JP2015523855A - Ａｐｏａ１及びａｂｃａ１発現を調節するための組成物及び方法 - Google Patents

Ａｐｏａ１及びａｂｃａ１発現を調節するための組成物及び方法 Download PDF

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JP2015523855A
JP2015523855A JP2015512861A JP2015512861A JP2015523855A JP 2015523855 A JP2015523855 A JP 2015523855A JP 2015512861 A JP2015512861 A JP 2015512861A JP 2015512861 A JP2015512861 A JP 2015512861A JP 2015523855 A JP2015523855 A JP 2015523855A
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nucleotide
oligonucleotide
nucleotides
stranded oligonucleotide
sequence
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JP2015523855A5 (enExample
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アーサー エム． クリーグ，
アーサー エム． クリーグ，
ロメシュ スブラマニアン，
ロメシュ スブラマニアン，
ジェイムズ マクスウィゲン，
ジェイムズ マクスウィゲン，
ジェニー ティー． リー，
ジェニー ティー． リー，
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ラナ セラピューティクス インコーポレイテッド
ラナ セラピューティクス インコーポレイテッド
ザ ジェネラル ホスピタル コーポレイション
ザ ジェネラル ホスピタル コーポレイション
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Publication of JP2015523855A publication Critical patent/JP2015523855A/ja
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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JP2015512861A 2012-05-16 2013-05-16 Ａｐｏａ１及びａｂｃａ１発現を調節するための組成物及び方法 Pending JP2015523855A (ja)

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US201261647949P 2012-05-16 2012-05-16
US61/647,949 2012-05-16
US201361785778P 2013-03-14 2013-03-14
US61/785,778 2013-03-14
PCT/US2013/041455 WO2013173647A1 (en) 2012-05-16 2013-05-16 Compositions and methods for modulating apoa1 and abca1 expression

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JP2015523855A true JP2015523855A (ja) 2015-08-20
JP2015523855A5 JP2015523855A5 (enExample) 2016-06-30

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US (1) US20150191722A1 (enExample)
EP (1) EP2849801A4 (enExample)
JP (1) JP2015523855A (enExample)
CN (1) CN104582737A (enExample)
AU (1) AU2013262658A1 (enExample)
BR (1) BR112014028645A2 (enExample)
CA (1) CA2873801A1 (enExample)
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021514182A (ja) * 2018-02-09 2021-06-10 ジェネンテック， インコーポレイテッド Ｔｍｅｍ１０６ｂ発現を調節するためのオリゴヌクレオチド
US11584932B2 (en) 2016-11-01 2023-02-21 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
US12319913B2 (en) 2018-10-31 2025-06-03 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011325956B2 (en) 2010-11-12 2016-07-14 The General Hospital Corporation Polycomb-associated non-coding RNAs
US9920317B2 (en) 2010-11-12 2018-03-20 The General Hospital Corporation Polycomb-associated non-coding RNAs
JP6129844B2 (ja) 2011-09-14 2017-05-17 ラナ セラピューティクス インコーポレイテッド 多量体オリゴヌクレオチド化合物
WO2013148283A1 (en) 2012-03-30 2013-10-03 Isis Pharmaceuticals, Inc. Compositions and methods for modulating tau expression for reducing seizure and modifying a neurodegenerative syndrome
JP2015523853A (ja) 2012-05-16 2015-08-20 ラナ セラピューティクス インコーポレイテッド Ａｔｐ２ａ２発現を調節するための組成物及び方法
EA201492121A1 (ru) 2012-05-16 2015-10-30 Рана Терапьютикс, Инк. Композиции и способы для модулирования экспрессии семейства генов гемоглобина
AU2013262709A1 (en) 2012-05-16 2015-01-22 Rana Therapeutics, Inc. Compositions and methods for modulating MECP2 expression
SG11201407486PA (en) 2012-05-16 2014-12-30 Rana Therapeutics Inc Compositions and methods for modulating utrn expression
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
KR20150030205A (ko) 2012-05-16 2015-03-19 라나 테라퓨틱스, 인크. Smn 유전자 패밀리 발현을 조절하기 위한 조성물 및 방법
CA2884608C (en) 2012-09-14 2025-05-20 Translate Bio Ma, Inc. MULTIMERIC OLIGONUCLEOTIDE COMPOUNDS
CN111254145A (zh) 2013-03-14 2020-06-09 Ionis制药公司 用于调节tau表达的组合物和方法
ES2787600T3 (es) * 2013-07-02 2020-10-16 Ionis Pharmaceuticals Inc Moduladores del receptor de la hormona del crecimiento
TWI657819B (zh) 2013-07-19 2019-05-01 美商Ionis製藥公司 用於調節τ蛋白表現之組合物
EP3033422A4 (en) 2013-08-16 2017-08-02 Rana Therapeutics Inc. Oligonucleotides targeting euchromatin regions of genes
US20170044540A1 (en) * 2014-04-22 2017-02-16 Mina Therapeutics Limited Sarna compositions and methods of use
AU2015252841B2 (en) 2014-05-01 2020-03-19 Ionis Pharmaceuticals, Inc. Compositions and methods for modulating growth hormone receptor expression
US10858650B2 (en) 2014-10-30 2020-12-08 The General Hospital Corporation Methods for modulating ATRX-dependent gene repression
WO2016130943A1 (en) 2015-02-13 2016-08-18 Rana Therapeutics, Inc. Hybrid oligonucleotides and uses thereof
EP3256590A4 (en) * 2015-02-13 2018-10-03 Translate Bio Ma, Inc. Targeting oligonucleotides and uses thereof to modulate gene expression
WO2016149455A2 (en) 2015-03-17 2016-09-22 The General Hospital Corporation The rna interactome of polycomb repressive complex 1 (prc1)
ES2963428T3 (es) 2016-09-29 2024-03-27 Biogen Ma Inc Compuestos y métodos para reducir la expresión de Tau
AU2017368050A1 (en) 2016-11-29 2019-06-20 Puretech Lyt, Inc. Exosomes for delivery of therapeutic agents
EP4219715A3 (en) 2017-09-08 2023-09-06 MiNA Therapeutics Limited Stabilized cebpa sarna compositions and methods of use
CA3075205A1 (en) 2017-09-08 2019-03-14 Mina Therapeutics Limited Stabilized hnf4a sarna compositions and methods of use
EP3700570B1 (en) * 2017-10-23 2025-01-08 Stoke Therapeutics, Inc. Antisense oligomers for treatment of non-sense mediated rna decay based conditions and diseases
WO2020007892A1 (en) * 2018-07-03 2020-01-09 F. Hoffmann-La Roche Ag Oligonucleotides for modulating tau expression
KR102598357B1 (ko) 2018-09-04 2023-11-07 프로토타입 앤드 프로덕션 시스템스, 인코포레이티드 프린트 모듈을 위한 순응형 프린트헤드 위치 결정 장치
EP4017539A1 (en) 2019-08-19 2022-06-29 MiNA Therapeutics Limited Oligonucleotide conjugate compositions and methods of use
US12194057B2 (en) * 2020-12-17 2025-01-14 Washington University NXTAR-derived oligonucleotides and uses thereof
WO2024042370A1 (en) 2022-08-26 2024-02-29 Waters Technologies Corporation Composite particles with non-porous hybrid organic-inorganic material

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008044958A (ja) * 2000-11-20 2008-02-28 Board Of Trustees Of The Univ Of Illinois 膜スカホールドタンパク質

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6617122B1 (en) * 1999-03-15 2003-09-09 Xenon Genetics, Inc. Process for identifying modulators of ABC1 activity
WO2002103015A2 (en) * 2001-06-14 2002-12-27 Active Pass Pharmaceuticals, Inc. Abca10 transporter
US7259150B2 (en) * 2001-08-07 2007-08-21 Isis Pharmaceuticals, Inc. Modulation of apolipoprotein (a) expression
US20050265927A1 (en) * 2004-05-17 2005-12-01 Yale University Intranasal delivery of nucleic acid molecules
WO2008103761A2 (en) * 2007-02-20 2008-08-28 Sequenom, Inc. Methods and compositions for cancer diagnosis and treatment based on nucleic acid methylation
CA2739464C (en) * 2008-10-03 2020-03-31 Curna, Inc. Treatment of apolipoprotein-a1 related diseases by inhibition of natural antisense transcript to apolipoprotein-a1
GB0821457D0 (en) * 2008-11-24 2008-12-31 Trillion Genomics Ltd Oligonucleotides
CN102459596B (zh) * 2009-05-06 2016-09-07 库尔纳公司 通过针对脂质转运和代谢基因的天然反义转录物的抑制治疗脂质转运和代谢基因相关疾病
EP2655621B1 (en) * 2010-12-20 2018-05-23 The General Hospital Corporation Polycomb-associated non-coding rnas
CN104583398A (zh) * 2012-05-16 2015-04-29 Rana医疗有限公司 用于调节基因表达的组合物和方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008044958A (ja) * 2000-11-20 2008-02-28 Board Of Trustees Of The Univ Of Illinois 膜スカホールドタンパク質

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BIOORG. MED. CHEM. LETT., vol. 22, JPN6017009553, 2012, pages 2963 - 2967, ISSN: 0003521140 *
ELECTROPHORESIS, vol. 24, JPN6017009552, 2003, pages 3748 - 3754, ISSN: 0003521139 *
J. CLIN. INVEST., vol. 116, no. 12, JPN6017009555, 2006, pages 3090 - 3100, ISSN: 0003521141 *
MOL. CELL, vol. 40, JPN6017009567, 2010, pages 939 - 953, ISSN: 0003521146 *
MOL. CELL. BIOL., vol. 28, no. 20, JPN6017009560, 2008, pages 6473 - 6482, ISSN: 0003521143 *
PLOS ONE, vol. Vol.7, Issue 5, JPN6017009563, 2012, pages 36365, ISSN: 0003521144 *
PROC. NATL. ACAD. SCI., vol. 106, no. 28, JPN6017009564, 2009, pages 11667 - 11672, ISSN: 0003521145 *
中尾光善: ""エピジェネティクス機構による遺伝子クラスター制御および細胞病態"", 上原記念生命科学財団研究報告集, vol. 23, JPN6017009557, 2003, pages 54, ISSN: 0003521142 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11584932B2 (en) 2016-11-01 2023-02-21 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
US12371693B2 (en) 2016-11-01 2025-07-29 The Research Foundation For The State University Of New York 5-halouracil-modified micrornas and their use in the treatment of cancer
JP2021514182A (ja) * 2018-02-09 2021-06-10 ジェネンテック， インコーポレイテッド Ｔｍｅｍ１０６ｂ発現を調節するためのオリゴヌクレオチド
JP7281474B2 (ja) 2018-02-09 2023-05-25 ジェネンテック， インコーポレイテッド Ｔｍｅｍ１０６ｂ発現を調節するためのオリゴヌクレオチド
US12319913B2 (en) 2018-10-31 2025-06-03 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer

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AU2013262658A1 (en) 2015-01-22
EA201492119A1 (ru) 2015-05-29
CA2873801A1 (en) 2013-11-21
WO2013173647A1 (en) 2013-11-21
EP2849801A4 (en) 2016-05-25
US20150191722A1 (en) 2015-07-09
BR112014028645A2 (pt) 2017-06-27
EP2849801A1 (en) 2015-03-25
CN104582737A (zh) 2015-04-29

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