JP2015523986A5 - - Google Patents
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- Publication number
- JP2015523986A5 JP2015523986A5 JP2015516113A JP2015516113A JP2015523986A5 JP 2015523986 A5 JP2015523986 A5 JP 2015523986A5 JP 2015516113 A JP2015516113 A JP 2015516113A JP 2015516113 A JP2015516113 A JP 2015516113A JP 2015523986 A5 JP2015523986 A5 JP 2015523986A5
- Authority
- JP
- Japan
- Prior art keywords
- laquinimod
- pharmaceutically acceptable
- acceptable salt
- effective amount
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- GKWPCEFFIHSJOE-UHFFFAOYSA-N laquinimod Chemical compound OC=1C2=C(Cl)C=CC=C2N(C)C(=O)C=1C(=O)N(CC)C1=CC=CC=C1 GKWPCEFFIHSJOE-UHFFFAOYSA-N 0.000 claims description 57
- 229960004577 laquinimod Drugs 0.000 claims description 57
- 150000003839 salts Chemical class 0.000 claims description 54
- 238000000034 method Methods 0.000 claims description 35
- 208000027866 inflammatory disease Diseases 0.000 claims description 16
- 206010061218 Inflammation Diseases 0.000 claims description 13
- 206010046851 Uveitis Diseases 0.000 claims description 13
- 230000004054 inflammatory process Effects 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 208000024891 symptom Diseases 0.000 claims description 8
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims description 7
- 208000002205 allergic conjunctivitis Diseases 0.000 claims description 7
- 208000024998 atopic conjunctivitis Diseases 0.000 claims description 7
- 210000001519 tissue Anatomy 0.000 claims description 7
- 210000003979 eosinophil Anatomy 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 210000004087 cornea Anatomy 0.000 claims description 5
- 210000000744 eyelid Anatomy 0.000 claims description 5
- 210000001525 retina Anatomy 0.000 claims description 5
- 239000000243 solution Substances 0.000 claims description 5
- 230000000007 visual effect Effects 0.000 claims description 5
- 208000023275 Autoimmune disease Diseases 0.000 claims description 4
- 210000000795 conjunctiva Anatomy 0.000 claims description 4
- 210000004561 lacrimal apparatus Anatomy 0.000 claims description 4
- 206010010755 Conjunctivitis viral Diseases 0.000 claims description 3
- 208000005914 Viral Conjunctivitis Diseases 0.000 claims description 3
- 201000007032 bacterial conjunctivitis Diseases 0.000 claims description 3
- 230000008595 infiltration Effects 0.000 claims description 3
- 238000001764 infiltration Methods 0.000 claims description 3
- 206010002198 Anaphylactic reaction Diseases 0.000 claims description 2
- 206010067671 Disease complication Diseases 0.000 claims description 2
- 206010061818 Disease progression Diseases 0.000 claims description 2
- 230000036783 anaphylactic response Effects 0.000 claims description 2
- 208000003455 anaphylaxis Diseases 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 230000005750 disease progression Effects 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 230000004044 response Effects 0.000 claims description 2
- 230000002207 retinal effect Effects 0.000 claims description 2
- 230000003111 delayed effect Effects 0.000 claims 1
- 239000003186 pharmaceutical solution Substances 0.000 claims 1
- 206010010741 Conjunctivitis Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000000737 periodic effect Effects 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 208000002691 Choroiditis Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010022557 Intermediate uveitis Diseases 0.000 description 1
- 206010022941 Iridocyclitis Diseases 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- 208000001344 Macular Edema Diseases 0.000 description 1
- 206010025415 Macular oedema Diseases 0.000 description 1
- 208000003971 Posterior uveitis Diseases 0.000 description 1
- 238000011366 aggressive therapy Methods 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 201000004612 anterior uveitis Diseases 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 201000010230 macular retinal edema Diseases 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 201000007407 panuveitis Diseases 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261655526P | 2012-06-05 | 2012-06-05 | |
| US61/655,526 | 2012-06-05 | ||
| PCT/US2013/044058 WO2013184650A2 (en) | 2012-06-05 | 2013-06-04 | Treatment of ocular inflammatory diseases using laquinimod |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017158674A Division JP2018024677A (ja) | 2012-06-05 | 2017-08-21 | ラキニモドを使用する眼炎症性疾患の治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015523986A JP2015523986A (ja) | 2015-08-20 |
| JP2015523986A5 true JP2015523986A5 (enExample) | 2016-07-21 |
Family
ID=49671002
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516113A Pending JP2015523986A (ja) | 2012-06-05 | 2013-06-04 | ラキニモドを使用する眼炎症性疾患の治療 |
| JP2017158674A Withdrawn JP2018024677A (ja) | 2012-06-05 | 2017-08-21 | ラキニモドを使用する眼炎症性疾患の治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017158674A Withdrawn JP2018024677A (ja) | 2012-06-05 | 2017-08-21 | ラキニモドを使用する眼炎症性疾患の治療 |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US20130324574A1 (enExample) |
| EP (1) | EP2854767A4 (enExample) |
| JP (2) | JP2015523986A (enExample) |
| AR (1) | AR092842A1 (enExample) |
| CA (1) | CA2874767A1 (enExample) |
| IL (1) | IL235874A0 (enExample) |
| RU (1) | RU2014151992A (enExample) |
| TW (1) | TW201400117A (enExample) |
| UY (1) | UY34843A (enExample) |
| WO (1) | WO2013184650A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013116657A1 (en) | 2012-02-03 | 2013-08-08 | Teva Pharmaceutical Industries Ltd. | USE OF LAQUINIMOD FOR TREATING CROHN'S DISEASE PATIENTS WHO FAILED FIRST-LINE ANTI-TNFα THERAPY |
| TW201400117A (zh) * | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
| TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ） |
| WO2015073697A1 (en) * | 2013-11-15 | 2015-05-21 | Teva Pharmaceutical Industries Ltd. | Treatment of glaucoma using laquinimod |
| HK1231413A1 (zh) | 2014-04-29 | 2017-12-22 | Teva Pharmaceutical Industries Ltd. | 用於治疗具有高残疾状况的复发-缓解型多发性硬化症(rrms)的患者的拉喹莫德 |
| CA3157394A1 (en) * | 2019-12-19 | 2021-06-24 | Helena ERIKSSON | Compounds for treatment of eye diseases associated with excessive vascularisation |
| AU2022248724A1 (en) * | 2021-04-01 | 2023-11-02 | Active Biotech Ab | Laquinimod formulation for ocular use |
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| US3024257A (en) | 1961-04-10 | 1962-03-06 | Frosst & Co Charles E | Stable preparations of alkali metal salts of estrone sulfate |
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| US20030124187A1 (en) | 1997-02-14 | 2003-07-03 | Smithkline Beecham Laboratoires Pharmaceutiques, | Pharmaceutical formulations comprising amoxycillin and clavulanate |
| US6696407B1 (en) | 1997-03-21 | 2004-02-24 | The Regents Of The University Of California | Huntington's disease treatment comprising administering aldose reductase inhibitors to increase striatal CNTF |
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| PL199781B1 (pl) | 1999-10-25 | 2008-10-31 | Active Biotech Ab | Nowe związki pochodne chinoliny, zastosowanie związków pochodnych chinoliny, zawierające je kompozycje farmaceutyczne i sposób ich wytwarzania |
| US6852323B2 (en) | 2000-07-21 | 2005-02-08 | The Regents Of The University Of California | Methods and compositions for preventing and treating male erectile dysfunction and female sexual arousal disorder |
| US6307050B1 (en) | 2000-08-29 | 2001-10-23 | R. T. Alamo Venture I Llc | Method of synthesizing flosequinan from 4-fluoroanthranilic acid |
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| US6875869B2 (en) | 2002-06-12 | 2005-04-05 | Active Biotech Ab | Process for the manufacture of quinoline derivatives |
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| US20070292461A1 (en) | 2003-08-04 | 2007-12-20 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
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| US20050074451A1 (en) | 2003-06-25 | 2005-04-07 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating rheumatoid arthritis |
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| CA2579038A1 (en) | 2004-09-02 | 2006-03-16 | Teva Pharmaceutical Industries, Ltd. | Combination therapy with glatiramer acetate and n-acetylcysteine for the treatment of multiple sclerosis |
| HRP20160455T1 (hr) | 2004-09-09 | 2016-07-15 | Yeda Research And Development Co., Ltd. | Smjese polipeptida, sastavi koji ih sadrže i postupci za njihovu pripremu, te njihove primjene |
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| BRPI0617477A2 (pt) | 2005-10-19 | 2011-07-26 | Teva Pharma | mistura de partÍculas cristalinas de laquinimod sàdica, composiÇço, processo de cristalizaÇço de laquinimod sàdica, laquinimod sàdica, e, processo para produzir uma composiÇço farmacÊutica |
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| CN101466379B (zh) | 2006-06-12 | 2012-10-31 | 泰华制药工业有限公司 | 稳定的拉喹莫德的制剂 |
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| NZ597378A (en) | 2009-06-19 | 2014-08-29 | Teva Pharma | Treatment of multiple sclerosis with laquinimod |
| BR112012002124A2 (pt) | 2009-07-30 | 2015-09-15 | Teva Pharma | tratamento da doença de crohn com laquinimode. |
| WO2011019375A1 (en) | 2009-08-10 | 2011-02-17 | Teva Pharmaceutical Industries Ltd. | Treatment of bdnf-related disorders using laquinimod |
| TWI620569B (zh) * | 2009-12-15 | 2018-04-11 | 遠景生物製藥股份有限公司 | 無刺激性眼用聚乙烯吡咯啶酮-碘組成物 |
| US20110217295A1 (en) | 2010-03-03 | 2011-09-08 | Asi Haviv | Treatment of lupus arthritis using laquinimod |
| KR20130006640A (ko) | 2010-03-03 | 2013-01-17 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드를 이용한 루푸스 신장염의 치료 |
| EA201290860A1 (ru) | 2010-03-03 | 2013-04-30 | Тева Фармасьютикал Индастриз Лтд. | Лечение ревматоидного артрита комбинацией лаквинимода и метотрексата |
| WO2011112586A2 (en) | 2010-03-08 | 2011-09-15 | Cornell University | Methods for diagnosing feline coronavirus infections |
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| JP5934202B2 (ja) | 2010-07-09 | 2016-06-15 | テバ ファーマシューティカル インダストリーズ リミティド | ５−クロロ−４−ヒドロキシ−１−メチル−２−オキソ−ｎ−フェニル−１，２−ジヒドロキノリン−３−カルボキサミドと、その塩及びその使用 |
| AU2011274496B2 (en) | 2010-07-09 | 2016-03-10 | Teva Pharmaceutical Industries Ltd. | Deuterated N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof |
| WO2012075490A2 (en) | 2010-12-03 | 2012-06-07 | Duke University | Anti-podoplanin antibodies and methods of use |
| PE20140872A1 (es) | 2010-12-07 | 2014-08-09 | Teva Pharma | Uso de laquinimod para reducir la fatiga, mejorar el estado funcional y mejorar la calidad de vida en pacientes con esclerosis multiple |
| SG10201606191PA (en) | 2011-07-28 | 2016-09-29 | Teva Pharma | Treatment of multiple sclerosis with combination of laquinimod and glatiramer acetate |
| HK1198278A1 (en) | 2011-07-28 | 2015-03-27 | Teva Pharmaceutical Industries Ltd. | Treatment of multiple sclerosis with combination of laquinimod and interferon-beta |
| SG11201401330YA (en) | 2011-10-12 | 2014-05-29 | Teva Pharma | Treatment of multiple sclerosis with combination of laquinimod and fingolimod |
| WO2013116657A1 (en) | 2012-02-03 | 2013-08-08 | Teva Pharmaceutical Industries Ltd. | USE OF LAQUINIMOD FOR TREATING CROHN'S DISEASE PATIENTS WHO FAILED FIRST-LINE ANTI-TNFα THERAPY |
| MX2014009889A (es) | 2012-02-16 | 2014-11-13 | Teva Pharma | N-etil-n-fenil-1,2-dihidro-4,5-di-hidroxi-1-metil-2-oxo-3-quinoli ncarboxamida, preparacion y usos de los mismos. |
| US20130259856A1 (en) | 2012-03-27 | 2013-10-03 | Teva Pharmaceutical Industries, Ltd. | Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate |
| TW201804997A (zh) | 2012-05-02 | 2018-02-16 | 以色列商泰瓦藥品工業有限公司 | 高劑量拉喹莫德(laquinimod)於治療多發性硬化症之用途 |
| TW201350467A (zh) | 2012-05-08 | 2013-12-16 | Teva Pharma | Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺 |
| TW201400117A (zh) * | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
| WO2014004733A1 (en) | 2012-06-26 | 2014-01-03 | The Regents Of The University Of California | Composition for lupus nephritis and methods of making and using the same |
| AR091706A1 (es) | 2012-07-11 | 2015-02-25 | Teva Pharma | Formulaciones de laquinimod sin agentes alcalinizantes |
| TW201410243A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療大麻素受體型１（ｃｂ１）媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ） |
| MX2015004564A (es) | 2012-10-12 | 2015-07-21 | Teva Pharma | Laquinimod para producir el daño talamico en la esclerosis multiple. |
| EA201590788A1 (ru) | 2012-11-07 | 2015-12-30 | Тева Фармасьютикал Индастриз Лтд. | Аминные соли лахинимода |
-
2013
- 2013-05-31 TW TW102119465A patent/TW201400117A/zh unknown
- 2013-06-03 UY UY0001034843A patent/UY34843A/es not_active Application Discontinuation
- 2013-06-03 AR ARP130101957A patent/AR092842A1/es unknown
- 2013-06-04 CA CA2874767A patent/CA2874767A1/en not_active Abandoned
- 2013-06-04 WO PCT/US2013/044058 patent/WO2013184650A2/en not_active Ceased
- 2013-06-04 EP EP13800213.4A patent/EP2854767A4/en not_active Withdrawn
- 2013-06-04 US US13/909,403 patent/US20130324574A1/en not_active Abandoned
- 2013-06-04 JP JP2015516113A patent/JP2015523986A/ja active Pending
- 2013-06-04 RU RU2014151992A patent/RU2014151992A/ru not_active Application Discontinuation
-
2014
- 2014-11-24 IL IL235874A patent/IL235874A0/en unknown
-
2017
- 2017-04-28 US US15/582,162 patent/US20170231971A1/en not_active Abandoned
- 2017-08-07 US US15/670,684 patent/US20170333420A1/en not_active Abandoned
- 2017-08-21 JP JP2017158674A patent/JP2018024677A/ja not_active Withdrawn
- 2017-11-17 US US15/816,402 patent/US11654140B2/en active Active
-
2021
- 2021-08-27 US US17/459,971 patent/US20210386731A1/en not_active Abandoned
-
2024
- 2024-07-16 US US18/774,728 patent/US20250134881A1/en active Pending
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