CN104884959B - 作为ibs的诊断标志物的微生物组抗体、应激因子和肥大细胞标志物 - Google Patents

作为ibs的诊断标志物的微生物组抗体、应激因子和肥大细胞标志物 Download PDF

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Publication number
CN104884959B
CN104884959B CN201380063446.2A CN201380063446A CN104884959B CN 104884959 B CN104884959 B CN 104884959B CN 201380063446 A CN201380063446 A CN 201380063446A CN 104884959 B CN104884959 B CN 104884959B
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CN
China
Prior art keywords
ibs
antibody
bacterial antigen
markers
marker
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Expired - Fee Related
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CN201380063446.2A
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English (en)
Chinese (zh)
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CN104884959A (zh
Inventor
S·辛格
N·驰-关凌
S-L·王
F·普林森
S·威斯汀
S·洛克腾
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Societe des Produits Nestle SA
Original Assignee
Societe dAssistance Technique pour Produits Nestle SA
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201380063446.2A 2012-10-05 2013-10-01 作为ibs的诊断标志物的微生物组抗体、应激因子和肥大细胞标志物 Expired - Fee Related CN104884959B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261710574P 2012-10-05 2012-10-05
US61/710,574 2012-10-05
US201361871853P 2013-08-29 2013-08-29
US61/871,853 2013-08-29
PCT/IB2013/059045 WO2014053996A2 (en) 2012-10-05 2013-10-01 Antibodies to microbiome, stress factors and mast cell markers as diagnostic markers for ibs

Publications (2)

Publication Number Publication Date
CN104884959A CN104884959A (zh) 2015-09-02
CN104884959B true CN104884959B (zh) 2017-12-01

Family

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Family Applications (1)

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CN201380063446.2A Expired - Fee Related CN104884959B (zh) 2012-10-05 2013-10-01 作为ibs的诊断标志物的微生物组抗体、应激因子和肥大细胞标志物

Country Status (9)

Country Link
US (1) US10184940B2 (enExample)
EP (1) EP2904395B1 (enExample)
JP (1) JP6329553B2 (enExample)
CN (1) CN104884959B (enExample)
AU (1) AU2013326133B2 (enExample)
CA (1) CA2886991A1 (enExample)
MX (1) MX360479B (enExample)
SG (2) SG11201502641YA (enExample)
WO (1) WO2014053996A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0720250D0 (en) * 2007-10-17 2007-11-28 Univ Edinburgh Immunogenic compositions containing escherichia coli h7 flagella and methods of use thereof
US20160096819A1 (en) * 2013-05-17 2016-04-07 Basf Se Process for preparing n-substituted 1h-pyrazole-5-carboxylic acid compounds and derivatives thereof
RU2015155552A (ru) 2013-05-24 2017-06-27 Нестек С.А. Путеспецифические способы прогнозирования диагноза синдрома раздраженного кишечника
WO2017079653A2 (en) 2015-11-06 2017-05-11 Vetica Labs, Inc. Methods of detecting inflammatory markers and treating inflammatory conditions in companion animals
EP3421616A1 (en) * 2017-06-29 2019-01-02 Tata Consultancy Services Limited Method and system for monitoring the gut health of an individual
CN111432825A (zh) * 2017-10-03 2020-07-17 赛里斯治疗公司 色胺代谢的操纵
JP6533930B1 (ja) * 2018-08-23 2019-06-26 一般社団法人日本農業フロンティア開発機構 疾病評価指標算出方法、装置、システム、及び、プログラム、並びに、疾病評価指標を算出するためのモデル作成方法。
US11884958B2 (en) 2019-04-30 2024-01-30 Mayo Foundation For Medical Education And Research Assessing and treating functional gastrointestinal disorders
WO2025071560A1 (en) * 2023-09-28 2025-04-03 Rutgers, The State University Of New Jersey Methods of diagnosing b cell malignancies, detecting b cell malignancy relapse, and treating thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060154276A1 (en) * 2004-05-13 2006-07-13 Prometheus Laboratories Inc. Methods of diagnosing inflammatory bowel disease
US20100094560A1 (en) * 2006-08-15 2010-04-15 Prometheus Laboratories Inc. Methods for diagnosing irritable bowel syndrome
US7943328B1 (en) * 2006-03-03 2011-05-17 Prometheus Laboratories Inc. Method and system for assisting in diagnosing irritable bowel syndrome
CN102480932A (zh) * 2009-09-01 2012-05-30 阿昂梅迪克斯公司 源于肠道共生细菌的细胞外小泡及利用其的疾病模型、疫苗、备选药物筛选方法与诊断方法
CN102712956A (zh) * 2009-10-30 2012-10-03 普罗米修斯实验室股份有限公司 肠易激综合征的诊断方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003298703A1 (en) * 2002-11-22 2004-06-18 Emory University Diagnostic tests and methods for diagnosing inflammatory bowel disease
US20080085524A1 (en) 2006-08-15 2008-04-10 Prometheus Laboratories Inc. Methods for diagnosing irritable bowel syndrome

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060154276A1 (en) * 2004-05-13 2006-07-13 Prometheus Laboratories Inc. Methods of diagnosing inflammatory bowel disease
US7943328B1 (en) * 2006-03-03 2011-05-17 Prometheus Laboratories Inc. Method and system for assisting in diagnosing irritable bowel syndrome
US20100094560A1 (en) * 2006-08-15 2010-04-15 Prometheus Laboratories Inc. Methods for diagnosing irritable bowel syndrome
CN102480932A (zh) * 2009-09-01 2012-05-30 阿昂梅迪克斯公司 源于肠道共生细菌的细胞外小泡及利用其的疾病模型、疫苗、备选药物筛选方法与诊断方法
CN102712956A (zh) * 2009-10-30 2012-10-03 普罗米修斯实验室股份有限公司 肠易激综合征的诊断方法

Also Published As

Publication number Publication date
MX360479B (es) 2018-11-05
EP2904395A2 (en) 2015-08-12
SG10201702773QA (en) 2017-06-29
US10184940B2 (en) 2019-01-22
EP2904395B1 (en) 2018-09-05
WO2014053996A3 (en) 2014-05-30
CA2886991A1 (en) 2014-04-10
SG11201502641YA (en) 2015-05-28
CN104884959A (zh) 2015-09-02
AU2013326133B2 (en) 2019-07-04
JP6329553B2 (ja) 2018-05-23
JP2015533213A (ja) 2015-11-19
US20150346200A1 (en) 2015-12-03
MX2015004271A (es) 2015-08-14
HK1213050A1 (en) 2016-06-24
WO2014053996A2 (en) 2014-04-10
AU2013326133A1 (en) 2015-04-23

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Effective date of registration: 20190723

Address after: Vevey

Patentee after: SOCIETE DES PRODUITS NESTLE S. A.

Address before: Vevey

Patentee before: Nestle Products Technical Assistance Co., Ltd.

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20171201

Termination date: 20201001