|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US4866132A
(en)
|
1986-04-17 |
1989-09-12 |
The Research Foundation Of State University Of New York |
Novel radiopaque barium polymer complexes, compositions of matter and articles prepared therefrom
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5811310A
(en)
|
1986-09-30 |
1998-09-22 |
Albert Einstein College Of Medicine Of Yeshiva Univ. |
The Alz-50 monoclonal antibody and diagnostic assay for alzheimer's disease
|
|
JPH02500329A
(ja)
|
1987-05-21 |
1990-02-08 |
クリエイテイブ・バイオマリキユールズ・インコーポレーテツド |
ターゲット化多機能蛋白質
|
|
US5256334A
(en)
|
1988-09-08 |
1993-10-26 |
The Research Foundation Of The State University Of New York |
Homogeneous radiopaque polymer-organobismuth composites
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
US5585362A
(en)
|
1989-08-22 |
1996-12-17 |
The Regents Of The University Of Michigan |
Adenovirus vectors for gene therapy
|
|
US5595732A
(en)
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
|
DE69233482T2
(de)
|
1991-05-17 |
2006-01-12 |
Merck & Co., Inc. |
Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
|
|
WO1993003369A1
(en)
|
1991-08-01 |
1993-02-18 |
Voorheis Paul H |
Diagnostic method for alzheimer's disease
|
|
US5733734A
(en)
|
1991-08-14 |
1998-03-31 |
The Trustees Of The University Of Pennsylvania |
Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments
|
|
ATE237694T1
(de)
|
1991-08-20 |
2003-05-15 |
Us Gov Health & Human Serv |
Adenovirus vermittelter gentransfer in den gastrointestinaltrakt
|
|
JP3540315B2
(ja)
|
1991-09-23 |
2004-07-07 |
メディカル リサーチ カウンシル |
キメラ抗体の製造−組合せアプローチ
|
|
ATE154642T1
(de)
|
1991-10-25 |
1997-07-15 |
Innogenetics Nv |
Monoklonale antikörper gegen das mikrotubulusassoziierte protein tau.
|
|
US5252479A
(en)
|
1991-11-08 |
1993-10-12 |
Research Corporation Technologies, Inc. |
Safe vector for gene therapy
|
|
DE69233528T2
(de)
|
1991-11-25 |
2006-03-16 |
Enzon, Inc. |
Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen
|
|
FR2688514A1
(fr)
|
1992-03-16 |
1993-09-17 |
Centre Nat Rech Scient |
Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant.
|
|
JP2579202Y2
(ja)
|
1992-04-10 |
1998-08-20 |
株式会社小松製作所 |
圧力補償弁を備えた操作弁
|
|
US5600392A
(en)
|
1992-11-25 |
1997-02-04 |
Copal Company Limited |
Position sensor
|
|
EP0673431A1
(en)
|
1992-12-03 |
1995-09-27 |
Genzyme Corporation |
Gene therapy for cystic fibrosis
|
|
US6010913A
(en)
|
1992-12-14 |
2000-01-04 |
N.V. Innogenetics S.A. |
Isolated human tau peptide
|
|
AU690092B2
(en)
|
1992-12-14 |
1998-04-23 |
N.V. Innogenetics S.A. |
Monoclonal antibodies directed against the microtubule-associated protein tau, hybridomas secreting these antibodies, antigen recognition by these monoclonal antibodies and their applications
|
|
US5346981A
(en)
|
1993-01-13 |
1994-09-13 |
Miles Inc. |
Radiopaque polyurethanes
|
|
DE614989T1
(de)
|
1993-02-17 |
1995-09-28 |
Morphosys Proteinoptimierung |
Verfahren für in vivo Selektion von Ligandenbindende Proteine.
|
|
EP0705344B8
(en)
|
1993-06-24 |
2006-05-10 |
Advec Inc. |
Adenovirus vectors for gene therapy
|
|
DE69435223D1
(de)
|
1993-10-25 |
2009-09-03 |
Canji Inc |
Rekombinanter Adenoviren-Vektor und Verfahren zur Verwendung
|
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
ATE335007T1
(de)
|
1993-12-21 |
2006-08-15 |
Innogenetics Nv |
Monoklonale antikörper gegen phf-tau, hybridomen die diese ausscheiden, antigenerkennung durch diesen antikörper und deren verwendungen
|
|
CA2195672A1
(en)
|
1994-07-29 |
1996-02-15 |
Eugeen Vanmechelen |
Monoclonal antibodies specific for an epitope of a particular subclass or form of phosphorylated tau, hybridomas secreting them, antigen recognition of these antibodies and their applications
|
|
US5625048A
(en)
|
1994-11-10 |
1997-04-29 |
The Regents Of The University Of California |
Modified green fluorescent proteins
|
|
US7427392B1
(en)
|
1994-11-14 |
2008-09-23 |
Elan Pharmaceuticals, Inc. |
Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau
|
|
SG119177A1
(en)
|
1994-12-09 |
2006-02-28 |
Imp College Innovations Ltd |
Identification of genes
|
|
WO1996019487A1
(en)
|
1994-12-22 |
1996-06-27 |
Nissan Chemical Industries, Ltd. |
Organobismuth derivatives and process for producing the same
|
|
US5958713A
(en)
|
1995-01-31 |
1999-09-28 |
Novo Nordisk A/S |
Method of detecting biologically active substances by using green fluorescent protein
|
|
US5670477A
(en)
|
1995-04-20 |
1997-09-23 |
Joseph F. Poduslo |
Method to enhance permeability of the blood/brain blood/nerve bariers to therapeutic agents
|
|
US5968738A
(en)
|
1995-12-06 |
1999-10-19 |
The Board Of Trustees Of The Leland Stanford Junior University |
Two-reporter FACS analysis of mammalian cells using green fluorescent proteins
|
|
US5874304A
(en)
|
1996-01-18 |
1999-02-23 |
University Of Florida Research Foundation, Inc. |
Humanized green fluorescent protein genes and methods
|
|
US6020192A
(en)
|
1996-01-18 |
2000-02-01 |
University Of Florida |
Humanized green fluorescent protein genes and methods
|
|
DE69708318T3
(de)
|
1996-08-27 |
2006-11-16 |
Novartis Vaccines and Diagnostics, Inc., Emeryville |
Neisseria meningitidis serogruppe b glykokonjugate und verfahren zu deren verwendung
|
|
US5976796A
(en)
|
1996-10-04 |
1999-11-02 |
Loma Linda University |
Construction and expression of renilla luciferase and green fluorescent protein fusion genes
|
|
TW371617B
(en)
|
1996-10-09 |
1999-10-11 |
Of Animal And Plant Health Inspection And Quarantine Council Of Agriculture Executive Yuan Bureau |
Method to transplant GFP into autographa californica multiple nuclear polyhedrosis virus for inflicting pest in an attempt to detect and flow up it existence and to improve life span against UV
|
|
WO1998022120A1
(en)
|
1996-11-19 |
1998-05-28 |
The Wistar Institute Of Anatomy & Biology |
Diagnostic and therapeutic reagents for alzheimer's disease
|
|
US6080849A
(en)
|
1997-09-10 |
2000-06-27 |
Vion Pharmaceuticals, Inc. |
Genetically modified tumor-targeted bacteria with reduced virulence
|
|
US6046305A
(en)
|
1997-12-12 |
2000-04-04 |
Macromed, Inc. |
Heterofunctionalized star-shaped poly(ethylene gycols) for protein modification
|
|
US20040014142A1
(en)
|
1998-07-03 |
2004-01-22 |
Innogenetics N.V. |
Differential diagnosis of neurodegeneration
|
|
US5985577A
(en)
|
1998-10-14 |
1999-11-16 |
The Trustees Of Columbia University In The City Of New York |
Protein conjugates containing multimers of green fluorescent protein
|
|
WO2001006989A2
(en)
|
1999-07-27 |
2001-02-01 |
Abgenix, Inc. |
Methods and compositions for inhibiting polypeptide accumulation associated with neurological disorders
|
|
BR0107851A
(pt)
|
2000-01-24 |
2002-10-29 |
Innogenetics Nv |
Diagnose de tauopatia
|
|
DE60141752D1
(de)
|
2000-06-30 |
2010-05-20 |
Innogenetics Nv |
Differentielle diagnose von neurologischen krankheiten
|
|
AU2001273361A1
(en)
|
2000-07-11 |
2002-01-21 |
Molecular Geriatrics Corporation |
Reagents and methods for identification of binding agents
|
|
AU2002222139A1
(en)
|
2000-12-09 |
2002-06-18 |
Cambridge University Technical Services Limited |
Hcv vaccines
|
|
US7466180B2
(en)
|
2000-12-12 |
2008-12-16 |
Intel Corporation |
Clock network
|
|
GB0101049D0
(en)
|
2001-01-15 |
2001-02-28 |
Univ Aberdeen |
Materials and methods relating to protein aggregation in neurodegenerative disease
|
|
AT500379B8
(de)
|
2001-02-02 |
2009-08-15 |
Axon Neuroscience |
Tau-proteine
|
|
GB0105924D0
(en)
|
2001-03-09 |
2001-04-25 |
Microscience Ltd |
Promoter
|
|
WO2002094191A2
(en)
|
2001-05-23 |
2002-11-28 |
New York University |
Detection of alzheimer's amyloid by magnetic resonance imaging
|
|
GB0117326D0
(en)
|
2001-07-16 |
2001-09-05 |
Univ Aberdeen |
Napthoquinone-type inhibitors of protein aggregation
|
|
CA2456121A1
(en)
|
2001-08-03 |
2003-02-20 |
Medical Research Council |
Intracellular antibodies
|
|
IL160701A0
(en)
|
2001-09-21 |
2004-08-31 |
Mitsubishi Pharma Corp |
3-substituted-4-pyrimidone derivatives
|
|
WO2004001421A2
(en)
|
2002-06-21 |
2003-12-31 |
Innogenetics N.V. |
Method for the diagnosis and differential diagnosis of neurological diseases
|
|
WO2004007722A2
(en)
|
2002-07-12 |
2004-01-22 |
Axon Neuroscience Forschungs- Und Entwicklungs Gmbh |
Transgenic animal expressing alzheimer’s tau protein
|
|
US7250551B2
(en)
|
2002-07-24 |
2007-07-31 |
President And Fellows Of Harvard College |
Transgenic mice expressing inducible human p25
|
|
DE60334460D1
(de)
|
2002-08-14 |
2010-11-18 |
Mitsubishi Chem Medience Corp |
Antikörper spezifisch für das tau-protein des zentralen nervensystems
|
|
EP1480041A1
(en)
|
2003-05-22 |
2004-11-24 |
Innogenetics N.V. |
Method for the prediction, diagnosis and differential diagnosis of Alzheimer's disease
|
|
DK1641822T3
(da)
|
2003-07-08 |
2013-07-22 |
Genentech Inc |
Heterologe il-17-a/f-polypeptider og terapeutiske anvendelser deraf.
|
|
US20050261475A1
(en)
|
2004-02-13 |
2005-11-24 |
Harvard Medical School |
Solid-phase capture-release-tag methods for phosphoproteomic analyses
|
|
US7238788B2
(en)
|
2004-02-18 |
2007-07-03 |
University Of Iowa Foundation |
Antibodies to phosphorylated tau, methods of making and methods of use
|
|
EP1721004A2
(en)
|
2004-02-24 |
2006-11-15 |
Innogenetics N.V. |
Method for determining the risk of developing a neurological disease
|
|
WO2005113798A2
(en)
|
2004-04-15 |
2005-12-01 |
University Of Florida Research Foundation, Inc. |
Proteolytic markers as diagnostic biomarkers for cancer, organ injury and muscle rehabilitation/exercise overtraining
|
|
US20100062001A1
(en)
|
2004-06-09 |
2010-03-11 |
Technion Research & Development |
Antibodies for selective apoptosis of cells
|
|
EP1771205B1
(en)
|
2004-06-18 |
2016-10-26 |
Ambrx, Inc. |
Novel antigen-binding polypeptides and their uses
|
|
CN1721437A
(zh)
*
|
2004-07-13 |
2006-01-18 |
中南大学 |
一种与Tau蛋白相关的多肽抗原及抗体
|
|
JP4730584B2
(ja)
|
2004-12-06 |
2011-07-20 |
東亞合成株式会社 |
抗菌ペプチド及びその利用
|
|
US20090016959A1
(en)
|
2005-02-18 |
2009-01-15 |
Richard Beliveau |
Delivery of antibodies to the central nervous system
|
|
EP1772732A1
(en)
|
2005-10-07 |
2007-04-11 |
Innogenetics N.V. |
Polymer replicated interdigitated electrode arrays for (bio)sensing applications
|
|
US8741260B2
(en)
|
2005-10-07 |
2014-06-03 |
Armagen Technologies, Inc. |
Fusion proteins for delivery of GDNF to the CNS
|
|
WO2007068105A1
(en)
|
2005-12-12 |
2007-06-21 |
Robarts Research Institute |
Method of diagnosing amyotrophic lateral sclerosis
|
|
US20070218491A1
(en)
|
2006-02-08 |
2007-09-20 |
Oligomerix, Inc. |
Oligomerization of amyloid proteins
|
|
US20110143380A1
(en)
|
2006-03-14 |
2011-06-16 |
The Washington University |
Alzheimer's disease biomarkers and methods of use
|
|
US8012936B2
(en)
|
2006-03-29 |
2011-09-06 |
New York University |
Tau fragments for immunotherapy
|
|
US8729225B2
(en)
|
2006-11-13 |
2014-05-20 |
Intrexon Corporation |
Glycogen synthase kinase heteropolyligand polypeptide
|
|
HRP20140049T1
(hr)
|
2007-01-05 |
2014-02-28 |
University Of Zürich |
Anti beta-amiloid antitijela i njihova upotreba
|
|
US20080220449A1
(en)
|
2007-02-08 |
2008-09-11 |
Oligomerix, Inc. |
Biomarkers and assays for Alzheimer's disease
|
|
WO2009002607A1
(en)
|
2007-05-01 |
2008-12-31 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for identifying transforming and tumor suppressor genes
|
|
PE20090329A1
(es)
|
2007-05-30 |
2009-03-27 |
Abbott Lab |
Anticuerpos humanizados contra el globulomero ab(20-42) y sus usos
|
|
US8481277B2
(en)
|
2007-08-21 |
2013-07-09 |
Washington University |
Alzheimer's diagnosis
|
|
JP2010536907A
(ja)
|
2007-08-31 |
2010-12-02 |
ニューリミューン セラピューティクス エイジー |
患者にアミロイドーシスおよびタンパク質凝集性障害における特異的免疫応答をもたらす方法
|
|
JP2010538611A
(ja)
|
2007-09-07 |
2010-12-16 |
ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク |
タウタンパク質スクリーニングアッセイ
|
|
US8506933B2
(en)
|
2007-11-30 |
2013-08-13 |
Msdx, Inc. |
Methods of detecting a neurological condition via analysis of circulating phagocytes
|
|
JP5781929B2
(ja)
|
2008-07-15 |
2015-09-24 |
ノバルティス アーゲー |
免疫原性の両親媒性ペプチド組成物
|
|
US20110312059A1
(en)
|
2008-08-20 |
2011-12-22 |
Oligomerix Inc. |
Tau protease compositions and methods
|
|
US20110288011A1
(en)
|
2008-12-05 |
2011-11-24 |
Jean-Paul Castaigne |
Peptide therapeutic conjugates and uses thereof
|
|
US9605054B2
(en)
|
2009-02-23 |
2017-03-28 |
The Board Of Trustees Of The University Of Illinois |
Composition and method for treating a tauopathy
|
|
UA107571C2
(xx)
|
2009-04-03 |
2015-01-26 |
|
Фармацевтична композиція
|
|
US8409584B2
(en)
|
2009-05-05 |
2013-04-02 |
New York University |
Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins
|
|
EP2430446A4
(en)
|
2009-05-11 |
2012-12-05 |
Nexus Dx Inc |
METHOD AND COMPOSITIONS FOR DETECTING ANALYTES
|
|
EP4218794A3
(en)
|
2009-06-10 |
2023-09-13 |
New York University |
Immunological targeting of pathological tau proteins
|
|
US8609097B2
(en)
|
2009-06-10 |
2013-12-17 |
Hoffmann-La Roche Inc. |
Use of an anti-Tau pS422 antibody for the treatment of brain diseases
|
|
CN102596236B
(zh)
|
2009-07-30 |
2015-06-24 |
辉瑞疫苗有限责任公司 |
抗原性Tau肽及其用途
|
|
EP2470211B1
(en)
|
2009-08-28 |
2016-01-27 |
The Board of Regents of The University of Texas System |
Antibodies that bind tau oligomers
|
|
CA2990678C
(en)
|
2009-11-06 |
2021-08-31 |
The J. David Gladstone Institutes |
Methods and compositions for modulating tau levels
|
|
WO2012020124A1
(en)
|
2010-08-12 |
2012-02-16 |
Ac Immune S.A. |
Vaccine engineering
|
|
WO2012045882A2
(en)
|
2010-10-07 |
2012-04-12 |
Ac Immune S.A. |
Pharmaceutical composition
|
|
LT2627672T
(lt)
|
2010-10-11 |
2018-12-10 |
Biogen International Neuroscience Gmbh |
Žmogaus antikūnai prieš tau baltymą
|
|
WO2012106363A2
(en)
*
|
2011-01-31 |
2012-08-09 |
Intellect Neurosciences Inc. |
Treatment of tauopathies
|
|
EP4086338A1
(en)
|
2011-03-17 |
2022-11-09 |
Minerva Biotechnologies Corporation |
Method for making pluripotent stem cells
|
|
GB201111361D0
(en)
|
2011-07-04 |
2011-08-17 |
Nordic Bioscience As |
Biochemical markers for neurodegenerative conditions
|
|
GB201112056D0
(en)
*
|
2011-07-14 |
2011-08-31 |
Univ Leuven Kath |
Antibodies
|
|
EP3275461A1
(en)
|
2011-09-19 |
2018-01-31 |
Axon Neuroscience SE |
Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease field
|
|
CA2811188C
(en)
|
2011-09-23 |
2020-04-28 |
Andrea Pfeifer |
Vaccine therapy
|
|
JP6358953B2
(ja)
|
2011-10-07 |
2018-07-18 |
エーシー イミューン エス.エー. |
タウを認識するホスホ特異的抗体
|
|
CA2853100A1
(en)
|
2011-10-24 |
2013-05-02 |
Intellect Neurosciences, Inc. |
Compositions and methods for treatment of proteinopathies
|
|
CA2859665C
(en)
|
2011-12-20 |
2024-05-21 |
Janssen Biotech, Inc. |
Anti-phf-tau antibodies and their uses
|
|
CA2869438C
(en)
|
2012-04-05 |
2021-08-17 |
Ac Immune S.A. |
Humanized tau antibody
|
|
EP2870176A4
(en)
|
2012-07-03 |
2016-09-28 |
Univ Washington |
ANTIBODIES DIRECTED AGAINST TAU
|
|
EP2885010B1
(en)
|
2012-08-16 |
2020-01-01 |
Ipierian, Inc. |
Methods of treating a tauopathy
|
|
US20140056901A1
(en)
|
2012-08-21 |
2014-02-27 |
The Institute For Molecular Medicine |
Anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies
|
|
US8980270B2
(en)
|
2013-01-18 |
2015-03-17 |
Ipierian, Inc. |
Methods of treating a tauopathy
|
|
SMT202000401T1
(it)
*
|
2013-06-10 |
2020-11-10 |
Ipierian Inc |
Metodi di trattamento di una taupatia
|
|
US20160122421A1
(en)
|
2013-06-10 |
2016-05-05 |
Ipierian, Inc. |
Methods of treating a tauopathy
|
|
BR112016010454A2
(pt)
|
2013-11-27 |
2017-12-05 |
Ipierian Inc |
métodos para tratar uma taupatia
|
|
CN105939722A
(zh)
|
2014-02-14 |
2016-09-14 |
伊皮埃里安股份有限公司 |
Tau肽,抗Tau抗体,及其使用方法
|