JP2015524444A - ライソゾーム蓄積症を治療するためのシクロデキストリン - Google Patents

ライソゾーム蓄積症を治療するためのシクロデキストリン Download PDF

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Publication number
JP2015524444A
JP2015524444A JP2015525640A JP2015525640A JP2015524444A JP 2015524444 A JP2015524444 A JP 2015524444A JP 2015525640 A JP2015525640 A JP 2015525640A JP 2015525640 A JP2015525640 A JP 2015525640A JP 2015524444 A JP2015524444 A JP 2015524444A
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cyclodextrin
disease
subject
compound
cholesterol
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Japanese (ja)
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JP2015524444A5 (enExample
Inventor
ジョン マッキュー，
ジョン マッキュー，
ウェイ チョン，
ウェイ チョン，
ミャオ シュウ，
ミャオ シュウ，
マンジュ スワループ，
マンジュ スワループ，
ジュアン ジェイ． マルガン，
ジュアン ジェイ． マルガン，
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United States Department of Health and Human Services
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United States Department of Health and Human Services
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Publication of JP2015524444A publication Critical patent/JP2015524444A/ja
Publication of JP2015524444A5 publication Critical patent/JP2015524444A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Materials Engineering (AREA)
  • General Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015525640A 2012-08-03 2013-08-03 ライソゾーム蓄積症を治療するためのシクロデキストリン Pending JP2015524444A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261679668P 2012-08-03 2012-08-03
US61/679,668 2012-08-03
PCT/US2013/053527 WO2014022841A1 (en) 2012-08-03 2013-08-03 Cyclodextrin for the treatment of lysosomal storage diseases

Related Child Applications (1)

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JP2018116666A Division JP2018162277A (ja) 2012-08-03 2018-06-20 ライソゾーム蓄積症を治療するためのシクロデキストリン

Publications (2)

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JP2015524444A true JP2015524444A (ja) 2015-08-24
JP2015524444A5 JP2015524444A5 (enExample) 2016-09-23

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JP2015525640A Pending JP2015524444A (ja) 2012-08-03 2013-08-03 ライソゾーム蓄積症を治療するためのシクロデキストリン
JP2018116666A Pending JP2018162277A (ja) 2012-08-03 2018-06-20 ライソゾーム蓄積症を治療するためのシクロデキストリン
JP2020026808A Active JP6858286B2 (ja) 2012-08-03 2020-02-20 ライソゾーム蓄積症を治療するためのシクロデキストリン

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JP2020026808A Active JP6858286B2 (ja) 2012-08-03 2020-02-20 ライソゾーム蓄積症を治療するためのシクロデキストリン

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US (2) US20150216895A1 (enExample)
EP (1) EP2879714B1 (enExample)
JP (3) JP2015524444A (enExample)
CN (2) CN107865968B (enExample)
AU (2) AU2013296170A1 (enExample)
CA (1) CA2880880C (enExample)
WO (1) WO2014022841A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018199287A1 (ja) * 2017-04-28 2018-11-01 国立大学法人京都大学 クリスタリン網膜症の処置および／または予防方法
JP2020176063A (ja) * 2019-04-15 2020-10-29 国立大学法人 熊本大学 ライソゾーム病の治療または予防のための医薬組成物

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CA2880880C (en) 2012-08-03 2021-01-26 John Mckew Cyclodextrin for the treatment of lysosomal storage diseases
WO2015083736A1 (ja) 2013-12-05 2015-06-11 国立大学法人熊本大学 コレステロール蓄積疾患治療薬、およびそのスクリーニング方法
KR20170012555A (ko) 2014-06-12 2017-02-02 더 유니버시티 오브 노트르 담 듀락 신경 질환 및 대뇌 상해의 치료를 위한 조성물 및 방법
US10239830B2 (en) * 2015-02-11 2019-03-26 Icahn School Of Medicine At Mount Sinai Benzenesulfonamide upregulators of NPC1 for Neimann-Pick disease and other lysosomal storage disorders
AU2016276774A1 (en) 2015-06-10 2018-01-18 Vtesse, Inc. Hydroxypropyl beta-cyclodextrin compositions and methods
EP3405501B1 (en) * 2016-01-21 2023-11-15 Aten Porus Lifesciences Cyclodextrin based polymers, methods, compositions and applications thereof
IL298681A (en) 2016-08-02 2023-01-01 Univ Virginia Commonwealth Preparations
CN109982718A (zh) 2016-09-19 2019-07-05 阿托恩波罗斯生命科学 基于环糊精的聚合物、方法、组合物及其应用
WO2019067145A1 (en) * 2017-08-28 2019-04-04 Asdera Llc USE OF CYCLODEXTRINS IN DISEASES AND DISORDERS INVOLVING PHOSPHOLIPID DISRUPTION
JP2020535235A (ja) * 2017-09-28 2020-12-03 アスデラ エルエルシー リン脂質の調節異常が関与する疾患および障害におけるシクロデキストリンの使用
EP3873604B1 (en) 2018-10-29 2024-08-21 Cyclo Therapeutics, Inc. Methods for treating alzheimer's disease with hp-[beta]-cyclodextrin
AU2020204925B2 (en) 2019-01-03 2025-11-20 Cyclarity Therapeutics, Inc. Cyclodextrin dimers, compositions thereof, and uses thereof
US12226431B2 (en) 2021-09-11 2025-02-18 Porosome Therapeutics, Inc. Aerosol and topical administration of a formulation containing cyclodextrin, quercetin and zinc, in combination or separately, to mitigate infection by enveloped viruses
JP7551339B2 (ja) * 2020-06-04 2024-09-17 株式会社三共 遊技機
JP7551340B2 (ja) * 2020-06-04 2024-09-17 株式会社三共 遊技機
WO2022051631A1 (en) * 2020-09-03 2022-03-10 University Of Notre Dame Du Lac Therapy to stimulate hippocampal neural progenitors and adult neurogenesis
US11446325B2 (en) * 2020-09-30 2022-09-20 Cyclolab Cyclodextrin Research And Development Laboratory Ltd. Cyclodextrin derivatives in the treatment or prevention of lysosomal neurodegenerative diseases
JP2025506676A (ja) 2022-02-18 2025-03-13 ベレン セラピューティクス ピー．ビー．シー． ヒドロキシプロピル－ベータ－シクロデキストリンの組成物及びその精製方法
WO2025090588A1 (en) 2023-10-24 2025-05-01 Minerva Neurosciences, Inc. Roluperidone for the treatment of lysosomal storage disorders and their symptoms

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JP2007504166A (ja) * 2003-08-29 2007-03-01 バイオマリン ファーマシューティカル インコーポレイテッド 脳およびその他の組織への治療用化合物の送達
WO2012012473A1 (en) * 2010-07-19 2012-01-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of delta tocopherol for the treatment of lysosomal storage disorders

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US6407079B1 (en) 1985-07-03 2002-06-18 Janssen Pharmaceutica N.V. Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation
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US5262404A (en) 1990-02-15 1993-11-16 The Trustees Of The University Of Pennsylvania/Childrens Hospital Corporation Cyclodextrin polymers and cyclodextrins immobilized on a solid surface
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018199287A1 (ja) * 2017-04-28 2018-11-01 国立大学法人京都大学 クリスタリン網膜症の処置および／または予防方法
JPWO2018199287A1 (ja) * 2017-04-28 2020-03-12 国立大学法人京都大学 クリスタリン網膜症の処置および／または予防方法
JP2020176063A (ja) * 2019-04-15 2020-10-29 国立大学法人 熊本大学 ライソゾーム病の治療または予防のための医薬組成物
JP7264452B2 (ja) 2019-04-15 2023-04-25 塩水港精糖株式会社 ライソゾーム病の治療または予防のための医薬組成物

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CA2880880C (en) 2021-01-26
HK1210960A1 (en) 2016-05-13
EP2879714B1 (en) 2021-04-14
AU2018202964A1 (en) 2018-05-17
CN107865968A (zh) 2018-04-03
WO2014022841A1 (en) 2014-02-06
AU2013296170A1 (en) 2015-03-12
CA2880880A1 (en) 2014-02-06
CN104684585A (zh) 2015-06-03
JP2018162277A (ja) 2018-10-18
JP2020097620A (ja) 2020-06-25
US20180110798A1 (en) 2018-04-26
US11020422B2 (en) 2021-06-01
JP6858286B2 (ja) 2021-04-14
EP2879714A1 (en) 2015-06-10
CN107865968B (zh) 2021-03-05
AU2018202964B2 (en) 2019-08-22
US20150216895A1 (en) 2015-08-06

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