JP2015524662A5 - - Google Patents
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- JP2015524662A5 JP2015524662A5 JP2015525545A JP2015525545A JP2015524662A5 JP 2015524662 A5 JP2015524662 A5 JP 2015524662A5 JP 2015525545 A JP2015525545 A JP 2015525545A JP 2015525545 A JP2015525545 A JP 2015525545A JP 2015524662 A5 JP2015524662 A5 JP 2015524662A5
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- 229920001184 polypeptide Polymers 0.000 claims description 77
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 77
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 77
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- 102100029199 Iduronate 2-sulfatase Human genes 0.000 claims description 30
- 101710096421 Iduronate 2-sulfatase Proteins 0.000 claims description 27
- 101000840540 Homo sapiens Iduronate 2-sulfatase Proteins 0.000 claims description 26
- 102000057422 human IDS Human genes 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 14
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261677959P | 2012-07-31 | 2012-07-31 | |
| US61/677,959 | 2012-07-31 | ||
| PCT/US2013/052939 WO2014022515A1 (en) | 2012-07-31 | 2013-07-31 | Dephosphorylated lysosomal storage disease proteins and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015524662A JP2015524662A (ja) | 2015-08-27 |
| JP2015524662A5 true JP2015524662A5 (https=) | 2016-08-25 |
| JP6433424B2 JP6433424B2 (ja) | 2018-12-05 |
Family
ID=48949266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015525545A Expired - Fee Related JP6433424B2 (ja) | 2012-07-31 | 2013-07-31 | 脱リン酸化されたリソソーム蓄積症タンパク質およびその使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9932565B2 (https=) |
| EP (1) | EP2880156B1 (https=) |
| JP (1) | JP6433424B2 (https=) |
| CN (1) | CN104662150B (https=) |
| AU (1) | AU2013296557B2 (https=) |
| CA (2) | CA2880162C (https=) |
| ES (1) | ES2647082T3 (https=) |
| WO (1) | WO2014022515A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003222568B2 (en) | 2002-01-11 | 2009-05-07 | Bioasis Technologies, Inc. | Use of P97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes |
| ES2582869T3 (es) | 2011-07-05 | 2016-09-15 | Bioasis Technologies Inc | Conjugados de P97-anticuerpo |
| CA2842492A1 (en) | 2011-08-05 | 2013-02-14 | Bioasis Technologies, Inc. | P97 fragments with transfer activity |
| ES2647082T3 (es) | 2012-07-31 | 2017-12-19 | Bioasis Technologies Inc | Proteínas desfosforiladas de la enfermedad de depósito lisosómico y métodos de uso de las mismas |
| JP6586412B2 (ja) | 2013-03-13 | 2019-10-02 | バイオアシス テクノロジーズ インコーポレイテッド | ｐ９７のフラグメントおよびその使用 |
| JP6603227B2 (ja) | 2014-02-03 | 2019-11-06 | バイオアシス テクノロジーズ インコーポレイテッド | Ｐ９７融合タンパク質 |
| DK3107562T3 (da) * | 2014-02-19 | 2019-12-16 | Bioasis Technologies Inc | P97-ids-fusionsproteiner |
| US10058619B2 (en) | 2014-05-01 | 2018-08-28 | Bioasis Technologies, Inc. | P97-polynucleotide conjugates |
| GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
| RU2673038C2 (ru) * | 2016-01-18 | 2018-11-21 | ООО "Международный Биотехнологический Центр "Генериум" | Лекарственное средство на основе бифункционального антитела для лечения мукополисахаридоза II типа |
| CN106282231B (zh) * | 2016-09-06 | 2020-01-03 | 陕西慧康生物科技有限责任公司 | 粘多糖贮积症ii型动物模型的构建方法及应用 |
| CA3043325A1 (en) | 2016-11-10 | 2018-05-17 | The Research Foundation For The State University Of New York | System, method and biomarkers for airway obstruction |
| JP7252211B2 (ja) * | 2017-09-08 | 2023-04-04 | ザ ヌムール ファウンデーション | リソソーム蓄積症を治療するための薬剤、デバイス、および血液循環システム、ならびにリソソーム蓄積症を治療するための方法 |
| AU2018345303B2 (en) | 2017-10-02 | 2025-09-18 | Denali Therapeutics Inc. | Fusion proteins comprising enzyme replacement therapy enzymes |
| AR116624A1 (es) * | 2018-10-10 | 2021-05-26 | Amicus Therapeutics Inc | Composiciones de polipéptidos estabilizados por enlaces disulfuro y métodos de uso |
| CN113301925A (zh) | 2018-12-19 | 2021-08-24 | 小利兰·斯坦福大学理事会 | 用于溶酶体靶向的双官能分子以及相关的组合物和方法 |
| CN110609078B (zh) * | 2019-09-20 | 2022-03-11 | 南京谱利健生物技术有限公司 | 一种检测蛋白磷酸化和乙酰氨基葡萄糖化关联作用的方法 |
| PE20231931A1 (es) | 2020-10-14 | 2023-12-01 | Denali Therapeutics Inc | Proteinas de fusion que comprenden enzimas sulfoglucosamina sulfohidrolasa y metodos de estas |
| AU2022310356A1 (en) | 2021-07-14 | 2024-01-25 | Lycia Therapeutics, Inc. | Asgpr cell surface receptor binding compounds and conjugates |
| US20240350653A1 (en) * | 2021-08-18 | 2024-10-24 | Joint-Stock Company "Generium" | Targeted delivery of therapeutic enzymes |
| CN114181318B (zh) * | 2021-11-08 | 2023-08-01 | 四川大学 | 一种组织特异性表达穿透血脑屏障的idua融合蛋白的重组腺相关病毒及应用 |
| EP4512892A1 (en) * | 2022-04-19 | 2025-02-26 | JCR Pharmaceuticals Co., Ltd. | Glycoprotein having reduced number of mannose-6-phosphates |
| EP4397687A4 (en) * | 2022-04-28 | 2025-09-24 | Linno Pharmaceuticals Inc | RECOMBINANT HARSA TO CROSS THE BLOOD-BRAIN BARRIER |
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| US4638045A (en) | 1985-02-19 | 1987-01-20 | Massachusetts Institute Of Technology | Non-peptide polyamino acid bioerodible polymers |
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-
2013
- 2013-07-31 ES ES13747600.8T patent/ES2647082T3/es active Active
- 2013-07-31 CN CN201380048133.XA patent/CN104662150B/zh not_active Expired - Fee Related
- 2013-07-31 AU AU2013296557A patent/AU2013296557B2/en not_active Ceased
- 2013-07-31 JP JP2015525545A patent/JP6433424B2/ja not_active Expired - Fee Related
- 2013-07-31 US US13/955,794 patent/US9932565B2/en active Active
- 2013-07-31 CA CA2880162A patent/CA2880162C/en active Active
- 2013-07-31 WO PCT/US2013/052939 patent/WO2014022515A1/en not_active Ceased
- 2013-07-31 CA CA3140358A patent/CA3140358A1/en active Pending
- 2013-07-31 EP EP13747600.8A patent/EP2880156B1/en not_active Not-in-force
-
2018
- 2018-04-02 US US15/943,160 patent/US11034943B2/en not_active Expired - Fee Related
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2021
- 2021-06-11 US US17/345,660 patent/US20210388330A1/en not_active Abandoned
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