JP2015529236A - ヘテロ二量体免疫グロブリンの精製 - Google Patents

ヘテロ二量体免疫グロブリンの精製 Download PDF

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Publication number
JP2015529236A
JP2015529236A JP2015532465A JP2015532465A JP2015529236A JP 2015529236 A JP2015529236 A JP 2015529236A JP 2015532465 A JP2015532465 A JP 2015532465A JP 2015532465 A JP2015532465 A JP 2015532465A JP 2015529236 A JP2015529236 A JP 2015529236A
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Prior art keywords
immunoglobulin
region
fragment
amino acid
protein
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Japanese (ja)
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JP2015529236A5 (show.php
Inventor
ブレイン，スタニスラス
コンペル，ファブリツィオ
オリエル，ロメイン
ワスマン，ポール
Original Assignee
グレンマーク ファーマシューティカルズ， エセ．アー．
グレンマーク ファーマシューティカルズ， エセ．アー．
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Publication of JP2015529236A publication Critical patent/JP2015529236A/ja
Publication of JP2015529236A5 publication Critical patent/JP2015529236A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2015532465A 2012-09-25 2013-09-25 ヘテロ二量体免疫グロブリンの精製 Pending JP2015529236A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261705278P 2012-09-25 2012-09-25
US61/705,278 2012-09-25
PCT/EP2013/069989 WO2014049003A1 (en) 2012-09-25 2013-09-25 Purification of hetero-dimeric immunoglobulins

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2018020450A Division JP2018104444A (ja) 2012-09-25 2018-02-07 ヘテロ二量体免疫グロブリンの精製
JP2018224809A Division JP6856610B2 (ja) 2012-09-25 2018-11-30 ヘテロ二量体免疫グロブリンの精製

Publications (2)

Publication Number Publication Date
JP2015529236A true JP2015529236A (ja) 2015-10-05
JP2015529236A5 JP2015529236A5 (show.php) 2016-11-10

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ID=49237223

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2015532465A Pending JP2015529236A (ja) 2012-09-25 2013-09-25 ヘテロ二量体免疫グロブリンの精製
JP2018020450A Pending JP2018104444A (ja) 2012-09-25 2018-02-07 ヘテロ二量体免疫グロブリンの精製
JP2018224809A Expired - Fee Related JP6856610B2 (ja) 2012-09-25 2018-11-30 ヘテロ二量体免疫グロブリンの精製
JP2020036853A Ceased JP2020105203A (ja) 2012-09-25 2020-03-04 ヘテロ二量体免疫グロブリンの精製
JP2022092045A Pending JP2022116326A (ja) 2012-09-25 2022-06-07 ヘテロ二量体免疫グロブリンの精製

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2018020450A Pending JP2018104444A (ja) 2012-09-25 2018-02-07 ヘテロ二量体免疫グロブリンの精製
JP2018224809A Expired - Fee Related JP6856610B2 (ja) 2012-09-25 2018-11-30 ヘテロ二量体免疫グロブリンの精製
JP2020036853A Ceased JP2020105203A (ja) 2012-09-25 2020-03-04 ヘテロ二量体免疫グロブリンの精製
JP2022092045A Pending JP2022116326A (ja) 2012-09-25 2022-06-07 ヘテロ二量体免疫グロブリンの精製

Country Status (11)

Country Link
US (2) US20150239991A1 (show.php)
EP (2) EP3401337A1 (show.php)
JP (5) JP2015529236A (show.php)
KR (1) KR20150076172A (show.php)
CN (1) CN104968685A (show.php)
AU (2) AU2013322710A1 (show.php)
CA (2) CA3061557A1 (show.php)
HK (1) HK1215950A1 (show.php)
IL (2) IL237872B (show.php)
IN (1) IN2015MN00139A (show.php)
WO (1) WO2014049003A1 (show.php)

Cited By (2)

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Publication number Priority date Publication date Assignee Title
JP2020105203A (ja) * 2012-09-25 2020-07-09 イクノス サイエンシズ エスエー ヘテロ二量体免疫グロブリンの精製
JP2021528435A (ja) * 2018-06-22 2021-10-21 ゲンマブ エー／エス ２つ以上の異なる抗体の制御された混合物を産生するための方法

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