JP2015527082A5 - - Google Patents
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- JP2015527082A5 JP2015527082A5 JP2015531202A JP2015531202A JP2015527082A5 JP 2015527082 A5 JP2015527082 A5 JP 2015527082A5 JP 2015531202 A JP2015531202 A JP 2015531202A JP 2015531202 A JP2015531202 A JP 2015531202A JP 2015527082 A5 JP2015527082 A5 JP 2015527082A5
- Authority
- JP
- Japan
- Prior art keywords
- zinc finger
- fad2
- domain
- cell
- dna binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 31
- 230000004568 DNA-binding Effects 0.000 claims description 16
- 101000877236 Siganus canaliculatus Acyl-CoA Delta-4 desaturase Proteins 0.000 claims description 16
- 238000003776 cleavage reaction Methods 0.000 claims description 15
- 108090000623 proteins and genes Proteins 0.000 claims description 15
- 230000007017 scission Effects 0.000 claims description 15
- 241000196324 Embryophyta Species 0.000 claims description 13
- 235000010469 Glycine max Nutrition 0.000 claims description 13
- 244000068988 Glycine max Species 0.000 claims description 13
- 101150058769 FAD2 gene Proteins 0.000 claims description 12
- 150000007523 nucleic acids Chemical group 0.000 claims description 12
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims description 10
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 8
- 239000011701 zinc Substances 0.000 claims description 8
- 229910052725 zinc Inorganic materials 0.000 claims description 8
- 108020001507 fusion proteins Proteins 0.000 claims description 7
- 102000037865 fusion proteins Human genes 0.000 claims description 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 6
- 101710185494 Zinc finger protein Proteins 0.000 claims description 6
- 102100023597 Zinc finger protein 816 Human genes 0.000 claims description 6
- 239000002773 nucleotide Substances 0.000 claims description 6
- 125000003729 nucleotide group Chemical group 0.000 claims description 6
- 101150039504 6 gene Proteins 0.000 claims description 4
- 230000006378 damage Effects 0.000 claims description 4
- 108010026638 endodeoxyribonuclease FokI Proteins 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 238000010356 CRISPR-Cas9 genome editing Methods 0.000 claims description 2
- 102100031780 Endonuclease Human genes 0.000 claims description 2
- 108010042407 Endonucleases Proteins 0.000 claims description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 2
- 102000018120 Recombinases Human genes 0.000 claims description 2
- 108010091086 Recombinases Proteins 0.000 claims description 2
- 230000002363 herbicidal effect Effects 0.000 claims description 2
- 239000004009 herbicide Substances 0.000 claims description 2
- 239000003550 marker Substances 0.000 claims description 2
- 230000014075 nitrogen utilization Effects 0.000 claims description 2
- 235000016709 nutrition Nutrition 0.000 claims description 2
- 108091033319 polynucleotide Proteins 0.000 claims description 2
- 102000040430 polynucleotide Human genes 0.000 claims description 2
- 239000002157 polynucleotide Substances 0.000 claims description 2
- 230000012865 response to insecticide Effects 0.000 claims description 2
- 108091008146 restriction endonucleases Proteins 0.000 claims description 2
- 230000009261 transgenic effect Effects 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 230000002103 transcriptional effect Effects 0.000 claims 1
- 230000010354 integration Effects 0.000 description 2
- RBSXHDIPCIWOMG-UHFFFAOYSA-N 1-(4,6-dimethoxypyrimidin-2-yl)-3-(2-ethylsulfonylimidazo[1,2-a]pyridin-3-yl)sulfonylurea Chemical compound CCS(=O)(=O)C=1N=C2C=CC=CN2C=1S(=O)(=O)NC(=O)NC1=NC(OC)=CC(OC)=N1 RBSXHDIPCIWOMG-UHFFFAOYSA-N 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261697886P | 2012-09-07 | 2012-09-07 | |
| US61/697,886 | 2012-09-07 | ||
| PCT/US2013/058299 WO2014039702A2 (en) | 2012-09-07 | 2013-09-05 | Fad2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020016485A Division JP2020096611A (ja) | 2012-09-07 | 2020-02-03 | Ｆａｄ２性能座および標的化切断を誘導することができる対応する標的部位特異的結合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015527082A JP2015527082A (ja) | 2015-09-17 |
| JP2015527082A5 true JP2015527082A5 (enExample) | 2016-09-23 |
| JP6704251B2 JP6704251B2 (ja) | 2020-06-03 |
Family
ID=50237761
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531202A Active JP6704251B2 (ja) | 2012-09-07 | 2013-09-05 | Ｆａｄ２性能座および標的化切断を誘導することができる対応する標的部位特異的結合タンパク質 |
| JP2015531201A Expired - Fee Related JP6792943B2 (ja) | 2012-09-07 | 2013-09-05 | Ｆａｄ２性能座および標的化切断を誘導することができる対応する標的部位特異的結合タンパク質 |
| JP2020016485A Withdrawn JP2020096611A (ja) | 2012-09-07 | 2020-02-03 | Ｆａｄ２性能座および標的化切断を誘導することができる対応する標的部位特異的結合タンパク質 |
| JP2020025358A Withdrawn JP2020110150A (ja) | 2012-09-07 | 2020-02-18 | Ｆａｄ２性能座および標的化切断を誘導することができる対応する標的部位特異的結合タンパク質 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531201A Expired - Fee Related JP6792943B2 (ja) | 2012-09-07 | 2013-09-05 | Ｆａｄ２性能座および標的化切断を誘導することができる対応する標的部位特異的結合タンパク質 |
| JP2020016485A Withdrawn JP2020096611A (ja) | 2012-09-07 | 2020-02-03 | Ｆａｄ２性能座および標的化切断を誘導することができる対応する標的部位特異的結合タンパク質 |
| JP2020025358A Withdrawn JP2020110150A (ja) | 2012-09-07 | 2020-02-18 | Ｆａｄ２性能座および標的化切断を誘導することができる対応する標的部位特異的結合タンパク質 |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US9963711B2 (enExample) |
| EP (4) | EP2893023B1 (enExample) |
| JP (4) | JP6704251B2 (enExample) |
| KR (2) | KR102147005B1 (enExample) |
| CN (4) | CN104780756B (enExample) |
| AR (2) | AR092480A1 (enExample) |
| AU (2) | AU2013312455B2 (enExample) |
| BR (1) | BR112015004980B1 (enExample) |
| CA (2) | CA2884084C (enExample) |
| CL (2) | CL2015000561A1 (enExample) |
| HK (2) | HK1213736A1 (enExample) |
| IL (2) | IL237537B (enExample) |
| MX (2) | MX352081B (enExample) |
| NZ (1) | NZ705742A (enExample) |
| RU (2) | RU2656159C2 (enExample) |
| TW (1) | TWI667348B (enExample) |
| UA (1) | UA118090C2 (enExample) |
| UY (3) | UY35020A (enExample) |
| WO (2) | WO2014039692A2 (enExample) |
| ZA (2) | ZA201501397B (enExample) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| UA116097C2 (uk) | 2011-12-11 | 2018-02-12 | Зе Стейт Оф Ізраел, Міністрі Оф Агрікалче Енд Руерал Девелопмент, Агрікалчерал Рісьоч Організейшн, (А.Р.О.), Волкані Сентре | Спосіб модуляції провідності устячка рослини |
| GB201122458D0 (en) | 2011-12-30 | 2012-02-08 | Univ Wageningen | Modified cascade ribonucleoproteins and uses thereof |
| FI3597749T3 (fi) | 2012-05-25 | 2023-10-09 | Univ California | Menetelmiä ja koostumuksia rna-ohjattua kohde-dna-modifikaatiota varten ja rna-ohjattua transkription modulaatiota varten |
| US20150225734A1 (en) | 2012-06-19 | 2015-08-13 | Regents Of The University Of Minnesota | Gene targeting in plants using dna viruses |
| UA118090C2 (uk) * | 2012-09-07 | 2018-11-26 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив |
| CA2884162C (en) | 2012-09-07 | 2020-12-29 | Dow Agrosciences Llc | Fad3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks |
| UA119135C2 (uk) | 2012-09-07 | 2019-05-10 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Спосіб отримання трансгенної рослини |
| KR101656236B1 (ko) * | 2012-10-23 | 2016-09-12 | 주식회사 툴젠 | 표적 DNA에 특이적인 가이드 RNA 및 Cas 단백질을 암호화하는 핵산 또는 Cas 단백질을 포함하는, 표적 DNA를 절단하기 위한 조성물 및 이의 용도 |
| MX367031B (es) | 2012-11-01 | 2019-08-02 | Cellectis | Plantas para la produccion de proteinas terapeuticas. |
| PT3363902T (pt) | 2012-12-06 | 2019-12-19 | Sigma Aldrich Co Llc | Modificação e regulação de genoma baseadas em crispr |
| US20140178561A1 (en) | 2012-12-21 | 2014-06-26 | Cellectis | Potatoes with reduced cold-induced sweetening |
| AU2014235794A1 (en) | 2013-03-14 | 2015-10-22 | Caribou Biosciences, Inc. | Compositions and methods of nucleic acid-targeting nucleic acids |
| US10113162B2 (en) | 2013-03-15 | 2018-10-30 | Cellectis | Modifying soybean oil composition through targeted knockout of the FAD2-1A/1B genes |
| EP2966983B1 (en) * | 2013-03-15 | 2021-07-28 | Cellectis | Modifying soybean oil composition through targeted knockout of the fad2-1a/1b genes |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| KR20230054509A (ko) | 2013-11-07 | 2023-04-24 | 에디타스 메디신, 인코포레이티드 | 지배적인 gRNA를 이용하는 CRISPR-관련 방법 및 조성물 |
| US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
| CA2952906A1 (en) | 2014-06-20 | 2015-12-23 | Cellectis | Potatoes with reduced granule-bound starch synthase |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| US9970030B2 (en) | 2014-08-27 | 2018-05-15 | Caribou Biosciences, Inc. | Methods for increasing CAS9-mediated engineering efficiency |
| CN107250148B (zh) | 2014-12-03 | 2021-04-16 | 安捷伦科技有限公司 | 具有化学修饰的指导rna |
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| WO2016174119A1 (en) * | 2015-04-28 | 2016-11-03 | Bayer Cropscience Nv | Brassica plants with modified seed oil composition |
| US10837024B2 (en) | 2015-09-17 | 2020-11-17 | Cellectis | Modifying messenger RNA stability in plant transformations |
| US12043852B2 (en) | 2015-10-23 | 2024-07-23 | President And Fellows Of Harvard College | Evolved Cas9 proteins for gene editing |
| EP4646936A3 (en) | 2016-02-02 | 2025-11-19 | Cellectis | Modifying soybean oil composition through targeted knockout of the fad3a/b/c genes |
| US10767175B2 (en) | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs |
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| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
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| KR20190127797A (ko) | 2017-03-10 | 2019-11-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 시토신에서 구아닌으로의 염기 편집제 |
| CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
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| CN107217070A (zh) * | 2017-05-22 | 2017-09-29 | 广东省农业科学院作物研究所 | 一种基于TALENs基因编辑花生育种方法 |
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