JP2015528294A5 - - Google Patents
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- Publication number
- JP2015528294A5 JP2015528294A5 JP2015530085A JP2015530085A JP2015528294A5 JP 2015528294 A5 JP2015528294 A5 JP 2015528294A5 JP 2015530085 A JP2015530085 A JP 2015530085A JP 2015530085 A JP2015530085 A JP 2015530085A JP 2015528294 A5 JP2015528294 A5 JP 2015528294A5
- Authority
- JP
- Japan
- Prior art keywords
- amplification
- phase
- nucleic acid
- oligonucleotide
- target nucleic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000003321 amplification Effects 0.000 claims description 128
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 128
- 238000000034 method Methods 0.000 claims description 46
- 239000000523 sample Substances 0.000 claims description 39
- 108091034117 Oligonucleotide Proteins 0.000 claims description 38
- 150000007523 nucleic acids Chemical group 0.000 claims description 33
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 32
- 239000011541 reaction mixture Substances 0.000 claims description 30
- 238000009396 hybridization Methods 0.000 claims description 18
- 238000006243 chemical reaction Methods 0.000 claims description 17
- 238000013518 transcription Methods 0.000 claims description 17
- 230000035897 transcription Effects 0.000 claims description 17
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims description 9
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 9
- 102100034343 Integrase Human genes 0.000 claims description 7
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims description 5
- 101710137500 T7 RNA polymerase Proteins 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 238000011088 calibration curve Methods 0.000 claims description 3
- 230000000295 complement effect Effects 0.000 claims description 3
- 239000002299 complementary DNA Substances 0.000 claims description 3
- 238000001668 nucleic acid synthesis Methods 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 238000003786 synthesis reaction Methods 0.000 claims description 3
- 230000002194 synthesizing effect Effects 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 101710203526 Integrase Proteins 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261695106P | 2012-08-30 | 2012-08-30 | |
| US61/695,106 | 2012-08-30 | ||
| US201361846538P | 2013-07-15 | 2013-07-15 | |
| US61/846,538 | 2013-07-15 | ||
| PCT/US2013/057458 WO2014036369A1 (en) | 2012-08-30 | 2013-08-30 | Multiphase nucleic acid amplification |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017228861A Division JP2018038424A (ja) | 2012-08-30 | 2017-11-29 | 多相核酸増幅 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015528294A JP2015528294A (ja) | 2015-09-28 |
| JP2015528294A5 true JP2015528294A5 (enExample) | 2016-09-15 |
| JP6464086B2 JP6464086B2 (ja) | 2019-02-06 |
Family
ID=49162273
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530085A Active JP6464086B2 (ja) | 2012-08-30 | 2013-08-30 | 多相核酸増幅 |
| JP2017228861A Withdrawn JP2018038424A (ja) | 2012-08-30 | 2017-11-29 | 多相核酸増幅 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017228861A Withdrawn JP2018038424A (ja) | 2012-08-30 | 2017-11-29 | 多相核酸増幅 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US9139870B2 (enExample) |
| EP (2) | EP2890814B1 (enExample) |
| JP (2) | JP6464086B2 (enExample) |
| CN (1) | CN104755630B (enExample) |
| AU (1) | AU2013308647B2 (enExample) |
| CA (1) | CA2883219C (enExample) |
| DK (1) | DK2890814T3 (enExample) |
| ES (1) | ES2761920T3 (enExample) |
| WO (1) | WO2014036369A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2890814T3 (da) | 2012-08-30 | 2019-12-16 | Gen Probe Inc | Flerfaset nukleinsyreamplificering |
| CN109863252B (zh) | 2016-10-19 | 2024-09-20 | 简·探针公司 | 用于检测或定量丙型肝炎病毒的组合物和方法 |
| CA3042451A1 (en) | 2016-11-21 | 2018-05-24 | Gen-Probe Incorporated | Compositions and methods for detecting or quantifying hepatitis b virus |
| US11377688B2 (en) | 2017-11-17 | 2022-07-05 | Gen-Probe Incorporated | Compositions and methods for detecting C1orf43 nucleic acid |
| US11499193B2 (en) | 2018-02-06 | 2022-11-15 | Gen-Probe Incorporated | Far-red dye probe formulations |
| US12454728B2 (en) * | 2018-08-21 | 2025-10-28 | Gen-Probe Incorporated | Compositions and methods for amplifying, detecting or quantifying human cytomegalovirus |
| CA3144452A1 (en) * | 2019-07-03 | 2021-01-07 | Gen-Probe Incorporated | Oligonucleotides for use in determining the presence of trichomonas vaginalis in a sample |
| WO2021041056A1 (en) | 2019-08-23 | 2021-03-04 | Gen-Probe Incorporated | Compositions, methods and kits for detecting treponema pallidum |
| AU2021230341C8 (en) | 2020-03-04 | 2026-05-07 | Gen-Probe Incorporated | Compositions and methods for detecting SARS-CoV-2 nucleic acid |
| WO2024054924A1 (en) | 2022-09-08 | 2024-03-14 | Gen-Probe Incorporated | Method of detecting nucleic acid analytes using dual-specificity primers |
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-
2013
- 2013-08-30 DK DK13760215.7T patent/DK2890814T3/da active
- 2013-08-30 AU AU2013308647A patent/AU2013308647B2/en active Active
- 2013-08-30 US US14/014,607 patent/US9139870B2/en active Active
- 2013-08-30 CN CN201380053605.0A patent/CN104755630B/zh active Active
- 2013-08-30 EP EP13760215.7A patent/EP2890814B1/en active Active
- 2013-08-30 WO PCT/US2013/057458 patent/WO2014036369A1/en not_active Ceased
- 2013-08-30 JP JP2015530085A patent/JP6464086B2/ja active Active
- 2013-08-30 EP EP19207485.4A patent/EP3640348A1/en not_active Withdrawn
- 2013-08-30 CA CA2883219A patent/CA2883219C/en active Active
- 2013-08-30 ES ES13760215T patent/ES2761920T3/es active Active
-
2015
- 2015-09-16 US US14/856,339 patent/US10196674B2/en active Active
-
2017
- 2017-11-29 JP JP2017228861A patent/JP2018038424A/ja not_active Withdrawn
-
2019
- 2019-01-07 US US16/241,778 patent/US11859238B2/en active Active
-
2021
- 2021-05-24 US US17/328,312 patent/US12351858B2/en active Active
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