JP2015532642A5 - - Google Patents
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- JP2015532642A5 JP2015532642A5 JP2015527533A JP2015527533A JP2015532642A5 JP 2015532642 A5 JP2015532642 A5 JP 2015532642A5 JP 2015527533 A JP2015527533 A JP 2015527533A JP 2015527533 A JP2015527533 A JP 2015527533A JP 2015532642 A5 JP2015532642 A5 JP 2015532642A5
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- 125000000217 alkyl group Chemical group 0.000 claims 85
- 125000000753 cycloalkyl group Chemical group 0.000 claims 33
- 125000003342 alkenyl group Chemical group 0.000 claims 17
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 125000000304 alkynyl group Chemical group 0.000 claims 14
- 125000000623 heterocyclic group Chemical group 0.000 claims 12
- 102000004311 liver X receptors Human genes 0.000 claims 11
- 108090000865 liver X receptors Proteins 0.000 claims 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims 10
- 125000001188 haloalkyl group Chemical group 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 125000005843 halogen group Chemical group 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 125000000449 nitro group Chemical class [O-][N+](*)=O 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 239000000556 agonist Substances 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 6
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 230000001028 anti-proliverative effect Effects 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 claims 2
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 2
- 102000013918 Apolipoproteins E Human genes 0.000 claims 2
- 108010025628 Apolipoproteins E Proteins 0.000 claims 2
- 229940125431 BRAF inhibitor Drugs 0.000 claims 2
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims 2
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 2
- 239000012275 CTLA-4 inhibitor Substances 0.000 claims 2
- 239000012824 ERK inhibitor Substances 0.000 claims 2
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 2
- 229940124647 MEK inhibitor Drugs 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 2
- 239000012270 PD-1 inhibitor Substances 0.000 claims 2
- 239000012668 PD-1-inhibitor Substances 0.000 claims 2
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 2
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 2
- 125000005157 alkyl carboxy group Chemical group 0.000 claims 2
- 238000011319 anticancer therapy Methods 0.000 claims 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 2
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- BFSMGDJOXZAERB-UHFFFAOYSA-N dabrafenib Chemical compound S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 BFSMGDJOXZAERB-UHFFFAOYSA-N 0.000 claims 2
- 229960002465 dabrafenib Drugs 0.000 claims 2
- 229960003901 dacarbazine Drugs 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229950009791 durvalumab Drugs 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 229960005386 ipilimumab Drugs 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 208000037819 metastatic cancer Diseases 0.000 claims 2
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108091025686 miR-199a stem-loop Proteins 0.000 claims 2
- 108091083769 miR-199a-1 stem-loop Proteins 0.000 claims 2
- 108091047470 miR-199a-2 stem-loop Proteins 0.000 claims 2
- 108091048350 miR-199a-3 stem-loop Proteins 0.000 claims 2
- 108091056793 miR-199a-4 stem-loop Proteins 0.000 claims 2
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 229960003301 nivolumab Drugs 0.000 claims 2
- 229940121655 pd-1 inhibitor Drugs 0.000 claims 2
- 229960002621 pembrolizumab Drugs 0.000 claims 2
- 208000016691 refractory malignant neoplasm Diseases 0.000 claims 2
- LIRYPHYGHXZJBZ-UHFFFAOYSA-N trametinib Chemical compound CC(=O)NC1=CC=CC(N2C(N(C3CC3)C(=O)C3=C(NC=4C(=CC(I)=CC=4)F)N(C)C(=O)C(C)=C32)=O)=C1 LIRYPHYGHXZJBZ-UHFFFAOYSA-N 0.000 claims 2
- 229960004066 trametinib Drugs 0.000 claims 2
- GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 claims 2
- 229960003862 vemurafenib Drugs 0.000 claims 2
- ASGMFNBUXDJWJJ-JLCFBVMHSA-N (1R,3R)-3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethylcyclopentane-1-carboxamide Chemical compound BrC1=NN(C2=NC(=NC=C21)N[C@H]1C[C@@](CC1)(C(=O)NC)C)C1=CC=C(C=C1)C=1SC(=NN=1)C ASGMFNBUXDJWJJ-JLCFBVMHSA-N 0.000 claims 1
- GHYOCDFICYLMRF-UTIIJYGPSA-N (2S,3R)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide Chemical compound C1(=CCCC1)C[C@@H](C(=O)[C@@]1(OC1)C)NC([C@H]([C@@H](C1=CC=C(C=C1)OC)O)NC([C@H](C)NC(CN1CCOCC1)=O)=O)=O GHYOCDFICYLMRF-UTIIJYGPSA-N 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- QBWKPGNFQQJGFY-QLFBSQMISA-N 3-[(1r)-1-[(2r,6s)-2,6-dimethylmorpholin-4-yl]ethyl]-n-[6-methyl-3-(1h-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine Chemical compound N1([C@H](C)C2=NSC(NC=3C4=NC=C(N4C=C(C)N=3)C3=CNN=C3)=C2)C[C@H](C)O[C@H](C)C1 QBWKPGNFQQJGFY-QLFBSQMISA-N 0.000 claims 1
- 125000001054 5 membered carbocyclic group Chemical group 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102100031168 CCN family member 2 Human genes 0.000 claims 1
- 101100463133 Caenorhabditis elegans pdl-1 gene Proteins 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 229940127007 Compound 39 Drugs 0.000 claims 1
- 102100029715 DnaJ homolog subfamily A member 4 Human genes 0.000 claims 1
- 101000777550 Homo sapiens CCN family member 2 Proteins 0.000 claims 1
- 101000866014 Homo sapiens DnaJ homolog subfamily A member 4 Proteins 0.000 claims 1
- 101001039207 Homo sapiens Low-density lipoprotein receptor-related protein 8 Proteins 0.000 claims 1
- 101000896414 Homo sapiens Nuclear nucleic acid-binding protein C1D Proteins 0.000 claims 1
- 101001043564 Homo sapiens Prolow-density lipoprotein receptor-related protein 1 Proteins 0.000 claims 1
- 102100040705 Low-density lipoprotein receptor-related protein 8 Human genes 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 102100021923 Prolow-density lipoprotein receptor-related protein 1 Human genes 0.000 claims 1
- 125000004171 alkoxy aryl group Chemical group 0.000 claims 1
- 239000002257 antimetastatic agent Substances 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 229940125797 compound 12 Drugs 0.000 claims 1
- 229940125782 compound 2 Drugs 0.000 claims 1
- 229940125846 compound 25 Drugs 0.000 claims 1
- 229940127573 compound 38 Drugs 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 125000004445 cyclohaloalkyl Chemical group 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- -1 ipilimumab Chemical compound 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 108091083606 miR-1908 stem-loop Proteins 0.000 claims 1
- 108091023818 miR-7 stem-loop Proteins 0.000 claims 1
- DYMRYCZRMAHYKE-UHFFFAOYSA-N n-diazonitramide Chemical compound [O-][N+](=O)N=[N+]=[N-] DYMRYCZRMAHYKE-UHFFFAOYSA-N 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- PIDFDZJZLOTZTM-KHVQSSSXSA-N ombitasvir Chemical compound COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)NC1=CC=C([C@H]2N([C@@H](CC2)C=2C=CC(NC(=O)[C@H]3N(CCC3)C(=O)[C@@H](NC(=O)OC)C(C)C)=CC=2)C=2C=CC(=CC=2)C(C)(C)C)C=C1 PIDFDZJZLOTZTM-KHVQSSSXSA-N 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261682339P | 2012-08-13 | 2012-08-13 | |
| US61/682,339 | 2012-08-13 | ||
| US201361784057P | 2013-03-14 | 2013-03-14 | |
| US61/784,057 | 2013-03-14 | ||
| PCT/US2013/054690 WO2014028461A2 (en) | 2012-08-13 | 2013-08-13 | Treatment and diagnosis of melanoma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018023820A Division JP6523502B2 (ja) | 2012-08-13 | 2018-02-14 | メラノーマの処置および診断 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015532642A JP2015532642A (ja) | 2015-11-12 |
| JP2015532642A5 true JP2015532642A5 (cg-RX-API-DMAC10.html) | 2016-09-29 |
| JP6320382B2 JP6320382B2 (ja) | 2018-05-09 |
Family
ID=50101591
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015527533A Active JP6320382B2 (ja) | 2012-08-13 | 2013-08-13 | メラノーマの処置および診断 |
| JP2018023820A Active JP6523502B2 (ja) | 2012-08-13 | 2018-02-14 | メラノーマの処置および診断 |
| JP2019083874A Active JP7005551B2 (ja) | 2012-08-13 | 2019-04-25 | メラノーマの処置および診断 |
| JP2021105207A Active JP7472080B2 (ja) | 2012-08-13 | 2021-06-24 | メラノーマの処置および診断 |
| JP2023223727A Pending JP2024041827A (ja) | 2012-08-13 | 2023-12-28 | メラノーマの処置および診断 |
| JP2026001136A Pending JP2026062949A (ja) | 2012-08-13 | 2026-01-06 | メラノーマの処置および診断 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018023820A Active JP6523502B2 (ja) | 2012-08-13 | 2018-02-14 | メラノーマの処置および診断 |
| JP2019083874A Active JP7005551B2 (ja) | 2012-08-13 | 2019-04-25 | メラノーマの処置および診断 |
| JP2021105207A Active JP7472080B2 (ja) | 2012-08-13 | 2021-06-24 | メラノーマの処置および診断 |
| JP2023223727A Pending JP2024041827A (ja) | 2012-08-13 | 2023-12-28 | メラノーマの処置および診断 |
| JP2026001136A Pending JP2026062949A (ja) | 2012-08-13 | 2026-01-06 | メラノーマの処置および診断 |
Country Status (10)
| Country | Link |
|---|---|
| US (8) | US9526710B2 (cg-RX-API-DMAC10.html) |
| EP (3) | EP4218935A1 (cg-RX-API-DMAC10.html) |
| JP (6) | JP6320382B2 (cg-RX-API-DMAC10.html) |
| CN (3) | CN110037999B (cg-RX-API-DMAC10.html) |
| AU (4) | AU2013302861A1 (cg-RX-API-DMAC10.html) |
| CA (2) | CA3211094A1 (cg-RX-API-DMAC10.html) |
| DK (1) | DK2882496T3 (cg-RX-API-DMAC10.html) |
| ES (2) | ES2941477T3 (cg-RX-API-DMAC10.html) |
| HU (1) | HUE046292T2 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2014028461A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110160080A1 (en) | 2008-05-14 | 2011-06-30 | Chang Sherman H | Diagnosis of Melanoma and Solar Lentigo by Nucleic Acid Analysis |
| SG11201405378VA (en) | 2012-03-02 | 2014-09-26 | Anayaderm Inc | Liver x receptor (lxr) modulators for the treatment of dermal diseases, disorders and conditions |
| WO2014028461A2 (en) * | 2012-08-13 | 2014-02-20 | The Rockefeller University | Treatment and diagnosis of melanoma |
| EP3041835B1 (en) | 2013-09-04 | 2020-04-08 | Ellora Therapeutics, Inc. | Liver x receptor (lxr) modulators |
| KR20160048997A (ko) | 2013-09-04 | 2016-05-04 | 알렉사르 테라퓨틱스 인코퍼레이티드 | 간 x 수용체 (lxr) 조절인자 |
| AU2015204572B2 (en) | 2014-01-10 | 2020-07-30 | Inspirna, Inc. | LXR agonists and uses thereof |
| WO2016179043A1 (en) | 2015-05-01 | 2016-11-10 | Dermtech, Inc. | Non-invasive skin collection system |
| WO2016100619A2 (en) * | 2014-12-17 | 2016-06-23 | Rgenix, Inc. | Treatment and diagnosis of cancer |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| JP2018527016A (ja) * | 2015-06-24 | 2018-09-20 | オックスフォード バイオダイナミックス リミテッド | 染色体相互作用の検出 |
| WO2017004151A1 (en) | 2015-06-29 | 2017-01-05 | Regents Of The University Of Minnesota | Anti-apobec3 antibodies and methods of making and using |
| WO2017004165A1 (en) * | 2015-06-29 | 2017-01-05 | Regents Of The University Of Minnesota | Apobec3b mutagenesis and immunotherapy |
| AU2017207291B2 (en) * | 2016-01-11 | 2023-06-15 | The Rockefeller University | Methods for the treatment of myeloid derived suppressor cells related disorders |
| EP3416668A4 (en) * | 2016-02-18 | 2020-02-19 | The Wistar Institute Of Anatomy And Biology | METHOD AND COMPOSITIONS FOR TREATING MELANOMA |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI822521B (zh) * | 2016-05-13 | 2023-11-11 | 美商再生元醫藥公司 | 藉由投予pd-1抑制劑治療皮膚癌之方法 |
| CN109689062B (zh) * | 2016-07-11 | 2023-02-17 | 丹娜法伯癌症研究院 | 使用抗PI3Kβ和抗免疫检查点药剂的组合治疗PTEN缺陷型上皮癌的方法 |
| US11040027B2 (en) | 2017-01-17 | 2021-06-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| ES2975417T3 (es) | 2017-03-03 | 2024-07-05 | Inspirna Inc | Formulaciones con estabilidad mejorada |
| CN106890315B (zh) * | 2017-03-16 | 2019-09-06 | 北京热休生物技术有限公司 | Apo-e蛋白及其多肽在治疗与预防癌症中的应用 |
| WO2018213302A1 (en) | 2017-05-16 | 2018-11-22 | Biomed Valley Discoveries, Inc. | Compositions and methods for treating cancer with atypical braf mutations |
| EP3713575A4 (en) | 2017-11-21 | 2021-08-25 | Rgenix, Inc. | POLYMORPHS AND THEIR USES |
| US11976332B2 (en) | 2018-02-14 | 2024-05-07 | Dermtech, Inc. | Gene classifiers and uses thereof in non-melanoma skin cancers |
| CA3121211A1 (en) * | 2018-11-28 | 2020-06-04 | Prevail Therapeutics, Inc. | Gene therapies for neurodegenerative disease |
| WO2020176846A2 (en) * | 2019-02-28 | 2020-09-03 | The Rockefeller University | Apoe genotyping in cancer prognostics and treatment |
| CA3134936A1 (en) | 2019-03-26 | 2020-10-01 | Dermtech, Inc. | Novel gene classifiers and uses thereof in skin cancers |
| JP2022530845A (ja) * | 2019-04-27 | 2022-07-04 | オクジェン アイエヌシー． | 眼疾患に対するａｄｅｎｏ随伴ウイルス連ウイルスベクター媒介遺伝子治療 |
| CN110218235B (zh) * | 2019-05-09 | 2020-09-25 | 中山大学 | 一种化合物及其制备方法和作为荧光偏振探针在LXRβ配体筛选中的应用 |
| AU2020345791A1 (en) * | 2019-09-11 | 2022-03-31 | Inspirna, Inc. | Methods of treating cancer |
| EP4034084B1 (en) | 2019-09-27 | 2025-11-05 | The Rockefeller University | Compositions and methods for treating metastatic gastrointestinal cancer |
| RU2716811C1 (ru) * | 2019-11-14 | 2020-03-16 | федеральное государственное бюджетное образовательное учреждение высшего образования "Новгородский государственный университет имени Ярослава Мудрого" | Способ ранней диагностики поверхностно распространяющихся меланом |
| JP7689964B2 (ja) | 2019-12-13 | 2025-06-09 | インスピルナ，インコーポレーテッド | 金属塩及びその使用 |
| US12037585B2 (en) | 2019-12-23 | 2024-07-16 | University Of Massachusetts | Oligonucleotides for tissue specific gene expression modulation |
| JP7888533B2 (ja) * | 2020-08-21 | 2026-07-13 | ツェー・エス・エル・ベーリング・アクチエンゲゼルシャフト | ヘモペキシン：ヘム複合体の検出に使用するためのｃｄ９１ポリペプチド |
| EP4376953A1 (en) * | 2021-07-30 | 2024-06-05 | Alnylam Pharmaceuticals, Inc. | Peptide ligands for cns and ocular delivery of rnai compounds |
| CN114276999A (zh) * | 2022-03-03 | 2022-04-05 | 中日友好医院(中日友好临床医学研究所) | 黑素瘤细胞株及其制备方法 |
Family Cites Families (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5324731A (en) | 1989-02-14 | 1994-06-28 | Amira, Inc. | Method of inhibiting transformation of cells in which purine metabolic enzyme activity is elevated |
| US5676978A (en) | 1989-02-14 | 1997-10-14 | Amira, Inc. | Methods of inhibiting undesirable cell growth using a combination of a cyclocreatine compound and a hyperplastic inhibitory agent |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5215882A (en) | 1989-11-30 | 1993-06-01 | Ortho Diagnostic Systems, Inc. | Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays |
| DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| DE69621507T2 (de) | 1995-03-28 | 2003-01-09 | Japan Science And Technology Corp., Kawaguchi | Verfahren zur molekularen Indexierung von Genen unter Verwendung von Restriktionsenzymen |
| US5843974A (en) * | 1995-06-06 | 1998-12-01 | Eli Lilly And Company | Methods of inhibiting melanoma using Benzothiophenes as cytotoxic agents per se |
| US5958342A (en) | 1996-05-17 | 1999-09-28 | Incyte Pharmaceuticals, Inc. | Jet droplet device |
| US6060240A (en) | 1996-12-13 | 2000-05-09 | Arcaris, Inc. | Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom |
| US6090556A (en) | 1997-04-07 | 2000-07-18 | Japan Science & Technology Corporation | Method for quantitatively determining the expression of a gene |
| US5994076A (en) | 1997-05-21 | 1999-11-30 | Clontech Laboratories, Inc. | Methods of assaying differential expression |
| ES2276481T3 (es) | 1997-12-12 | 2007-06-16 | The University Of Western Ontario | Peptido apoep1.b novedoso, composiciones y sus usos. |
| US6004755A (en) | 1998-04-07 | 1999-12-21 | Incyte Pharmaceuticals, Inc. | Quantitative microarray hybridizaton assays |
| US6048695A (en) | 1998-05-04 | 2000-04-11 | Baylor College Of Medicine | Chemically modified nucleic acids and methods for coupling nucleic acids to solid support |
| US6087112A (en) | 1998-12-30 | 2000-07-11 | Oligos Etc. Inc. | Arrays with modified oligonucleotide and polynucleotide compositions |
| US6316503B1 (en) | 1999-03-15 | 2001-11-13 | Tularik Inc. | LXR modulators |
| US8257750B2 (en) | 1999-04-30 | 2012-09-04 | Kibow Biotech, Inc. | Calcium carbonate compositions for preventing or treating hyperphosphatemia |
| AU2001280576A1 (en) | 2000-07-18 | 2002-01-30 | Uab Research Foundation | Tissue-specific self-inactivating gene therapy vector |
| WO2002020737A2 (en) | 2000-09-07 | 2002-03-14 | Vanderbilt University | Genome engineering by cell-permeable dna site-specific recombinases |
| DE60107449T2 (de) | 2000-09-18 | 2005-12-08 | Glaxo Group Ltd., Greenford | Substituierte aminopropoxyarylderivate als lxr agonisten |
| AU2002219718A1 (en) | 2000-12-13 | 2002-06-24 | Sca Hygiene Products Zeist B.V. | Process for oxidising primary alcohols |
| JP2003033179A (ja) | 2001-07-05 | 2003-02-04 | Asahi Kasei Corp | 可逆的遺伝子導入ベクター |
| EP1497270A4 (en) * | 2002-03-27 | 2006-01-04 | Smithkline Beecham Corp | AMID COMPOUNDS AND METHOD FOR THEIR USE |
| AU2003226094A1 (en) | 2002-03-27 | 2003-10-13 | Smithkline Beecham Corporation | Compounds and methods |
| JP2005521721A (ja) | 2002-03-27 | 2005-07-21 | スミスクライン・ビーチャム・コーポレイション | 酸およびエステル化合物ならびにその使用方法 |
| EP1552010B1 (en) | 2002-07-19 | 2010-06-09 | Althea Technologies, Inc. | Strategies for gene expression analysis |
| WO2004078939A2 (en) | 2003-03-03 | 2004-09-16 | University Of Massachusetts | REGULATION OF Mdm2 FUNCTION |
| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| US20050130919A1 (en) | 2003-07-18 | 2005-06-16 | University Of Massachusetts | Regulatable promoters for synthesis of small hairpin RNA |
| AU2004283053A1 (en) | 2003-10-20 | 2005-05-06 | Nsgene A/S | In vivo gene therapy of Parkinson's Disease |
| JP2007516258A (ja) | 2003-12-12 | 2007-06-21 | ワイス | 心臓血管の疾患治療に有用なキノリン誘導体 |
| FR2865736B1 (fr) | 2004-02-02 | 2006-07-14 | Synt Em | Inhibiteurs de l'angiogenese, compositions les contenant et leur utilisation pour le traitement des maladies liees a une deregulation de l'angiogenese |
| WO2005112620A2 (en) | 2004-05-18 | 2005-12-01 | Massachusetts Institute Of Technology | A cre-lox based method for conditional rna interference |
| JP5575357B2 (ja) * | 2004-07-02 | 2014-08-20 | 第一三共株式会社 | 組織因子産生抑制剤 |
| DE602005017895D1 (de) | 2004-07-07 | 2010-01-07 | Merck & Co Inc | Pyrazolamid-derivate, diese verbindungen enthaltende zusammensetzungen und anwendungsverfahren |
| US20060058311A1 (en) | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
| PL1802566T3 (pl) | 2004-10-01 | 2009-05-29 | Hoffmann La Roche | Podstawione heksafluoroizopropanolem pochodne eteru |
| RU2382029C2 (ru) | 2004-12-22 | 2010-02-20 | Ф.Хоффманн-Ля Рош Аг | Новые производные циклогексана |
| SE0500055D0 (sv) | 2005-01-10 | 2005-01-10 | Astrazeneca Ab | Therapeutic agents 3 |
| MX2007008370A (es) | 2005-01-10 | 2007-08-21 | Astrazeneca Ab | Derivados de 1,1-dioxidos de isotiazol-3 (2h) -ona como moduladores del receptor del higado x. |
| SE0500056D0 (sv) | 2005-01-10 | 2005-01-10 | Astrazeneca Ab | Therapeutic agents 4 |
| WO2006073364A1 (en) | 2005-01-10 | 2006-07-13 | Astrazeneca Ab | Derivatives of isothiazol-3 (2h)-thione 1,1-dioxides as liver x receptor modulators |
| SE0500058D0 (sv) | 2005-01-10 | 2005-01-10 | Astrazeneca Ab | Therapeutic agents 5 |
| RU2007131400A (ru) | 2005-03-01 | 2009-04-10 | Вайет (Us) | Соединения циннолина и их применение в качестве модуляторов х-рецепторов печени |
| US8318760B2 (en) | 2005-03-21 | 2012-11-27 | Merck Sharp & Dohme Corp. | Substituted aryl and heteroaryl derivatives, compositions containing such compounds and methods of use |
| KR101363278B1 (ko) | 2005-06-27 | 2014-02-21 | 엑셀리시스 페이턴트 컴퍼니 엘엘씨 | 이미다졸계 ｌｘｒ 변조제 |
| NZ567140A (en) | 2005-10-07 | 2011-09-30 | Exelixis Inc | Azetidines as MEK inhibitors for the treatment of proliferative diseases |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| US7790745B2 (en) | 2005-10-21 | 2010-09-07 | Bristol-Myers Squibb Company | Tetrahydroisoquinoline LXR Modulators |
| US20090062260A1 (en) | 2005-11-14 | 2009-03-05 | Irm Llc | Compounds and compositions as lxr modulators |
| WO2007081335A1 (en) | 2006-01-12 | 2007-07-19 | Merck & Co., Inc. | Therapeutic compounds for treating dyslipidemic conditions |
| US20100279918A1 (en) | 2006-03-20 | 2010-11-04 | Burnham Institute For Medical Research | Chimeric Constructs Between Cancer-Homing Peptides and Cell-Penetrating Peptides Coupled to Anticancer Drugs and/or Diagnostic Agent/Agents |
| WO2008011071A2 (en) * | 2006-07-19 | 2008-01-24 | The Regents Of The University Of California | Interactions of hedgehog and liver x receptor signaling pathways |
| TW200825054A (en) | 2006-10-18 | 2008-06-16 | Wyeth Corp | Quinoline compounds |
| US8324367B2 (en) | 2006-11-03 | 2012-12-04 | Medtronic, Inc. | Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity |
| US8168666B2 (en) | 2006-11-30 | 2012-05-01 | Kowa Company, Ltd. | Substituted carbinol compound |
| EP2121621B1 (en) | 2006-12-08 | 2014-05-07 | Exelixis Patent Company LLC | Lxr and fxr modulators |
| JP2008179562A (ja) | 2007-01-24 | 2008-08-07 | Kowa Co | Ｌｘｒアゴニスト |
| US8993628B2 (en) | 2007-02-23 | 2015-03-31 | City Of Hope | Synthetic ligands selective for LXRβ over LXRα, identification and methods of use thereof |
| US20100273816A1 (en) | 2007-05-18 | 2010-10-28 | Ronald Charles Bernotas | Quinazoline Compounds |
| CA2691673A1 (en) | 2007-06-29 | 2009-01-08 | Avi Biopharma, Inc. | Tissue specific peptide conjugates and methods |
| KR101171507B1 (ko) | 2007-08-13 | 2012-08-07 | 에프. 호프만-라 로슈 아게 | 신규 피페라진 아마이드 유도체 |
| TW200922582A (en) | 2007-08-20 | 2009-06-01 | Organon Nv | N-benzyl, N'-arylcarbonylpiperazine derivatives |
| US8039493B2 (en) | 2007-09-27 | 2011-10-18 | Hoffmann-La Roche Inc. | Biaryl sulfonamide derivatives |
| DK2205737T3 (da) * | 2007-10-04 | 2013-05-21 | Santaris Pharma As | Mikromirer |
| WO2009060198A1 (en) | 2007-11-09 | 2009-05-14 | Peregrine Pharmaceuticals, Inc. | Anti-vegf antibody compositions and methods |
| US8236753B2 (en) * | 2007-12-10 | 2012-08-07 | The Brigham And Women's Hospital, Inc. | RAP variants for drug delivery and methods of use thereof |
| EP2235020A1 (en) | 2007-12-21 | 2010-10-06 | Wyeth LLC | Pyrazolo [1,5-a] pyrimidine compounds |
| CA2710458A1 (en) | 2007-12-21 | 2009-07-09 | Wyeth Llc | Imidazo [1,2-b] pyridazine compounds as modulators of liver x receptors |
| WO2009086123A1 (en) | 2007-12-21 | 2009-07-09 | Wyeth | Imidazo [1,2-a] pyridine compounds |
| AU2008345696A1 (en) | 2007-12-21 | 2009-07-09 | Wyeth Llc | Benzimidazole compounds |
| US7919509B2 (en) | 2008-02-29 | 2011-04-05 | Kowa Company, Ltd. | 2-oxochromene derivatives |
| AU2009255357A1 (en) * | 2008-05-29 | 2009-12-10 | Bristol-Myers Squibb Company | Methods for predicting patient response to modulation of the co-stimulatory pathway |
| CN102137680A (zh) * | 2008-07-01 | 2011-07-27 | 克格诺西有限公司 | 用apoe肽治疗癌症的方法 |
| WO2010036959A2 (en) | 2008-09-26 | 2010-04-01 | Dana-Farber Cancer Institute | Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor |
| US20120156216A1 (en) * | 2009-03-02 | 2012-06-21 | Youngman Oh | Methods and Compositions for Treatment of Tumor Metastasis |
| MY153958A (en) * | 2009-05-28 | 2015-04-30 | Exelixis Patent Co Llc | Lxr modulators |
| WO2011115892A1 (en) * | 2010-03-15 | 2011-09-22 | Griffin Patrick R | Modulators of the retinoic acid receptor-related orphan receptors |
| US9421218B2 (en) * | 2010-04-13 | 2016-08-23 | New York University | Compositions and methods for treatment of melanoma |
| JP5851400B2 (ja) | 2010-06-16 | 2016-02-03 | Ｌｓｉｐファンド運営合同会社 | 大腸腫瘍の検出方法 |
| EP2474617A1 (en) * | 2011-01-11 | 2012-07-11 | InteRNA Technologies BV | Mir for treating neo-angiogenesis |
| US20130004481A1 (en) * | 2011-01-12 | 2013-01-03 | Boehringer Ingelheim International Gmbh | Anticancer therapy |
| TW201242953A (en) | 2011-03-25 | 2012-11-01 | Bristol Myers Squibb Co | Imidazole prodrug LXR modulators |
| WO2013043569A1 (en) * | 2011-09-20 | 2013-03-28 | Vical Incorporated | Synergistic anti-tumor efficacy using alloantigen combination immunotherapy |
| WO2014028461A2 (en) * | 2012-08-13 | 2014-02-20 | The Rockefeller University | Treatment and diagnosis of melanoma |
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