JP2015532592A5 - - Google Patents
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- JP2015532592A5 JP2015532592A5 JP2015527645A JP2015527645A JP2015532592A5 JP 2015532592 A5 JP2015532592 A5 JP 2015532592A5 JP 2015527645 A JP2015527645 A JP 2015527645A JP 2015527645 A JP2015527645 A JP 2015527645A JP 2015532592 A5 JP2015532592 A5 JP 2015532592A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 48
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 10
- 210000003722 extracellular fluid Anatomy 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 150000001413 amino acids Chemical class 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 208000034799 Tauopathies Diseases 0.000 claims 4
- 108010064397 amyloid beta-protein (1-40) Proteins 0.000 claims 4
- 108010064539 amyloid beta-protein (1-42) Proteins 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 210000002569 neuron Anatomy 0.000 claims 4
- 101710137189 Amyloid-beta A4 protein Proteins 0.000 claims 3
- 101710151993 Amyloid-beta precursor protein Proteins 0.000 claims 3
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims 3
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 3
- 230000008499 blood brain barrier function Effects 0.000 claims 3
- 210000001218 blood-brain barrier Anatomy 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 claims 2
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 claims 2
- 206010037211 Psychomotor hyperactivity Diseases 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000007423 decrease Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 230000006872 improvement Effects 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 230000007659 motor function Effects 0.000 claims 2
- 210000004897 n-terminal region Anatomy 0.000 claims 2
- 230000001537 neural effect Effects 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 238000003259 recombinant expression Methods 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 229920001059 synthetic polymer Polymers 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108700029229 Transcriptional Regulatory Elements Proteins 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 238000004220 aggregation Methods 0.000 claims 1
- 210000001130 astrocyte Anatomy 0.000 claims 1
- 210000005013 brain tissue Anatomy 0.000 claims 1
- 210000003710 cerebral cortex Anatomy 0.000 claims 1
- 230000006999 cognitive decline Effects 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 230000003920 cognitive function Effects 0.000 claims 1
- 230000006735 deficit Effects 0.000 claims 1
- 238000009792 diffusion process Methods 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 210000000274 microglia Anatomy 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 210000004898 n-terminal fragment Anatomy 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 210000002243 primary neuron Anatomy 0.000 claims 1
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 1
- 230000009467 reduction Effects 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261683902P | 2012-08-16 | 2012-08-16 | |
| US61/683,902 | 2012-08-16 | ||
| US201361754085P | 2013-01-18 | 2013-01-18 | |
| US61/754,085 | 2013-01-18 | ||
| US201361781823P | 2013-03-14 | 2013-03-14 | |
| US61/781,823 | 2013-03-14 | ||
| US201361813797P | 2013-04-19 | 2013-04-19 | |
| US61/813,797 | 2013-04-19 | ||
| US201361833355P | 2013-06-10 | 2013-06-10 | |
| US61/833,355 | 2013-06-10 | ||
| PCT/US2013/055203 WO2014028777A2 (en) | 2012-08-16 | 2013-08-15 | Methods of treating a tauopathy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015532592A JP2015532592A (ja) | 2015-11-12 |
| JP2015532592A5 true JP2015532592A5 (enExample) | 2016-09-29 |
| JP6290212B2 JP6290212B2 (ja) | 2018-03-07 |
Family
ID=50101612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015527645A Expired - Fee Related JP6290212B2 (ja) | 2012-08-16 | 2013-08-15 | タウオパチーの処置方法 |
Country Status (32)
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| WO2010043047A1 (en) | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Conjugates of glp-1 agonists and uses thereof |
| WO2014008404A1 (en) | 2012-07-03 | 2014-01-09 | Washington University | Antibodies to tau |
| JP6290212B2 (ja) | 2012-08-16 | 2018-03-07 | アイピエリアン，インコーポレイティド | タウオパチーの処置方法 |
| US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
| JP6674888B2 (ja) | 2013-03-13 | 2020-04-01 | プロセナ バイオサイエンシーズ リミテッド | タウ免疫療法 |
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| JP6629201B2 (ja) * | 2013-11-27 | 2020-01-15 | アイピエリアン，インコーポレイティド | タウオパチーの処置方法 |
| CA2932958A1 (en) | 2013-12-20 | 2015-06-25 | F. Hoffmann-La Roche Ag | Humanized anti-tau(ps422) antibodies and methods of use |
| NZ630610A (en) * | 2014-02-14 | 2019-05-31 | Ipierian Inc | Tau peptides, anti-tau antibodies, and methods of use thereof |
| AR100978A1 (es) * | 2014-06-26 | 2016-11-16 | Hoffmann La Roche | LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS |
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| CA2991451A1 (en) * | 2015-07-06 | 2017-01-12 | Ucb Biopharma Sprl | Tau-binding antibodies |
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