JP2015526487A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015526487A5 JP2015526487A5 JP2015528857A JP2015528857A JP2015526487A5 JP 2015526487 A5 JP2015526487 A5 JP 2015526487A5 JP 2015528857 A JP2015528857 A JP 2015528857A JP 2015528857 A JP2015528857 A JP 2015528857A JP 2015526487 A5 JP2015526487 A5 JP 2015526487A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- alkyl
- pharmaceutically acceptable
- mesomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210323870 | 2012-09-04 | ||
| CN201210323870.3 | 2012-09-04 | ||
| PCT/CN2013/082273 WO2014036897A1 (zh) | 2012-09-04 | 2013-08-26 | 咪唑啉类衍生物、其制备方法及其在医药上的应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015526487A JP2015526487A (ja) | 2015-09-10 |
| JP2015526487A5 true JP2015526487A5 (enExample) | 2017-12-21 |
| JP6262733B2 JP6262733B2 (ja) | 2018-01-17 |
Family
ID=50236528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015528857A Active JP6262733B2 (ja) | 2012-09-04 | 2013-08-26 | イミダゾリン誘導体、その製造法、およびそれらの医薬への適用 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9586947B2 (enExample) |
| EP (1) | EP2894151B1 (enExample) |
| JP (1) | JP6262733B2 (enExample) |
| KR (1) | KR102189940B1 (enExample) |
| CN (1) | CN103958480B (enExample) |
| AU (1) | AU2013312587B2 (enExample) |
| BR (1) | BR112015004637B1 (enExample) |
| CA (1) | CA2883545C (enExample) |
| CY (1) | CY1123649T1 (enExample) |
| DK (1) | DK2894151T3 (enExample) |
| ES (1) | ES2835248T3 (enExample) |
| HR (1) | HRP20202050T1 (enExample) |
| HU (1) | HUE052904T2 (enExample) |
| LT (1) | LT2894151T (enExample) |
| MX (1) | MX368844B (enExample) |
| PT (1) | PT2894151T (enExample) |
| RS (1) | RS61242B1 (enExample) |
| RU (1) | RU2639145C2 (enExample) |
| SI (1) | SI2894151T1 (enExample) |
| SM (1) | SMT202000672T1 (enExample) |
| TW (1) | TWI617546B (enExample) |
| WO (1) | WO2014036897A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102189940B1 (ko) * | 2012-09-04 | 2020-12-14 | 샹하이 헨그루이 파마수티컬 컴퍼니 리미티드 | 이미다졸린 유도체, 이의 제조 방법, 및 이들의 의약에서의 용도 |
| HK1245791A1 (zh) * | 2015-01-20 | 2018-08-31 | 阿尔维纳斯运营股份有限公司 | 用於雄激素受体的靶向降解的化合物和方法 |
| US12312316B2 (en) | 2015-01-20 | 2025-05-27 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| CN108137507A (zh) | 2015-07-10 | 2018-06-08 | 阿尔维纳斯股份有限公司 | 基于mdm2的蛋白水解调节剂和相关的使用方法 |
| CA2988436A1 (en) * | 2015-07-13 | 2017-01-19 | Arvinas, Inc. | Alanine-based modulators of proteolysis and associated methods of use |
| SMT202000258T1 (it) * | 2015-09-10 | 2020-07-08 | Jiangsu Hengrui Medicine Co | Forma cristallina di inibitore del recettore degli androgeni e procedimento di preparazione dello stesso |
| CN106518773A (zh) * | 2015-09-10 | 2017-03-22 | 江苏恒瑞医药股份有限公司 | 一种雄性激素受体抑制剂的结晶形式及其制备方法 |
| TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
| US9963433B2 (en) * | 2016-01-29 | 2018-05-08 | Wayne State University | Anticancer drugs including the chemical structures of an androgen receptor ligand and a histone deacetylase inhibitor |
| KR20180109991A (ko) | 2016-02-19 | 2018-10-08 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 이미다졸린 유도체를 함유하는 약학적 조성물 |
| CN110167556A (zh) * | 2016-07-08 | 2019-08-23 | 詹森药业有限公司 | 用于治疗癌症的硫代乙内酰脲雄性激素受体拮抗剂 |
| CN110023297A (zh) * | 2016-07-08 | 2019-07-16 | 詹森药业有限公司 | 作为雄性激素受体拮抗剂的取代的乙内酰脲和硫代己内酰脲衍生物 |
| KR102125661B1 (ko) | 2017-02-13 | 2020-06-22 | 강푸 바이오파마슈티칼즈 리미티드 | 전립선암 치료용 조합, 약학 조성물 및 치료 방법 |
| CN112300076B (zh) * | 2017-12-13 | 2022-10-25 | 江苏恒瑞医药股份有限公司 | 一种雄性激素受体抑制剂的晶型及其制备方法 |
| CN110684046B (zh) * | 2018-07-06 | 2023-05-12 | 江苏恒瑞医药股份有限公司 | 一种新的咪唑啉类衍生物的制备方法 |
| CN108976171B (zh) * | 2018-08-27 | 2020-06-16 | 长沙泽达医药科技有限公司 | 化合物、组合物及其在药物制备中的用途 |
| WO2020061103A1 (en) | 2018-09-18 | 2020-03-26 | Nikang Therapeutics, Inc. | Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors |
| CN112584836A (zh) * | 2018-10-22 | 2021-03-30 | 江苏恒瑞医药股份有限公司 | 一种ar拮抗剂联合parp抑制剂在制备治疗前列腺癌的药物中的用途 |
| CN119219606A (zh) * | 2018-12-19 | 2024-12-31 | 细胞基因公司 | 经取代的3-((3-氨基苯基)氨基)哌啶-2，6-二酮化合物、其组合物及使用它们的治疗方法 |
| BR112021012186A2 (pt) * | 2018-12-19 | 2021-08-31 | Celgene Corporation | Compostos de 3-((3-aminofenil)amino)piperidina-2,6-diona substituídos, composições dos mesmos e métodos de tratamento com os mesmos |
| GB201908511D0 (en) | 2019-06-13 | 2019-07-31 | Adorx Therapeutics Ltd | Hydroxamate compounds |
| CN113929628A (zh) * | 2020-06-29 | 2022-01-14 | 江苏恒瑞医药股份有限公司 | 一种咪唑啉衍生物的制备方法 |
| CN113024513A (zh) * | 2021-03-22 | 2021-06-25 | 中国药科大学 | 新型雄激素受体降解剂、制备方法和医药用途 |
| CN117327019A (zh) * | 2022-06-23 | 2024-01-02 | 南京思聚生物医药有限公司 | 一种局部作用的雄激素受体拮抗剂的应用 |
| CN115850186B (zh) * | 2023-02-07 | 2024-04-09 | 长沙泽达医药科技有限公司 | 一种乙撑硫脲衍生物的晶型及用途 |
| CN118993935B (zh) * | 2024-10-23 | 2025-02-14 | 江苏恒瑞医药股份有限公司 | 咪唑啉衍生物或其盐的制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6713474B2 (en) | 1998-09-18 | 2004-03-30 | Abbott Gmbh & Co. Kg | Pyrrolopyrimidines as therapeutic agents |
| SE0100902D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| US7399775B2 (en) | 2001-12-27 | 2008-07-15 | Daiichi Pharmaceutical Co., Ltd. | β-amyloid protein production/secretion inhibitor |
| AU2003279442A1 (en) * | 2002-10-04 | 2004-04-23 | Laboratoires Fournier S.A. | 2-thiohydantoine derivative compounds and use thereof for the treatment of diabetes |
| KR20070106969A (ko) * | 2004-09-09 | 2007-11-06 | 추가이 세이야쿠 가부시키가이샤 | 신규 이미다졸리딘 유도체 및 그 용도 |
| US20070015782A1 (en) | 2005-04-15 | 2007-01-18 | Eisai Co., Ltd. | Benzimidazole compound |
| US7709517B2 (en) * | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
| CA2608436C (en) * | 2005-05-13 | 2015-03-24 | The Regents Of The University Of California | Diarylhydantoin compounds and their use in the treatment of hyperproliferative disorders |
| CL2007001873A1 (es) | 2006-06-27 | 2008-01-04 | Takeda Pharmaceutical | Acido((3s))-6-((¨2,6-dimetil-4-(3-(metilsulfonil)-propoxi)bifenil-3-il)metoxi-2,3-dihidro-1-benzofuran-3-il)acetico o una sal del mismo |
| CN102388048B (zh) | 2009-02-10 | 2014-07-30 | 阿斯利康(瑞典)有限公司 | 三唑并[4，3-b]哒嗪衍生物及其用于前列腺癌的用途 |
| CN101817787B (zh) * | 2009-02-26 | 2013-07-24 | 童友之 | 抗前列腺癌的雄性激素受体拮抗剂 |
| US8710086B2 (en) * | 2009-04-09 | 2014-04-29 | Medivation Technologies, Inc. | Substituted di-arylhydantoin and di-arylthiohydantoin compounds and methods of use thereof |
| US8450374B2 (en) | 2009-06-29 | 2013-05-28 | University Of Delaware | Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal |
| EP2480544A1 (en) | 2009-09-22 | 2012-08-01 | Boehringer Ingelheim International GmbH | Compounds which selectively modulate the cb2 receptor |
| JP2013519732A (ja) | 2010-02-17 | 2013-05-30 | アムジエン・インコーポレーテツド | 疼痛治療のためのナトリウムチャンネル阻害薬としてのアリールカルボキサミド誘導体 |
| RU2434851C1 (ru) | 2010-07-22 | 2011-11-27 | Александр Васильевич Иващенко | Циклические n, n'-диарилтиомочевины или n, n'-диарилмочевины - антагонисты андрогенных рецепторов, противораковое средство, способ получения и применения |
| JP2013532688A (ja) | 2010-07-26 | 2013-08-19 | ブリストル−マイヤーズ スクイブ カンパニー | Ｃｙｐ１７阻害剤として有用なスルホンアミド化合物 |
| US9139565B2 (en) * | 2010-09-28 | 2015-09-22 | Georgia Tech Research Corporation | Histone deacetylase (HDAC) inhibitors targeting prostate tumors and methods of making and using thereof |
| US8815271B2 (en) | 2010-11-03 | 2014-08-26 | Dow Agrosciences, Llc. | Pesticidal compositions and processes related thereto |
| CN103608333B (zh) * | 2011-03-10 | 2016-01-06 | 苏州开拓药业有限公司 | 雄激素受体拮抗剂及其用途 |
| KR102189940B1 (ko) * | 2012-09-04 | 2020-12-14 | 샹하이 헨그루이 파마수티컬 컴퍼니 리미티드 | 이미다졸린 유도체, 이의 제조 방법, 및 이들의 의약에서의 용도 |
-
2013
- 2013-08-26 KR KR1020157007651A patent/KR102189940B1/ko active Active
- 2013-08-26 CN CN201380004069.5A patent/CN103958480B/zh active Active
- 2013-08-26 MX MX2015002602A patent/MX368844B/es active IP Right Grant
- 2013-08-26 WO PCT/CN2013/082273 patent/WO2014036897A1/zh not_active Ceased
- 2013-08-26 BR BR112015004637-1A patent/BR112015004637B1/pt active IP Right Grant
- 2013-08-26 JP JP2015528857A patent/JP6262733B2/ja active Active
- 2013-08-26 ES ES13835193T patent/ES2835248T3/es active Active
- 2013-08-26 CA CA2883545A patent/CA2883545C/en active Active
- 2013-08-26 HR HRP20202050TT patent/HRP20202050T1/hr unknown
- 2013-08-26 SI SI201331826T patent/SI2894151T1/sl unknown
- 2013-08-26 AU AU2013312587A patent/AU2013312587B2/en active Active
- 2013-08-26 PT PT138351937T patent/PT2894151T/pt unknown
- 2013-08-26 LT LTEP13835193.7T patent/LT2894151T/lt unknown
- 2013-08-26 EP EP13835193.7A patent/EP2894151B1/en active Active
- 2013-08-26 SM SM20200672T patent/SMT202000672T1/it unknown
- 2013-08-26 RS RS20201565A patent/RS61242B1/sr unknown
- 2013-08-26 RU RU2015110122A patent/RU2639145C2/ru active
- 2013-08-26 US US14/425,207 patent/US9586947B2/en active Active
- 2013-08-26 DK DK13835193.7T patent/DK2894151T3/da active
- 2013-08-26 HU HUE13835193A patent/HUE052904T2/hu unknown
- 2013-08-30 TW TW102131223A patent/TWI617546B/zh active
-
2017
- 2017-01-20 US US15/411,517 patent/US9895355B2/en active Active
-
2020
- 2020-12-18 CY CY20201101202T patent/CY1123649T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2015110122A (ru) | Производные имидазолина, способы их получения и их применение в медицине | |
| TWI674258B (zh) | Ｄｎａ烷化劑 | |
| JP2017533968A5 (enExample) | ||
| WO2017195216A4 (en) | Cyclopropyl-amide compounds as dual lsd1/hdac inhibitors | |
| CN110582483A (zh) | 含邻氨基杂芳环炔基的化合物及其制备方法和用途 | |
| JP2007509116A5 (enExample) | ||
| JP2015531773A (ja) | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 | |
| JP2013518106A5 (enExample) | ||
| RU2014113679A (ru) | N-(2-амино-6,6-дифтор-4,4а,5,6,7,7а-гексагидро-циклопента[e][1,3]оксазин-4-ил)-фенил)-амиды в качестве ингибиторов бета-секретазы 1 | |
| JP2014185188A (ja) | フェニルおよびベンゾジオキシニル置換インダゾール誘導体 | |
| CA2727378A1 (en) | New co-crystal compound of rivaroxaban and malonic acid | |
| IL228072A (en) | Quinazoline compound is converted to alkyl and methods of use | |
| CN103804358A (zh) | 一类二芳基乙内酰脲衍生物、其制备方法、药物组合物和应用 | |
| JP2018527328A (ja) | 置換３−（３−アニリノ−１−シクロヘキシル−１ｈ−ベンズイミダゾール−５−イル）プロパン酸誘導体を調製する方法 | |
| JP2013521301A5 (enExample) | ||
| CA3050239A1 (en) | Pyrimidine compound and pharmaceutical use thereof | |
| WO2014031755A1 (en) | Fendiline derivatives and methods of use thereof | |
| JP2019535825A5 (enExample) | ||
| AU2015367540B2 (en) | Substituted Pyridyl-cycloalkyl-carboxylic acids, compositions containing them and medical uses thereof | |
| JP2017536342A5 (enExample) | ||
| WO2014164756A1 (en) | Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use | |
| RU2012126112A (ru) | Соединение, некоторые его новые формы, фармацевтические композиции на его основе и способы получения и применения | |
| JP2009531363A5 (enExample) | ||
| JP5575357B2 (ja) | 組織因子産生抑制剤 | |
| AU2022224918A1 (en) | Novel pyrazole derivatives |