JP2015533833A5 - - Google Patents
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- JP2015533833A5 JP2015533833A5 JP2015536909A JP2015536909A JP2015533833A5 JP 2015533833 A5 JP2015533833 A5 JP 2015533833A5 JP 2015536909 A JP2015536909 A JP 2015536909A JP 2015536909 A JP2015536909 A JP 2015536909A JP 2015533833 A5 JP2015533833 A5 JP 2015533833A5
- Authority
- JP
- Japan
- Prior art keywords
- xaa
- group
- lys
- peptide dimer
- asp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 56
- 239000000539 dimer Substances 0.000 claims description 55
- 238000000034 method Methods 0.000 claims description 38
- 150000001875 compounds Chemical class 0.000 claims description 36
- 125000005647 linker group Chemical group 0.000 claims description 31
- 150000008574 D-amino acids Chemical class 0.000 claims description 28
- 239000008194 pharmaceutical composition Substances 0.000 claims description 21
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 19
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 12
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 8
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims description 8
- 125000003118 aryl group Chemical group 0.000 claims description 7
- PECYZEOJVXMISF-UWTATZPHSA-N 3-amino-D-alanine Chemical compound NC[C@@H](N)C(O)=O PECYZEOJVXMISF-UWTATZPHSA-N 0.000 claims description 6
- -1 His Chemical group 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 230000008827 biological function Effects 0.000 claims description 6
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 6
- 239000000178 monomer Substances 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- AHLPHDHHMVZTML-SCSAIBSYSA-N D-Ornithine Chemical compound NCCC[C@@H](N)C(O)=O AHLPHDHHMVZTML-SCSAIBSYSA-N 0.000 claims description 5
- 208000015943 Coeliac disease Diseases 0.000 claims description 4
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 4
- 208000011231 Crohn disease Diseases 0.000 claims description 4
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 4
- 239000002702 enteric coating Substances 0.000 claims description 4
- 238000009505 enteric coating Methods 0.000 claims description 4
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims description 4
- WLJVNTCWHIRURA-UHFFFAOYSA-N pimelic acid Chemical compound OC(=O)CCCCCC(O)=O WLJVNTCWHIRURA-UHFFFAOYSA-N 0.000 claims description 4
- 125000000539 amino acid group Chemical group 0.000 claims description 3
- 230000000699 topical effect Effects 0.000 claims description 3
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 claims description 2
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims description 2
- IEXKUCOGQITOPO-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO IEXKUCOGQITOPO-UHFFFAOYSA-N 0.000 claims description 2
- GDYYIJNDPMFMTB-UHFFFAOYSA-N 2-[3-(carboxymethyl)phenyl]acetic acid Chemical compound OC(=O)CC1=CC=CC(CC(O)=O)=C1 GDYYIJNDPMFMTB-UHFFFAOYSA-N 0.000 claims description 2
- SLWIPPZWFZGHEU-UHFFFAOYSA-N 2-[4-(carboxymethyl)phenyl]acetic acid Chemical compound OC(=O)CC1=CC=C(CC(O)=O)C=C1 SLWIPPZWFZGHEU-UHFFFAOYSA-N 0.000 claims description 2
- 206010006458 Bronchitis chronic Diseases 0.000 claims description 2
- NCFSMLBHQUAMHH-UHFFFAOYSA-N C1=CN=NN=C1.CC(C)(C)OC(=O)C1=C(C(O)=O)C=CC=C1C(O)=O Chemical compound C1=CN=NN=C1.CC(C)(C)OC(=O)C1=C(C(O)=O)C=CC=C1C(O)=O NCFSMLBHQUAMHH-UHFFFAOYSA-N 0.000 claims description 2
- 206010009137 Chronic sinusitis Diseases 0.000 claims description 2
- 102000008186 Collagen Human genes 0.000 claims description 2
- 108010035532 Collagen Proteins 0.000 claims description 2
- 208000005577 Gastroenteritis Diseases 0.000 claims description 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims description 2
- 206010061218 Inflammation Diseases 0.000 claims description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 2
- 206010033645 Pancreatitis Diseases 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 206010062164 Seronegative arthritis Diseases 0.000 claims description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
- 150000001408 amides Chemical class 0.000 claims description 2
- 230000003872 anastomosis Effects 0.000 claims description 2
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims description 2
- 235000010290 biphenyl Nutrition 0.000 claims description 2
- 239000004305 biphenyl Substances 0.000 claims description 2
- 125000006267 biphenyl group Chemical group 0.000 claims description 2
- 206010006451 bronchitis Diseases 0.000 claims description 2
- 238000002512 chemotherapy Methods 0.000 claims description 2
- 208000003167 cholangitis Diseases 0.000 claims description 2
- 201000001352 cholecystitis Diseases 0.000 claims description 2
- 208000023819 chronic asthma Diseases 0.000 claims description 2
- 208000007451 chronic bronchitis Diseases 0.000 claims description 2
- 208000017760 chronic graft versus host disease Diseases 0.000 claims description 2
- 208000027157 chronic rhinosinusitis Diseases 0.000 claims description 2
- 206010009887 colitis Diseases 0.000 claims description 2
- 229920001436 collagen Polymers 0.000 claims description 2
- WRZXKWFJEFFURH-UHFFFAOYSA-N dodecaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO WRZXKWFJEFFURH-UHFFFAOYSA-N 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 208000037902 enteropathy Diseases 0.000 claims description 2
- 230000002349 favourable effect Effects 0.000 claims description 2
- 210000005095 gastrointestinal system Anatomy 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 2
- 230000004054 inflammatory process Effects 0.000 claims description 2
- 208000028774 intestinal disease Diseases 0.000 claims description 2
- 238000007918 intramuscular administration Methods 0.000 claims description 2
- 238000007913 intrathecal administration Methods 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 208000004396 mastitis Diseases 0.000 claims description 2
- 208000008275 microscopic colitis Diseases 0.000 claims description 2
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 claims description 2
- 238000002663 nebulization Methods 0.000 claims description 2
- 230000003256 osteocytic effect Effects 0.000 claims description 2
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims description 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
- 230000000087 stabilizing effect Effects 0.000 claims description 2
- 238000007920 subcutaneous administration Methods 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 1
- NBZBKCUXIYYUSX-UHFFFAOYSA-N iminodiacetic acid Chemical compound OC(=O)CNCC(O)=O NBZBKCUXIYYUSX-UHFFFAOYSA-N 0.000 claims 1
- 238000002271 resection Methods 0.000 claims 1
- 210000001215 vagina Anatomy 0.000 claims 1
- 229940122065 Alpha4beta7 integrin antagonist Drugs 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 102000006495 integrins Human genes 0.000 description 3
- 108010044426 integrins Proteins 0.000 description 3
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 2
- QFGCFKJIPBRJGM-UHFFFAOYSA-N 12-[(2-methylpropan-2-yl)oxy]-12-oxododecanoic acid Chemical compound CC(C)(C)OC(=O)CCCCCCCCCCC(O)=O QFGCFKJIPBRJGM-UHFFFAOYSA-N 0.000 description 1
- 206010017969 Gastrointestinal inflammatory conditions Diseases 0.000 description 1
- 150000007824 aliphatic compounds Chemical class 0.000 description 1
- 150000001491 aromatic compounds Chemical class 0.000 description 1
- 238000012321 colectomy Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002390 heteroarenes Chemical class 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261712722P | 2012-10-11 | 2012-10-11 | |
| US61/712,722 | 2012-10-11 | ||
| US201361807714P | 2013-04-02 | 2013-04-02 | |
| US61/807,714 | 2013-04-02 | ||
| US14/050,349 US9273093B2 (en) | 2012-10-11 | 2013-10-10 | α4β7 peptide dimer antagonists |
| US14/050,349 | 2013-10-10 | ||
| PCT/US2013/064439 WO2014059213A1 (en) | 2012-10-11 | 2013-10-11 | NOVEL α4ß7 PEPTIDE DIMER ANTAGONISTS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018191587A Division JP2019001825A (ja) | 2012-10-11 | 2018-10-10 | 新規なα４β７ペプチド二量体拮抗薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015533833A JP2015533833A (ja) | 2015-11-26 |
| JP2015533833A5 true JP2015533833A5 (enExample) | 2016-12-01 |
| JP6480865B2 JP6480865B2 (ja) | 2019-03-13 |
Family
ID=50477907
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015536909A Active JP6480865B2 (ja) | 2012-10-11 | 2013-10-11 | 新規なα４β７ペプチド二量体拮抗薬 |
| JP2018191587A Pending JP2019001825A (ja) | 2012-10-11 | 2018-10-10 | 新規なα４β７ペプチド二量体拮抗薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018191587A Pending JP2019001825A (ja) | 2012-10-11 | 2018-10-10 | 新規なα４β７ペプチド二量体拮抗薬 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9273093B2 (enExample) |
| EP (1) | EP2906584B1 (enExample) |
| JP (2) | JP6480865B2 (enExample) |
| KR (1) | KR20150084808A (enExample) |
| CN (1) | CN105102470A (enExample) |
| AU (2) | AU2013329135B2 (enExample) |
| CA (1) | CA2888479A1 (enExample) |
| HK (1) | HK1213583A1 (enExample) |
| IL (1) | IL238123A0 (enExample) |
| IN (1) | IN2015DN03039A (enExample) |
| NZ (1) | NZ706909A (enExample) |
| SG (2) | SG11201502812WA (enExample) |
| WO (1) | WO2014059213A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9273093B2 (en) | 2012-10-11 | 2016-03-01 | Protagonist Therapeutics, Inc. | α4β7 peptide dimer antagonists |
| US10351626B2 (en) | 2013-03-14 | 2019-07-16 | The Scripps Research Institute | Targeting agent antibody conjugates and uses thereof |
| KR102236829B1 (ko) | 2013-03-15 | 2021-04-07 | 프로타고니스트 테라퓨틱스, 인코포레이티드 | 헵시딘 유사체 및 이의 용도 |
| US20140294901A1 (en) * | 2013-04-02 | 2014-10-02 | Protagonist Therapeutics, Inc. | Novel a4b7 peptide dimer antagonists |
| JP6822839B2 (ja) | 2013-09-13 | 2021-01-27 | ザ・スクリップス・リサーチ・インスティテュート | 修飾された治療剤、及びその組成物 |
| AU2014364589B2 (en) | 2013-12-18 | 2020-02-27 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| KR102787208B1 (ko) * | 2014-05-16 | 2025-03-27 | 프로타고니스트 테라퓨틱스, 인코포레이티드 | α4β7 인테그린 티오에테르 펩티드 길항제 |
| SG11201700327WA (en) | 2014-07-17 | 2017-02-27 | Protagonist Therapeutics Inc | Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases |
| WO2016054445A1 (en) * | 2014-10-01 | 2016-04-07 | Protagonist Therapeutics, Inc. | Novel cyclic monomer and dimer peptides having integrin antagonist activity |
| KR20170108936A (ko) | 2014-10-01 | 2017-09-27 | 프로타고니스트 테라퓨틱스, 인코포레이티드 | 신규한 α4β7 펩타이드 단량체 및 이량체 길항제 |
| CN107921098A (zh) * | 2015-06-17 | 2018-04-17 | 加州生物医学研究所 | 修饰的治疗剂及其组合物 |
| US10787490B2 (en) | 2015-07-15 | 2020-09-29 | Protaganist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| CN108348581B (zh) | 2015-09-04 | 2022-07-01 | 斯克利普斯研究所 | 胰岛素免疫球蛋白融合蛋白 |
| CN108699110B (zh) | 2015-10-23 | 2023-04-28 | 特温特大学 | 整合素结合肽及其用途 |
| WO2017079820A1 (en) | 2015-11-11 | 2017-05-18 | Encycle Therapeutics, Inc. | CYCLIC PEPTIDES TARGETING α4β7 INTEGRIN |
| WO2017100540A2 (en) | 2015-12-09 | 2017-06-15 | The California Institute For Biomedical Research | Relaxin immunoglobulin fusion proteins and methods of use |
| CA3009834A1 (en) | 2015-12-30 | 2017-07-06 | Protagonist Therapeutics, Inc. | Analogues of hepcidin mimetics with improved in vivo half lives |
| AU2017213886B2 (en) | 2016-02-04 | 2024-03-07 | The California Institute For Biomedical Research | Humanized anti-CD3 antibodies, conjugates and uses thereof |
| US10407468B2 (en) | 2016-03-23 | 2019-09-10 | Protagonist Therapeutics, Inc. | Methods for synthesizing α4β7 peptide antagonists |
| US11111273B2 (en) | 2016-11-11 | 2021-09-07 | Zealand Pharma A/S | Cyclic peptides multimers targeting alpha-4-beta-7 integrin |
| KR20200015540A (ko) * | 2017-05-10 | 2020-02-12 | 인사이클 세라퓨틱스, 인코포레이티드 | α4β7 인테그린을 타겟팅하는 호모데틱 사이클릭 펩타이드 |
| US10278957B2 (en) | 2017-09-11 | 2019-05-07 | Protagonist Therapeutics, Inc. | Opioid agonist peptides and uses thereof |
| WO2019157268A1 (en) | 2018-02-08 | 2019-08-15 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
| US20220185846A1 (en) * | 2019-03-28 | 2022-06-16 | Protagonist Therapeutics, Inc. | Methods for synthesizing beta-homoamino acids |
| JP7534382B2 (ja) | 2019-07-10 | 2024-08-14 | プロタゴニスト セラピューティクス， インコーポレイテッド | インターロイキン－２３受容体のペプチド阻害剤及び炎症性疾患を治療するためのその使用 |
| AU2021205415A1 (en) * | 2020-01-10 | 2022-07-21 | Protagonist Therapeutics, Inc. | Methods for treating inflammatory bowel diseases with α4β7 integrin antagonists |
| IL294680A (en) | 2020-01-15 | 2022-09-01 | Janssen Biotech Inc | Peptide inhibitors of the interleukin-23 receptor and their use for the treatment of inflammatory diseases |
| KR20220141808A (ko) | 2020-01-15 | 2022-10-20 | 얀센 바이오테크 인코포레이티드 | 인터루킨-23 수용체의 펩티드 억제제 및 염증성 질환을 치료하기 위한 이의 용도 |
| WO2022109328A1 (en) | 2020-11-20 | 2022-05-27 | Janssen Pharmaceutica Nv | Compositions of peptide inhibitors of interleukin-23 receptor |
| MX2023014771A (es) | 2021-06-09 | 2024-03-19 | Scripps Research Inst | Conjugados peptidicos duales gip/glp-1 de accion prolongada y metodos de uso. |
| JP2024525732A (ja) | 2021-07-14 | 2024-07-12 | ヤンセン バイオテツク，インコーポレーテツド | インターロイキン－２３受容体の脂質化ペプチド阻害剤 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4684620A (en) | 1984-09-04 | 1987-08-04 | Gibson-Stephens Neuropharmaceuticals, Inc. | Cyclic polypeptides having mu-receptor specificity |
| US4724229A (en) * | 1986-09-30 | 1988-02-09 | Smithkline Beckman Corporation | Arg-arg-arg-vasopressin antagonists |
| CA2106314A1 (en) * | 1991-04-05 | 1992-10-06 | John P. Burnier | Platelet aggregation inhibitors having high specification for gpiibiiia |
| US6037324A (en) | 1996-01-04 | 2000-03-14 | Leukosite, Inc. | Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor |
| US5990084A (en) | 1996-04-19 | 1999-11-23 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| GB9613112D0 (en) | 1996-06-21 | 1996-08-28 | Zeneca Ltd | Chemical compounds |
| WO1999002194A1 (en) * | 1997-07-11 | 1999-01-21 | Innerdyne, Inc. | Methods and systems for preparing and sealing radiation delivery structures |
| US6818617B1 (en) | 1997-08-15 | 2004-11-16 | Temple University- Of The Commonwealth System Of Higher Education | EC-3, an inhibitor of α4β1 and α4β7 integrins |
| CA2309338A1 (en) | 1997-11-24 | 1999-06-03 | Merck & Co., Inc. | Cyclic amino acid derivatives as cell adhesion inhibitors |
| EP1100473A2 (en) * | 1998-07-28 | 2001-05-23 | InnerDyne, Inc. | Absorbable brachytherapy and chemotherapy delivery devices and methods |
| AUPP616498A0 (en) | 1998-09-25 | 1998-10-15 | University Of Queensland, The | Synthesis of cyclic peptides |
| AUPP616598A0 (en) | 1998-09-25 | 1998-10-15 | University Of Queensland, The | Auxiliary for amide bond formation |
| AUPP660698A0 (en) | 1998-10-21 | 1998-11-12 | University Of Queensland, The | A method of protein engineering |
| KR20010110750A (ko) | 1999-04-12 | 2001-12-13 | 앤드류 앵뉴 | 인테그린 길항제로서의 치환된 비사이클릭 헤테로아릴화합물 |
| WO2001068586A2 (en) | 2000-03-14 | 2001-09-20 | Novartis Ag | α4β1 AND α4β7 INTEGRIN INHIBITORS |
| DE10107707A1 (de) | 2001-02-19 | 2002-08-29 | Wilex Biotechnology Gmbh | Antagonisten für alpha¶4¶beta¶7¶-Integrin |
| AUPS039702A0 (en) | 2002-02-08 | 2002-03-07 | University Of Queensland, The | Common protein surface shapes and uses therefor |
| WO2004058307A1 (en) | 2002-12-18 | 2004-07-15 | Wyeth | Methods for screening, treating and diagnosing inflammatory bowel disease and compositions thereof |
| US20070032417A1 (en) | 2002-12-24 | 2007-02-08 | Walter And Eliza Hall Institute Of Medical Research | Peptides and therapeutic uses thereof |
| PL2332968T3 (pl) | 2003-11-05 | 2017-08-31 | Dana-Farber Cancer Institute, Inc. | Stabilizowane alfa-helikalne peptydy i ich zastosowania |
| EP1695255B1 (en) | 2003-12-19 | 2016-09-07 | Applied Biosystems, LLC | Methods and systems for protein and peptide evidence assembly |
| JP4315982B2 (ja) | 2004-01-09 | 2009-08-19 | ファイザー インコーポレイティッド | ＭＡｄＣＡＭに対する抗体 |
| US8536140B2 (en) | 2004-03-12 | 2013-09-17 | Mti Meta Tech Inc. | Methods for treating inflammatory bowel disease |
| JP2008504239A (ja) | 2004-06-24 | 2008-02-14 | ザ ウォルター アンド エリザ ホール インスティテュート オブ メディカル リサーチ | 複合体およびその治療的使用 |
| WO2006062685A2 (en) | 2004-11-11 | 2006-06-15 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
| WO2006058539A2 (en) | 2004-11-30 | 2006-06-08 | Gastrotech Pharma A/S | Growth hormone secretagogue receptor 1a ligands |
| CA2655372A1 (en) | 2006-06-13 | 2007-12-21 | Zymogenetics, Inc. | Il-17 and il-23 antagonists and methods of using the same |
| US9193790B2 (en) | 2006-12-07 | 2015-11-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Use of antagonists of the interaction between HIV GP120 and A4B7 integrin |
| US20080260820A1 (en) | 2007-04-19 | 2008-10-23 | Gilles Borrelly | Oral dosage formulations of protease-resistant polypeptides |
| CA2683145C (en) | 2007-04-27 | 2018-06-12 | Katherine E. Lewis | Antagonists to il-17a, il-17f, and il-23p19 and methods of use |
| WO2009002947A2 (en) * | 2007-06-22 | 2008-12-31 | Affymax, Inc. | Compounds and peptides that bind the trail receptor |
| JP2011501941A (ja) | 2007-07-06 | 2011-01-20 | バロリゼイション エイチエスジェイ， ソシエテ アン コマンディテ | Ｉｌ−２３レセプターのアンタゴニストおよびその使用 |
| WO2009039185A1 (en) * | 2007-09-17 | 2009-03-26 | The Trustees Of Columbia University In The City Of New York | Uses of immunologically modified scaffold for tissue prevascularization and cell transplantation |
| WO2009045536A2 (en) | 2007-10-05 | 2009-04-09 | The University Of North Carolina At Chapel Hill | Receptor targeted oligonucleotides |
| DE102009007381A1 (de) * | 2009-01-29 | 2010-08-05 | Amp-Therapeutics Gmbh & Co. Kg | Antibiotische Peptide |
| US8999935B2 (en) | 2009-02-11 | 2015-04-07 | New York University | Treatment of osteoporosis in peri- and post-menopausal women with hepcidin |
| CN102459311B (zh) * | 2009-04-08 | 2015-08-19 | 武田药品工业株式会社 | 神经调节肽u衍生物 |
| US9523073B2 (en) | 2010-03-31 | 2016-12-20 | Medical Diagnostic Laboratories, Llc | Elisa for a naturally-occurring soluble truncated form of IL-23 receptor |
| WO2012101599A2 (en) | 2011-01-27 | 2012-08-02 | Ramot At Tel-Aviv University Ltd. | Glycogen synthase kinase-3 inhibitors |
| US8946150B2 (en) | 2011-06-14 | 2015-02-03 | Medical Diagnostic Laboratories, LLC. | Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof |
| US9169292B2 (en) | 2011-06-14 | 2015-10-27 | Medical Diagnostic Laboratories, Llc | Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof |
| JP6571333B2 (ja) | 2011-12-09 | 2019-09-04 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 改変ミニヘプシジンペプチドおよびその使用方法 |
| WO2013177432A1 (en) | 2012-05-23 | 2013-11-28 | The University Of Chicago | Methods of treating obesity |
| US9273093B2 (en) | 2012-10-11 | 2016-03-01 | Protagonist Therapeutics, Inc. | α4β7 peptide dimer antagonists |
| WO2014127316A2 (en) | 2013-02-15 | 2014-08-21 | Srx Cardio, Llc | Proprotein convertase subtilisin/kexin type 9 (pcsk9) allosteric binding ligands to mudulate serum low density lipoprotein (ldl) levels |
| US20140294902A1 (en) | 2013-04-02 | 2014-10-02 | Protagonist Therapeutics, Inc. | Novel a4b7 peptide antagonists |
| US20140294901A1 (en) | 2013-04-02 | 2014-10-02 | Protagonist Therapeutics, Inc. | Novel a4b7 peptide dimer antagonists |
| DK3013351T3 (da) | 2013-06-24 | 2020-01-27 | Canbas Co Ltd | Peptider og peptidmimetika i kombinationanvendelser og behandlinger til cancerpatient-subpopulationer |
-
2013
- 2013-10-10 US US14/050,349 patent/US9273093B2/en active Active
- 2013-10-11 AU AU2013329135A patent/AU2013329135B2/en active Active
- 2013-10-11 CN CN201380064713.8A patent/CN105102470A/zh active Pending
- 2013-10-11 KR KR1020157011369A patent/KR20150084808A/ko not_active Ceased
- 2013-10-11 EP EP13845982.1A patent/EP2906584B1/en active Active
- 2013-10-11 NZ NZ706909A patent/NZ706909A/en unknown
- 2013-10-11 WO PCT/US2013/064439 patent/WO2014059213A1/en not_active Ceased
- 2013-10-11 JP JP2015536909A patent/JP6480865B2/ja active Active
- 2013-10-11 IN IN3039DEN2015 patent/IN2015DN03039A/en unknown
- 2013-10-11 SG SG11201502812WA patent/SG11201502812WA/en unknown
- 2013-10-11 CA CA2888479A patent/CA2888479A1/en active Pending
- 2013-10-11 HK HK16101620.8A patent/HK1213583A1/zh unknown
- 2013-10-11 SG SG10201702979SA patent/SG10201702979SA/en unknown
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2015
- 2015-04-02 IL IL238123A patent/IL238123A0/en unknown
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2016
- 2016-01-19 US US15/000,923 patent/US20160368966A1/en not_active Abandoned
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2018
- 2018-03-06 AU AU2018201599A patent/AU2018201599A1/en not_active Abandoned
- 2018-10-10 JP JP2018191587A patent/JP2019001825A/ja active Pending
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2019
- 2019-02-22 US US16/282,908 patent/US20190248870A1/en not_active Abandoned
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