JP2015533142A - エルタペネム中間体の製造 - Google Patents

エルタペネム中間体の製造 Download PDF

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Publication number
JP2015533142A
JP2015533142A JP2015536143A JP2015536143A JP2015533142A JP 2015533142 A JP2015533142 A JP 2015533142A JP 2015536143 A JP2015536143 A JP 2015536143A JP 2015536143 A JP2015536143 A JP 2015536143A JP 2015533142 A JP2015533142 A JP 2015533142A
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Japan
Prior art keywords
formula
compound
salt
solvate
residue
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JP2015536143A
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English (en)
Japanese (ja)
Inventor
レンガウアー，ハンネス
エンドル，ビルギット
フェルツマン，ボルフガング
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Sandoz AG
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Sandoz AG
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Publication of JP2015533142A publication Critical patent/JP2015533142A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2015536143A 2012-10-12 2013-10-11 エルタペネム中間体の製造 Pending JP2015533142A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12188351 2012-10-12
EP12188351.6 2012-10-12
PCT/EP2013/071252 WO2014057079A1 (en) 2012-10-12 2013-10-11 Preparation of ertapenem intermediates

Publications (1)

Publication Number Publication Date
JP2015533142A true JP2015533142A (ja) 2015-11-19

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ID=47022553

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015536143A Pending JP2015533142A (ja) 2012-10-12 2013-10-11 エルタペネム中間体の製造

Country Status (9)

Country Link
US (2) US9546171B2 (enEXAMPLES)
EP (1) EP2906561A1 (enEXAMPLES)
JP (1) JP2015533142A (enEXAMPLES)
KR (1) KR20150065176A (enEXAMPLES)
CN (1) CN104703986A (enEXAMPLES)
AU (1) AU2013328585A1 (enEXAMPLES)
CA (1) CA2887098A1 (enEXAMPLES)
IN (1) IN2015DN02513A (enEXAMPLES)
WO (1) WO2014057079A1 (enEXAMPLES)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015533142A (ja) * 2012-10-12 2015-11-19 サンド・アクチエンゲゼルシヤフト エルタペネム中間体の製造
CN113880839A (zh) * 2021-11-01 2022-01-04 石药集团中诺药业（石家庄）有限公司 一种厄他培南钠粗品的合成新方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06506704A (ja) * 1992-02-04 1994-07-28 ゼネカ　リミテッド 抗生物質組成物
US5872250A (en) * 1997-07-30 1999-02-16 Merck & Co., Inc. Process for synthesizing carbapenem antibiotics
CN1752090A (zh) * 2005-10-20 2006-03-29 上海交通大学 尔他培南钠盐的制备方法
CN101935321A (zh) * 2010-07-20 2011-01-05 深圳市海滨制药有限公司 1β甲基碳青霉烯类抗生素的合成方法
US20110288289A1 (en) * 2010-05-19 2011-11-24 Savior Lifetec Corporation Preparation of Carbapenem Intermediate and Their Use
KR20120007331A (ko) * 2010-07-14 2012-01-20 주식회사 경보제약 카르바페넴계 화합물들의 개선된 제조방법
CN102351861A (zh) * 2011-08-16 2012-02-15 湖南欧亚生物有限公司 一种厄他培南的工业化制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR008255A1 (es) 1996-07-12 1999-12-29 Merck & Co Inc Procedimiento para sintetizar antibioticos de carbapenem
NZ500955A (en) 1997-06-16 2001-06-29 Merck & Co Inc Stabilized 1-beta-methyl-carbapenem intermediates and synthetic use
AU2002331885B2 (en) 2001-09-26 2007-07-26 Merck & Co., Inc. Crystalline forms of ertapenem sodium
US8293894B2 (en) 2006-11-20 2012-10-23 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of carbapenem antibiotic
EP2426131B1 (en) * 2009-04-30 2016-08-17 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. Intermediates of carbapenem, compositions containing them and preparation methods thereof
US8729260B2 (en) * 2010-05-19 2014-05-20 Savior Lifetec Corporation Process for the preparation of carbapenem using cabapenem intermediates and recovery of cabapenem
CN102731502B (zh) * 2011-04-13 2016-08-03 石药集团中奇制药技术（石家庄）有限公司 一种碳青霉烯抗生素的制备方法
CN102432611B (zh) * 2011-11-09 2013-11-20 上海希迈医药科技有限公司 一种双保护厄他培南结晶体及其制备方法
CN102731508A (zh) * 2012-07-03 2012-10-17 浙江海翔川南药业有限公司 一种晶体形式的厄他培南中间体及其制备方法和应用
JP2015533142A (ja) * 2012-10-12 2015-11-19 サンド・アクチエンゲゼルシヤフト エルタペネム中間体の製造

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06506704A (ja) * 1992-02-04 1994-07-28 ゼネカ　リミテッド 抗生物質組成物
US5872250A (en) * 1997-07-30 1999-02-16 Merck & Co., Inc. Process for synthesizing carbapenem antibiotics
CN1752090A (zh) * 2005-10-20 2006-03-29 上海交通大学 尔他培南钠盐的制备方法
US20110288289A1 (en) * 2010-05-19 2011-11-24 Savior Lifetec Corporation Preparation of Carbapenem Intermediate and Their Use
KR20120007331A (ko) * 2010-07-14 2012-01-20 주식회사 경보제약 카르바페넴계 화합물들의 개선된 제조방법
CN101935321A (zh) * 2010-07-20 2011-01-05 深圳市海滨制药有限公司 1β甲基碳青霉烯类抗生素的合成方法
CN102351861A (zh) * 2011-08-16 2012-02-15 湖南欧亚生物有限公司 一种厄他培南的工业化制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ZHANG Y.-F. ET AL., JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY, vol. 38, no. 4, JPN5015010645, 2007, CN, pages 305 - 310, ISSN: 0003740672 *
上木 達生、他, プロセス化学 —医薬品合成から製造まで, JPN7017002135, 30 July 2008 (2008-07-30), pages 27 - 53, ISSN: 0003740673 *

Also Published As

Publication number Publication date
IN2015DN02513A (enEXAMPLES) 2015-09-11
WO2014057079A1 (en) 2014-04-17
CN104703986A (zh) 2015-06-10
US20170166570A1 (en) 2017-06-15
EP2906561A1 (en) 2015-08-19
KR20150065176A (ko) 2015-06-12
AU2013328585A1 (en) 2015-04-09
CA2887098A1 (en) 2014-04-17
US20150274732A1 (en) 2015-10-01
US9546171B2 (en) 2017-01-17

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