CN101014358A - 色素上皮所衍生因子的生物活性及使用方法 - Google Patents

色素上皮所衍生因子的生物活性及使用方法 Download PDF

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CN101014358A
CN101014358A CNA200480039358XA CN200480039358A CN101014358A CN 101014358 A CN101014358 A CN 101014358A CN A200480039358X A CNA200480039358X A CN A200480039358XA CN 200480039358 A CN200480039358 A CN 200480039358A CN 101014358 A CN101014358 A CN 101014358A
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pedf
amino acid
tissue
peptide
symptom
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P·童
H·刘
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Johns Hopkins University
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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CNA200480039358XA 2003-10-29 2004-10-29 色素上皮所衍生因子的生物活性及使用方法 Pending CN101014358A (zh)

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US51537403P 2003-10-29 2003-10-29
US60/515,374 2003-10-29

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US (1) US20080293626A1 (enExample)
EP (1) EP1684692A2 (enExample)
JP (1) JP2007509984A (enExample)
CN (1) CN101014358A (enExample)
AU (1) AU2004285562B2 (enExample)
WO (1) WO2005041887A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102757497A (zh) * 2012-07-16 2012-10-31 中山大学 一种抗pedf单克隆抗体及其制备方法和应用
CN104903345A (zh) * 2012-09-17 2015-09-09 财团法人台湾基督长老教会马偕纪念社会事业基金会马偕纪念医院 Pedf衍生的多肽在治疗脱发和/或毛发脱色中的用途
CN111760019A (zh) * 2019-08-16 2020-10-13 董红燕 Pedf在制备保护肺损伤药物中的应用
CN112390877A (zh) * 2019-08-16 2021-02-23 董红燕 Pedf衍生多肽组合物及其在制备保护肺损伤药物中的应用
CN113727990A (zh) * 2019-08-27 2021-11-30 曹友平 短合成肽及其治疗视网膜退化性疾病和/或组织损伤的用途
CN114057831A (zh) * 2020-08-07 2022-02-18 三凡生技研发股份有限公司 促进血管增生的短链胜肽及其促进糖尿病伤口愈合的用途

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WO2006054278A2 (en) 2004-11-16 2006-05-26 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Variants of pigment epithelium derived factor and uses thereof
EP1858542A4 (en) * 2005-02-24 2009-08-19 Joslin Diabetes Center Inc COMPOSITIONS AND METHOD FOR THE TREATMENT OF VASPEREPERMABILITY
AU2006313318B2 (en) 2005-11-14 2012-04-05 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Improved variants of pigment epithelium derived factor and uses thereof
US20090069241A1 (en) * 2006-02-15 2009-03-12 Yale University Compositions and Methods for Use of Pigment Epithelial Derived Factor (PEDF) Peptide Fragments
ES2329636B2 (es) * 2006-02-17 2010-07-26 Universitat De Valencia, Estudi General (Participa Con El 70%) Uso del factor pedf para inducir la auto-renovacion de celulas madre.
US20100119512A1 (en) * 2007-01-25 2010-05-13 Joslin Diabetes Center Methods of diagnosing, treating, and preventing increased vascular permeability
US20110092427A1 (en) 2008-03-18 2011-04-21 National University Corporation Hokkaido Universit y Polypeptide and pharmaceutical composition containing the polypeptide
JP2013507373A (ja) * 2009-10-08 2013-03-04 ニューロテック ユーエスエー， インコーポレイテッド 被包された細胞ベースの送達系におけるｐｅｄｆの使用
EP2508196B1 (en) 2011-03-23 2018-09-26 Mackay Memorial Hospital Use of PEDF-derived polypeptides for promoting stem cells proliferation and wound healing
US20130046283A1 (en) * 2011-05-05 2013-02-21 Medtronic Vascular, Inc. Methods and intravascular treatment devices for treatment of atherosclerosis
TWI554521B (zh) * 2011-10-19 2016-10-21 台灣基督長老教會馬偕醫療財團法人馬偕紀念醫院 色素上皮衍生因子衍生之多胜肽於治療禿髮和／或毛髮脫色之用途
US9815878B2 (en) 2012-09-19 2017-11-14 Mackay Memorial Hospital Use of PEDF-derived polypeptides for preventing and/or ameliorating skin aging
TWI449532B (zh) * 2012-09-19 2014-08-21 Mackay Memorial Hospital 色素上皮衍生因子衍生之多胜肽於預防和／或緩和皮膚老化之用途
TWI491407B (zh) * 2012-09-20 2015-07-11 Mackay Memorial Hospital 色素上皮衍生因子衍生之多胜肽於治療骨性關節炎之用途
CN104903344B (zh) * 2012-09-20 2018-09-04 财团法人台湾基督长老教会马偕纪念社会事业基金会马偕纪念医院 Pedf衍生的多肽在治疗骨关节炎中的用途
US9611314B2 (en) 2013-09-13 2017-04-04 The Penn State Research Foundation Functional peptide analogs of PEDF
US11230719B2 (en) * 2014-03-26 2022-01-25 Denovo Biopharma Llc Retroviral vector having immune-stimulating activity
JP6896641B2 (ja) * 2015-03-02 2021-06-30 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ 血管新生阻害ペプチド
WO2018067244A1 (en) * 2016-10-07 2018-04-12 Brim Biotechnology, Inc. Compositions comprising pedf-derived short peptides and uses thereof
JP6469767B2 (ja) * 2017-07-05 2019-02-13 マクカイ メモリアル ホスピタル 皮膚老化を予防及び／又は改善するためのｐｅｄｆ−由来ポリペプチドの使用
JP6522063B2 (ja) * 2017-08-10 2019-05-29 マクカイ メモリアル ホスピタル 脱毛症及び／又は毛髪色素脱失を治療するためのｐｅｄｆ由来のポリペプチドの使用
EA202092366A1 (ru) * 2018-04-08 2021-01-26 Брим Байотекнолоджи, Инк. Применение происходящих из pedf коротких пептидов при лечении остеоартрита
JP2022550907A (ja) * 2019-10-06 2022-12-05 ブリム バイオテクノロジー インク Ｐｅｄｆ由来短ペプチド（ｐｄｓｐ）を含む組成物及びその使用
WO2025117767A1 (en) * 2023-11-29 2025-06-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Modified pigment epithelium-derived factor peptides and methods of use

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US7105496B2 (en) * 1998-07-23 2006-09-12 Northwestern University Methods and compositions for inhibiting angiogenesis
US6821775B1 (en) * 2000-02-11 2004-11-23 Genvec, Inc. Viral vector encoding pigment epithelium-derived factor
ATE413185T1 (de) * 2000-02-23 2008-11-15 Univ Northwestern Pharmazeutische zusammensetzung zur angiogenese- hemmung mittels eines pedf-fragmentes
JP2004505609A (ja) * 2000-04-03 2004-02-26 オックスフォード　グリコサイエンシズ（ユーケー）　リミテッド 核酸分子、ポリペプチド、ならびにアルツハイマー病の診断および処置を含むそれらの使用
IL147444A0 (en) * 2002-01-03 2002-08-14 Yeda Res & Dev Process for the production of pigment epithelium derived factor (pedf) from human blood and uses thereof
US20030158112A1 (en) * 2002-02-15 2003-08-21 Johns Hopkins University School Of Medicine Selective induction of apoptosis to treat ocular disease
AU2003275259A1 (en) * 2002-09-26 2004-04-19 Northwestern University Anti-angiogenic fragments of pigment epithelium-derived factor (pedf)
EP1567198A4 (en) * 2002-12-02 2006-05-31 Genvec Inc MATERIALS AND METHOD FOR THE TREATMENT OF EYE DISEASES
US20050260180A1 (en) * 2004-03-12 2005-11-24 Genvec, Inc. Materials and methods for treating vascular leakage in the eye

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102757497A (zh) * 2012-07-16 2012-10-31 中山大学 一种抗pedf单克隆抗体及其制备方法和应用
CN102757497B (zh) * 2012-07-16 2014-09-17 中山大学 一种抗pedf单克隆抗体及其制备方法和应用
CN104903345A (zh) * 2012-09-17 2015-09-09 财团法人台湾基督长老教会马偕纪念社会事业基金会马偕纪念医院 Pedf衍生的多肽在治疗脱发和/或毛发脱色中的用途
US9938328B2 (en) 2012-09-17 2018-04-10 Mackay Memorial Hospital Use of PEDF-derived polypeptides for treating alopecia and/or hair depigmentation
CN104903345B (zh) * 2012-09-17 2019-02-15 财团法人台湾基督长老教会马偕纪念社会事业基金会马偕纪念医院 Pedf衍生的多肽在治疗脱发和/或毛发脱色中的用途
CN112390877A (zh) * 2019-08-16 2021-02-23 董红燕 Pedf衍生多肽组合物及其在制备保护肺损伤药物中的应用
CN111760019A (zh) * 2019-08-16 2020-10-13 董红燕 Pedf在制备保护肺损伤药物中的应用
CN112390877B (zh) * 2019-08-16 2022-10-04 董红燕 Pedf衍生多肽组合物及其在制备保护肺损伤药物中的应用
CN111760019B (zh) * 2019-08-16 2023-09-05 董红燕 Pedf在制备保护慢性肺损伤药物中的应用
CN113727990A (zh) * 2019-08-27 2021-11-30 曹友平 短合成肽及其治疗视网膜退化性疾病和/或组织损伤的用途
CN113727990B (zh) * 2019-08-27 2024-05-28 曹友平 短合成肽及其治疗视网膜退化性疾病和/或组织损伤的用途
CN114057831A (zh) * 2020-08-07 2022-02-18 三凡生技研发股份有限公司 促进血管增生的短链胜肽及其促进糖尿病伤口愈合的用途
CN114057831B (zh) * 2020-08-07 2024-03-12 三凡生技研发股份有限公司 促进血管增生的短链胜肽及其促进糖尿病伤口愈合的用途

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