JP2015529198A5 - - Google Patents
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- Publication number
- JP2015529198A5 JP2015529198A5 JP2015528571A JP2015528571A JP2015529198A5 JP 2015529198 A5 JP2015529198 A5 JP 2015529198A5 JP 2015528571 A JP2015528571 A JP 2015528571A JP 2015528571 A JP2015528571 A JP 2015528571A JP 2015529198 A5 JP2015529198 A5 JP 2015529198A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- immunogenic carrier
- conjugate
- protein
- nhc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 41
- 230000002163 immunogen Effects 0.000 claims description 26
- 102000004169 proteins and genes Human genes 0.000 claims description 14
- 108090000623 proteins and genes Proteins 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 101000800130 Bos taurus Thyroglobulin Proteins 0.000 claims description 8
- 108010058846 Ovalbumin Proteins 0.000 claims description 8
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims description 8
- 229940092253 ovalbumin Drugs 0.000 claims description 8
- URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 description 6
- 229960004431 quetiapine Drugs 0.000 description 6
- 125000005647 linker group Chemical group 0.000 description 3
- 125000006850 spacer group Chemical group 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 2
- 239000012491 analyte Substances 0.000 description 2
- 125000003710 aryl alkyl group Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 238000003556 assay Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 238000002967 competitive immunoassay Methods 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261691462P | 2012-08-21 | 2012-08-21 | |
| US61/691,462 | 2012-08-21 | ||
| PCT/US2013/055724 WO2014031600A1 (en) | 2012-08-21 | 2013-08-20 | Haptens of quetiapine for use in immunoassays |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015529198A JP2015529198A (ja) | 2015-10-05 |
| JP2015529198A5 true JP2015529198A5 (cg-RX-API-DMAC7.html) | 2016-04-14 |
| JP6131415B2 JP6131415B2 (ja) | 2017-05-24 |
Family
ID=49081009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015528571A Active JP6131415B2 (ja) | 2012-08-21 | 2013-08-20 | イムノアッセイに使用するためのクエチアピンのハプテン |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9304126B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3305784B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6131415B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN104736536B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2013305935B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2882557C (cg-RX-API-DMAC7.html) |
| ES (2) | ES2822907T3 (cg-RX-API-DMAC7.html) |
| PL (2) | PL3305784T3 (cg-RX-API-DMAC7.html) |
| PT (2) | PT3305784T (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014031600A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015529199A (ja) | 2012-08-21 | 2015-10-05 | オルソ−クリニカル ダイアグノスティクス，インコーポレイティド | パリペリドンハプテンに対する抗体及びその使用 |
| ES2822004T3 (es) | 2012-08-21 | 2021-04-28 | Janssen Pharmaceutica Nv | Anticuerpos contra quetiapina y uso de los mismos |
| WO2014031584A1 (en) | 2012-08-21 | 2014-02-27 | Janssen Pharmaceutica Nv | Haptens of aripiprazole and their use in immunoassays |
| JP6389176B2 (ja) | 2012-08-21 | 2018-09-12 | ヤンセン ファーマシューティカ エヌ．ベー． | アリピプラゾールハプテンに対する抗体及びその使用 |
| PT3305784T (pt) * | 2012-08-21 | 2020-10-23 | Janssen Pharmaceutica Nv | Haptenos de quetiapina para utilização em ensaios imunológicos |
| CN108517014A (zh) | 2012-08-21 | 2018-09-11 | 詹森药业有限公司 | 利培酮半抗原的抗体及其用途 |
| JP6450314B2 (ja) | 2012-08-21 | 2019-01-09 | ヤンセン ファーマシューティカ エヌ．ベー． | クエチアピンハプテンに対する抗体及びその使用 |
| JP6389177B2 (ja) | 2012-08-21 | 2018-09-12 | ヤンセン ファーマシューティカ エヌ．ベー． | オランザピンハプテンに対する抗体及びその使用 |
| CN107043424B (zh) | 2012-08-21 | 2021-03-16 | 詹森药业有限公司 | 利培酮的抗体及其用途 |
| AU2013305901B2 (en) | 2012-08-21 | 2017-10-26 | Saladax Biomedical Inc. | Antibodies to olanzapine and use thereof |
| CN104736561B (zh) | 2012-08-21 | 2018-06-12 | 詹森药业有限公司 | 帕潘立酮的抗体及其用途 |
| AU2013305879B2 (en) | 2012-08-21 | 2017-10-12 | Saladax Biomedical Inc. | Antibodies to aripiprazole and use thereof |
| BR112017017719A2 (pt) * | 2015-02-20 | 2018-04-10 | Idexx Lab Inc | imunoensaio homogêneo com compensação para sinal antecedente |
| CA3008809A1 (en) | 2015-12-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Antibodies to risperidone and use thereof |
| WO2017106508A1 (en) | 2015-12-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Antibodies to quetiapine and use thereof |
| US11422136B2 (en) | 2017-10-19 | 2022-08-23 | Idexx Laboratories, Inc. | Detection of symmetrical dimethylarginine |
| CN113811356B (zh) | 2019-03-08 | 2025-01-03 | 美国迈胜医疗系统有限公司 | 用于粒子治疗系统的准直器和射程调节器 |
| CN111808046B (zh) * | 2020-06-30 | 2022-11-11 | 杭州同舟生物技术有限公司 | 一种喹硫平人工半抗原、人工抗原及其制备方法和应用 |
| CN116354904B (zh) * | 2023-04-26 | 2023-08-01 | 北京丹大生物技术有限公司 | 一种喹硫平衍生物半抗原、抗原、抗喹硫平抗体及其应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| NO305125B1 (no) | 1992-05-29 | 1999-04-06 | Lilly Industries Ltd | Farmas°ytiske forbindelser |
| US6034078A (en) | 1992-05-29 | 2000-03-07 | Eli Lilly And Company Limited | Thienobenzodiazepine compounds |
| US5395933A (en) | 1992-08-07 | 1995-03-07 | Eastman Kodak Company | Carbamazepine hapten analogues |
| US6958156B2 (en) | 2000-12-15 | 2005-10-25 | Vyrex Corporation | Isoflavone derivatives |
| US7193065B2 (en) * | 2001-07-13 | 2007-03-20 | Roche Diagnostics Operations, Inc. | Protease inhibitor conjugates and antibodies useful in immunoassay |
| ES2297142T3 (es) | 2002-03-28 | 2008-05-01 | Eli Lilly And Company | Arilbenzodiazepinas sustituidas con piperazina y su uso como antagonistas del receptor de dopamina para el tratamiento de trastornos psicoticos. |
| AU2003264915A1 (en) | 2002-08-05 | 2004-02-25 | Eli Lilly And Company | Piperazine substituted aryl benzodiazepines |
| PT1664007E (pt) * | 2003-09-23 | 2010-02-15 | Fermion Oy | Preparação de quetiapina |
| TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
| FR2878850B1 (fr) * | 2004-12-02 | 2008-10-31 | Cis Bio Internat Sa | Derives de l'inositol-1-phosphate |
| KR20100075455A (ko) | 2007-09-27 | 2010-07-02 | 노파르티스 아게 | 약물 모니터링 분석법 |
| US20100069356A1 (en) | 2008-09-17 | 2010-03-18 | Auspex Pharmaceuticals, Inc. | Dibenzothiazepine modulators of dopamine, alpha adrenergic, and serotonin receptors |
| WO2010043893A1 (en) | 2008-10-14 | 2010-04-22 | Astrazeneca Ab | Fused, spirocyclic heteroaromatic compounds for the treatment of bacterial infections |
| EP2194048A1 (en) | 2008-12-02 | 2010-06-09 | Dirk Sartor | Nitrate esters for the treatment of vascular and metabolic diseases |
| JP5544024B2 (ja) | 2009-12-31 | 2014-07-09 | ケムファーム・インコーポレーテッド | クエチアピンのアミノ酸結合体、その製造法及び使用法 |
| HUE042945T2 (hu) * | 2010-03-11 | 2019-07-29 | Kempharm Inc | Kvetiapin zsírsav-konjugátumai, eljárás ugyanannak elkészítésére és felhasználására |
| US8088594B2 (en) | 2010-03-16 | 2012-01-03 | Saladax Biomedical Inc. | Risperidone immunoassay |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| US8623324B2 (en) | 2010-07-21 | 2014-01-07 | Aat Bioquest Inc. | Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates |
| JP5757497B2 (ja) * | 2010-10-06 | 2015-07-29 | 公立大学法人大阪府立大学 | シガトキシン類ｃｔｘ１ｂおよび５４−デオキシ−ｃｔｘ１ｂを認識するモノクローナル抗体およびそれを用いるシガトキシン類検出キット |
| NZ722096A (en) | 2011-12-15 | 2016-11-25 | Alkermes Pharma Ireland Ltd | Prodrugs of secondary amine compounds |
| PT3305784T (pt) * | 2012-08-21 | 2020-10-23 | Janssen Pharmaceutica Nv | Haptenos de quetiapina para utilização em ensaios imunológicos |
-
2013
- 2013-08-20 PT PT171843402T patent/PT3305784T/pt unknown
- 2013-08-20 CN CN201380054991.5A patent/CN104736536B/zh active Active
- 2013-08-20 CA CA2882557A patent/CA2882557C/en active Active
- 2013-08-20 ES ES17184340T patent/ES2822907T3/es active Active
- 2013-08-20 PT PT137537775T patent/PT2888257T/pt unknown
- 2013-08-20 ES ES13753777.5T patent/ES2645433T3/es active Active
- 2013-08-20 US US13/970,667 patent/US9304126B2/en active Active
- 2013-08-20 CN CN201710438822.1A patent/CN107266432B/zh active Active
- 2013-08-20 WO PCT/US2013/055724 patent/WO2014031600A1/en not_active Ceased
- 2013-08-20 PL PL17184340T patent/PL3305784T3/pl unknown
- 2013-08-20 EP EP17184340.2A patent/EP3305784B1/en active Active
- 2013-08-20 PL PL13753777T patent/PL2888257T3/pl unknown
- 2013-08-20 AU AU2013305935A patent/AU2013305935B2/en not_active Ceased
- 2013-08-20 EP EP13753777.5A patent/EP2888257B1/en active Active
- 2013-08-20 JP JP2015528571A patent/JP6131415B2/ja active Active
-
2017
- 2017-11-20 AU AU2017264980A patent/AU2017264980B2/en not_active Ceased
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