiciones para inhibir el crecimiento de celulas neoplasicas. |
| EP1514933A1 (en) | 1999-07-08 | 2005-03-16 | Research Association for Biotechnology | Secretory protein or membrane protein |
| CN1373672A (zh) * | 1999-07-12 | 2002-10-09 | 杰南技术公司 | 应用结合cd20的拮抗剂阻断对外来抗原的免疫应答 |
| EP1242443A4 (en) | 1999-12-23 | 2005-06-22 | Nuvelo Inc | NEW NUCLEIC ACIDS AND POLYPEPTIDES |
| WO2001051513A2 (en) | 2000-01-14 | 2001-07-19 | Corixa Corporation | Ovarian tumor-associated sequences |
| KR20080023768A (ko) | 2000-03-30 | 2008-03-14 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체 |
| AU6531101A (en) | 2000-06-02 | 2001-12-17 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| JP2004506413A (ja) | 2000-06-23 | 2004-03-04 | ジェネンテック・インコーポレーテッド | 血管形成に関与する疾患の診断と治療のための組成物と方法 |
| AU2001271973A1 (en) | 2000-07-20 | 2002-02-05 | Kevin P. Baker | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| EP1354040A2 (en) | 2000-07-20 | 2003-10-22 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| AU8470301A (en) | 2000-08-03 | 2002-02-18 | Wim-Van Schooten | Production of humanized antibodies in transgenic animals |
| ES2405944T3 (es) | 2000-11-30 | 2013-06-04 | Medarex, Inc. | Ácidos nucleicos que codifican las secuencias de inmunoglobulina humana reorganizadas a partir de ratones transcromoscómicos transgénicos zadas |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| AU2002314495A1 (en) * | 2001-06-20 | 2003-01-02 | Prochon Biotech Ltd. | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
| KR100628425B1 (ko) | 2001-06-20 | 2006-09-28 | 제넨테크, 인크. | 종양의 진단 및 치료를 위한 방법 및 이를 위한 조성물 |
| CA2379661A1 (en) * | 2002-03-28 | 2003-09-28 | Kursad Turksen | Paracellular drug delivery system |
| CA2481507A1 (en) | 2002-04-16 | 2003-10-30 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| JP2006516089A (ja) | 2002-10-02 | 2006-06-22 | ジェネンテック・インコーポレーテッド | 腫瘍の診断と治療のための組成物と方法 |
| KR100932340B1 (ko) | 2002-10-17 | 2009-12-16 | 젠맵 에이/에스 | Ｃｄ20에 대한 인간 모노클로날 항체 |
| WO2004060270A2 (en) | 2002-10-18 | 2004-07-22 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| AT500651B9 (de) | 2003-05-27 | 2010-04-15 | Altropus Gmbh | Aktiv immunisierender antikörper |
| AU2004256425A1 (en) | 2003-06-09 | 2005-01-20 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| WO2006033664A1 (en) | 2004-03-08 | 2006-03-30 | Avalon Pharmaceuticals | Determining cancer-linked genes and therapeutic targets using molecular cytogenetic methods |
| US7431927B2 (en) * | 2005-03-24 | 2008-10-07 | Epitomics, Inc. | TNFα-neutralizing antibodies |
| ITRM20050297A1 (it) * | 2005-06-08 | 2006-12-09 | Univ Siena | Anticorpi diretti contro la proteina basica della mielina che riconoscono un epitopo del cd64 e uso di essi come immunodepressivi. |
| EP2520588A1 (en) * | 2005-08-19 | 2012-11-07 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| EP1790664A1 (en) * | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
| AR063086A1 (es) * | 2006-10-02 | 2008-12-23 | Medarex Inc | Anticuerpos humanos que se unen a cxcr4 y usos de los mismos |
| CA2668484A1 (en) * | 2006-11-13 | 2008-05-22 | F. Hoffmann-La Roche Ag | Cancerous disease modifying antibodies 180706-02 |
| EP2138576A4 (en) | 2007-03-16 | 2011-02-23 | Kyowa Hakko Kirin Co Ltd | ANTI-CLAUDIN-4 ANTIBODY |
| EP1997832A1 (en) | 2007-05-29 | 2008-12-03 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against Claudin-18 for treatment of cancer |
| WO2009025759A1 (en) * | 2007-08-17 | 2009-02-26 | Progenics Pharmaceuticals (Nevada), Inc. | Tight junction proteins associated with infection and entry of hepatitis c virus (hcv), methods and uses thereof |
| WO2009028663A1 (ja) | 2007-08-30 | 2009-03-05 | Kyowa Hakko Kirin Co., Ltd. | 抗Claudin-3抗体 |
| EP2060583A1 (en) | 2007-10-23 | 2009-05-20 | Ganymed Pharmaceuticals AG | Identification of tumor-associated markers for diagnosis and therapy |
| AU2009203464A1 (en) * | 2008-01-11 | 2009-07-16 | Forerunner Pharma Research Co., Ltd. | Anti-CLDN6 antibody |
| AU2009234259A1 (en) | 2008-04-11 | 2009-10-15 | Bionovo, Inc. | Anticancer methods employing extracts of Gleditsia sinensis Lam |
| WO2010043650A2 (en) | 2008-10-14 | 2010-04-22 | Ablynx Nv | Amino acid sequences directed against cellular receptors for viruses and bacteria |
| DE102009026960A1 (de) | 2008-12-18 | 2010-07-01 | Robert Bosch Gmbh | Verfahren zur Steuerung einer Bremsbetätigung eines Hybridfahrzeugs |
| NZ594480A (en) | 2009-02-20 | 2013-11-29 | Ganymed Pharmaceuticals Ag | Methods and compositions for diagnosis and treatment of cancer |
| EP2221063A1 (en) | 2009-02-20 | 2010-08-25 | Ganymed Pharmaceuticals AG | Methods and compositions for diagnosis and treatment of cancer |
| EP2322555A1 (en) | 2009-11-11 | 2011-05-18 | Ganymed Pharmaceuticals AG | Antibodies specific for claudin 6 (CLDN6) |
| HRP20171749T1 (hr) | 2009-11-11 | 2018-01-26 | Ganymed Pharmaceuticals Gmbh | Protutijela specifična za claudin 6 (cldn6) |
| EP2404936A1 (en) | 2010-07-06 | 2012-01-11 | Ganymed Pharmaceuticals AG | Cancer therapy using CLDN6 target-directed antibodies in vivo |
| AU2012258087B2 (en) | 2011-05-13 | 2017-07-20 | Astellas Pharma Inc. | Antibodies for treatment of cancer expressing claudin 6 |
| EP2605017A1 (de) | 2011-12-16 | 2013-06-19 | Protagen AG | Markersequenzen für gynäkologisches Malignom und deren Verwendung |
| WO2014015148A1 (en) | 2012-07-19 | 2014-01-23 | Amgen Inc. | Human btnl3 proteins, nucleic acids, and antibodies and uses thereof |
| US10093736B2 (en) * | 2012-11-13 | 2018-10-09 | Biontech Ag | Agents for treatment of claudin expressing cancer diseases |
| DK3708579T3 (da) * | 2014-04-01 | 2024-07-22 | Biontech Cell & Gene Therapies Gmbh | Claudin-6-specifikke immunreceptorer og t-celleepitoper |
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