JP2015535003A5 - - Google Patents

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Publication number
JP2015535003A5
JP2015535003A5 JP2015540226A JP2015540226A JP2015535003A5 JP 2015535003 A5 JP2015535003 A5 JP 2015535003A5 JP 2015540226 A JP2015540226 A JP 2015540226A JP 2015540226 A JP2015540226 A JP 2015540226A JP 2015535003 A5 JP2015535003 A5 JP 2015535003A5
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JP
Japan
Prior art keywords
acid
formula
lipase
group
methyl
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JP2015540226A
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English (en)
Japanese (ja)
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JP2015535003A (ja
JP6482465B2 (ja
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Priority claimed from PCT/IB2013/002435 external-priority patent/WO2014072785A2/en
Publication of JP2015535003A publication Critical patent/JP2015535003A/ja
Publication of JP2015535003A5 publication Critical patent/JP2015535003A5/ja
Application granted granted Critical
Publication of JP6482465B2 publication Critical patent/JP6482465B2/ja
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JP2015540226A 2012-11-07 2013-11-04 プレガバリンの調製方法 Active JP6482465B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN3228/MUM/2012 2012-11-07
IN3228MU2012 2012-11-07
PCT/IB2013/002435 WO2014072785A2 (en) 2012-11-07 2013-11-04 A process for the preparation of pregabalin

Publications (3)

Publication Number Publication Date
JP2015535003A JP2015535003A (ja) 2015-12-07
JP2015535003A5 true JP2015535003A5 (https=) 2016-12-22
JP6482465B2 JP6482465B2 (ja) 2019-03-13

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ID=50685262

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015540226A Active JP6482465B2 (ja) 2012-11-07 2013-11-04 プレガバリンの調製方法

Country Status (5)

Country Link
US (1) US10023885B2 (https=)
EP (1) EP2916832B1 (https=)
JP (1) JP6482465B2 (https=)
CA (1) CA2888877C (https=)
WO (1) WO2014072785A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105463037A (zh) * 2015-11-26 2016-04-06 太仓运通生物化工有限公司 一种以异丁基丁二腈为中间体合成普瑞巴林的方法
CN105481708A (zh) * 2015-11-26 2016-04-13 太仓运通生物化工有限公司 一种以氰乙酸甲酯、异戊醛为原料合成普瑞巴林的方法
CN108424900B (zh) * 2018-02-09 2020-11-03 浙江工业大学 一种腈水解酶突变体及其构建方法和应用
CN110174467B (zh) * 2018-10-25 2022-04-08 武汉武药制药有限公司 一种高效液相色谱法分析分离2,4-二氰基-3-异丁基戊二酰胺的方法
WO2020183376A1 (en) * 2019-03-11 2020-09-17 Hikal Limited Greener and economic process for preparation of pregabalin
CN113179630A (zh) * 2019-11-26 2021-07-27 海蔻有限公司 用于制备普瑞巴林的改进方法
CN111004138A (zh) * 2019-12-12 2020-04-14 南京恒道医药科技有限公司 一种左乙拉西坦关键中间体s-2-氨基丁酸甲酯的绿色生产方法及其装置
CN111100856B (zh) * 2020-01-13 2021-12-07 浙江工业大学 腈水解酶突变体及在普瑞巴林手性中间体合成中的应用
EP4103168A4 (en) * 2020-02-14 2024-04-24 Council Of Scientific & Industrial Research PROCESS FOR PREPARING GAMMA-AMINO-BUTYRIC ACIDS AND THEIR ANALOGS
CN114425386B (zh) * 2020-10-14 2023-08-29 中国石油化工股份有限公司 脂肪酸甲酯乙氧基化催化剂
CN112521299B (zh) * 2020-12-15 2022-08-16 内蒙古永太化学有限公司 一种普瑞巴林中间体的制备方法
CN112941122B (zh) * 2021-02-23 2022-12-09 浙江工业大学 一种(s)-3-氰基-5-甲基己酸的制备方法
CN113149823B (zh) * 2021-03-29 2023-12-08 上海青平药业有限公司 一种2-r1戊酸的制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197819B1 (en) 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
US5616793A (en) 1995-06-02 1997-04-01 Warner-Lambert Company Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5637767A (en) 1995-06-07 1997-06-10 Warner-Lambert Company Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
FR2856922B1 (fr) 2003-07-01 2005-08-12 Oreal Composition tinctoriale comprenant au moins une base d'oxydation, le 2-chloro 6-methyl 3-aminophenol et la 3-methyl 1-phenyl 5-pyrazolone
UA82292C2 (uk) 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
KR20070087596A (ko) 2005-09-19 2007-08-28 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ)-(+)-3-(아미노메틸)-5-메틸헥산산의 비대칭 합성
US7462738B2 (en) 2006-05-24 2008-12-09 Teva Pharmaceutical Industries Ltd. Processes for the preparation of R-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
KR20080036060A (ko) 2006-05-31 2008-04-24 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린의 중간체의 제조에 효소 분할을 이용하는 방법
WO2008062460A2 (en) 2006-10-06 2008-05-29 Cadila Healthcare Limited Crystalline forms of pregabalin
MX2008014759A (es) 2007-03-22 2009-03-09 Teva Pharma Sintesis del acido (s)-(+)-3-(aminometil)-5-metil hexanoico.
WO2008137512A2 (en) 2007-05-03 2008-11-13 Dr. Reddy's Laboratories Ltd. Process for preparing pregabalin via hofmann reaction and crystalline form thereof
WO2008138874A1 (en) 2007-05-09 2008-11-20 Chemo Ibérica, S.A. Process for preparing (s)-pregabalin by optical resolution of racemic pregabalin
WO2009001372A2 (en) 2007-06-25 2008-12-31 Manne Satyanarayana Reddy A novel process for the preparation of pregabalin
WO2009044409A2 (en) 2007-10-01 2009-04-09 Natco Pharma Limited Novel resolution process for pregabalin
ITMI20072262A1 (it) 2007-12-03 2009-06-04 Dipharma Francis Srl Procedimento per la preparazione di acido (s)(+)-3-(amminometil)-5-metilesanoico
US20100312010A1 (en) 2007-12-18 2010-12-09 Watson Pharma Private Limited Process for the Preparation of (S)-Pregabalin
WO2009081208A1 (en) 2007-12-26 2009-07-02 Generics [Uk] Limited Processes to pregabalin
US20110144383A1 (en) 2008-02-18 2011-06-16 Matrix Laboratories Limited Process for preparing (s)-3-(aminomethyl)-5-methylhexanoic acid
EP2262761A1 (en) 2008-04-04 2010-12-22 Generics [UK] Limited Novel process
WO2011141923A2 (en) 2010-05-14 2011-11-17 Lupin Limited Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin

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