JP2015535289A5 - - Google Patents
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- JP2015535289A5 JP2015535289A5 JP2015540796A JP2015540796A JP2015535289A5 JP 2015535289 A5 JP2015535289 A5 JP 2015535289A5 JP 2015540796 A JP2015540796 A JP 2015540796A JP 2015540796 A JP2015540796 A JP 2015540796A JP 2015535289 A5 JP2015535289 A5 JP 2015535289A5
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- PURKAOJPTOLRMP-UHFFFAOYSA-N CC(C)(C)c(cc(C(C)(C)C)c(O)c1)c1NC(C1=CNc2ccccc2C1=O)=O Chemical compound CC(C)(C)c(cc(C(C)(C)C)c(O)c1)c1NC(C1=CNc2ccccc2C1=O)=O PURKAOJPTOLRMP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261721622P | 2012-11-02 | 2012-11-02 | |
| US61/721,622 | 2012-11-02 | ||
| US201261728328P | 2012-11-20 | 2012-11-20 | |
| US61/728,328 | 2012-11-20 | ||
| US201361770668P | 2013-02-28 | 2013-02-28 | |
| US61/770,668 | 2013-02-28 | ||
| US201361824005P | 2013-05-16 | 2013-05-16 | |
| US61/824,005 | 2013-05-16 | ||
| US201361840668P | 2013-06-28 | 2013-06-28 | |
| US61/840,668 | 2013-06-28 | ||
| PCT/US2013/067952 WO2014071122A1 (en) | 2012-11-02 | 2013-11-01 | Pharmaceutical compositions for the treatment of cftr mediated diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018038741A Division JP2018090626A (ja) | 2012-11-02 | 2018-03-05 | Ｃｆｔｒが媒介する疾患の処置のための医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015535289A JP2015535289A (ja) | 2015-12-10 |
| JP2015535289A5 true JP2015535289A5 (https=) | 2016-12-15 |
| JP6302923B2 JP6302923B2 (ja) | 2018-03-28 |
Family
ID=50628072
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540796A Active JP6302923B2 (ja) | 2012-11-02 | 2013-11-01 | Ｃｆｔｒが媒介する疾患の処置のための医薬組成物 |
| JP2018038741A Withdrawn JP2018090626A (ja) | 2012-11-02 | 2018-03-05 | Ｃｆｔｒが媒介する疾患の処置のための医薬組成物 |
| JP2019087813A Active JP7003085B2 (ja) | 2012-11-02 | 2019-05-07 | Ｃｆｔｒが媒介する疾患の処置のための医薬組成物 |
| JP2021214209A Pending JP2022034069A (ja) | 2012-11-02 | 2021-12-28 | Ｃｆｔｒが媒介する疾患の処置のための医薬組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018038741A Withdrawn JP2018090626A (ja) | 2012-11-02 | 2018-03-05 | Ｃｆｔｒが媒介する疾患の処置のための医薬組成物 |
| JP2019087813A Active JP7003085B2 (ja) | 2012-11-02 | 2019-05-07 | Ｃｆｔｒが媒介する疾患の処置のための医薬組成物 |
| JP2021214209A Pending JP2022034069A (ja) | 2012-11-02 | 2021-12-28 | Ｃｆｔｒが媒介する疾患の処置のための医薬組成物 |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US20140163068A1 (https=) |
| EP (3) | EP2914248B2 (https=) |
| JP (4) | JP6302923B2 (https=) |
| KR (1) | KR102396897B1 (https=) |
| CN (2) | CN111671751A (https=) |
| AR (1) | AR093340A1 (https=) |
| AU (4) | AU2013337730B2 (https=) |
| BR (1) | BR112015009913B1 (https=) |
| CA (1) | CA2890106C (https=) |
| CL (1) | CL2015001148A1 (https=) |
| CY (1) | CY1121070T1 (https=) |
| DK (2) | DK3470063T3 (https=) |
| ES (2) | ES2694290T5 (https=) |
| FI (2) | FI2914248T4 (https=) |
| HR (2) | HRP20181740T4 (https=) |
| HU (2) | HUE039864T2 (https=) |
| IL (2) | IL283276B2 (https=) |
| LT (2) | LT2914248T (https=) |
| MX (2) | MX368353B (https=) |
| NZ (2) | NZ745659A (https=) |
| PL (2) | PL3470063T3 (https=) |
| PT (2) | PT2914248T (https=) |
| RS (2) | RS66596B1 (https=) |
| SG (3) | SG10201913581UA (https=) |
| SI (2) | SI3470063T1 (https=) |
| SM (2) | SMT201800590T1 (https=) |
| TR (1) | TR201815218T4 (https=) |
| TW (2) | TW201422253A (https=) |
| UA (2) | UA117464C2 (https=) |
| WO (1) | WO2014071122A1 (https=) |
Families Citing this family (98)
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|---|---|---|---|---|
| RU2006111093A (ru) | 2003-09-06 | 2007-10-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы атр-связывающих кассетных транспортеров |
| US7977322B2 (en) | 2004-08-20 | 2011-07-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| RS56037B1 (sr) | 2004-06-24 | 2017-09-29 | Vertex Pharma | Modulatori atp-vezujućih kasetnih transportera |
| US7999113B2 (en) | 2005-08-11 | 2011-08-16 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| CN102775396B (zh) * | 2005-11-08 | 2014-10-08 | 沃泰克斯药物股份有限公司 | Atp-结合弹夹转运蛋白的杂环调控剂 |
| EP3219705B1 (en) | 2005-12-28 | 2020-03-11 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of the amorphous form of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| USRE50453E1 (en) | 2006-04-07 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| EP2674428B1 (en) | 2006-04-07 | 2016-04-06 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| CN104447716A (zh) | 2007-05-09 | 2015-03-25 | 沃泰克斯药物股份有限公司 | Cftr调节剂 |
| JP5389030B2 (ja) | 2007-08-24 | 2014-01-15 | バーテックス ファーマシューティカルズ インコーポレイテッド | （特に）嚢胞性線維症の処置に有用なイソチアゾロピリジノン |
| SI2578571T1 (sl) | 2007-11-16 | 2016-01-29 | Vertex Pharmaceuticals Incorporated | Izokinolinski modulatorji prenašalcev z atp-vezavno kaseto |
| EP3683218B1 (en) | 2007-12-07 | 2024-09-18 | Vertex Pharmaceuticals Incorporated | Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid |
| US20100036130A1 (en) | 2007-12-07 | 2010-02-11 | Vertex Pharmaceuticals Incorporated | Processes for producing cycloalkylcarboxamido-pyridine benzoic acids |
| MX365732B (es) | 2007-12-07 | 2019-06-12 | Vertex Pharma | Procesos para producir acidos cicloalquilcarboxamido-piridin benzoicos. |
| NZ720282A (en) | 2008-02-28 | 2017-12-22 | Vertex Pharma | Heteroaryl derivatives as cftr modulators |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| PL2408750T3 (pl) | 2009-03-20 | 2016-02-29 | Vertex Pharma | Sposób otrzymywania modulatorów błonowego regulatora przewodnictwa swoistego dla mukowiscydozy |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| MX2012011655A (es) | 2010-04-07 | 2012-11-23 | Vertex Pharma | Formas solidas de acido 3-(6-(1-(2,2-difluorobenzo [d][1-3]dioxol-5-il]ciclopropanocarboxamido)-3-metilpiridin-2-il) benzoico. |
| JP2013523833A (ja) | 2010-04-07 | 2013-06-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | ３−（６−（１−（２，２−ジフルオロベンゾ［ｄ］［１，３］ジオキソール−５−イル）シクロプロパンカルボキサミド）−３−メチルピリジン−２−イル）安息香酸の医薬組成物およびその投与 |
| MX353408B (es) | 2010-04-22 | 2018-01-11 | Vertex Pharma | Proceso para producir compuestos de cicloalquilcarboxamido-indol. |
| HUE047354T2 (hu) | 2011-05-18 | 2020-04-28 | Vertex Pharmaceuticals Europe Ltd | Ivacaftor deuterizált származékai |
| WO2013070961A1 (en) | 2011-11-08 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| PE20141702A1 (es) | 2012-01-06 | 2014-11-19 | Abide Therapeutics Inc | Compuestos de carbamato y preparacion y uso de los mismos |
| NZ727015A (en) | 2012-01-25 | 2017-12-22 | Vertex Pharma | Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid |
| JP2015511583A (ja) | 2012-02-27 | 2015-04-20 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 薬学的組成物およびその投与 |
| AR092857A1 (es) | 2012-07-16 | 2015-05-06 | Vertex Pharma | Composiciones farmaceuticas de (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)-n-(1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il)-1h-indol-5-il)ciclopropancarboxamida y administracion de las mismas |
| EP2914248B2 (en) * | 2012-11-02 | 2023-10-18 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions for the treatment of cftr mediated diseases |
| US9303918B2 (en) * | 2013-03-15 | 2016-04-05 | Monosol Rx, Llc | Process for drying a wet film with control of loss on drying |
| US20160074374A1 (en) * | 2013-04-26 | 2016-03-17 | Vertex Pharmaceuticals Incorporated | Correctors acting through msd1 of cftr protein |
| AU2014349010C1 (en) * | 2013-11-12 | 2020-08-06 | Vertex Pharmaceuticals Incorporated | Process of preparing pharmaceutical compositions for the treatment of CFTR mediated diseases |
| RU2744460C2 (ru) | 2014-04-15 | 2021-03-09 | Вертекс Фармасьютикалз Инкорпорейтед | Фармацевтические композиции для лечения заболеваний, опосредованных муковисцидозным трансмембранным регулятором проводимости |
| MA41051B1 (fr) | 2014-10-06 | 2020-11-30 | Vertex Pharma | Modulateurs du régulateur de conductance transmembranaire de la mucoviscidose |
| CN107250113B (zh) | 2014-10-07 | 2019-03-29 | 弗特克斯药品有限公司 | 囊性纤维化跨膜传导调节蛋白的调节剂的共晶 |
| RU2691136C2 (ru) | 2014-11-18 | 2019-06-11 | Вертекс Фармасьютикалз Инкорпорейтед | Способ проведения высокопроизводительной тестовой высокоэффективной жидкостной хроматографии |
| CN113413387A (zh) | 2015-05-11 | 2021-09-21 | H.隆德贝克有限公司 | 治疗炎症或神经性疼痛的方法 |
| EP3352758A2 (en) | 2015-09-25 | 2018-08-01 | Vertex Pharmaceuticals (Europe) Limited | Deuterated cftr potentiators |
| WO2017151725A1 (en) * | 2016-03-03 | 2017-09-08 | Nivalis Therapeutics, Inc. | Formulations of an s-nitrosoglutathione reductase inhibitor |
| CA3019380A1 (en) | 2016-03-31 | 2017-10-05 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| US10206915B2 (en) | 2016-04-25 | 2019-02-19 | Druggability Technologies Ip Holdco Limited | Complexes of Ivacaftor and its salts and derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
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| US11253509B2 (en) | 2017-06-08 | 2022-02-22 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| MA49631A (fr) | 2017-07-17 | 2020-05-27 | Vertex Pharma | Méthodes de traitement de la fibrose kystique |
| JP7121794B2 (ja) | 2017-08-02 | 2022-08-18 | バーテックス ファーマシューティカルズ インコーポレイテッド | ピロリジン化合物を調製するためのプロセス |
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| MA51206A (fr) | 2017-12-01 | 2020-10-07 | Vertex Pharma | Procédés pour préparer des modulateurs de régulateur de conductance transmembranaire de mucoviscidose |
| EP3720849A2 (en) | 2017-12-08 | 2020-10-14 | Vertex Pharmaceuticals Incorporated | Processes for making modulators of cystic fibrosis transmembrane conductance regulator |
| TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
| JP7214743B2 (ja) | 2018-02-15 | 2023-01-30 | バーテックス ファーマシューティカルズ インコーポレイテッド | 嚢胞性線維症膜コンダクタンス制御因子のモジュレーターとしての大環状分子、それらの医薬組成物、嚢胞性線維症の治療におけるそれらの使用、及びそれらの製造方法 |
| WO2019195739A1 (en) | 2018-04-05 | 2019-10-10 | Alexander Russell Abela | Modulators of cystic fibrosis transmembrane conductance regulator |
| EP3774825A1 (en) | 2018-04-13 | 2021-02-17 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| EA202191361A1 (ru) | 2018-11-14 | 2021-08-11 | Вертекс Фармасьютикалз Инкорпорейтед | Способы лечения муковисцидоза |
| UY38630A (es) | 2019-04-03 | 2020-10-30 | Vertex Pharma | Agentes moduladores del regulador de la conductancia transmembrana de la fibrosis quística |
| WO2020214921A1 (en) | 2019-04-17 | 2020-10-22 | Vertex Pharmaceuticals Incorporated | Solid forms of modulators of cftr |
| TWI899097B (zh) | 2019-08-14 | 2025-10-01 | 美商維泰克斯製藥公司 | 製備cftr調節劑之方法 |
| WO2021030552A1 (en) | 2019-08-14 | 2021-02-18 | Vertex Pharmaceuticals Incorporated | Crystalline forms of cftr modulators |
| TWI867024B (zh) | 2019-08-14 | 2024-12-21 | 美商維泰克斯製藥公司 | 囊腫纖維化跨膜傳導調節蛋白之調節劑 |
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| US11904006B2 (en) | 2019-12-11 | 2024-02-20 | University Of Iowa Research Foundation | Poly(diaminosulfide) particle-based vaccine |
| WO2021214550A1 (en) | 2020-04-21 | 2021-10-28 | H. Lundbeck A/S | Synthesis of a monoacylglycerol lipase inhibitor |
| WO2022194399A1 (en) | 2020-07-13 | 2022-09-22 | Idorsia Pharmaceuticals Ltd | Macrocycles as cftr modulators |
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| IL300413A (en) | 2020-08-13 | 2023-04-01 | Vertex Pharma | Crystal forms of CFTR modulators |
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| WO2022076622A2 (en) | 2020-10-07 | 2022-04-14 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
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| US12324802B2 (en) | 2020-11-18 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
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| CA3211232A1 (en) * | 2021-03-09 | 2022-09-15 | Hemant Bhagwat NARKHEDE | Oral film of cftr modulator(s) |
| JP2025506382A (ja) | 2022-02-03 | 2025-03-11 | バーテックス ファーマシューティカルズ インコーポレイテッド | 嚢胞性線維症の治療方法 |
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| CA3258118A1 (en) | 2022-04-06 | 2023-10-12 | Vertex Pharmaceuticals Incorporated | MODULATORS OF THE TRANSMEMBRANE CONDUCTANCE REGULATOR IN CYSTIC FIBROSIS |
| WO2023224931A1 (en) | 2022-05-16 | 2023-11-23 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
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