JP2015522526A5 - - Google Patents
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- Publication number
- JP2015522526A5 JP2015522526A5 JP2015510590A JP2015510590A JP2015522526A5 JP 2015522526 A5 JP2015522526 A5 JP 2015522526A5 JP 2015510590 A JP2015510590 A JP 2015510590A JP 2015510590 A JP2015510590 A JP 2015510590A JP 2015522526 A5 JP2015522526 A5 JP 2015522526A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- antibody construct
- construct
- monovalent antibody
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims description 48
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 48
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 48
- 239000000427 antigen Substances 0.000 claims description 25
- 102000036639 antigens Human genes 0.000 claims description 25
- 108091007433 antigens Proteins 0.000 claims description 25
- 102000004169 proteins and genes Human genes 0.000 claims description 16
- 108090000623 proteins and genes Proteins 0.000 claims description 16
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 14
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 14
- 239000000833 heterodimer Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- 238000002844 melting Methods 0.000 claims description 8
- 230000008018 melting Effects 0.000 claims description 8
- 150000001413 amino acids Chemical class 0.000 claims description 5
- 229960002087 pertuzumab Drugs 0.000 claims description 4
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 238000012986 modification Methods 0.000 claims description 3
- 230000004048 modification Effects 0.000 claims description 3
- 229960000575 trastuzumab Drugs 0.000 claims description 3
- 102000009490 IgG Receptors Human genes 0.000 claims description 2
- 108010073807 IgG Receptors Proteins 0.000 claims description 2
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 14
- 210000004027 cell Anatomy 0.000 claims 10
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 210000004962 mammalian cell Anatomy 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 2
- 230000005888 antibody-dependent cellular phagocytosis Effects 0.000 claims 2
- 101100402572 Arabidopsis thaliana MS5 gene Proteins 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 1
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000015694 estrogen receptors Human genes 0.000 claims 1
- 108010038795 estrogen receptors Proteins 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 229960003387 progesterone Drugs 0.000 claims 1
- 239000000186 progesterone Substances 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 101150029707 ERBB2 gene Proteins 0.000 description 22
- 230000035772 mutation Effects 0.000 description 14
- 229940022353 herceptin Drugs 0.000 description 5
- 230000009824 affinity maturation Effects 0.000 description 2
- 239000012636 effector Substances 0.000 description 2
- 238000000329 molecular dynamics simulation Methods 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261645547P | 2012-05-10 | 2012-05-10 | |
| US61/645,547 | 2012-05-10 | ||
| US201261671640P | 2012-07-13 | 2012-07-13 | |
| US61/671,640 | 2012-07-13 | ||
| US201261722070P | 2012-11-02 | 2012-11-02 | |
| US61/722,070 | 2012-11-02 | ||
| US201361762812P | 2013-02-08 | 2013-02-08 | |
| US61/762,812 | 2013-02-08 | ||
| PCT/CA2013/050358 WO2013166604A1 (en) | 2012-05-10 | 2013-05-08 | Single-arm monovalent antibody constructs and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522526A JP2015522526A (ja) | 2015-08-06 |
| JP2015522526A5 true JP2015522526A5 (https=) | 2017-11-02 |
| JP6849868B2 JP6849868B2 (ja) | 2021-03-31 |
Family
ID=49550028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015510590A Expired - Fee Related JP6849868B2 (ja) | 2012-05-10 | 2013-05-08 | シングルアーム一価抗体構築物およびその用途 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20150125449A1 (https=) |
| EP (1) | EP2847224A4 (https=) |
| JP (1) | JP6849868B2 (https=) |
| KR (1) | KR20150008171A (https=) |
| CN (1) | CN104520327B (https=) |
| AU (1) | AU2013258844B2 (https=) |
| CA (1) | CA2873720A1 (https=) |
| RU (1) | RU2014148704A (https=) |
| WO (1) | WO2013166604A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2635607T3 (pl) | 2010-11-05 | 2020-05-18 | Zymeworks Inc. | Projekt stabilnego przeciwciała heterodimerowego z mutacjami w domenie FC |
| AU2012222833B2 (en) | 2011-03-03 | 2017-03-16 | Zymeworks Inc. | Multivalent heteromultimer scaffold design and constructs |
| CA2854233C (en) | 2011-11-04 | 2020-05-12 | Zymeworks Inc. | Stable heterodimeric antibody design with mutations in the fc domain |
| MX361875B (es) | 2012-03-14 | 2018-12-18 | Regeneron Pharma | Moléculas de unión de antígeno multiespecifícas y usos de las mismas. |
| WO2014004586A1 (en) | 2012-06-25 | 2014-01-03 | Zymeworks Inc. | Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells |
| CN104768571B (zh) | 2012-07-13 | 2018-11-09 | 酵活有限公司 | 多价异多聚体支架设计和构建体 |
| EP2914634B1 (en) * | 2012-11-02 | 2017-12-06 | Zymeworks Inc. | Crystal structures of heterodimeric fc domains |
| US9914785B2 (en) | 2012-11-28 | 2018-03-13 | Zymeworks Inc. | Engineered immunoglobulin heavy chain-light chain pairs and uses thereof |
| WO2015006507A1 (en) | 2013-07-09 | 2015-01-15 | Annexon, Inc. | Methods of treatment for alzheimer's disease and huntington's disease |
| AU2014348552A1 (en) * | 2013-11-13 | 2016-06-02 | Zymeworks Inc. | Monovalent antigen binding constructs targeting EGFR and/or HER2 and uses thereof |
| HRP20250551T1 (hr) | 2013-11-27 | 2025-06-20 | Zymeworks Bc Inc. | Bispecifični antigen-vezujući konstrukti koji ciljaju her2 |
| EP3223848B1 (en) | 2014-11-27 | 2024-11-27 | Zymeworks BC Inc. | Methods of using bispecific antigen-binding constructs targeting her2 |
| US10336816B2 (en) * | 2015-02-24 | 2019-07-02 | Academia Sinica | Phage-displayed single-chain variable fragment library |
| US11028182B2 (en) | 2015-05-13 | 2021-06-08 | Zymeworks Inc. | Antigen-binding constructs targeting HER2 |
| MY189159A (en) | 2015-07-06 | 2022-01-29 | Regeneron Pharma | Multispecific antigen-binding molecules and uses thereof |
| WO2017008169A1 (en) | 2015-07-15 | 2017-01-19 | Zymeworks Inc. | Drug-conjugated bi-specific antigen-binding constructs |
| EP3337826A1 (en) | 2015-08-20 | 2018-06-27 | Sutro Biopharma, Inc. | Anti-tim-3 antibodies, compositions comprising anti-tim-3 antibodies and methods of making and using anti-tim-3 antibodies |
| WO2017091719A1 (en) | 2015-11-24 | 2017-06-01 | Annexon, Inc. | Anti-complement factor c1q fab fragments and uses thereof |
| CN109153727A (zh) * | 2016-04-15 | 2019-01-04 | 酵活有限公司 | 靶向免疫治疗剂的多特异性抗原结合构建体 |
| WO2017190079A1 (en) | 2016-04-28 | 2017-11-02 | Regeneron Pharmaceuticals, Inc. | Methods of making multispecific antigen-binding molecules |
| WO2018156777A1 (en) * | 2017-02-22 | 2018-08-30 | Sutro Biopharma, Inc. | Pd-1/tim-3 bi-specific antibodies, compositions thereof, and methods of making and using the same |
| JOP20190222A1 (ar) | 2017-04-11 | 2019-09-24 | Zymeworks Inc | الأجسام المضادة ثنائية النوعية المضادة لـ pd-l1 والمضادة لـ tim-3 |
| AR112603A1 (es) | 2017-07-10 | 2019-11-20 | Lilly Co Eli | Anticuerpos biespecíficos inhibidores de punto de control |
| US12240875B2 (en) | 2017-12-08 | 2025-03-04 | argenx BV | Use of FCRN antagonists for treatment of generalized myasthenia gravis |
| MX2020011487A (es) | 2018-04-30 | 2020-12-07 | Regeneron Pharma | Anticuerpos y moleculas biespecificas de union al antigeno que se unen a her2 y/o aplp2, conjugados y usos de estos. |
| CA3101462A1 (en) | 2018-06-08 | 2019-12-12 | Argenx Bvba | Compositions and methods for treating immune thrombocytopenia |
| MX2021001915A (es) | 2018-08-17 | 2021-05-31 | Regeneron Pharma | Metodo y sistema de cromatografia para determinar la cantidad y pureza de una proteina multimerica. |
| BR112022013554A2 (pt) | 2020-01-08 | 2022-09-06 | argenx BV | Métodos para tratar distúrbios do pênfigo |
| WO2022225329A1 (ko) * | 2021-04-20 | 2022-10-27 | 고려대학교 산학협력단 | 향상된 암세포 사멸효능을 갖는 비대칭 항체 |
| WO2023114763A1 (en) * | 2021-12-13 | 2023-06-22 | Annexon, Inc. | Anti-complement factor c1q antibodies with single binding arms and uses thereof |
| CA3258000A1 (en) | 2022-06-15 | 2023-12-21 | argenx BV | FCRN/ANTIGEN BINDING MOLECULES AND METHODS OF USE |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658672B (zh) * | 2002-10-08 | 2017-09-26 | 免疫医疗公司 | 用iii类抗cea单克隆抗体和治疗剂进行联合治疗 |
| KR100956913B1 (ko) * | 2003-12-19 | 2010-05-11 | 제넨테크, 인크. | 치료제로서 유용한 일가 항체 단편 |
| GB0614780D0 (en) * | 2006-07-25 | 2006-09-06 | Ucb Sa | Biological products |
| EP2144930A1 (en) * | 2007-04-18 | 2010-01-20 | ZymoGenetics, Inc. | Single chain fc, methods of making and methods of treatment |
| ES2563027T3 (es) * | 2008-01-07 | 2016-03-10 | Amgen Inc. | Método para fabricación de moléculas heterodímeras Fc de anticuerpos utilizando efectos de conducción electrostática |
| EP2260056A1 (en) * | 2008-03-06 | 2010-12-15 | Genentech, Inc. | Combination therapy with c-met and her antagonists |
| MX2011004050A (es) * | 2008-10-17 | 2011-05-10 | Genentech Inc | Metodo de tratamiento. |
| BR112012024489A2 (pt) * | 2010-03-29 | 2016-05-31 | Zymeworks Inc | anticorpos com função efetora suprimida ou aumentada |
| DK2560993T3 (da) * | 2010-04-20 | 2024-10-14 | Genmab As | Heterodimeric antibody fc-containing proteins and methods for production thereof |
| JP6082344B2 (ja) * | 2010-05-27 | 2017-02-15 | ゲンマブ エー／エス | Ｈｅｒ２エピトープに対するモノクローナル抗体 |
| SG10201505217WA (en) * | 2010-07-09 | 2015-08-28 | Biogen Hemophilia Inc | Chimeric clotting factors |
| PL2635607T3 (pl) * | 2010-11-05 | 2020-05-18 | Zymeworks Inc. | Projekt stabilnego przeciwciała heterodimerowego z mutacjami w domenie FC |
| PL2859017T3 (pl) * | 2012-06-08 | 2019-07-31 | Sutro Biopharma, Inc. | Przeciwciała zawierające swoiste dla miejsca, niewystępujące naturalnie reszty aminokwasowe, sposoby ich wytwarzania i sposoby ich zastosowania |
| CA2929834A1 (en) * | 2013-11-13 | 2015-05-21 | Zymeworks Inc. | Methods using monovalent antigen binding constructs targeting her2 |
| JP6531010B2 (ja) * | 2015-08-19 | 2019-06-12 | 本田技研工業株式会社 | 駆動装置、輸送機器及び蓄電器制御方法 |
-
2013
- 2013-05-08 US US14/399,789 patent/US20150125449A1/en not_active Abandoned
- 2013-05-08 JP JP2015510590A patent/JP6849868B2/ja not_active Expired - Fee Related
- 2013-05-08 EP EP13788508.3A patent/EP2847224A4/en not_active Withdrawn
- 2013-05-08 RU RU2014148704A patent/RU2014148704A/ru not_active Application Discontinuation
- 2013-05-08 CA CA2873720A patent/CA2873720A1/en not_active Abandoned
- 2013-05-08 WO PCT/CA2013/050358 patent/WO2013166604A1/en not_active Ceased
- 2013-05-08 AU AU2013258844A patent/AU2013258844B2/en not_active Ceased
- 2013-05-08 CN CN201380036769.2A patent/CN104520327B/zh not_active Expired - Fee Related
- 2013-05-08 KR KR1020147034415A patent/KR20150008171A/ko not_active Ceased
-
2016
- 2016-10-20 US US15/298,625 patent/US20170174783A1/en not_active Abandoned
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