CA2892747C - Binding proteins comprising at least two repeat domains against her2. - Google Patents
Binding proteins comprising at least two repeat domains against her2. Download PDFInfo
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- CA2892747C CA2892747C CA2892747A CA2892747A CA2892747C CA 2892747 C CA2892747 C CA 2892747C CA 2892747 A CA2892747 A CA 2892747A CA 2892747 A CA2892747 A CA 2892747A CA 2892747 C CA2892747 C CA 2892747C
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- ankyrin repeat
- her2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cell Biology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12195156.0A EP2738180A1 (en) | 2012-11-30 | 2012-11-30 | Binding proteins comprising at least two binding domains against HER2. |
| EP12195156.0 | 2012-11-30 | ||
| PCT/EP2013/075290 WO2014083208A1 (en) | 2012-11-30 | 2013-12-02 | Binding proteins comprising at least two repeat domains against her2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2892747A1 CA2892747A1 (en) | 2014-06-05 |
| CA2892747C true CA2892747C (en) | 2022-07-19 |
Family
ID=47257683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2892747A Active CA2892747C (en) | 2012-11-30 | 2013-12-02 | Binding proteins comprising at least two repeat domains against her2. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10370414B2 (OSRAM) |
| EP (2) | EP2738180A1 (OSRAM) |
| JP (1) | JP6410724B2 (OSRAM) |
| KR (1) | KR102290592B1 (OSRAM) |
| CN (1) | CN104918959A (OSRAM) |
| AU (2) | AU2013351096C9 (OSRAM) |
| CA (1) | CA2892747C (OSRAM) |
| HK (1) | HK1211297A1 (OSRAM) |
| MX (1) | MX366223B (OSRAM) |
| RU (1) | RU2664464C9 (OSRAM) |
| WO (1) | WO2014083208A1 (OSRAM) |
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| TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質 |
| DK2643349T3 (da) * | 2010-11-26 | 2019-11-25 | Molecular Partners Ag | Designede repeat-proteiner, der binder til serumalbumin |
| EP2906591A1 (en) * | 2012-10-15 | 2015-08-19 | Universität Zürich | Bispecific her2 ligands for cancer therapy |
| US11453708B2 (en) | 2013-05-31 | 2022-09-27 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to hepatocyte growth factor |
| EP3074424B1 (en) | 2013-11-27 | 2025-02-12 | Zymeworks BC Inc. | Bispecific antigen-binding constructs targeting her2 |
| WO2016082044A1 (en) | 2014-11-27 | 2016-06-02 | Zymeworks Inc. | Methods of using bispecific antigen-binding constructs targeting her2 |
| US10858405B2 (en) | 2015-02-06 | 2020-12-08 | Navigo Proteins Gmbh | EGFR binding proteins |
| PH12017501792B1 (en) | 2015-04-02 | 2022-07-20 | Molecular Partners Ag | Recombinant binding proteins and their use |
| US10808042B2 (en) | 2015-07-16 | 2020-10-20 | Navigo Proteins Gmbh | Immunoglobulin-binding proteins and their use in affinity purification |
| WO2017013136A1 (en) * | 2015-07-20 | 2017-01-26 | Scil Proteins Gmbh | Novel binding proteins based on di-ubiquitin muteins and methods for generation |
| JP6881760B2 (ja) * | 2015-07-20 | 2021-06-02 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | ジユビキチン変異タンパク質に基づくＨｅｒ２結合タンパク質 |
| JP2019526526A (ja) | 2016-05-04 | 2019-09-19 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | ペプチドリンカーを含む化学的部分の部位特異的カップリングのための標的化合物 |
| RU2627215C1 (ru) * | 2016-05-24 | 2017-08-03 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Нижегородский государственный университет им. Н.И. Лобачевского" | Рекомбинантный таргетный токсин, специфичный к клеткам, экспрессирующим рецептор her2 |
| CN109963864B (zh) | 2016-08-11 | 2024-01-02 | 瑞普利金公司 | 用于亲和色谱的碱性稳定性fc结合蛋白 |
| AU2017331329B2 (en) * | 2016-09-22 | 2020-10-29 | Molecular Partners Ag | Recombinant binding proteins and their use |
| BR112019011277A2 (pt) | 2016-12-02 | 2019-10-22 | University Of Southern California | polinucleotídeo, sistema de expressão recombinante, vetor, polipeptídeo, célula recombinante, polipeptídeo de receptor imune sintético isolado ou heterodímero de polipeptídeo, célula efetora imune ou célula-tronco, população de células imunes ou efetoras, métodos de fabricação de uma célula efetora imune que expressa sir, de geração de uma população de células modificadas por rna, de fornecimento de imunidade antidoença e de tratamento ou prevenção de uma doença, composição, uso ou método, kit, e, sequência de aminoácidos. |
| EP3706804B1 (en) | 2017-11-07 | 2022-02-23 | Navigo Proteins GmbH | Fusion proteins with specificity for ed-b and long serum half-life for diagnosis or treatment of cancer |
| US20220298212A1 (en) * | 2019-06-04 | 2022-09-22 | Molecular Partners Ag | Recombinant 4-1bb binding proteins and their use |
| SG11202112925PA (en) * | 2019-06-04 | 2021-12-30 | Molecular Partners Ag | Recombinant fap binding proteins and their use |
| AR119080A1 (es) | 2019-06-04 | 2021-11-24 | Molecular Partners Ag | Proteínas multiespecíficas |
| JP7742309B2 (ja) | 2019-06-04 | 2025-09-19 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 改善された安定性を有する設計されたアンキリン反復ドメイン |
| JP7725446B2 (ja) | 2019-07-26 | 2025-08-19 | ユハン コーポレーション | 抗ｈｅｒ２／抗４－１ｂｂ二重特異性抗体及びその使用 |
| CN114929730A (zh) | 2019-12-11 | 2022-08-19 | 分子合作伙伴股份公司 | 重组肽-mhc复合物结合蛋白及其生成和用途 |
| WO2021224686A1 (en) | 2020-05-06 | 2021-11-11 | Molecular Partners Ag | Novel ankyrin repeat binding proteins and their uses |
| JP2023528204A (ja) | 2020-05-14 | 2023-07-04 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 多選択性タンパク質 |
| WO2021229076A1 (en) * | 2020-05-14 | 2021-11-18 | Molecular Partners Ag | Recombinant cd40 binding proteins and their use |
| WO2022130300A1 (en) | 2020-12-16 | 2022-06-23 | Molecular Partners Ag | Novel slow-release prodrugs |
| JP2024508969A (ja) | 2021-03-09 | 2024-02-28 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 新規のＤＡＲＰｉｎに基づくＣＤ３３エンゲージャ |
| AU2022232216A1 (en) | 2021-03-09 | 2023-10-05 | Molecular Partners Ag | Protease cleavable prodrugs |
| WO2022190018A1 (en) | 2021-03-09 | 2022-09-15 | Molecular Partners Ag | Novel darpin based cd123 engagers |
| KR20230155464A (ko) | 2021-03-09 | 2023-11-10 | 몰리큘라 파트너스 아게 | 신규한 DARPin-기반 다중특이성 T-세포 인게이저 |
| WO2023110983A1 (en) | 2021-12-14 | 2023-06-22 | Molecular Partners Ag | Designed repeat domains with dual binding specificity and their use |
| WO2024028278A1 (en) | 2022-08-01 | 2024-02-08 | Molecular Partners Ag | Charge modified designed repeat domains and their use |
| WO2024038307A1 (en) | 2022-08-19 | 2024-02-22 | Novartis Ag | Dosing regimens for sars-cov-2 binding molecules |
| WO2024179981A1 (en) | 2023-02-27 | 2024-09-06 | Molecular Partners Ag | Darpins for use in reducing renal accumulation of drugs |
| WO2024251628A1 (en) | 2023-06-06 | 2024-12-12 | Molecular Partners Ag | Recombinant cd16a binding proteins and their use |
| WO2025146491A1 (en) | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent |
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| AU4308689A (en) | 1988-09-02 | 1990-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5348867A (en) | 1991-11-15 | 1994-09-20 | George Georgiou | Expression of proteins on bacterial surface |
| US7371376B1 (en) | 1996-10-18 | 2008-05-13 | Genentech, Inc. | Anti-ErbB2 antibodies |
| CA2196496A1 (en) | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| DE69834032T2 (de) | 1997-04-23 | 2006-12-07 | Universität Zürich | Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren |
| HK1039355B (en) | 1998-12-02 | 2007-09-21 | Bristol-Myers Squibb Company | Dna-protein fusions and uses thereof |
| US7417130B2 (en) | 2000-09-08 | 2008-08-26 | University Of Zurich | Collection of repeat proteins comprising repeat modules |
| CN1997382A (zh) * | 2004-05-05 | 2007-07-11 | 梅里麦克制药股份有限公司 | 调节生物活性的双特异性结合剂 |
| KR20190126461A (ko) * | 2004-07-22 | 2019-11-11 | 제넨테크, 인크. | Ｈｅｒ２ 항체 조성물 |
| BRPI0613593A2 (pt) | 2005-07-08 | 2011-01-18 | Univ Zuerich | método de teste "phage display" filamentoso, vetor de fago ou de fagomìdeo e biblioteca de vetores de fago ou fagomìdeo |
| SI2402754T2 (sl) | 2006-03-06 | 2023-09-29 | Amunix Operating Inc. | Nestrukturirani rekombinantni polimeri in njihove uporabe |
| PL2173890T3 (pl) | 2007-06-21 | 2011-07-29 | Univ Muenchen Tech | Białka czynne biologicznie o zwiększonej stabilności in vivo i (lub) in vitro |
| CA2700391A1 (en) | 2007-09-24 | 2009-04-02 | University Of Zuerich | Designed armadillo repeat proteins |
| EP2215125A1 (en) | 2007-11-27 | 2010-08-11 | Ablynx N.V. | Method for obtaining polypeptide constructs comprising two or more single domain antibodies |
| US20100260668A1 (en) | 2008-04-29 | 2010-10-14 | Abbott Laboratories | Dual Variable Domain Immunoglobulins and Uses Thereof |
| CN102272148A (zh) | 2008-11-03 | 2011-12-07 | 分子组合公司 | 抑制vegf-a受体相互作用的结合蛋白 |
| TW201120210A (en) * | 2009-11-05 | 2011-06-16 | Hoffmann La Roche | Glycosylated repeat-motif-molecule conjugates |
| TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質 |
| DK2643349T3 (da) | 2010-11-26 | 2019-11-25 | Molecular Partners Ag | Designede repeat-proteiner, der binder til serumalbumin |
| KR20140039203A (ko) | 2011-04-29 | 2014-04-01 | 얀센 바이오테크 인코포레이티드 | Il4/il13 결합 반복 단백질 및 용도 |
| WO2012162418A1 (en) * | 2011-05-23 | 2012-11-29 | The University Of North Carolina At Chapel Hill | Methods and compositions for heterodimeric targeting ligands |
| WO2014001442A1 (en) | 2012-06-28 | 2014-01-03 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
| EP2906591A1 (en) | 2012-10-15 | 2015-08-19 | Universität Zürich | Bispecific her2 ligands for cancer therapy |
| US11453708B2 (en) | 2013-05-31 | 2022-09-27 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to hepatocyte growth factor |
-
2012
- 2012-11-30 EP EP12195156.0A patent/EP2738180A1/en not_active Withdrawn
-
2013
- 2013-12-02 RU RU2015120663A patent/RU2664464C9/ru active
- 2013-12-02 WO PCT/EP2013/075290 patent/WO2014083208A1/en not_active Ceased
- 2013-12-02 HK HK15110090.1A patent/HK1211297A1/xx unknown
- 2013-12-02 KR KR1020157017376A patent/KR102290592B1/ko not_active Expired - Fee Related
- 2013-12-02 EP EP13811818.7A patent/EP2925784B1/en active Active
- 2013-12-02 JP JP2015544498A patent/JP6410724B2/ja not_active Expired - Fee Related
- 2013-12-02 MX MX2015006548A patent/MX366223B/es active IP Right Grant
- 2013-12-02 CN CN201380062520.9A patent/CN104918959A/zh active Pending
- 2013-12-02 US US14/648,611 patent/US10370414B2/en active Active
- 2013-12-02 AU AU2013351096A patent/AU2013351096C9/en not_active Ceased
- 2013-12-02 CA CA2892747A patent/CA2892747C/en active Active
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2018
- 2018-11-01 AU AU2018256592A patent/AU2018256592A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014083208A8 (en) | 2014-10-30 |
| WO2014083208A1 (en) | 2014-06-05 |
| US10370414B2 (en) | 2019-08-06 |
| KR20150091138A (ko) | 2015-08-07 |
| JP2015537044A (ja) | 2015-12-24 |
| BR112015012436A2 (pt) | 2017-09-12 |
| MX2015006548A (es) | 2015-10-15 |
| CN104918959A (zh) | 2015-09-16 |
| HK1211297A1 (zh) | 2016-05-20 |
| JP6410724B2 (ja) | 2018-10-24 |
| RU2664464C9 (ru) | 2018-12-19 |
| MX366223B (es) | 2019-07-03 |
| AU2013351096C1 (en) | 2018-11-08 |
| WO2014083208A9 (en) | 2014-12-24 |
| RU2664464C2 (ru) | 2018-08-17 |
| AU2013351096B2 (en) | 2018-08-09 |
| EP2925784A1 (en) | 2015-10-07 |
| CA2892747A1 (en) | 2014-06-05 |
| AU2013351096A1 (en) | 2015-07-09 |
| US20150299265A1 (en) | 2015-10-22 |
| AU2013351096C9 (en) | 2019-01-31 |
| RU2015120663A (ru) | 2017-01-10 |
| KR102290592B1 (ko) | 2021-08-19 |
| EP2925784B1 (en) | 2021-02-17 |
| AU2018256592A1 (en) | 2018-11-22 |
| EP2738180A1 (en) | 2014-06-04 |
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