JP2017524727A5 - - Google Patents

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Publication number

JP2017524727A5

JP2017524727A5 JP2017514978A JP2017514978A JP2017524727A5 JP 2017524727 A5 JP2017524727 A5 JP 2017524727A5 JP 2017514978 A JP2017514978 A JP 2017514978A JP 2017514978 A JP2017514978 A JP 2017514978A JP 2017524727 A5 JP2017524727 A5 JP 2017524727A5

Authority

JP

Japan

Prior art keywords

diabetic

pharmaceutical composition

sequence

seq

composition according

Prior art date

2015-05-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 206010012601 diabetes mellitus Diseases 0.000 claims 21
• 239000008194 pharmaceutical composition Substances 0.000 claims 21
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
• 208000035475 disorder Diseases 0.000 claims 11
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 10
• 150000001413 amino acids Chemical class 0.000 claims 10
• 206010012689 Diabetic retinopathy Diseases 0.000 claims 9
• 230000001684 chronic effect Effects 0.000 claims 9
• 230000004770 neurodegeneration Effects 0.000 claims 9
• 208000015122 neurodegenerative disease Diseases 0.000 claims 8
• 235000001014 amino acid Nutrition 0.000 claims 6
• 230000002265 prevention Effects 0.000 claims 6
• 108090000765 processed proteins & peptides Proteins 0.000 claims 6
• 201000009101 diabetic angiopathy Diseases 0.000 claims 5
• 229920001184 polypeptide Polymers 0.000 claims 5
• 102000004196 processed proteins & peptides Human genes 0.000 claims 5
• 210000001525 retina Anatomy 0.000 claims 5
• 230000002207 retinal effect Effects 0.000 claims 5
• 201000001320 Atherosclerosis Diseases 0.000 claims 4
• 208000007342 Diabetic Nephropathies Diseases 0.000 claims 4
• 208000008960 Diabetic foot Diseases 0.000 claims 4
• 208000013600 Diabetic vascular disease Diseases 0.000 claims 4
• 208000001344 Macular Edema Diseases 0.000 claims 4
• 206010025415 Macular oedema Diseases 0.000 claims 4
• 208000007014 Retinitis pigmentosa Diseases 0.000 claims 4
• 208000033679 diabetic kidney disease Diseases 0.000 claims 4
• 201000002249 diabetic peripheral angiopathy Diseases 0.000 claims 4
• 201000010230 macular retinal edema Diseases 0.000 claims 4
• 206010012667 Diabetic glaucoma Diseases 0.000 claims 3
• 208000005764 Peripheral Arterial Disease Diseases 0.000 claims 3
• 208000030831 Peripheral arterial occlusive disease Diseases 0.000 claims 3
• 101000687790 Homo sapiens Suppressor of cytokine signaling 1 Proteins 0.000 claims 2
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
• 241001529936 Murinae Species 0.000 claims 2
• 102000058018 Suppressor of Cytokine Signaling 1 Human genes 0.000 claims 2
• 108700027336 Suppressor of Cytokine Signaling 1 Proteins 0.000 claims 2
• 102000058192 human SOCS1 Human genes 0.000 claims 2
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
• 239000002773 nucleotide Substances 0.000 claims 2
• 125000003729 nucleotide group Chemical group 0.000 claims 2
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 2
• 206010054044 Diabetic microangiopathy Diseases 0.000 claims 1
• 208000010412 Glaucoma Diseases 0.000 claims 1
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
• 235000003704 aspartic acid Nutrition 0.000 claims 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 230000002496 gastric effect Effects 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 239000002157 polynucleotide Substances 0.000 claims 1
• 102000040430 polynucleotide Human genes 0.000 claims 1
• 108091033319 polynucleotide Proteins 0.000 claims 1
• 230000000241 respiratory effect Effects 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1
• 230000000699 topical effect Effects 0.000 claims 1