JP2015533213A5 - - Google Patents
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- Publication number
- JP2015533213A5 JP2015533213A5 JP2015535149A JP2015535149A JP2015533213A5 JP 2015533213 A5 JP2015533213 A5 JP 2015533213A5 JP 2015535149 A JP2015535149 A JP 2015535149A JP 2015535149 A JP2015535149 A JP 2015535149A JP 2015533213 A5 JP2015533213 A5 JP 2015533213A5
- Authority
- JP
- Japan
- Prior art keywords
- bacterial antigen
- ibs
- markers
- array
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001580 bacterial effect Effects 0.000 claims 22
- 239000000427 antigen Substances 0.000 claims 18
- 102000036639 antigens Human genes 0.000 claims 18
- 108091007433 antigens Proteins 0.000 claims 18
- 238000000034 method Methods 0.000 claims 18
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 13
- 210000003630 histaminocyte Anatomy 0.000 claims 8
- 239000003550 marker Substances 0.000 claims 7
- 239000002771 cell marker Substances 0.000 claims 4
- 238000007477 logistic regression Methods 0.000 claims 4
- 238000007619 statistical method Methods 0.000 claims 4
- 241000588724 Escherichia coli Species 0.000 claims 3
- 230000000890 antigenic effect Effects 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 claims 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims 2
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 claims 1
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims 1
- 101100227198 Campylobacter jejuni flaA gene Proteins 0.000 claims 1
- 101100173787 Campylobacter jejuni flaB gene Proteins 0.000 claims 1
- 206010010774 Constipation Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 241001333951 Escherichia coli O157 Species 0.000 claims 1
- 241000607768 Shigella Species 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 claims 1
- 229960000258 corticotropin Drugs 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims 1
- 229960002986 dinoprostone Drugs 0.000 claims 1
- 229960001340 histamine Drugs 0.000 claims 1
- 229960000890 hydrocortisone Drugs 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 claims 1
- 229940076279 serotonin Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261710574P | 2012-10-05 | 2012-10-05 | |
| US61/710,574 | 2012-10-05 | ||
| US201361871853P | 2013-08-29 | 2013-08-29 | |
| US61/871,853 | 2013-08-29 | ||
| PCT/IB2013/059045 WO2014053996A2 (en) | 2012-10-05 | 2013-10-01 | Antibodies to microbiome, stress factors and mast cell markers as diagnostic markers for ibs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015533213A JP2015533213A (ja) | 2015-11-19 |
| JP2015533213A5 true JP2015533213A5 (enExample) | 2016-11-24 |
| JP6329553B2 JP6329553B2 (ja) | 2018-05-23 |
Family
ID=49447585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015535149A Expired - Fee Related JP6329553B2 (ja) | 2012-10-05 | 2013-10-01 | Ｉｂｓの診断マーカーとしての微生物バイオームに対する抗体、ストレス因子及びマスト細胞マーカー |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10184940B2 (enExample) |
| EP (1) | EP2904395B1 (enExample) |
| JP (1) | JP6329553B2 (enExample) |
| CN (1) | CN104884959B (enExample) |
| AU (1) | AU2013326133B2 (enExample) |
| CA (1) | CA2886991A1 (enExample) |
| MX (1) | MX360479B (enExample) |
| SG (2) | SG11201502641YA (enExample) |
| WO (1) | WO2014053996A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0720250D0 (en) * | 2007-10-17 | 2007-11-28 | Univ Edinburgh | Immunogenic compositions containing escherichia coli h7 flagella and methods of use thereof |
| US20160096819A1 (en) * | 2013-05-17 | 2016-04-07 | Basf Se | Process for preparing n-substituted 1h-pyrazole-5-carboxylic acid compounds and derivatives thereof |
| RU2015155552A (ru) | 2013-05-24 | 2017-06-27 | Нестек С.А. | Путеспецифические способы прогнозирования диагноза синдрома раздраженного кишечника |
| WO2017079653A2 (en) | 2015-11-06 | 2017-05-11 | Vetica Labs, Inc. | Methods of detecting inflammatory markers and treating inflammatory conditions in companion animals |
| EP3421616A1 (en) * | 2017-06-29 | 2019-01-02 | Tata Consultancy Services Limited | Method and system for monitoring the gut health of an individual |
| CN111432825A (zh) * | 2017-10-03 | 2020-07-17 | 赛里斯治疗公司 | 色胺代谢的操纵 |
| JP6533930B1 (ja) * | 2018-08-23 | 2019-06-26 | 一般社団法人日本農業フロンティア開発機構 | 疾病評価指標算出方法、装置、システム、及び、プログラム、並びに、疾病評価指標を算出するためのモデル作成方法。 |
| US11884958B2 (en) | 2019-04-30 | 2024-01-30 | Mayo Foundation For Medical Education And Research | Assessing and treating functional gastrointestinal disorders |
| WO2025071560A1 (en) * | 2023-09-28 | 2025-04-03 | Rutgers, The State University Of New Jersey | Methods of diagnosing b cell malignancies, detecting b cell malignancy relapse, and treating thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003298703A1 (en) * | 2002-11-22 | 2004-06-18 | Emory University | Diagnostic tests and methods for diagnosing inflammatory bowel disease |
| US20060154276A1 (en) * | 2004-05-13 | 2006-07-13 | Prometheus Laboratories Inc. | Methods of diagnosing inflammatory bowel disease |
| US7943328B1 (en) * | 2006-03-03 | 2011-05-17 | Prometheus Laboratories Inc. | Method and system for assisting in diagnosing irritable bowel syndrome |
| US20080085524A1 (en) | 2006-08-15 | 2008-04-10 | Prometheus Laboratories Inc. | Methods for diagnosing irritable bowel syndrome |
| US20100094560A1 (en) * | 2006-08-15 | 2010-04-15 | Prometheus Laboratories Inc. | Methods for diagnosing irritable bowel syndrome |
| WO2011027971A2 (ko) * | 2009-09-01 | 2011-03-10 | 주식회사이언메딕스 | 장내 공생 세균유래 세포밖 소포체, 및 이를 이용한 질병모델, 백신, 후보 약물 탐색 방법, 및 진단 방법 |
| EP2494074A4 (en) * | 2009-10-30 | 2013-06-12 | Nestec Sa | METHOD FOR DIAGNOSING IRRITATION SYNDROME |
-
2013
- 2013-10-01 JP JP2015535149A patent/JP6329553B2/ja not_active Expired - Fee Related
- 2013-10-01 CN CN201380063446.2A patent/CN104884959B/zh not_active Expired - Fee Related
- 2013-10-01 AU AU2013326133A patent/AU2013326133B2/en not_active Expired - Fee Related
- 2013-10-01 MX MX2015004271A patent/MX360479B/es active IP Right Grant
- 2013-10-01 WO PCT/IB2013/059045 patent/WO2014053996A2/en not_active Ceased
- 2013-10-01 EP EP13779635.5A patent/EP2904395B1/en not_active Not-in-force
- 2013-10-01 SG SG11201502641YA patent/SG11201502641YA/en unknown
- 2013-10-01 CA CA2886991A patent/CA2886991A1/en not_active Abandoned
- 2013-10-01 SG SG10201702773QA patent/SG10201702773QA/en unknown
-
2015
- 2015-03-30 US US14/673,660 patent/US10184940B2/en active Active
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