JP2015537044A5 - - Google Patents

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Publication number
JP2015537044A5
JP2015537044A5 JP2015544498A JP2015544498A JP2015537044A5 JP 2015537044 A5 JP2015537044 A5 JP 2015537044A5 JP 2015544498 A JP2015544498 A JP 2015544498A JP 2015544498 A JP2015544498 A JP 2015544498A JP 2015537044 A5 JP2015537044 A5 JP 2015537044A5
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JP
Japan
Prior art keywords
ankyrin repeat
repeat domain
amino acid
binding protein
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2015544498A
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English (en)
Japanese (ja)
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JP2015537044A (ja
JP6410724B2 (ja
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Priority claimed from EP12195156.0A external-priority patent/EP2738180A1/en
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Publication of JP2015537044A publication Critical patent/JP2015537044A/ja
Publication of JP2015537044A5 publication Critical patent/JP2015537044A5/ja
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Publication of JP6410724B2 publication Critical patent/JP6410724B2/ja
Expired - Fee Related legal-status Critical Current
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JP2015544498A 2012-11-30 2013-12-02 少なくとも２つの抗ｈｅｒ２反復ドメインを含む結合タンパク質 Expired - Fee Related JP6410724B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12195156.0 2012-11-30
EP12195156.0A EP2738180A1 (en) 2012-11-30 2012-11-30 Binding proteins comprising at least two binding domains against HER2.
PCT/EP2013/075290 WO2014083208A1 (en) 2012-11-30 2013-12-02 Binding proteins comprising at least two repeat domains against her2

Publications (3)

Publication Number Publication Date
JP2015537044A JP2015537044A (ja) 2015-12-24
JP2015537044A5 true JP2015537044A5 (OSRAM) 2016-12-28
JP6410724B2 JP6410724B2 (ja) 2018-10-24

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Family Applications (1)

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JP2015544498A Expired - Fee Related JP6410724B2 (ja) 2012-11-30 2013-12-02 少なくとも２つの抗ｈｅｒ２反復ドメインを含む結合タンパク質

Country Status (11)

Country Link
US (1) US10370414B2 (OSRAM)
EP (2) EP2738180A1 (OSRAM)
JP (1) JP6410724B2 (OSRAM)
KR (1) KR102290592B1 (OSRAM)
CN (1) CN104918959A (OSRAM)
AU (2) AU2013351096C9 (OSRAM)
CA (1) CA2892747C (OSRAM)
HK (1) HK1211297A1 (OSRAM)
MX (1) MX366223B (OSRAM)
RU (1) RU2664464C9 (OSRAM)
WO (1) WO2014083208A1 (OSRAM)

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RU2627215C1 (ru) * 2016-05-24 2017-08-03 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Нижегородский государственный университет им. Н.И. Лобачевского" Рекомбинантный таргетный токсин, специфичный к клеткам, экспрессирующим рецептор her2
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CA3139041A1 (en) * 2019-06-04 2020-12-10 Christian REICHEN Recombinant 4-1bb binding proteins and their use
CA3139051A1 (en) 2019-06-04 2020-12-10 Christian REICHEN Multispecific proteins
KR20220016944A (ko) 2019-06-04 2022-02-10 몰리큘라 파트너스 아게 개선된 안정성을 갖는 설계된 안키린 반복 도메인
CA3147423A1 (en) 2019-07-26 2021-02-04 Abl Bio Inc. Anti-her2/anti-4-1bb bispecific antibody and use thereof
WO2021116462A1 (en) * 2019-12-11 2021-06-17 Molecular Partners Ag Designed ankyrin repeat domains with altered surface residues
TW202208404A (zh) 2020-05-06 2022-03-01 瑞士商分子組合公司 新穎錨蛋白重複結合蛋白質及其用途
EP4149960A1 (en) * 2020-05-14 2023-03-22 Molecular Partners AG Recombinant cd40 binding proteins and their use
BR112022023049A2 (pt) 2020-05-14 2022-12-20 Molecular Partners Ag Proteínas multiespecíficas
JP2023554351A (ja) 2020-12-16 2023-12-27 モレキュラー パートナーズ アクチェンゲゼルシャフト 新規の徐放性プロドラッグ
AU2022231913A1 (en) 2021-03-09 2023-09-28 Molecular Partners Ag Novel darpin based cd33 engagers
JP2024509904A (ja) 2021-03-09 2024-03-05 モレキュラー パートナーズ アクチェンゲゼルシャフト 新規なＤＡＲＰｉｎに基づく多重特異性Ｔ細胞エンゲージャ
JP2024509890A (ja) 2021-03-09 2024-03-05 モレキュラー パートナーズ アクチェンゲゼルシャフト プロテアーゼ切断可能なプロドラッグ
US20240150475A1 (en) 2021-03-09 2024-05-09 Molecular Partners Ag Novel darpin based cd123 engagers
WO2023110983A1 (en) 2021-12-14 2023-06-22 Molecular Partners Ag Designed repeat domains with dual binding specificity and their use
CN119731200A (zh) 2022-08-01 2025-03-28 分子合作伙伴股份公司 经电荷修饰设计的重复结构域及其用途
WO2024038307A1 (en) 2022-08-19 2024-02-22 Novartis Ag Dosing regimens for sars-cov-2 binding molecules
WO2024179981A1 (en) 2023-02-27 2024-09-06 Molecular Partners Ag Darpins for use in reducing renal accumulation of drugs
WO2024251628A1 (en) 2023-06-06 2024-12-12 Molecular Partners Ag Recombinant cd16a binding proteins and their use
WO2025146491A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent

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US10093740B2 (en) 2012-10-15 2018-10-09 Universitat Zurich Bispecific HER2 ligands for cancer therapy
US11453708B2 (en) 2013-05-31 2022-09-27 Molecular Partners Ag Designed ankyrin repeat proteins binding to hepatocyte growth factor

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