JP2007509984A5 - - Google Patents
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- JP2007509984A5 JP2007509984A5 JP2006538385A JP2006538385A JP2007509984A5 JP 2007509984 A5 JP2007509984 A5 JP 2007509984A5 JP 2006538385 A JP2006538385 A JP 2006538385A JP 2006538385 A JP2006538385 A JP 2006538385A JP 2007509984 A5 JP2007509984 A5 JP 2007509984A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- pedf
- composition according
- peptide
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 33
- 102100035846 Pigment epithelium-derived factor Human genes 0.000 claims 23
- 108090000102 pigment epithelium-derived factor Proteins 0.000 claims 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims 17
- 201000010099 disease Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 210000001519 tissue Anatomy 0.000 claims 10
- 150000001413 amino acids Chemical group 0.000 claims 6
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 4
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 4
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 4
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 235000013922 glutamic acid Nutrition 0.000 claims 4
- 239000004220 glutamic acid Substances 0.000 claims 4
- 229960000310 isoleucine Drugs 0.000 claims 4
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 4
- 201000007914 proliferative diabetic retinopathy Diseases 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 230000033115 angiogenesis Effects 0.000 claims 3
- 230000008728 vascular permeability Effects 0.000 claims 3
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 2
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010029164 Nephrotic syndrome Diseases 0.000 claims 2
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 2
- 206010040047 Sepsis Diseases 0.000 claims 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000033679 diabetic kidney disease Diseases 0.000 claims 2
- 210000002889 endothelial cell Anatomy 0.000 claims 2
- 108010072683 pigment epithelium-derived factor receptor Proteins 0.000 claims 2
- 150000003384 small molecules Chemical class 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 210000005084 renal tissue Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51537403P | 2003-10-29 | 2003-10-29 | |
| PCT/US2004/036245 WO2005041887A2 (en) | 2003-10-29 | 2004-10-29 | Pigment epithelium-derived factor, novel biological activity and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007509984A JP2007509984A (ja) | 2007-04-19 |
| JP2007509984A5 true JP2007509984A5 (enExample) | 2007-12-13 |
Family
ID=34549400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538385A Pending JP2007509984A (ja) | 2003-10-29 | 2004-10-29 | 色素上皮由来因子、その新規な生物活性及びその使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080293626A1 (enExample) |
| EP (1) | EP1684692A2 (enExample) |
| JP (1) | JP2007509984A (enExample) |
| CN (1) | CN101014358A (enExample) |
| AU (1) | AU2004285562B2 (enExample) |
| WO (1) | WO2005041887A2 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004324918B2 (en) | 2004-11-16 | 2011-10-06 | Yeda Research And Development Co.Ltd. At The Weizmann Institute Of Science | Variants of pigment epithelium derived factor and uses thereof |
| US8841259B2 (en) | 2005-02-24 | 2014-09-23 | Joslin Diabetes Center | Compositions and methods for treating vascular permeability |
| WO2007054949A2 (en) | 2005-11-14 | 2007-05-18 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Improved variants of pigment epithelium derived factor and uses thereof |
| EP1986676A4 (en) * | 2006-02-15 | 2009-11-04 | Univ Yale Inc | COMPOSITIONS AND METHODS FOR USE OF PEDF (PIGMENT-BASED EPITHELIC DERIVED FACTOR) PEPTIDE FRAGMENTS |
| ES2329636B2 (es) * | 2006-02-17 | 2010-07-26 | Universitat De Valencia, Estudi General (Participa Con El 70%) | Uso del factor pedf para inducir la auto-renovacion de celulas madre. |
| US20100119512A1 (en) * | 2007-01-25 | 2010-05-13 | Joslin Diabetes Center | Methods of diagnosing, treating, and preventing increased vascular permeability |
| CN101977931A (zh) * | 2008-03-18 | 2011-02-16 | 国立大学法人北海道大学 | 多肽及包含该多肽的药物组合物 |
| CA2776748A1 (en) * | 2009-10-08 | 2011-04-14 | Neurotech Usa, Inc. | Use of pedf in an encapsulated cell-based delivery system |
| EP2508196B1 (en) | 2011-03-23 | 2018-09-26 | Mackay Memorial Hospital | Use of PEDF-derived polypeptides for promoting stem cells proliferation and wound healing |
| US20130046283A1 (en) * | 2011-05-05 | 2013-02-21 | Medtronic Vascular, Inc. | Methods and intravascular treatment devices for treatment of atherosclerosis |
| TWI554521B (zh) * | 2011-10-19 | 2016-10-21 | 台灣基督長老教會馬偕醫療財團法人馬偕紀念醫院 | 色素上皮衍生因子衍生之多胜肽於治療禿髮和／或毛髮脫色之用途 |
| CN102757497B (zh) * | 2012-07-16 | 2014-09-17 | 中山大学 | 一种抗pedf单克隆抗体及其制备方法和应用 |
| EP2895502B1 (en) | 2012-09-17 | 2018-09-05 | Mackay Memorial Hospital | Use of pedf-derived polypeptides for treating alopecia and/or hair depigmentation |
| CN104903346B (zh) * | 2012-09-19 | 2019-04-09 | 财团法人台湾基督长老教会马偕纪念社会事业基金会马偕纪念医院 | Pedf衍生的多肽在预防和/或缓和皮肤老化中的用途 |
| TWI449532B (zh) * | 2012-09-19 | 2014-08-21 | Mackay Memorial Hospital | 色素上皮衍生因子衍生之多胜肽於預防和／或緩和皮膚老化之用途 |
| JP6208763B2 (ja) * | 2012-09-20 | 2017-10-11 | マクカイ メモリアル ホスピタル | 変形性関節症を治療するためのｐｅｄｆ−由来のポリペプチドの使用 |
| TWI491407B (zh) * | 2012-09-20 | 2015-07-11 | Mackay Memorial Hospital | 色素上皮衍生因子衍生之多胜肽於治療骨性關節炎之用途 |
| WO2015038891A2 (en) | 2013-09-13 | 2015-03-19 | The Penn State Research Foundation | Functional peptide analogs of pedf |
| US11230719B2 (en) * | 2014-03-26 | 2022-01-25 | Denovo Biopharma Llc | Retroviral vector having immune-stimulating activity |
| JP6896641B2 (ja) * | 2015-03-02 | 2021-06-30 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ | 血管新生阻害ペプチド |
| KR20190066030A (ko) * | 2016-10-07 | 2019-06-12 | 브림 바이오테크놀로지, 인코퍼레이티드 | Pedf-유래 짧은 펩타이드를 포함하는 조성물 및 그것의 사용 |
| JP6469767B2 (ja) * | 2017-07-05 | 2019-02-13 | マクカイ メモリアル ホスピタル | 皮膚老化を予防及び／又は改善するためのｐｅｄｆ−由来ポリペプチドの使用 |
| JP6522063B2 (ja) * | 2017-08-10 | 2019-05-29 | マクカイ メモリアル ホスピタル | 脱毛症及び／又は毛髪色素脱失を治療するためのｐｅｄｆ由来のポリペプチドの使用 |
| EA202092366A1 (ru) * | 2018-04-08 | 2021-01-26 | Брим Байотекнолоджи, Инк. | Применение происходящих из pedf коротких пептидов при лечении остеоартрита |
| CN111760019B (zh) * | 2019-08-16 | 2023-09-05 | 董红燕 | Pedf在制备保护慢性肺损伤药物中的应用 |
| CN112390877B (zh) * | 2019-08-16 | 2022-10-04 | 董红燕 | Pedf衍生多肽组合物及其在制备保护肺损伤药物中的应用 |
| US12221494B2 (en) * | 2019-08-27 | 2025-02-11 | Mackay Memorial Hospital | Short synthetic peptides and their uses for treating retinal degenerative diseases and/or tissue injuries |
| JP2022550907A (ja) * | 2019-10-06 | 2022-12-05 | ブリム バイオテクノロジー インク | Ｐｅｄｆ由来短ペプチド（ｐｄｓｐ）を含む組成物及びその使用 |
| CN114057831B (zh) * | 2020-08-07 | 2024-03-12 | 三凡生技研发股份有限公司 | 促进血管增生的短链胜肽及其促进糖尿病伤口愈合的用途 |
| WO2025117767A1 (en) * | 2023-11-29 | 2025-06-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modified pigment epithelium-derived factor peptides and methods of use |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010021382A1 (en) * | 1991-03-29 | 2001-09-13 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists |
| US6451763B1 (en) * | 1992-06-04 | 2002-09-17 | The United States Of America As Represented By The Department Of Health And Human Services | Retinal pigmented epithelium derived neurotrophic factor and methods of use |
| US7105496B2 (en) * | 1998-07-23 | 2006-09-12 | Northwestern University | Methods and compositions for inhibiting angiogenesis |
| US6821775B1 (en) * | 2000-02-11 | 2004-11-23 | Genvec, Inc. | Viral vector encoding pigment epithelium-derived factor |
| EP1265627B1 (en) * | 2000-02-23 | 2008-11-05 | Northwestern University | Pharmaceutical compositions for inhibiting angiogenesis by pedf fragments |
| US20020164668A1 (en) * | 2000-04-03 | 2002-11-07 | Durham L. Kathryn | Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of alzheimer's disease |
| IL147444A0 (en) * | 2002-01-03 | 2002-08-14 | Yeda Res & Dev | Process for the production of pigment epithelium derived factor (pedf) from human blood and uses thereof |
| US20030158112A1 (en) * | 2002-02-15 | 2003-08-21 | Johns Hopkins University School Of Medicine | Selective induction of apoptosis to treat ocular disease |
| AU2003275259A1 (en) * | 2002-09-26 | 2004-04-19 | Northwestern University | Anti-angiogenic fragments of pigment epithelium-derived factor (pedf) |
| WO2004050027A2 (en) * | 2002-12-02 | 2004-06-17 | Genvec, Inc. | Materials and methods for treating ocular-related disorders |
| WO2005089811A1 (en) * | 2004-03-12 | 2005-09-29 | Genvec, Inc. | Materials for treating vascular leakage in the eye |
-
2004
- 2004-10-29 CN CNA200480039358XA patent/CN101014358A/zh active Pending
- 2004-10-29 WO PCT/US2004/036245 patent/WO2005041887A2/en not_active Ceased
- 2004-10-29 EP EP04810174A patent/EP1684692A2/en not_active Withdrawn
- 2004-10-29 JP JP2006538385A patent/JP2007509984A/ja active Pending
- 2004-10-29 AU AU2004285562A patent/AU2004285562B2/en not_active Ceased
-
2006
- 2006-04-26 US US11/413,118 patent/US20080293626A1/en not_active Abandoned