|
US7723296B2
(en)
|
2001-01-18 |
2010-05-25 |
Genzyme Corporation |
Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof
|
|
US7560424B2
(en)
|
2001-04-30 |
2009-07-14 |
Zystor Therapeutics, Inc. |
Targeted therapeutic proteins
|
|
AU2003222568B2
(en)
|
2002-01-11 |
2009-05-07 |
Bioasis Technologies, Inc. |
Use of P97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes
|
|
PT2441467E
(pt)
|
2003-01-31 |
2015-10-12 |
Sinai School Medicine |
Terapia combinada para o tratamento de transtornos associados a uma deficiência proteica
|
|
EP1877099B1
(en)
|
2005-04-06 |
2012-09-19 |
Genzyme Corporation |
Therapeutic conjugates comprising a lysosomal enzyme, polysialic acid and a targeting moiety
|
|
EP2932982B1
(en)
|
2005-05-17 |
2018-10-03 |
Amicus Therapeutics, Inc. |
A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives
|
|
SI2457920T1
(en)
|
2007-01-18 |
2018-02-28 |
Genzyme Corporation |
Oligosaccharides containing the amino acid group and their conjugates
|
|
EP2192924B1
(en)
|
2007-08-20 |
2017-10-11 |
Protalix Ltd. |
Saccharide-containing protein conjugates and uses thereof
|
|
US7722865B2
(en)
|
2008-01-18 |
2010-05-25 |
Biomarin Pharmaceutical Inc. |
Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof
|
|
CN105274072A
(zh)
|
2008-01-18 |
2016-01-27 |
生物马林药物股份有限公司 |
制备活性高度磷酸化人溶酶体硫酸酯酶及其应用
|
|
WO2009131698A2
(en)
*
|
2008-04-23 |
2009-10-29 |
Iowa State University Research Foundation, Inc. |
PHOSPHORYLATED RECOMBINANT N-ACETYL-alpha-D- GLUCOSAMINIDASE (NaGlu) AND USES THEREOF
|
|
US20100119502A1
(en)
*
|
2008-11-11 |
2010-05-13 |
Amicus Therapeutics, Inc. |
Therapy regimens, dosing regimens and stable medicaments for the treatment of pompe disease
|
|
CA3040973A1
(en)
|
2008-12-16 |
2010-07-01 |
Genzyme Corporation |
Oligosaccharide-protein conjugates
|
|
CA2752373C
(en)
*
|
2009-02-20 |
2017-10-10 |
To-Bbb Holding B.V. |
Glutathione-based drug delivery system
|
|
WO2010117957A2
(en)
|
2009-04-06 |
2010-10-14 |
Mayo Foundation For Medical Education And Research |
Methods and materials for delivering molecules
|
|
EP2475376B1
(en)
*
|
2009-06-17 |
2016-03-30 |
BioMarin Pharmaceutical Inc. |
Formulations for lysosomal enzymes
|
|
US9194011B2
(en)
|
2009-11-17 |
2015-11-24 |
Protalix Ltd. |
Stabilized alpha-galactosidase and uses thereof
|
|
DK2538968T3
(en)
*
|
2010-02-24 |
2017-12-11 |
Chiesi Farm Spa |
PROCEDURE FOR THE PREPARATION AND PURIFICATION OF RECOMBINANT LYSOSOMAL ALFA MANNOSIDASE
|
|
JPWO2011108451A1
(ja)
*
|
2010-03-01 |
2013-06-27 |
日本ケミカルリサーチ株式会社 |
遺伝子ノックアウト細胞を用いた組換え体リソソーム酵素の製造方法
|
|
RS62620B1
(sr)
|
2010-06-25 |
2021-12-31 |
Shire Human Genetic Therapies |
Metode i kompozicije za isporuku cns akrilsulfataze a
|
|
EP2588132A4
(en)
*
|
2010-06-25 |
2014-10-15 |
Shire Human Genetic Therapies |
METHOD AND COMPOSITIONS FOR DELIVERING BETA GALACTOCEREBROSIDASE INTO THE CNS
|
|
NZ605874A
(en)
|
2010-06-25 |
2015-02-27 |
Shire Human Genetic Therapies |
Methods and compositions for cns delivery of heparan n-sulfatase
|
|
NZ605873A
(en)
|
2010-06-25 |
2015-02-27 |
Shire Human Genetic Therapies |
Methods and compositions for cns delivery of arylsulfatase a
|
|
SMT201600385T1
(it)
|
2010-06-25 |
2017-03-08 |
Shire Human Genetic Therapies |
Trasporto di agenti terapeutici all’snc
|
|
CN103179980B
(zh)
|
2010-06-25 |
2016-09-28 |
夏尔人类遗传性治疗公司 |
艾杜糖醛酸-2-硫酸酯酶的cns递送的方法和组合物
|
|
US8956859B1
(en)
|
2010-08-13 |
2015-02-17 |
Aviex Technologies Llc |
Compositions and methods for determining successful immunization by one or more vaccines
|
|
CN103443270B
(zh)
|
2011-01-20 |
2017-06-06 |
普罗塔里克斯有限公司 |
用于在植物和植物细胞中表达α‑半乳糖苷酶的核酸构建体
|
|
JP5665065B2
(ja)
|
2011-04-28 |
2015-02-04 |
国立大学法人大阪大学 |
リソソーム病治療用医薬組成物
|
|
JP5959114B2
(ja)
*
|
2011-05-19 |
2016-08-02 |
学校法人 明治薬科大学 |
リン酸化糖鎖を含有する組換えヒトサポシンbタンパク質及びその用途
|
|
TW201307563A
(zh)
*
|
2011-05-19 |
2013-02-16 |
Shire Human Genetic Therapies |
純化乙醯肝素-n-硫酸酯酶之方法
|
|
US9387236B2
(en)
*
|
2011-06-10 |
2016-07-12 |
Prothera Inc. |
Pharmaceutical compositions containing protease and methods for the treatment of lysosomal storage diseases
|
|
ES2582869T3
(es)
|
2011-07-05 |
2016-09-15 |
Bioasis Technologies Inc |
Conjugados de P97-anticuerpo
|
|
CA2842492A1
(en)
|
2011-08-05 |
2013-02-14 |
Bioasis Technologies, Inc. |
P97 fragments with transfer activity
|
|
US20140377244A1
(en)
|
2011-12-23 |
2014-12-25 |
Shire Human Genetic Therapies, Inc. |
Stable formulations for cns delivery of arylsulfatase a
|
|
KR20200032244A
(ko)
|
2012-03-07 |
2020-03-25 |
아미쿠스 세라퓨틱스, 인코포레이티드 |
폼페병의 치료를 위한 고농도 알파-글루코시다제 조성물
|
|
HRP20210398T1
(hr)
|
2012-05-03 |
2021-05-28 |
Amicus Therapeutics, Inc. |
Režimi doziranja za liječenje pompeove bolesti
|
|
ES2647082T3
(es)
|
2012-07-31 |
2017-12-19 |
Bioasis Technologies Inc |
Proteínas desfosforiladas de la enfermedad de depósito lisosómico y métodos de uso de las mismas
|
|
EA201590582A1
(ru)
*
|
2012-12-07 |
2016-01-29 |
Шир Хьюман Дженетик Терапис, Инк. |
Способы и композиции для лечения мукополисахаридоза типа iiia с использованием интратекального введения
|
|
JP6586412B2
(ja)
|
2013-03-13 |
2019-10-02 |
バイオアシス テクノロジーズ インコーポレイテッド |
p97のフラグメントおよびその使用
|
|
JP6603227B2
(ja)
|
2014-02-03 |
2019-11-06 |
バイオアシス テクノロジーズ インコーポレイテッド |
P97融合タンパク質
|
|
DK3107562T3
(da)
|
2014-02-19 |
2019-12-16 |
Bioasis Technologies Inc |
P97-ids-fusionsproteiner
|
|
US10058619B2
(en)
|
2014-05-01 |
2018-08-28 |
Bioasis Technologies, Inc. |
P97-polynucleotide conjugates
|
|
WO2016054231A1
(en)
*
|
2014-09-30 |
2016-04-07 |
Amicus Therapeutics, Inc. |
Highly potent acid alpha-glucosidase with enhanced carbohydrates
|
|
GB201508025D0
(en)
|
2015-05-11 |
2015-06-24 |
Ucl Business Plc |
Fabry disease gene therapy
|
|
KR102510941B1
(ko)
*
|
2015-12-30 |
2023-03-20 |
아미쿠스 세라퓨틱스, 인코포레이티드 |
폼페병 치료용의 강화된 산 알파-글루코시다제
|
|
TWI759291B
(zh)
*
|
2016-03-30 |
2022-04-01 |
美商阿米庫斯醫療股份有限公司 |
用於選擇高m6p重組蛋白之方法
|
|
US10227577B2
(en)
*
|
2016-03-30 |
2019-03-12 |
Amicus Therapeutics, Inc. |
Method for selection of high M6P recombinant proteins
|
|
IL325155A
(en)
|
2016-03-30 |
2026-02-01 |
Amicus Therapeutics Inc |
Formulations containing recombinant acid alpha-glucosidase
|
|
EA039750B1
(ru)
*
|
2017-03-30 |
2022-03-10 |
Амикус Терапьютикс, Инк. |
Способ отбора рекомбинантных белков с высоким содержанием m6p
|
|
EP3624831B1
(en)
|
2017-05-15 |
2023-03-29 |
Amicus Therapeutics, Inc. |
Recombinant human acid alpha-glucosidase
|
|
FI3635009T3
(fi)
|
2017-06-07 |
2026-04-07 |
Regeneron Pharma |
Koostumuksia ja menetelmiä entsyymien internalisoimiseksi
|
|
JP7779653B2
(ja)
|
2018-02-07 |
2025-12-03 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
治療用タンパク質送達のための方法および組成物
|
|
EP3793591A1
(en)
|
2018-05-17 |
2021-03-24 |
Regeneron Pharmaceuticals, Inc. |
Anti-cd63 antibodies, conjugates, and uses thereof
|
|
KR20220129547A
(ko)
|
2019-12-20 |
2022-09-23 |
코덱시스, 인코포레이티드 |
조작된 산성 알파-글루코시다제 변이체
|
|
WO2025007035A2
(en)
*
|
2023-06-30 |
2025-01-02 |
Crosswalk Therapeutics, Inc. |
Engineered acid alpha-glucosidase variants
|