JP2015523328A5 - - Google Patents
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- Publication number
- JP2015523328A5 JP2015523328A5 JP2015511443A JP2015511443A JP2015523328A5 JP 2015523328 A5 JP2015523328 A5 JP 2015523328A5 JP 2015511443 A JP2015511443 A JP 2015511443A JP 2015511443 A JP2015511443 A JP 2015511443A JP 2015523328 A5 JP2015523328 A5 JP 2015523328A5
- Authority
- JP
- Japan
- Prior art keywords
- ctla
- polypeptide
- amino acid
- acid sequence
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 21
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims 21
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 21
- 229920001184 polypeptide Polymers 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 238000000034 method Methods 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 2
- 102000054189 human CD80 Human genes 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 2
- 101000946850 Homo sapiens T-lymphocyte activation antigen CD86 Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 102000049849 human CD86 Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261645686P | 2012-05-11 | 2012-05-11 | |
| US61/645,686 | 2012-05-11 | ||
| PCT/US2013/030179 WO2013169338A1 (en) | 2012-05-11 | 2013-03-11 | Ctla-4 variants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015523328A JP2015523328A (ja) | 2015-08-13 |
| JP2015523328A5 true JP2015523328A5 (cg-RX-API-DMAC7.html) | 2016-03-31 |
| JP6228971B2 JP6228971B2 (ja) | 2017-11-08 |
Family
ID=49551120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015511443A Active JP6228971B2 (ja) | 2012-05-11 | 2013-03-11 | Ｃｔｌａ−４バリアント |
Country Status (17)
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4119857A1 (de) | 1991-06-17 | 1992-12-24 | Basf Lacke & Farben | Ueberzugsmittel auf der basis von carboxylgruppenhaltigen polymeren und epoxidharzen |
| RU2671465C2 (ru) * | 2012-05-11 | 2018-10-31 | Медиммьюн Лимитед | Варианты ctla-4 |
| PL2867251T3 (pl) * | 2012-06-29 | 2020-03-31 | Bristol-Myers Squibb Company | Sposoby zmniejszania agregacji glikoprotein |
| WO2014138188A1 (en) * | 2013-03-07 | 2014-09-12 | The General Hospital Corporation | Human ctla4 mutants and use thereof |
| CN105916883B (zh) * | 2014-01-28 | 2019-12-03 | 北京韩美药品有限公司 | 双功能融合蛋白及其制备方法和用途 |
| EP3244907B1 (en) * | 2015-01-13 | 2020-02-19 | City of Hope | Ctla4-binding protein peptide-linker masks |
| MA41459A (fr) | 2015-02-03 | 2017-12-12 | Als Therapy Development Inst | Anticorps anti-cd40l et méthodes pour traiter des maladies ou des troubles liés aux cd40l |
| EP3283508B1 (en) | 2015-04-17 | 2021-03-17 | Alpine Immune Sciences, Inc. | Immunomodulatory proteins with tunable affinities |
| US11351224B2 (en) | 2015-08-21 | 2022-06-07 | Iucf-Hyu (Industry-University Cooperation Foundation Hanyang University) | Pharmaceutical composition for preventing and treating transplant rejection |
| CN108137659B (zh) | 2015-08-21 | 2021-11-26 | 汉阳大学校产学协力团 | 具有预防或治疗中枢神经系统疾病作用的肽和包含其作为活性成分的药物组合物 |
| WO2017034244A1 (ko) * | 2015-08-21 | 2017-03-02 | 한양대학교 산학협력단 | 중추신경계 질환에 대한 예방 또는 치료효과를 갖는 펩타이드 및 이를 유효성분으로 하는 중추신경계 질환 예방 및 치료용 약학적 조성물 |
| JP2018534245A (ja) * | 2015-09-14 | 2018-11-22 | アルパイン イミューン サイエンシズ インコーポレイテッド | 調整可能なバリアント免疫グロブリンスーパーファミリードメインおよび改変細胞療法 |
| MA44082A (fr) | 2015-12-14 | 2018-10-24 | Macrogenics Inc | Molécules bispécifiques présentant une immunoréactivité par rapport à pd-1 et à ctla-4 et leurs procédés d'utilisation |
| KR101918456B1 (ko) * | 2015-12-15 | 2018-11-16 | 앱클론(주) | Cd80 및 cd86에 특이적으로 결합하는 항체 |
| KR20190006495A (ko) | 2016-04-15 | 2019-01-18 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Cd80 변이체 면역조절 단백질 및 그의 용도 |
| KR20230051602A (ko) | 2016-04-15 | 2023-04-18 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Icos 리간드 변이체 면역조절 단백질 및 그의 용도 |
| US11471488B2 (en) | 2016-07-28 | 2022-10-18 | Alpine Immune Sciences, Inc. | CD155 variant immunomodulatory proteins and uses thereof |
| WO2018022945A1 (en) | 2016-07-28 | 2018-02-01 | Alpine Immune Sciences, Inc. | Cd112 variant immunomodulatory proteins and uses thereof |
| EP3596115A1 (en) | 2017-03-16 | 2020-01-22 | Alpine Immune Sciences, Inc. | Pd-l2 variant immunomodulatory proteins and uses thereof |
| WO2018170026A2 (en) | 2017-03-16 | 2018-09-20 | Alpine Immune Sciences, Inc. | Cd80 variant immunomodulatory proteins and uses thereof |
| RU2022108410A (ru) | 2017-05-24 | 2022-04-05 | ЭйЭлЭс ТЕРАПИ ДЕВЕЛОПМЕНТ ИНСТИТЬЮТ | Терапевтические антитела против лиганда cd40 |
| KR102813968B1 (ko) * | 2017-10-10 | 2025-05-29 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Ctla-4 변이체 면역조절 단백질 및 이의 용도 |
| SG11202003078VA (en) | 2017-10-18 | 2020-05-28 | Alpine Immune Sciences Inc | Variant icos ligand immunomodulatory proteins and related compositions and methods |
| BR112020013236A2 (pt) | 2018-01-03 | 2020-12-01 | Alpine Immune Sciences, Inc. | proteínas imunomoduladoras de múltiplos domínios e métodos de seu uso |
| WO2019241758A1 (en) | 2018-06-15 | 2019-12-19 | Alpine Immune Sciences, Inc. | Pd-1 variant immunomodulatory proteins and uses thereof |
| WO2020088645A1 (en) | 2018-11-02 | 2020-05-07 | Beijing Vdjbio Co., Ltd. | Modified ctla4 and methods of use thereof |
| WO2020210596A1 (en) * | 2019-04-10 | 2020-10-15 | University Of Kentucky Research Foundation | Modified prostate apoptosis response-4 (par-4) polypeptide, and methods of production and use |
| CA3166299A1 (en) * | 2020-01-11 | 2021-07-15 | Paul STABACH | Compositions and methods for treating, ameliorating, and/or preventing diseases or disorders caused by or associated with dnase1 and/or dnase1l3 deficiency |
| EP4045533B1 (en) | 2020-03-26 | 2023-11-15 | Vanderbilt University | Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (sars-cov-2) |
| CA3171795A1 (en) * | 2020-04-06 | 2021-10-14 | Jintang DU | Modular synthetic receptors and methods of use |
| EP4142792A4 (en) | 2020-05-01 | 2024-11-27 | Kashiv Biosciences, LLC | An improved process of purification of protein |
| CN112661865A (zh) * | 2020-12-31 | 2021-04-16 | 厚朴生物科技（苏州）有限公司 | 针对新型冠状病毒的疫苗以及其应用 |
| US20250236640A1 (en) * | 2021-10-08 | 2025-07-24 | Kashiv Biosciences, Llc | Separation of pre-peak in fusion protein sample by using size exclusion high performance liquid chromatography |
| CA3234496A1 (en) * | 2021-10-08 | 2023-04-13 | Kashiv Biosciences, Llc | Separation of pre-peak and post-peak in fusion protein sample by using size exclusion high performance liquid chromatography |
| CA3242952A1 (en) * | 2021-12-17 | 2025-04-29 | Kashiv Biosciences, Llc | IMPROVED DOSAGE METHOD FOR DETERMINING THE POTENCY OF A RECOMBINATING PROTEIN |
| TW202342510A (zh) | 2022-02-18 | 2023-11-01 | 英商Ｒｑ生物科技有限公司 | 抗體 |
| WO2024211211A1 (en) | 2023-04-03 | 2024-10-10 | Regeneron Pharmaceuticals, Inc. | Methods of improving transplant survival using il-2 receptor gamma chain antibodies |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU661854B2 (en) | 1991-06-27 | 1995-08-10 | Bristol-Myers Squibb Company | CTL4A receptor, fusion proteins containing it and uses thereof |
| US6750334B1 (en) | 1996-02-02 | 2004-06-15 | Repligen Corporation | CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor |
| JP2000515731A (ja) * | 1996-06-14 | 2000-11-28 | スミスクライン・ビーチャム・コーポレイション | ６量体融合タンパク質およびその使用 |
| US7094874B2 (en) | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
| MXPA02011534A (es) * | 2000-05-26 | 2004-08-12 | Bristol Myers Squibb Co | Moleculas mutantes ctla4 solubles y uso de las mismas. |
| US20040132101A1 (en) * | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| US7563443B2 (en) * | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| JP4784772B2 (ja) | 2005-07-07 | 2011-10-05 | 東芝ライテック株式会社 | 放電灯点灯装置および電球形蛍光ランプ |
| GB0620934D0 (en) * | 2006-10-20 | 2006-11-29 | Cambridge Antibody Tech | Protein variants |
| EP2222697B1 (en) * | 2007-11-01 | 2012-12-05 | Perseid Therapeutics LLC | Immunosuppressive polypeptides and nucleic acids |
| PT3053932T (pt) * | 2010-02-19 | 2020-10-21 | Xencor Inc | Novas imunoadesinas ctla4-ig |
| KR20130049775A (ko) * | 2010-03-12 | 2013-05-14 | 애브비 바이오테라퓨틱스 인크. | Ｃｔｌａ４ 단백질 및 이의 용도 |
| RU2671465C2 (ru) * | 2012-05-11 | 2018-10-31 | Медиммьюн Лимитед | Варианты ctla-4 |
-
2013
- 2013-03-11 RU RU2014150092A patent/RU2671465C2/ru active
- 2013-03-11 SG SG10201609447XA patent/SG10201609447XA/en unknown
- 2013-03-11 PL PL17163638T patent/PL3207938T3/pl unknown
- 2013-03-11 CA CA2868748A patent/CA2868748C/en active Active
- 2013-03-11 MX MX2018003741A patent/MX385969B/es unknown
- 2013-03-11 US US14/399,685 patent/US9884902B2/en active Active
- 2013-03-11 ES ES17163638T patent/ES2777778T3/es active Active
- 2013-03-11 SG SG11201405968SA patent/SG11201405968SA/en unknown
- 2013-03-11 JP JP2015511443A patent/JP6228971B2/ja active Active
- 2013-03-11 CN CN201710735648.7A patent/CN107540742B/zh active Active
- 2013-03-11 MX MX2014013092A patent/MX355234B/es active IP Right Grant
- 2013-03-11 DK DK17163638.4T patent/DK3207938T3/da active
- 2013-03-11 EP EP17163638.4A patent/EP3207938B1/en active Active
- 2013-03-11 HK HK15110585.3A patent/HK1209644A1/xx unknown
- 2013-03-11 BR BR112014026718-9A patent/BR112014026718B1/pt active IP Right Grant
- 2013-03-11 WO PCT/US2013/030179 patent/WO2013169338A1/en not_active Ceased
- 2013-03-11 CN CN201380024763.3A patent/CN104302309B/zh active Active
- 2013-03-11 HU HUE17163638A patent/HUE048925T2/hu unknown
- 2013-03-11 EP EP13787673.6A patent/EP2863936A4/en not_active Withdrawn
- 2013-03-11 AU AU2013260172A patent/AU2013260172B2/en active Active
- 2013-03-11 KR KR1020147031064A patent/KR102133060B1/ko active Active
-
2017
- 2017-12-21 US US15/850,990 patent/US20180208639A1/en not_active Abandoned
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