JP2015532592A5 - - Google Patents
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- JP2015532592A5 JP2015532592A5 JP2015527645A JP2015527645A JP2015532592A5 JP 2015532592 A5 JP2015532592 A5 JP 2015532592A5 JP 2015527645 A JP2015527645 A JP 2015527645A JP 2015527645 A JP2015527645 A JP 2015527645A JP 2015532592 A5 JP2015532592 A5 JP 2015532592A5
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- Prior art keywords
- amino acid
- seq
- acid sequence
- antibody
- variant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 48
- 102000004965 antibodies Human genes 0.000 claims 46
- 108090001123 antibodies Proteins 0.000 claims 46
- 210000001175 Cerebrospinal Fluid Anatomy 0.000 claims 10
- 210000003722 Extracellular Fluid Anatomy 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000005614 monoclonal antibodies Human genes 0.000 claims 5
- 108010045030 monoclonal antibodies Proteins 0.000 claims 5
- 230000035693 Fab Effects 0.000 claims 4
- 208000005613 Tauopathy Diseases 0.000 claims 4
- 210000002569 neurons Anatomy 0.000 claims 4
- 102100017796 APP Human genes 0.000 claims 3
- 108060000460 APP Proteins 0.000 claims 3
- 210000001218 Blood-Brain Barrier Anatomy 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- 210000004897 N-terminal region Anatomy 0.000 claims 2
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 2
- 206010037211 Psychomotor hyperactivity Diseases 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- 210000004027 cells Anatomy 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000003834 intracellular Effects 0.000 claims 2
- 230000001404 mediated Effects 0.000 claims 2
- 230000001537 neural Effects 0.000 claims 2
- 238000003259 recombinant expression Methods 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 229920001059 synthetic polymer Polymers 0.000 claims 2
- 201000002242 tauopathy Diseases 0.000 claims 2
- 210000001130 Astrocytes Anatomy 0.000 claims 1
- 101700044176 BACE Proteins 0.000 claims 1
- 210000004556 Brain Anatomy 0.000 claims 1
- 210000003710 Cerebral Cortex Anatomy 0.000 claims 1
- 206010057668 Cognitive disease Diseases 0.000 claims 1
- 230000036947 Dissociation constant Effects 0.000 claims 1
- 108020004999 Messenger RNA Proteins 0.000 claims 1
- 210000000274 Microglia Anatomy 0.000 claims 1
- 210000004898 N-terminal fragment Anatomy 0.000 claims 1
- 230000036462 Unbound Effects 0.000 claims 1
- 238000004220 aggregation Methods 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 210000003008 brain-resident macrophage Anatomy 0.000 claims 1
- 230000003920 cognitive function Effects 0.000 claims 1
- 238000009792 diffusion process Methods 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229920002106 messenger RNA Polymers 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 230000000865 phosphorylative Effects 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 210000002243 primary neuron Anatomy 0.000 claims 1
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 1
- 230000001105 regulatory Effects 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
- 230000002103 transcriptional Effects 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261683902P | 2012-08-16 | 2012-08-16 | |
| US61/683,902 | 2012-08-16 | ||
| US201361754085P | 2013-01-18 | 2013-01-18 | |
| US61/754,085 | 2013-01-18 | ||
| US201361781823P | 2013-03-14 | 2013-03-14 | |
| US61/781,823 | 2013-03-14 | ||
| US201361813797P | 2013-04-19 | 2013-04-19 | |
| US61/813,797 | 2013-04-19 | ||
| US201361833355P | 2013-06-10 | 2013-06-10 | |
| US61/833,355 | 2013-06-10 | ||
| PCT/US2013/055203 WO2014028777A2 (en) | 2012-08-16 | 2013-08-15 | Methods of treating a tauopathy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015532592A JP2015532592A (ja) | 2015-11-12 |
| JP2015532592A5 true JP2015532592A5 (ru) | 2016-09-29 |
| JP6290212B2 JP6290212B2 (ja) | 2018-03-07 |
Family
ID=50101612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015527645A Active JP6290212B2 (ja) | 2012-08-16 | 2013-08-15 | タウオパチーの処置方法 |
Country Status (32)
| Country | Link |
|---|---|
| US (6) | US9567395B2 (ru) |
| EP (2) | EP3685854A1 (ru) |
| JP (1) | JP6290212B2 (ru) |
| KR (1) | KR102076384B1 (ru) |
| CN (1) | CN104736185B (ru) |
| AU (1) | AU2013302540B2 (ru) |
| BR (1) | BR112015003326A2 (ru) |
| CA (1) | CA2882034C (ru) |
| CL (1) | CL2015000352A1 (ru) |
| CY (1) | CY1123515T1 (ru) |
| DK (1) | DK2885010T3 (ru) |
| EA (2) | EA035976B1 (ru) |
| ES (1) | ES2775192T3 (ru) |
| GB (1) | GB2507207A (ru) |
| HK (1) | HK1208175A1 (ru) |
| HR (1) | HRP20200036T1 (ru) |
| HU (1) | HUE048780T2 (ru) |
| IL (1) | IL237153B (ru) |
| LT (1) | LT2885010T (ru) |
| ME (1) | ME03667B (ru) |
| MX (1) | MX359817B (ru) |
| MY (1) | MY176838A (ru) |
| NZ (2) | NZ630542A (ru) |
| PE (1) | PE20150646A1 (ru) |
| PH (1) | PH12015500196B1 (ru) |
| PL (1) | PL2885010T3 (ru) |
| PT (1) | PT2885010T (ru) |
| RS (1) | RS60080B1 (ru) |
| SG (2) | SG11201500888SA (ru) |
| SI (1) | SI2885010T1 (ru) |
| TN (1) | TN2015000050A1 (ru) |
| WO (1) | WO2014028777A2 (ru) |
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| US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
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| MY176838A (en) | 2012-08-16 | 2020-08-24 | Ipierian Inc | Methods of treating a tauopathy |
| US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
| US10501531B2 (en) | 2013-03-13 | 2019-12-10 | Prothena Biosciences Limited | Tau immunotherapy |
| WO2014200921A1 (en) * | 2013-06-10 | 2014-12-18 | Ipierian, Inc. | Methods of treating a tauopathy |
| US20160289309A1 (en) * | 2013-11-27 | 2016-10-06 | Ipierian, Inc. | Methods of treating a tauopathy |
| ES2778498T3 (es) | 2013-12-20 | 2020-08-10 | Hoffmann La Roche | Anticuerpos anti-tau(pS422) humanizados y procedimientos de uso |
| US10400018B2 (en) | 2014-02-14 | 2019-09-03 | Ipierian, Inc. | Tau peptides, anti-tau antibodies, and methods of use thereof |
| AR100978A1 (es) | 2014-06-26 | 2016-11-16 | Hoffmann La Roche | LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS |
| TW202136296A (zh) * | 2014-06-27 | 2021-10-01 | 美商Ｃ２Ｎ醫療診斷有限責任公司 | 人類化抗-tau抗體 |
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| WO2017191561A1 (en) | 2016-05-02 | 2017-11-09 | Prothena Biosciences Limited | Antibodies recognizing tau |
| US10752679B2 (en) | 2016-05-02 | 2020-08-25 | Prothena Biosciences Limited | Tau immunotherapy |
| PE20190261A1 (es) | 2016-05-02 | 2019-02-25 | Prothena Biosciences Ltd | Anticuerpos que reconocen tau |
| DK3484916T3 (da) | 2016-07-12 | 2021-04-06 | H Lundbeck As | Antistoffer specifikke for hyperphosphoryleret tau og fremgangsmåder til anvendelse deraf |
| EP3487524A4 (en) * | 2016-07-20 | 2020-03-25 | Anahit Ghochikyan | HUMANIZED ANTI-TAU ANTIBODIES, COMPOSITIONS AND MANUFACTURING METHODS AND METHODS OF USE IN THE TREATMENT, DIAGNOSIS AND MONITORING OF TAUOPATHIES |
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| CN110520440A (zh) | 2017-02-17 | 2019-11-29 | 戴纳立制药公司 | 抗τ抗体及其使用方法 |
| JP2018139530A (ja) * | 2017-02-27 | 2018-09-13 | 帝人ファーマ株式会社 | 認知症治療又は予防のためのヒト化抗体及びその製造方法、並びにそれを用いた認知症治療剤又は予防剤 |
| SG10201911225WA (en) | 2017-03-28 | 2020-01-30 | Genentech Inc | Methods of treating neurodegenerative diseases |
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| EP3638694A1 (en) * | 2017-06-16 | 2020-04-22 | Bristol-Myers Squibb Company | Compositions and methods for treating tauopathies |
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| CN108103027B (zh) * | 2018-02-02 | 2021-12-24 | 中国医学科学院血液病医院（血液学研究所） | 高效率血细胞重编程同时实现基因编辑的方法 |
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