JP2015533372A5 - - Google Patents
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- Publication number
- JP2015533372A5 JP2015533372A5 JP2015537303A JP2015537303A JP2015533372A5 JP 2015533372 A5 JP2015533372 A5 JP 2015533372A5 JP 2015537303 A JP2015537303 A JP 2015537303A JP 2015537303 A JP2015537303 A JP 2015537303A JP 2015533372 A5 JP2015533372 A5 JP 2015533372A5
- Authority
- JP
- Japan
- Prior art keywords
- body structural
- alpha body
- structural sequence
- polypeptide
- positively charged
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 14
- 229920001184 polypeptide Polymers 0.000 claims 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims 13
- 101100177642 Rattus norvegicus Hgs gene Proteins 0.000 claims 4
- 101100129853 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) SRB2 gene Proteins 0.000 claims 4
- OFHCOWSQAMBJIW-AVJTYSNKSA-N alfacalcidol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 claims 4
- 230000003834 intracellular effect Effects 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 101100339677 Arabidopsis thaliana HRS1 gene Proteins 0.000 claims 2
- 101100129874 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) PGD1 gene Proteins 0.000 claims 2
- 101100129591 Schizosaccharomyces pombe (strain 972 / ATCC 24843) mcp6 gene Proteins 0.000 claims 2
- 229940024606 amino acid Drugs 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 230000008827 biological function Effects 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261716783P | 2012-10-22 | 2012-10-22 | |
| EP12189485.1 | 2012-10-22 | ||
| EP12189485 | 2012-10-22 | ||
| US61/716,783 | 2012-10-22 | ||
| PCT/EP2013/072050 WO2014064092A1 (en) | 2012-10-22 | 2013-10-22 | Polypeptides capable of cellular internalization |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015533372A JP2015533372A (ja) | 2015-11-24 |
| JP2015533372A5 true JP2015533372A5 (enExample) | 2016-12-08 |
Family
ID=47046473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015537303A Pending JP2015533372A (ja) | 2012-10-22 | 2013-10-22 | 細胞インターナリゼーション可能なポリペプチド |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10023647B2 (enExample) |
| EP (1) | EP2909233B1 (enExample) |
| JP (1) | JP2015533372A (enExample) |
| AU (1) | AU2013336753B2 (enExample) |
| CA (1) | CA2888930C (enExample) |
| DK (1) | DK2909233T3 (enExample) |
| WO (1) | WO2014064092A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2909235B1 (en) * | 2012-10-22 | 2017-03-29 | Complix NV | Polypeptides specifically binding to il-23 |
| EP3650465A1 (en) | 2018-11-12 | 2020-05-13 | Navigo Proteins Gmbh | Novel populations of polypeptides having a triple-helical structure |
| EP4036117A1 (en) | 2021-01-27 | 2022-08-03 | Complix NV | Mcl-1 binding alphabodies and uses thereof |
| WO2023203127A1 (en) | 2022-04-20 | 2023-10-26 | Vib Vzw | Alphabody-based degrader molecules |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ551934A (en) * | 2004-06-24 | 2009-09-25 | Inst Medical W & E Hall | Conjugates comprising a targeting moiety and a peptide that mimics the apoptosis-inducing BH3-only proteins |
| CA2658015A1 (en) * | 2006-03-30 | 2007-10-11 | Diatos S.A. | Camptothecin-peptide conjugates and pharmaceutical compositions containing the same |
| EP2161278B1 (en) | 2008-09-08 | 2012-05-23 | Complix N.V. | Single-chain coiled coil scaffold |
| JP2012510806A (ja) * | 2008-12-08 | 2012-05-17 | コンプリクス エン ヴェー | 単鎖逆平行コイルドコイルタンパク質 |
| JP5731986B2 (ja) | 2008-12-09 | 2015-06-10 | ダナ ファーバー キャンサー インスティテュート インコーポレイテッド | Ｍｃｌ−１の特異的調節の方法及び組成物 |
| US9221886B2 (en) * | 2009-04-28 | 2015-12-29 | President And Fellows Of Harvard College | Supercharged proteins for cell penetration |
| GB2471692A (en) | 2009-07-08 | 2011-01-12 | Complix Nv | HIV gp41-binding single-chain coiled-coil peptide comprising heptad repeats |
| GB2471693A (en) | 2009-07-08 | 2011-01-12 | Complix Nv | Parathyroid hormone related protein antagonists |
| US20130261049A1 (en) * | 2011-01-06 | 2013-10-03 | Complix Sa | Alphabodies specifically binding to class-i viral fusion proteins and methods for producing the same |
| BR112013017363A2 (pt) * | 2011-01-06 | 2016-08-30 | Complix Sa | biblioteca de alphabody de cadeia única, mistura de bibliotecas de alphabody, ácido nucleico ou biblioteca de vetor, biblioteca de células hospedeiras, uso de uma biblioteca de alphabody de cadeia única, método para a produção de uma biblioteca de alphabody de cadeia única, método para a produção de um ou mais polipeptídeos de alphabody de cadeia única, polipeptíceo de alphabody de cadeia única, ácido nucleico, vetor e célula hospedeira |
| US20140294828A1 (en) | 2011-01-06 | 2014-10-02 | Complix Sa | Alphabodies specifically binding to viral proteins and methods for producing the same |
| JP2014504869A (ja) | 2011-01-06 | 2014-02-27 | コンプリクス エン ヴェー | サイトカインもしくは成長因子および／またはサイトカイン受容体もしくは成長因子受容体に特異的に結合するアルファボディー |
| CA2860666A1 (en) * | 2012-01-06 | 2013-07-11 | Complix Nv | Binding agents to intracellular target molecules |
-
2013
- 2013-10-22 AU AU2013336753A patent/AU2013336753B2/en not_active Ceased
- 2013-10-22 JP JP2015537303A patent/JP2015533372A/ja active Pending
- 2013-10-22 CA CA2888930A patent/CA2888930C/en active Active
- 2013-10-22 EP EP13788700.6A patent/EP2909233B1/en active Active
- 2013-10-22 US US14/437,063 patent/US10023647B2/en active Active
- 2013-10-22 WO PCT/EP2013/072050 patent/WO2014064092A1/en not_active Ceased
- 2013-10-22 DK DK13788700.6T patent/DK2909233T3/en active